This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008] See more...

Aliases for RRP15 Gene

Aliases for RRP15 Gene

  • Ribosomal RNA Processing 15 Homolog 2 3 5
  • KIAA0507 2 3 4
  • Ribosomal RNA-Processing Protein 15 3 4
  • RRP15-Like Protein 3 4
  • CGI-115 2 3
  • Ribosomal RNA Processing 15 Homolog (S. Cerevisiae) 2
  • RRP15 5

External Ids for RRP15 Gene

Previous HGNC Symbols for RRP15 Gene

  • KIAA0507

Previous GeneCards Identifiers for RRP15 Gene

  • GC01P216526
  • GC01P218458
  • GC01P189126

Summaries for RRP15 Gene

Entrez Gene Summary for RRP15 Gene

  • This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for RRP15 Gene

RRP15 (Ribosomal RNA Processing 15 Homolog) is a Protein Coding gene. Diseases associated with RRP15 include Robinow Syndrome, Autosomal Dominant 1 and Neuronal Ceroid Lipofuscinosis.

Gene Wiki entry for RRP15 Gene

Additional gene information for RRP15 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RRP15 Gene

Genomics for RRP15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RRP15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RRP15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RRP15

Top Transcription factor binding sites by QIAGEN in the RRP15 gene promoter:
  • Bach2
  • c-Myc
  • Evi-1
  • Max1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-5
  • RFX1
  • TGIF

Genomic Locations for RRP15 Gene

Genomic Locations for RRP15 Gene
chr1:218,285,293-218,337,983
(GRCh38/hg38)
Size:
52,691 bases
Orientation:
Plus strand
chr1:218,458,629-218,511,325
(GRCh37/hg19)
Size:
52,697 bases
Orientation:
Plus strand

Genomic View for RRP15 Gene

Genes around RRP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP15 Gene

Proteins for RRP15 Gene

  • Protein details for RRP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B9-RRP15_HUMAN
    Recommended name:
    RRP15-like protein
    Protein Accession:
    Q9Y3B9

    Protein attributes for RRP15 Gene

    Size:
    282 amino acids
    Molecular mass:
    31484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34110.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH20641.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RRP15 Gene

Post-translational modifications for RRP15 Gene

Other Protein References for RRP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP15 Gene

Domains & Families for RRP15 Gene

Gene Families for RRP15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRP15 Gene

InterPro:
Blocks:
  • Protein of unknown function DUF1665
ProtoNet:

Suggested Antigen Peptide Sequences for RRP15 Gene

GenScript: Design optimal peptide antigens:
  • RRP15 protein (A0JLN3_HUMAN)
  • Ribosomal RNA-processing protein 15 (RRP15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3B9

UniProtKB/Swiss-Prot:

RRP15_HUMAN :
  • Belongs to the RRP15 family.
Family:
  • Belongs to the RRP15 family.
genes like me logo Genes that share domains with RRP15: view

Function for RRP15 Gene

Phenotypes From GWAS Catalog for RRP15 Gene

genes like me logo Genes that share phenotypes with RRP15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRP15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP15 Gene

Localization for RRP15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP15 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytoskeleton 1
cytosol 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA 21873635
genes like me logo Genes that share ontologies with RRP15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RRP15 Gene

Pathways & Interactions for RRP15 Gene

PathCards logo

SuperPathways for RRP15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA 21873635
GO:0000470 maturation of LSU-rRNA IBA 21873635
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with RRP15: view

No data available for Pathways by source and SIGNOR curated interactions for RRP15 Gene

Drugs & Compounds for RRP15 Gene

No Compound Related Data Available

Transcripts for RRP15 Gene

mRNA/cDNA for RRP15 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRP15

Alternative Splicing Database (ASD) splice patterns (SP) for RRP15 Gene

No ASD Table

Relevant External Links for RRP15 Gene

GeneLoc Exon Structure for
RRP15

Expression for RRP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RRP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRP15 Gene

This gene is overexpressed in Lung (34.8) and Adrenal (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRP15 Gene



Protein tissue co-expression partners for RRP15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RRP15

SOURCE GeneReport for Unigene cluster for RRP15 Gene:

Hs.660109

Evidence on tissue expression from TISSUES for RRP15 Gene

  • Skin(2.6)
genes like me logo Genes that share expression patterns with RRP15: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP15 Gene

Orthologs for RRP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for RRP15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RRP15 30 31
  • 99.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RRP15 30 31
  • 83.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RRP15 30 31
  • 82.51 (n)
OneToMany
-- 31
  • 68 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Rrp15 30 17 31
  • 77.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rrp15 30
  • 76.24 (n)
Oppossum
(Monodelphis domestica)
Mammalia RRP15 31
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RRP15 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RRP15 30 31
  • 70.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RRP15 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rrp15 30
  • 66 (n)
Str.6662 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18622 30
Zebrafish
(Danio rerio)
Actinopterygii rrp15 30 31
  • 63.78 (n)
OneToOne
wufa20e10 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13265 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG3817 31
  • 26 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
OneToOne
Species where no ortholog for RRP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RRP15 Gene

ENSEMBL:
Gene Tree for RRP15 (if available)
TreeFam:
Gene Tree for RRP15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RRP15: view image

Paralogs for RRP15 Gene

No data available for Paralogs for RRP15 Gene

Variants for RRP15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RRP15 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
709022 Benign: not provided 218,331,057(+) GC/G FRAMESHIFT_VARIANT
rs11118075 - p.Lys149Asn
rs34358288 - p.Ala32Val
rs3737978 - p.Lys230Arg

Additional dbSNP identifiers (rs#s) for RRP15 Gene

Structural Variations from Database of Genomic Variants (DGV) for RRP15 Gene

Variant ID Type Subtype PubMed ID
esv3588869 CNV gain 21293372
nsv1005829 CNV gain 25217958
nsv4598 CNV deletion 18451855

Variation tolerance for RRP15 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRP15 Gene

Human Gene Mutation Database (HGMD)
RRP15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRP15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP15 Gene

Disorders for RRP15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RRP15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
robinow syndrome, autosomal dominant 1
  • drs1
neuronal ceroid lipofuscinosis
  • batten disease
- elite association - COSMIC cancer census association via MalaCards
Search RRP15 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RRP15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRP15 Gene

Publications for RRP15 Gene

  1. The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells. (PMID: 28099941) Dong Z … Jiang W (Oncotarget 2017) 2 3
  2. Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation. (PMID: 15769876) De Marchis ML … Fatica A (RNA (New York, N.Y.) 2005) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4
  5. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3

Products for RRP15 Gene

Sources for RRP15 Gene