Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RRP12 Gene

Aliases for RRP12 Gene

  • Ribosomal RNA Processing 12 Homolog 2 3 5
  • KIAA0690 2 3 4
  • Ribosomal RNA Processing 12 Homolog (S. Cerevisiae) 2
  • RRP12-Like Protein 3

External Ids for RRP12 Gene

Previous HGNC Symbols for RRP12 Gene

  • KIAA0690

Previous GeneCards Identifiers for RRP12 Gene

  • GC10M099107
  • GC10M092741

Summaries for RRP12 Gene

GeneCards Summary for RRP12 Gene

RRP12 (Ribosomal RNA Processing 12 Homolog) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Gene Wiki entry for RRP12 Gene

Additional gene information for RRP12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP12 Gene

Genomics for RRP12 Gene

GeneHancer (GH) Regulatory Elements for RRP12 Gene

Promoters and enhancers for RRP12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I097424 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.9 -896 4.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SP3 PGAM1 RRP12 LOC644215 GC10M097416 TM9SF3 MARVELD1 RPL13AP5 EXOSC1 LOXL4 GC10P097430
GH10I097399 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 589.6 +25.2 25199 2.5 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 E2F8 FOS SP3 ZHX2 RRP12 ENSG00000231970 ENSG00000200737 PGAM1 MMS19 UBTD1 ARHGAP19 RPL34P20 LOC644215
GH10I097405 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 38.2 +18.6 18588 3.8 HDGF ATF1 MLX ARID4B SIN3A ZNF2 ZNF48 TCF12 ARID2 ZNF143 FRAT2 RRP12 FRAT1 ARHGAP19 ZDHHC16 EXOSC1 MMS19 UBTD1 HOGA1 ENSG00000249967
GH10I097355 Enhancer 1 Ensembl ENCODE dbSUPER 34.1 +69.8 69808 2.1 SRF CTCF ZNF654 MAX REST RAD21 ELK1 ZNF143 ZBTB33 RRP12 ARHGAP19 SLIT1 SLIT1-AS1 ENSG00000249967 HOGA1 C10orf62 PI4K2A PGAM1 FRAT2
GH10I097412 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 22.2 +12.0 12009 3.1 ELF3 ATF1 TAF9B NFRKB BMI1 ZNF121 POLR2B EGR1 FOS ATF7 RRP12 ZDHHC16 EXOSC1 MMS19 UBTD1 PGAM1 LCOR ZFYVE27 ARHGAP19 FRAT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RRP12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RRP12 gene promoter:

Genomic Locations for RRP12 Gene

Genomic Locations for RRP12 Gene
chr10:97,356,358-97,426,076
(GRCh38/hg38)
Size:
69,719 bases
Orientation:
Minus strand
chr10:99,116,115-99,161,127
(GRCh37/hg19)

Genomic View for RRP12 Gene

Genes around RRP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP12 Gene

Proteins for RRP12 Gene

  • Protein details for RRP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTH9-RRP12_HUMAN
    Recommended name:
    RRP12-like protein
    Protein Accession:
    Q5JTH9
    Secondary Accessions:
    • B4DK00
    • E9PCK7
    • Q5JTH8
    • Q69YK4
    • Q96E87
    • Q9BUH3
    • Q9Y4C7

    Protein attributes for RRP12 Gene

    Size:
    1297 amino acids
    Molecular mass:
    143702 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31665.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRP12 Gene

Post-translational modifications for RRP12 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RRP12 Gene

Domains & Families for RRP12 Gene

Gene Families for RRP12 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for RRP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JTH9

UniProtKB/Swiss-Prot:

RRP12_HUMAN :
  • Belongs to the RRP12 family.
Family:
  • Belongs to the RRP12 family.
genes like me logo Genes that share domains with RRP12: view

Function for RRP12 Gene

Phenotypes From GWAS Catalog for RRP12 Gene

Gene Ontology (GO) - Molecular Function for RRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with RRP12: view
genes like me logo Genes that share phenotypes with RRP12: view

Animal Model Products

CRISPR Products

miRNA for RRP12 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP12 Gene

Localization for RRP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP12 Gene

Nucleus, nucleolus. Nucleus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP12 gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with RRP12: view

Pathways & Interactions for RRP12 Gene

SuperPathways for RRP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RRP12 Gene

Drugs & Compounds for RRP12 Gene

No Compound Related Data Available

Transcripts for RRP12 Gene

Unigene Clusters for RRP12 Gene

Ribosomal RNA processing 12 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: - -
SP7:
SP8: -
SP9:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RRP12 Gene

GeneLoc Exon Structure for
RRP12
ECgene alternative splicing isoforms for
RRP12

Expression for RRP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRP12 Gene

mRNA differential expression in normal tissues according to GTEx for RRP12 Gene

This gene is overexpressed in Whole Blood (x4.9) and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for RRP12 Gene

This gene is overexpressed in Bone (11.8) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRP12 Gene



Protein tissue co-expression partners for RRP12 Gene

NURSA nuclear receptor signaling pathways regulating expression of RRP12 Gene:

RRP12

SOURCE GeneReport for Unigene cluster for RRP12 Gene:

Hs.434251

mRNA Expression by UniProt/SwissProt for RRP12 Gene:

Q5JTH9-RRP12_HUMAN
Tissue specificity: Weakly expressed. Expressed at intermediate level in testis and ovary.

Evidence on tissue expression from TISSUES for RRP12 Gene

  • Nervous system(4.7)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with RRP12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP12 Gene

Orthologs for RRP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRP12 33 34
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia RRP12 33 34
  • 89.17 (n)
cow
(Bos Taurus)
Mammalia RRP12 33 34
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Rrp12 33 16 34
  • 87.1 (n)
rat
(Rattus norvegicus)
Mammalia Rrp12 33
  • 86.89 (n)
oppossum
(Monodelphis domestica)
Mammalia RRP12 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRP12 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRP12 33 34
  • 73.16 (n)
lizard
(Anolis carolinensis)
Reptilia RRP12 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp12 33
  • 66.56 (n)
zebrafish
(Danio rerio)
Actinopterygii rrp12 33 34
  • 63.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002961 33
  • 46.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2691 33 34
  • 46.05 (n)
worm
(Caenorhabditis elegans)
Secernentea Y46E12BL.2 33 34
  • 42.72 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL014C 33
  • 40.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F27269g 33
  • 40.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP12 33 34 36
  • 38.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34357 33
  • 40.66 (n)
rice
(Oryza sativa)
Liliopsida Os02g0782100 33
  • 41.31 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01675 33
  • 44.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for RRP12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP12 Gene

ENSEMBL:
Gene Tree for RRP12 (if available)
TreeFam:
Gene Tree for RRP12 (if available)

Paralogs for RRP12 Gene

No data available for Paralogs for RRP12 Gene

Variants for RRP12 Gene

Sequence variations from dbSNP and Humsavar for RRP12 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000066791 -- 97,399,081(-) C/T intron_variant
rs1000107939 -- 97,381,032(-) C/T intron_variant
rs1000115977 -- 97,397,883(-) C/G/T intron_variant
rs1000269205 -- 97,375,029(-) T/G intron_variant
rs1000323402 -- 97,362,707(-) G/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RRP12 Gene

Variant ID Type Subtype PubMed ID
nsv948157 CNV duplication 23825009
nsv831952 CNV loss 17160897
nsv825535 CNV gain 20364138
nsv552025 CNV loss 21841781
nsv467440 CNV loss 19166990
nsv1110852 OTHER inversion 24896259
esv2739895 CNV deletion 23290073
esv2739884 CNV deletion 23290073
dgv1369n54 CNV loss 21841781
dgv119n27 CNV loss 19166990

Variation tolerance for RRP12 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.30; 98.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRP12 Gene

Human Gene Mutation Database (HGMD)
RRP12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP12 Gene

Disorders for RRP12 Gene

Additional Disease Information for RRP12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RRP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP12 Gene

Publications for RRP12 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for RRP12 Gene

Sources for RRP12 Gene

Content
Loading form....