Aliases for RRNAD1 Gene

Aliases for RRNAD1 Gene

  • Ribosomal RNA Adenine Dimethylase Domain Containing 1 2 3 5
  • Ribosomal RNA Adenine Dimethylase Domain-Containing Protein 1 3 4
  • Protein RRNAD1 3 4
  • METTL25B 2 3
  • C1orf66 3 4
  • CGI-41 2 3
  • Chromosome 1 Open Reading Frame 66 2
  • RRNAD1 5

External Ids for RRNAD1 Gene

Previous HGNC Symbols for RRNAD1 Gene

  • C1orf66

Previous GeneCards Identifiers for RRNAD1 Gene

  • GC01P156699

Summaries for RRNAD1 Gene

GeneCards Summary for RRNAD1 Gene

RRNAD1 (Ribosomal RNA Adenine Dimethylase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity. An important paralog of this gene is METTL25.

Additional gene information for RRNAD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RRNAD1 Gene

Genomics for RRNAD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RRNAD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RRNAD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RRNAD1

Genomic Locations for RRNAD1 Gene

Genomic Locations for RRNAD1 Gene
chr1:156,728,442-156,736,960
(GRCh38/hg38)
Size:
8,519 bases
Orientation:
Plus strand
chr1:156,698,234-156,706,752
(GRCh37/hg19)
Size:
8,519 bases
Orientation:
Plus strand

Genomic View for RRNAD1 Gene

Genes around RRNAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRNAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRNAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRNAD1 Gene

Proteins for RRNAD1 Gene

  • Protein details for RRNAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FB5-RRNAD_HUMAN
    Recommended name:
    Protein RRNAD1
    Protein Accession:
    Q96FB5
    Secondary Accessions:
    • D3DVC7
    • Q4VX71
    • Q5SZ03
    • Q9Y358

    Protein attributes for RRNAD1 Gene

    Size:
    475 amino acids
    Molecular mass:
    52981 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34037.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for RRNAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRNAD1 Gene

Post-translational modifications for RRNAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRNAD1 Gene

Domains & Families for RRNAD1 Gene

Gene Families for RRNAD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RRNAD1 Gene

Suggested Antigen Peptide Sequences for RRNAD1 Gene

GenScript: Design optimal peptide antigens:
  • Ribosomal RNA adenine dimethylase domain-containing protein 1 (RRNAD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96FB5

UniProtKB/Swiss-Prot:

RRNAD_HUMAN :
  • Belongs to the RRNAD1 family.
Family:
  • Belongs to the RRNAD1 family.
genes like me logo Genes that share domains with RRNAD1: view

Function for RRNAD1 Gene

Phenotypes From GWAS Catalog for RRNAD1 Gene

Gene Ontology (GO) - Molecular Function for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA --
GO:0008649 rRNA methyltransferase activity IEA --
genes like me logo Genes that share ontologies with RRNAD1: view
genes like me logo Genes that share phenotypes with RRNAD1: view

Animal Model Products

CRISPR Products

miRNA for RRNAD1 Gene

miRTarBase miRNAs that target RRNAD1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRNAD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRNAD1 Gene

Localization for RRNAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRNAD1 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRNAD1 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

Pathways & Interactions for RRNAD1 Gene

PathCards logo

SuperPathways for RRNAD1 Gene

No Data Available

Interacting Proteins for RRNAD1 Gene

Selected Interacting proteins: Q96FB5-RRNAD_HUMAN for RRNAD1 Gene via IID

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000154 rRNA modification IEA --
GO:0031167 rRNA methylation IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

No data available for Pathways by source and SIGNOR curated interactions for RRNAD1 Gene

Drugs & Compounds for RRNAD1 Gene

No Compound Related Data Available

Transcripts for RRNAD1 Gene

mRNA/cDNA for RRNAD1 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRNAD1

Alternative Splicing Database (ASD) splice patterns (SP) for RRNAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - - - - -
SP10: - -
SP11: - -

ExUns: 11f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RRNAD1 Gene

GeneLoc Exon Structure for
RRNAD1

Expression for RRNAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RRNAD1 Gene

Protein differential expression in normal tissues from HIPED for RRNAD1 Gene

This gene is overexpressed in Bone marrow stromal cell (58.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRNAD1 Gene



Protein tissue co-expression partners for RRNAD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RRNAD1

SOURCE GeneReport for Unigene cluster for RRNAD1 Gene:

Hs.512597

Evidence on tissue expression from TISSUES for RRNAD1 Gene

  • Eye(4.3)
genes like me logo Genes that share expression patterns with RRNAD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRNAD1 Gene

Orthologs for RRNAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRNAD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RRNAD1 30 31
  • 98.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C1ORF66 31
  • 91 (a)
OneToOne
RRNAD1 30
  • 87.69 (n)
Cow
(Bos Taurus)
Mammalia RRNAD1 30 31
  • 90.46 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rrnad1 30 17 31
  • 85.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rrnad1 30
  • 84.98 (n)
Oppossum
(Monodelphis domestica)
Mammalia RRNAD1 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RRNAD1 30 31
  • 62.24 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RRNAD1 31
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rrnad1 30
  • 60.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25332 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100332368 30
  • 58.08 (n)
rrnad1 31 31
  • 41 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG2906 30 31
  • 45.59 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007607 30
  • 45.14 (n)
Worm
(Caenorhabditis elegans)
Secernentea F25H2.12 30 31
  • 41.11 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G16650 30
  • 39.97 (n)
Rice
(Oryza sativa)
Liliopsida Os12g0610500 30
  • 43.88 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToOne
Species where no ortholog for RRNAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RRNAD1 Gene

ENSEMBL:
Gene Tree for RRNAD1 (if available)
TreeFam:
Gene Tree for RRNAD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RRNAD1: view image

Paralogs for RRNAD1 Gene

Paralogs for RRNAD1 Gene

genes like me logo Genes that share paralogs with RRNAD1: view

Variants for RRNAD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RRNAD1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs4311877 - p.Val400Leu

Additional dbSNP identifiers (rs#s) for RRNAD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RRNAD1 Gene

Variant ID Type Subtype PubMed ID
esv1475923 CNV insertion 17803354
esv2495964 CNV insertion 19546169
esv3326332 CNV duplication 20981092
esv3578200 CNV loss 25503493
nsv831648 CNV loss 17160897

Variation tolerance for RRNAD1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRNAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRNAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRNAD1 Gene

Disorders for RRNAD1 Gene

No disorders were found for RRNAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRNAD1 Gene

Publications for RRNAD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4
  2. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. (PMID: 310876) Peterson RJ … Marsh CL (Journal of periodontology 1979) 2 3
  3. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) Willer CJ … Global Lipids Genetics Consortium (Nature genetics 2013) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3
  5. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3

Products for RRNAD1 Gene

Sources for RRNAD1 Gene