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Aliases for RRNAD1 Gene

Aliases for RRNAD1 Gene

  • Ribosomal RNA Adenine Dimethylase Domain Containing 1 2 3 5
  • Ribosomal RNA Adenine Dimethylase Domain-Containing Protein 1 3 4
  • C1orf66 3 4
  • Chromosome 1 Open Reading Frame 66 2
  • Protein RRNAD1 3
  • METTL25B 3
  • CGI-41 3

External Ids for RRNAD1 Gene

Previous HGNC Symbols for RRNAD1 Gene

  • C1orf66

Summaries for RRNAD1 Gene

GeneCards Summary for RRNAD1 Gene

RRNAD1 (Ribosomal RNA Adenine Dimethylase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity. An important paralog of this gene is METTL25.

Additional gene information for RRNAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRNAD1 Gene

Genomics for RRNAD1 Gene

GeneHancer (GH) Regulatory Elements for RRNAD1 Gene

Promoters and enhancers for RRNAD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I156725 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.7 -655 5.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 ISG20L2 RRNAD1 HDGF MRPL24 GC01M156724 PIR61627
GH01I156111 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 63.3 -607.1 -607053 19.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 LMNA GON4L CLK2 RRNAD1 KHDC4 LOC246784 MSTO1 MSTO2P PRCC ISG20L2
GH01I156486 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 55.2 -229.6 -229578 25.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 MEF2D RRNAD1 GON4L KHDC4 ENSG00000271267 MSTO2P MSTO1 LOC246784 ISG20L2 ENSG00000246203
GH01I156765 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 51.2 +39.5 39504 4.5 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 MEF2D NBN HDGF PRCC RRNAD1 GON4L KHDC4 LOC246784 ISG20L2 CCT3 MRPL24 LRRC71
GH01I156656 Enhancer 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 54.3 -64.2 -64183 15.3 CLOCK MLX ZFP64 DMAP1 IRF4 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 GON4L KHDC4 RRNAD1 LOC246784 PRCC MSTO2P LMNA ISG20L2 YY1AP1 CCT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RRNAD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RRNAD1 Gene

Genomic Locations for RRNAD1 Gene
8,519 bases
Plus strand

Genomic View for RRNAD1 Gene

Genes around RRNAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRNAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRNAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRNAD1 Gene

Proteins for RRNAD1 Gene

  • Protein details for RRNAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RRNAD1
    Protein Accession:
    Secondary Accessions:
    • D3DVC7
    • Q4VX71
    • Q5SZ03
    • Q9Y358

    Protein attributes for RRNAD1 Gene

    475 amino acids
    Molecular mass:
    52981 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34037.1; Type=Frameshift; Positions=154, 165; Evidence={ECO:0000305};

    Alternative splice isoforms for RRNAD1 Gene


neXtProt entry for RRNAD1 Gene

Post-translational modifications for RRNAD1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RRNAD1 Gene

Domains & Families for RRNAD1 Gene

Gene Families for RRNAD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RRNAD1 Gene

Suggested Antigen Peptide Sequences for RRNAD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRNAD1 family.
  • Belongs to the RRNAD1 family.
genes like me logo Genes that share domains with RRNAD1: view

Function for RRNAD1 Gene

Phenotypes From GWAS Catalog for RRNAD1 Gene

Gene Ontology (GO) - Molecular Function for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA --
GO:0008649 rRNA methyltransferase activity IEA --
genes like me logo Genes that share ontologies with RRNAD1: view
genes like me logo Genes that share phenotypes with RRNAD1: view

miRNA for RRNAD1 Gene

miRTarBase miRNAs that target RRNAD1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRNAD1 Gene

Localization for RRNAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRNAD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRNAD1 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

Pathways & Interactions for RRNAD1 Gene

SuperPathways for RRNAD1 Gene

No Data Available

Interacting Proteins for RRNAD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000357199 Q96FB5-RRNAD_HUMAN for RRNAD1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031167 rRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

No data available for Pathways by source and SIGNOR curated interactions for RRNAD1 Gene

Drugs & Compounds for RRNAD1 Gene

No Compound Related Data Available

Transcripts for RRNAD1 Gene

Unigene Clusters for RRNAD1 Gene

Ribosomal RNA adenine dimethylase domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRNAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP9: - - - - - -
SP10: - -
SP11: - -

ExUns: 11f

Relevant External Links for RRNAD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRNAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRNAD1 Gene

Protein differential expression in normal tissues from HIPED for RRNAD1 Gene

This gene is overexpressed in Bone marrow stromal cell (58.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRNAD1 Gene

Protein tissue co-expression partners for RRNAD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RRNAD1 Gene:


SOURCE GeneReport for Unigene cluster for RRNAD1 Gene:


Evidence on tissue expression from TISSUES for RRNAD1 Gene

  • Eye(4.3)
genes like me logo Genes that share expression patterns with RRNAD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRNAD1 Gene

Orthologs for RRNAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRNAD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRNAD1 33 34
  • 98.04 (n)
(Canis familiaris)
Mammalia C1ORF66 34
  • 91 (a)
  • 87.69 (n)
(Bos Taurus)
Mammalia RRNAD1 33 34
  • 90.46 (n)
(Mus musculus)
Mammalia Rrnad1 33 16 34
  • 85.89 (n)
(Rattus norvegicus)
Mammalia Rrnad1 33
  • 84.98 (n)
(Monodelphis domestica)
Mammalia RRNAD1 34
  • 74 (a)
(Gallus gallus)
Aves RRNAD1 33 34
  • 62.24 (n)
(Anolis carolinensis)
Reptilia RRNAD1 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rrnad1 33
  • 60.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25332 33
(Danio rerio)
Actinopterygii LOC100332368 33
  • 58.08 (n)
rrnad1 34 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2906 33 34
  • 45.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007607 33
  • 45.14 (n)
(Caenorhabditis elegans)
Secernentea F25H2.12 33 34
  • 41.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16650 33
  • 39.97 (n)
(Oryza sativa)
Liliopsida Os12g0610500 33
  • 43.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for RRNAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRNAD1 Gene

Gene Tree for RRNAD1 (if available)
Gene Tree for RRNAD1 (if available)

Paralogs for RRNAD1 Gene

Paralogs for RRNAD1 Gene

genes like me logo Genes that share paralogs with RRNAD1: view

Variants for RRNAD1 Gene

Sequence variations from dbSNP and Humsavar for RRNAD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000265049 -- 156,735,212(+) C/G intron_variant
rs1000402548 -- 156,731,851(+) G/T intron_variant
rs1000456130 -- 156,731,518(+) G/T intron_variant
rs1000639299 -- 156,734,891(+) T/C intron_variant
rs1001183087 -- 156,729,224(+) A/G 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RRNAD1 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV loss 17160897
esv3578200 CNV loss 25503493
esv3326332 CNV duplication 20981092
esv2495964 CNV insertion 19546169
esv1475923 CNV insertion 17803354

Variation tolerance for RRNAD1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRNAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRNAD1 Gene

Disorders for RRNAD1 Gene

Additional Disease Information for RRNAD1

No disorders were found for RRNAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRNAD1 Gene

Publications for RRNAD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. (PMID: 310876) Peterson RJ … Marsh CL (Journal of periodontology 1979) 2 3 58
  3. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) Willer CJ … Global Lipids Genetics Consortium (Nature genetics 2013) 3 58
  4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for RRNAD1 Gene

Sources for RRNAD1 Gene

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