Aliases for RRM2 Gene
External Ids for RRM2 Gene
Previous HGNC Symbols for RRM2 Gene
Previous GeneCards Identifiers for RRM2 Gene
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
GeneCards Summary for RRM2 Gene
RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) is a Protein Coding gene. Diseases associated with RRM2 include Choriocarcinoma and Pancreatic Cancer. Among its related pathways are purine nucleotides de novo biosynthesis and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. An important paralog of this gene is RRM2B.
UniProtKB/Swiss-Prot Summary for RRM2 Gene
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.