This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths ... See more...

Aliases for RRM2 Gene

Aliases for RRM2 Gene

  • Ribonucleotide Reductase Regulatory Subunit M2 2 3 5
  • Ribonucleoside-Diphosphate Reductase Subunit M2 3 4
  • Ribonucleotide Reductase M2 Polypeptide 2 3
  • Ribonucleotide Reductase Small Subunit 3 4
  • Ribonucleotide Reductase Small Chain 3 4
  • EC 1.17.4.1 4 51
  • RR2 3 4
  • Chromosome 2 Open Reading Frame 48 2
  • Uncharacterized Protein C2orf48 3
  • FLJ25102 2
  • C2orf48 3
  • RR2M 3
  • RRM2 5
  • R2 3

External Ids for RRM2 Gene

Previous HGNC Symbols for RRM2 Gene

  • C2orf48

Previous GeneCards Identifiers for RRM2 Gene

  • GC02P010047
  • GC02P010314
  • GC02P010267
  • GC02P010284
  • GC02P010213
  • GC02P010179
  • GC02P010262

Summaries for RRM2 Gene

Entrez Gene Summary for RRM2 Gene

  • This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

CIViC Summary for RRM2 Gene

GeneCards Summary for RRM2 Gene

RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) is a Protein Coding gene. Diseases associated with RRM2 include Choriocarcinoma and Mental Retardation, X-Linked, Syndromic, Wu Type. Among its related pathways are E2F transcription factor network and Hepatitis C and Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. An important paralog of this gene is RRM2B.

UniProtKB/Swiss-Prot Summary for RRM2 Gene

  • Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

Gene Wiki entry for RRM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RRM2 Gene

Genomics for RRM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RRM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RRM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RRM2

Top Transcription factor binding sites by QIAGEN in the RRM2 gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • CREB
  • deltaCREB
  • Sp1

Genomic Locations for RRM2 Gene

Genomic Locations for RRM2 Gene
chr2:10,120,698-10,211,725
(GRCh38/hg38)
Size:
91,028 bases
Orientation:
Plus strand
chr2:10,262,455-10,271,546
(GRCh37/hg19)
Size:
9,092 bases
Orientation:
Plus strand

Genomic View for RRM2 Gene

Genes around RRM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRM2 Gene

Proteins for RRM2 Gene

  • Protein details for RRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31350-RIR2_HUMAN
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit M2
    Protein Accession:
    P31350
    Secondary Accessions:
    • B2R9B5
    • J3KP43
    • Q5WRU7

    Protein attributes for RRM2 Gene

    Size:
    389 amino acids
    Molecular mass:
    44878 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    • Heterodimer of a large and a small subunit.
    SequenceCaution:
    • Sequence=DA477511; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2.

    Three dimensional structures from OCA and Proteopedia for RRM2 Gene

    Alternative splice isoforms for RRM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRM2 Gene

Selected DME Specific Peptides for RRM2 Gene

P31350:
  • VEGIFFSG
  • EARCFYGF
  • EYQRMGV
  • AEASFWTAEE
  • RFVIFPI
  • ALPVKLIGMNC
  • EEVDLSKD
  • KPSEERVREII
  • MPGLTFSNELI
  • GKTNFFEK
  • LFNAIET
  • LAFFAASDGIV
  • ENIHSEMYSLL
  • HSEMYSLLIDTY
  • YIEFVAD
  • KKADWALRWI
  • FAAVEGI
  • SNELISRDEGLH
  • NPFDFMENISL
  • MYKKAEASFWT
  • SDGIVNENL
  • AFAAVEG
  • HVLAFFA
  • FYGFQIA
  • FLTEALP

Post-translational modifications for RRM2 Gene

  • Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.
  • Ubiquitination at Lys23, Lys61, Lys217, and Lys311
  • Modification sites at PhosphoSitePlus

Domains & Families for RRM2 Gene

Gene Families for RRM2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RRM2 Gene

InterPro:
Blocks:
  • Ribonucleotide reductase
ProtoNet:

Suggested Antigen Peptide Sequences for RRM2 Gene

GenScript: Design optimal peptide antigens:
  • Ribonucleotide reductase M2 subunit (Q9UKM0_HUMAN)
  • Ribonucleotide reductase small subunit (RIR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31350

UniProtKB/Swiss-Prot:

RIR2_HUMAN :
  • Belongs to the ribonucleoside diphosphate reductase small chain family.
Family:
  • Belongs to the ribonucleoside diphosphate reductase small chain family.
genes like me logo Genes that share domains with RRM2: view

Function for RRM2 Gene

Molecular function for RRM2 Gene

UniProtKB/Swiss-Prot Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10014};.
GENATLAS Biochemistry:
ribonucleotide diphosphate reductase M2 polypeptide,pyrimidine biosynthetic pathway

Enzyme Numbers (IUBMB) for RRM2 Gene

Phenotypes From GWAS Catalog for RRM2 Gene

Gene Ontology (GO) - Molecular Function for RRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor NAS 1627826
GO:0005515 protein binding IPI 17726094
GO:0008199 ferric iron binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with RRM2: view
genes like me logo Genes that share phenotypes with RRM2: view

Animal Models for RRM2 Gene

MGI Knock Outs for RRM2:
  • Rrm2 Rrm2<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for RRM2 Gene

miRTarBase miRNAs that target RRM2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRM2

Clone Products

  • Addgene plasmids for RRM2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RRM2 Gene

Localization for RRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRM2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRM2 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005971 ribonucleoside-diphosphate reductase complex IEA --
genes like me logo Genes that share ontologies with RRM2: view

Pathways & Interactions for RRM2 Gene

genes like me logo Genes that share pathways with RRM2: view

UniProtKB/Swiss-Prot P31350-RIR2_HUMAN

  • Pathway: Genetic information processing; DNA replication.

SIGNOR curated interactions for RRM2 Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication IEA --
GO:0009262 deoxyribonucleotide metabolic process IEA --
GO:0009263 deoxyribonucleotide biosynthetic process ISS --
GO:0015949 nucleobase-containing small molecule interconversion TAS --
genes like me logo Genes that share ontologies with RRM2: view

Drugs & Compounds for RRM2 Gene

(27) Drugs for RRM2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Target, inhibitor Apoptosis inducer in CLL cells 105
Gemcitabine Approved Pharma inhibitor, Biomarker Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2451
Hydroxyurea Approved Pharma inhibitor 259
Clofarabine Approved, Investigational Pharma inhibitor, binder Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 167
Iron Approved, Experimental Pharma 1560

(8) Additional Compounds for RRM2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • D-1beta-Ribofuranosylcytosine diphosphate
  • Deoxycytidine diphosphate
  • 2'-Deoxycytidine 5'-diphosphoric acid
800-73-7
dGDP
  • 2'-Deoxyguanosine 5'-diphosphate
  • Deoxyguanosine diphosphate
  • 2'-Deoxyguanosine 5'-diphosphoric acid
  • Deoxyguanosine diphosphoric acid
  • 2'-Deoxy-GDP
3493-09-2
Trypanothione disulfide
  • 2-amino-4-[4-(4-amino-4-CARBOXY-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyrIC ACID
  • Oxidized trypanothione
  • Trypanothiondisulfid
  • TSST
  • 2-amino-4-[4-(4-amino-4-CARBOXY-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyrate

(5) ApexBio Compounds for RRM2 Gene

Compound Action Cas Number
Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 123318-82-1
Fludarabine Phosphate (Fludara) Inhibits STAT1 activation and DNA synthesis 75607-67-9
Gemcitabine 95058-81-4
Hydroxyurea 127-07-1
Triapine Ribonucleotide reductase inhibitor 236392-56-6
genes like me logo Genes that share compounds with RRM2: view

Transcripts for RRM2 Gene

mRNA/cDNA for RRM2 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRM2

Clone Products

  • Addgene plasmids for RRM2

Alternative Splicing Database (ASD) splice patterns (SP) for RRM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for RRM2 Gene

GeneLoc Exon Structure for
RRM2

Expression for RRM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RRM2 Gene

mRNA differential expression in normal tissues according to GTEx for RRM2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for RRM2 Gene

This gene is overexpressed in Ovary (53.3) and Breast (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRM2 Gene



Protein tissue co-expression partners for RRM2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RRM2

SOURCE GeneReport for Unigene cluster for RRM2 Gene:

Hs.226390

Evidence on tissue expression from TISSUES for RRM2 Gene

  • Skin(4.8)
  • Nervous system(4.7)
  • Muscle(4.6)
  • Intestine(4.1)
  • Kidney(4.1)
  • Liver(3.8)
  • Blood(3.8)
  • Stomach(3.7)
  • Lung(2.9)
  • Lymph node(2.6)
  • Eye(2.6)
  • Bone marrow(2.6)
  • Heart(2.4)
  • Pancreas(2.3)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with RRM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRM2 Gene

Orthologs for RRM2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RRM2 30
  • 96.44 (n)
Dog
(Canis familiaris)
Mammalia RRM2 30 31
  • 91.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RRM2 30 31
  • 91.43 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia RRM2 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Rrm2 30 17 31
  • 88.17 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100359539 30
  • 86.89 (n)
Chicken
(Gallus gallus)
Aves RRM2 30 31
  • 79.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RRM2 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rrm2.2 30
  • 77.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia rrm2-prov 30
Zebrafish
(Danio rerio)
Actinopterygii rrm2 30 31 31
  • 84 (a)
OneToMany
LOC100330864 30
  • 74.78 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12256 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006818 30
  • 70.62 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta RnrS 30 31 32
  • 70.52 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rnr-2 30 31 32
  • 64.9 (n)
ManyToMany
F58F9.1 31
  • 13 (a)
ManyToMany
F19G12.2 31 32
  • 10 (a)
ManyToMany
Y57G11C.21 31
  • 9 (a)
ManyToMany
F54H12.2 31
  • 6 (a)
ManyToMany
K09F6.5 31
  • 5 (a)
ManyToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAL136C 30
  • 67.18 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNR2 30 31 33
  • 64.39 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15103g 30
  • 64.18 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons TSO2 30
  • 62.04 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0127900 30
  • 62.48 (n)
Os.9043 30
Barley
(Hordeum vulgare)
Liliopsida Hv.2712 30
Corn
(Zea mays)
Liliopsida Zm.5996 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2425 31
  • 70 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU07887 30
  • 65.96 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes suc22 30
  • 64.69 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4812 30
Species where no ortholog for RRM2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RRM2 Gene

ENSEMBL:
Gene Tree for RRM2 (if available)
TreeFam:
Gene Tree for RRM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RRM2: view image

Paralogs for RRM2 Gene

Paralogs for RRM2 Gene

(2) SIMAP similar genes for RRM2 Gene using alignment to 2 proteins:

  • RIR2_HUMAN
  • C9JXC1_HUMAN

Pseudogenes.org Pseudogenes for RRM2 Gene

genes like me logo Genes that share paralogs with RRM2: view

Variants for RRM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RRM2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
711013 Benign: not provided 10,122,846(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs13406078 - p.Pro90Leu
rs7423163 - p.Trp119Ser

Additional dbSNP identifiers (rs#s) for RRM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RRM2 Gene

Variant ID Type Subtype PubMed ID
dgv146e55 CNV gain 17911159
dgv3715n100 CNV gain 25217958
esv2176584 CNV deletion 18987734
esv2719634 CNV deletion 23290073
esv2719635 CNV deletion 23290073
esv2719636 CNV deletion 23290073
esv2759024 CNV gain 17122850
esv3372133 CNV duplication 20981092
esv3589793 CNV gain 21293372
nsv1072921 CNV deletion 25765185
nsv1117229 CNV tandem duplication 24896259
nsv818977 CNV gain 17921354
nsv954759 CNV deletion 24416366

Variation tolerance for RRM2 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRM2 Gene

Disorders for RRM2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RRM2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
choriocarcinoma
  • chorioepithelioma
mental retardation, x-linked, syndromic, wu type
  • mrxsw
skin melanoma
  • melanoma, cutaneous malignant
pancreatic cancer
  • pancreatic carcinoma
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search RRM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RRM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RRM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRM2 Gene

Publications for RRM2 Gene

  1. Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and promoter analyses. (PMID: 11978970) Zhou B … Yen Y (Cytogenetics and cell genetics 2001) 3 4 23
  2. Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancer. (PMID: 19639316) Ferrandina G … Del Tacca M (Cancer chemotherapy and pharmacology 2010) 3 23
  3. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. (PMID: 20159953) Niida H … Nakanishi M (Genes & development 2010) 3 23
  4. Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene. (PMID: 20155784) Cohen D … Shaul Y (Hepatology (Baltimore, Md.) 2010) 3 23
  5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E … Dorak MT (Molecular human reproduction 2010) 3 41

Products for RRM2 Gene

Sources for RRM2 Gene