Aliases for RRM1 Gene
External Ids for RRM1 Gene
Previous GeneCards Identifiers for RRM1 Gene
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for RRM1 Gene
RRM1 (Ribonucleotide Reductase Catalytic Subunit M1) is a Protein Coding gene. Diseases associated with RRM1 include Lung Cancer and Autosomal Dominant Progressive External Ophthalmoplegia. Among its related pathways are E2F transcription factor network and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include purine nucleotide binding and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.
UniProtKB/Swiss-Prot Summary for RRM1 Gene
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.