Aliases for RREB1 Gene
External Ids for RREB1 Gene
Previous GeneCards Identifiers for RREB1 Gene
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
GeneCards Summary for RREB1 Gene
RREB1 (Ras Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with RREB1 include Vulvar Melanoma and Tumoral Calcinosis, Normophosphatemic, Familial. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is ZBTB48.
UniProtKB/Swiss-Prot for RREB1 Gene
Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.