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This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of th... See more...
Aliases for RRAS2 Gene
Aliases for RRAS2 Gene
External Ids for RRAS2 Gene
- HGNC: 17271
- Entrez Gene: 22800
- Ensembl: ENSG00000133818
- OMIM: 600098
- UniProtKB: P62070
Previous GeneCards Identifiers for RRAS2 Gene
- GC11M015479
- GC11M015047
- GC11M014339
- GC11M014264
- GC11M014256
- GC11M013981
Summaries for RRAS2 Gene
-
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
GeneCards Summary for RRAS2 Gene
RRAS2 (RAS Related 2) is a Protein Coding gene. Diseases associated with RRAS2 include Noonan Syndrome 12 and Noonan Syndrome 1. Among its related pathways are NGF Pathway and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RRAS.
UniProtKB/Swiss-Prot Summary for RRAS2 Gene
-
GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes (PubMed:31130282). Involved in the regulation of MAPK signaling pathway (PubMed:31130282, PubMed:31130285). Regulation of craniofacial development (PubMed:31130282, PubMed:31130285).
Additional gene information for RRAS2 Gene
- HGNC(17271)
- Entrez Gene(22800)
- Ensembl(ENSG00000133818)
- OMIM(600098)
- UniProtKB(P62070)
- Open Targets Platform(ENSG00000133818)
- Monarch Initiative
- Search for RRAS2 at DataMed
- Search for RRAS2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RRAS2 Gene
Genomics for RRAS2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RRAS2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J014356 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 610.5 | +6.5 | 6497 | 3.6 | SP1 CREB1 TEAD4 PRDM10 ZNF629 IKZF1 POLR2A BACH1 LARP7 ZNF143 | RRAS2 L13714-048 SPON1 | |
| GH11J014335 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE dbSUPER | 605 | +25.4 | 25416 | 9.4 | CREB1 GATAD2A TEAD4 ZNF629 LEF1 SOX13 JUND ZNF143 PKNOX1 ZNF24 | RRAS2 COPB1 CYP2R1 L13714-048 SPON1 | |
| GH11J014362 | Enhancer | 0.3 | Ensembl | 600.7 | +1.6 | 1605 | 0.6 | HNF4A | RRAS2 L13714-048 SPON1 | |
| GH11J014364 | Enhancer | 0.2 | Ensembl | 610.2 | +0.1 | 105 | 0.4 | RRAS2 piR-32214-080 L13714-048 SPON1 | ||
| GH11J013461 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 10 | +901.5 | 901517 | 3.2 | BRCA1 ARHGAP35 SP1 GATAD2A PRDM10 REST TFE3 LEF1 SOX13 IKZF1 | BTBD10 ENSG00000287548 lnc-PTH-3 RRAS2 piR-43105-076 ARNTL |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RRAS2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RRAS2
- Top Transcription factor binding sites by QIAGEN in the RRAS2 gene promoter:
-
- NF-kappaB
- NF-kappaB1
- p300
- PPAR-gamma1
- PPAR-gamma2
- RSRFC4
Genomic Locations for RRAS2 Gene
Genomic Locations for RRAS2 Gene
- chr11:14,277,920-14,364,506
- (GRCh38/hg38)
- Size:
- 86,587 bases
- Orientation:
- Minus strand
- chr11:14,299,466-14,386,052
- (GRCh37/hg19)
- Size:
- 86,587 bases
- Orientation:
- Minus strand
Genomic View for RRAS2 Gene
Genes around RRAS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.2 by HGNC
- 11p15.2 by Entrez Gene
- 11p15.2 by Ensembl
RRAS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RRAS2 Gene
Proteins for RRAS2 Gene
-
Protein details for RRAS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62070-RRAS2_HUMAN
- Recommended name:
- Ras-related protein R-Ras2
- Protein Accession:
- P62070
- B2R9Z3
- B7Z5Z2
- B7Z6C4
- B7Z7H6
- P17082
Protein attributes for RRAS2 Gene
- Size:
- 204 amino acids
- Molecular mass:
- 23400 Da
- Quaternary structure:
-
- Interacts with RASSF5.
- SequenceCaution:
-
- Sequence=AAA36545.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAM12638.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for RRAS2 Gene
Post-translational modifications for RRAS2 Gene
- May be post-translationally modified by both palmitoylation and polyisoprenylation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RRAS2 Gene
Antibody Products
- LifeSpan BioSciences TC21 / RRAS2 Monoclonal Antibody
- G Biosciences Immunotag™ RRAS2 Antibody
- GeneTex Anti-TC21 antibody [N1C3] and Anti-TC21 antibody
- Novus Biologicals Antibodies for RRAS2
- Invitrogen Antibodies for RRAS2 (AFLGC-RRAS2)
-
Custom Antibody ServicesProSci Antibodies for RRAS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for RRAS2
Protein Products
-
OriGene Purified Proteins for RRAS2
- Search Origene for MassSpec and Protein Over-expression Lysates for RRAS2
- Origene Custom Protein Services for RRAS2
- ProSpec Recombinant Proteins for RRAS2
- antibodies-online: Show 10 available RRAS2 Proteins ranked by validation data
- Compare Top RRAS2 Proteins
-
Quality Products:
-
Abcam proteins for RRAS2
No data available for DME Specific Peptides for RRAS2 Gene
Domains & Families for RRAS2 Gene
Gene Families for RRAS2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for RRAS2 Gene
- InterPro:
- Blocks:
-
- GTP-binding nuclear protein Ran
- Ras small GTPase, Ras type
- Ras small GTPase, Rho type
- ProtoNet:
Suggested Antigen Peptide Sequences for RRAS2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ61162, highly similar to Ras-related protein R-Ras2 (B7Z5Z2_HUMAN)
- cDNA FLJ51083, highly similar to Ras-related protein R-Ras2 (B7Z6C4_HUMAN)
- cDNA FLJ52173, highly similar to Ras-related protein R-Ras2 (B7Z7H6_HUMAN)
- Teratocarcinoma oncogene (RRAS2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62070- Family:
-
- Belongs to the small GTPase superfamily. Ras family.
Function for RRAS2 Gene
Molecular function for RRAS2 Gene
- UniProtKB/Swiss-Prot Function:
- GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes (PubMed:31130282). Involved in the regulation of MAPK signaling pathway (PubMed:31130282, PubMed:31130285). Regulation of craniofacial development (PubMed:31130282, PubMed:31130285).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence={ECO:0000269|PubMed:31130282};.
Enzyme Numbers (IUBMB) for RRAS2 Gene
Phenotypes From GWAS Catalog for RRAS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | TAS,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 12620389 |
| GO:0005525 | GTP binding | IBA | 21873635 |
| GO:0019003 | GDP binding | IBA | 21873635 |
Phenotypes for RRAS2 Gene
- MGI mutant phenotypes for RRAS2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for RRAS2:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Moderately decreased NFAT1-GFP nuclear translocation
- Increased cell number in G2M, increased nuclei size in G2M
- Inconclusive
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased viability (cell death)
Animal Models for RRAS2 Gene
- MGI Knock Outs for RRAS2:
-
- Rras2 Rras2<tm1Itl>
Animal Model Products
-
Taconic Biosciences Mouse Models for RRAS2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RRAS2 - Select products 50% OFF >
- * RRAS2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RRAS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RRAS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RRAS2
miRNA for RRAS2 Gene
- miRTarBase miRNAs that target RRAS2
-
- hsa-miR-124-3p (MIRT022861)
- hsa-miR-7-5p (MIRT025875)
- hsa-miR-93-5p (MIRT028141)
- hsa-miR-26b-5p (MIRT029816)
- hsa-miR-19b-3p (MIRT031260)
- hsa-miR-624-3p (MIRT053416)
- hsa-miR-651-3p (MIRT265276)
- hsa-miR-23b-3p (MIRT438004)
- hsa-miR-580-3p (MIRT468893)
- hsa-miR-4697-3p (MIRT468894)
- hsa-miR-935 (MIRT468895)
- hsa-miR-548t-5p (MIRT468896)
- hsa-miR-548az-5p (MIRT468897)
- hsa-miR-548n (MIRT468898)
- hsa-miR-223-3p (MIRT468899)
- hsa-miR-3609 (MIRT485131)
- hsa-miR-548ah-5p (MIRT485132)
- hsa-miR-106a-3p (MIRT534557)
- hsa-miR-3662 (MIRT534558)
- hsa-miR-2681-5p (MIRT554573)
- hsa-miR-7848-3p (MIRT554574)
- hsa-miR-1252-5p (MIRT554575)
- hsa-miR-944 (MIRT554576)
- hsa-miR-599 (MIRT571670)
- hsa-miR-3161 (MIRT571671)
- hsa-miR-19a-3p (MIRT571672)
- hsa-miR-4504 (MIRT571673)
- hsa-miR-549a (MIRT571674)
- hsa-miR-5590-3p (MIRT571675)
- hsa-miR-142-5p (MIRT571676)
- hsa-miR-1255b-2-3p (MIRT571677)
- hsa-miR-4796-3p (MIRT571678)
- hsa-miR-526b-3p (MIRT571679)
- hsa-miR-519d-3p (MIRT571680)
- hsa-miR-20b-5p (MIRT571681)
- hsa-miR-20a-5p (MIRT571682)
- hsa-miR-17-5p (MIRT571683)
- hsa-miR-106b-5p (MIRT571684)
- hsa-miR-106a-5p (MIRT571685)
- mmu-miR-3065-5p (MIRT581257)
- mmu-miR-703 (MIRT581258)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RRAS2
- Browse OriGene Inhibitory RNA Products For RRAS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRAS2
Clone Products
- Applied Biological Materials (abm): Clones for RRAS2 - Select products 50% OFF >
- * RRAS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202123
- MR202123
- MR202123L3
- MR202123L4
- RC204591
- RC204591L3
- RC204591L4
- RC220668
- RC220668L3
- RC220668L4
- RC229556
- RC229556L3
- RC229556L4
- RC229627
- RC229627L3
- RC229627L4
- RG204591
- RG220668
- RG229556
- RG229627
- RR200798
- RR200798L3
- RR200798L4
- MR202123L3V
- MR202123L4V
- RC204591L3V
- RC204591L4V
- RC220668L3V
- RC220668L4V
- RC229556L3V
- RC229556L4V
- RC229627L3V
- RC229627L4V
- RR200798L3V
- RR200798L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RRAS2
- Addgene plasmids for RRAS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RRAS2
Cell Line Products
-
Horizon Cell Lines for RRAS2
No data available for Transcription Factor Targets and HOMER Transcription for RRAS2 Gene
Localization for RRAS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RRAS2 Gene
- Cell membrane. Lipid-anchor. Cytoplasmic side. Golgi apparatus membrane. Lipid-anchor.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| endoplasmic reticulum | 4 |
| cytosol | 4 |
| nucleus | 3 |
| golgi apparatus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005783 | endoplasmic reticulum | NAS | 10777492 |
| GO:0005886 | plasma membrane | NAS,IBA | 21873635 |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0016020 | membrane | HDA | 16210410 |
Pathways & Interactions for RRAS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
|
| 2 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Internalin Pathway
.31
|
| 3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
|
Breast Cancer Regulation by Stathmin1
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
|
| 5 | CNTF Signaling |
CNTF Signaling
.50
FLT3 Signaling
.50
IL-3 Pathway
.46
|
OSM Pathway
.46
Nur77-Induced AICD in Macrophage
.45
|
Pathways by source for RRAS2 Gene
1 BioSystems pathway for RRAS2 Gene
11 KEGG pathways for RRAS2 Gene
2 GeneGo (Thomson Reuters) pathways for RRAS2 Gene
- G-protein signaling G-Protein alpha-12 signaling pathway
- G-protein signaling TC21 regulation pathway
108 Qiagen pathways for RRAS2 Gene
- 14-3-3 Induced Intracellular Signaling
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Agrin Interactions at Neuromuscular Junction
- Akt Signaling
Interacting Proteins for RRAS2 Gene
Selected Interacting proteins:
P62070-RRAS2_HUMAN
ENSP00000256196
for RRAS2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RRAS2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001649 | osteoblast differentiation | HDA | 16210410 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007265 | Ras protein signal transduction | IBA | 21873635 |
| GO:0009987 | cellular process | IEA | -- |
| GO:0030335 | positive regulation of cell migration | IEA | -- |
Drugs & Compounds for RRAS2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for RRAS2 Gene
mRNA/cDNA for RRAS2 Gene
- 4 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000256196 2343 nts (view in UCSC)
- ENST00000414023 1884 nts (view in UCSC)
- ENST00000526063 970 nts (view in UCSC)
- ENST00000526717 815 nts (view in UCSC)
- ENST00000529237 1278 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RRAS2 - Select products 50% OFF >
- * RRAS2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RRAS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RRAS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RRAS2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RRAS2
- Browse OriGene Inhibitory RNA Products For RRAS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRAS2
Clone Products
- Applied Biological Materials (abm): Clones for RRAS2 - Select products 50% OFF >
- * RRAS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202123
- MR202123
- MR202123L3
- MR202123L4
- RC204591
- RC204591L3
- RC204591L4
- RC220668
- RC220668L3
- RC220668L4
- RC229556
- RC229556L3
- RC229556L4
- RC229627
- RC229627L3
- RC229627L4
- RG204591
- RG220668
- RG229556
- RG229627
- RR200798
- RR200798L3
- RR200798L4
- MR202123L3V
- MR202123L4V
- RC204591L3V
- RC204591L4V
- RC220668L3V
- RC220668L4V
- RC229556L3V
- RC229556L4V
- RC229627L3V
- RC229627L4V
- RR200798L3V
- RR200798L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RRAS2
- Addgene plasmids for RRAS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RRAS2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | - |
Relevant External Links for RRAS2 Gene
- GeneLoc Exon Structure for
- RRAS2
Expression for RRAS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
This gene is overexpressed in Bone (14.0) and Adipocyte (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRAS2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RRAS2
SOURCE GeneReport for Unigene cluster for RRAS2 Gene:
Hs.502004mRNA Expression by UniProt/SwissProt for RRAS2 Gene:
P62070-RRAS2_HUMAN
Tissue specificity:
Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
Evidence on tissue expression from TISSUES for RRAS2 Gene
- Heart(4.4)
- Nervous system(4.4)
- Liver(4.4)
- Bone(4.2)
- Kidney(2.3)
- Blood(2.2)
- Spleen(2.1)
- Muscle(2.1)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for RRAS2
-
OriGene qPCR primer pairs and template standards for RRAS2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAS2 Gene
Orthologs for RRAS2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RRAS2 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RRAS2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RRAS2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RRAS2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rras2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rras2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RRAS2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RRAS2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RRAS2 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11640 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.9521 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rras2 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002812 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ras64B 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ras-1 30 31 32 |
|
OneToMany | |
| ras-2 32 |
|
|
|||
| C08F8.7 32 |
|
|
|||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C13387g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAS1 30 31 33 |
|
ManyToMany | |
| RAS2 31 |
|
ManyToMany | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL262W 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU08823 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ras1 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2254 30 |
|
- Species where no ortholog for RRAS2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RRAS2 Gene
- ENSEMBL:
- Gene Tree for RRAS2 (if available)
- TreeFam:
- Gene Tree for RRAS2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RRAS2: view image
Paralogs for RRAS2 Gene
Paralogs for RRAS2 Gene
(93) SIMAP similar genes for RRAS2 Gene using alignment to 6 proteins:
- RRAS2_HUMAN
- B7Z5Z2_HUMAN
- E9PK85_HUMAN
- E9PQ87_HUMAN
- E9PQC5_HUMAN
- E9PQK5_HUMAN
- N-ras
- K-ras
- K-RAS
- c-bas/has
- RRAS
- MRAS
- KRAS
- HRAS
- RERG
- RAP1B
- RALB
- DKFZp547A0616
- RAP2B
- RALA
- RAP2A
- RAP1A
- NRAS
- NKIRAS2
- RIT1
- DKFZp686J06205
- RIT2
- RHEB
- RAB17
- RAP2C
- RAB15
- RAB27B
- RAB2B
- RAB39B
- RAB30
- DIRAS1
- RAB3A
- RAB2A
- RAB23
- RAB1B
- RAB1C
- RAB6A
- RAB8B
- RAB4A
- RAB21
- RAB1A
- RAB12
- DKFZp313C1541
- RAB37
- RASL12
- RAB8A
- RAB41
- RAB3B
- RAB7A
- RASL11B
- DIRAS2
- RAB4B
- RAB26
- RHEBL1
- RANP1
- RAB6B
- RAB5A
- RAB5B
- RAB9A
- RAB3D
- RAB31
- RAB39A
- RAB11B
- RAB13
- RAB5C
- RAB3C
- RAB10
- RASEF
- RASD1
- RAB27A
- RAB40C
- TC4
- RASD2
- RAB9B
- RAB7B
- RAB18
- RRAD
- RHOF
- REM2
- REM1
- RASL11A
- RAB43
- RAB35
- RHOD
- RAB14
- DIRAS3
- RERGL
- RAB44
- RHOG
- RAB6C
- ARHG
- NKIRAS1
- ERAS
- RAB11A
Pseudogenes.org Pseudogenes for RRAS2 Gene
Variants for RRAS2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RRAS2 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 626910 | Pathogenic: Noonan syndrome | 14,358,797(-) | A/ACGCCGCCCC | INFRAME_INSERTION,INTRON_VARIANT | |
| 626911 | Pathogenic: Noonan syndrome | 14,358,803(-) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
| 626912 | Pathogenic: Noonan syndrome; NOONAN SYNDROME 12 | 14,294,851(-) | C/T | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 626913 | Pathogenic: Noonan syndrome; NOONAN SYNDROME 12 | 14,358,792(-) | T/TGCCCACGCC | INFRAME_INSERTION,INTRON_VARIANT | |
| rs113954997 | Pathogenic: Neoplasm of ovary; Noonan syndrome; NOONAN SYNDROME 12. Noonan syndrome 12 (NS12) [MIM:618624] | 14,294,844(-) | T/Ap.Gln72Leu | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1660n54 | CNV | gain | 21841781 |
| dgv1661n54 | CNV | gain+loss | 21841781 |
| esv1753534 | CNV | deletion | 17803354 |
| esv25684 | CNV | loss | 19812545 |
| esv2744128 | CNV | deletion | 23290073 |
| esv3547346 | CNV | deletion | 23714750 |
| esv3578250 | CNV | gain | 25503493 |
| esv4848 | CNV | loss | 18987735 |
| esv6194 | CNV | loss | 19470904 |
| esv990130 | CNV | insertion | 20482838 |
| esv990812 | CNV | deletion | 20482838 |
| nsv1076498 | CNV | deletion | 25765185 |
| nsv1122585 | CNV | deletion | 24896259 |
| nsv1131021 | CNV | deletion | 24896259 |
| nsv1136125 | CNV | deletion | 24896259 |
| nsv1146392 | CNV | deletion | 26484159 |
| nsv38548 | CNV | deletion | 16902084 |
| nsv957175 | CNV | deletion | 24416366 |
| nsv975887 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.36;
7.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RRAS2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RRAS2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAS2 Gene
Disorders for RRAS2 Gene
(6) MalaCards diseases for RRAS2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| noonan syndrome 12 |
|
|
| noonan syndrome 1 |
|
|
| ovarian cancer |
|
|
| teratocarcinoma |
|
|
| juvenile myelomonocytic leukemia |
|
|
Search RRAS2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RRAS2_HUMAN- Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269 PubMed:8052619}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Noonan syndrome 12 (NS12) [MIM:618624]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS12 inheritance is autosomal dominant. There is considerable variability in severity. {ECO:0000269 PubMed:31130282, ECO:0000269 PubMed:31130285}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for RRAS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for RRAS2 Gene
Publications for RRAS2 Gene
- A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. (PMID: 19047159) Rokavec M … Brauch H (Cancer research 2008) 3 23 41
- A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. (PMID: 8052619) Chan AM … Aaronson SA (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4
- Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (PMID: 2108320) Drivas GT … D'Eustachio P (Molecular and cellular biology 1990) 2 3 4
- Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome. (PMID: 31130282) Capri Y … Zenker M (American journal of human genetics 2019) 3 4
- Germline-Activating RRAS2 Mutations Cause Noonan Syndrome. (PMID: 31130285) Niihori T … Aoki Y (American journal of human genetics 2019) 3 4
ExternalLinks
Products for RRAS2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RRAS2
- Search Origene for MassSpec and Protein Over-expression Lysates for RRAS2
- Origene Custom Protein Services for RRAS2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RRAS2
- Browse OriGene Inhibitory RNA Products For RRAS2
- OriGene qPCR primer pairs for RRAS2
- OriGene qPCR primer pairs and template standards for RRAS2
- OriGene CRISPR knockouts for RRAS2
- MG202123
- MR202123
- MR202123L3
- MR202123L4
- RC204591
- RC204591L3
- RC204591L4
- RC220668
- RC220668L3
- RC220668L4
- RC229556
- RC229556L3
- RC229556L4
- RC229627
- RC229627L3
- RC229627L4
- RG204591
- RG220668
- RG229556
- RG229627
- RR200798
- RR200798L3
- RR200798L4
- MR202123L3V
- MR202123L4V
- RC204591L3V
- RC204591L4V
- RC220668L3V
- RC220668L4V
- RC229556L3V
- RC229556L4V
- RC229627L3V
- RC229627L4V
- RR200798L3V
- RR200798L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RRAS2
- Sino Biological Human cDNA Clone for RRAS2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RRAS2
- Novus Biologicals proteins and lysates for RRAS2
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam proteins for RRAS2
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- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for RRAS2
- Taconic Biosciences Mouse Models for RRAS2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RRAS2 (AFLGC-RRAS2)
- VectorBuilder Custom and pre-made DNA vectors for RRAS2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RRAS2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RRAS2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RRAS2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RRAS2
- Addgene plasmids for RRAS2
- antibodies-online: Show 17 available RRAS2 Antibodies ranked by validation data
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- antibodies-online: Search results for available RRAS2 related products ranked by validation data
- antibodies-online: Show 10 available RRAS2 Proteins ranked by validation data
- Compare Top RRAS2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RRAS2
- Search Santa Cruz Biotechnology (SCBT) for RRAS2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RRAS2
- Custom Antibody ServicesProSci Antibodies for RRAS2
- Search for RRAS2 Proteins at ProSci
- Horizon Cell Lines for RRAS2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RRAS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RRAS2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RRAS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRAS2
Sources for RRAS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB