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This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
RRAS2 (RAS Related 2) is a Protein Coding gene. Diseases associated with RRAS2 include Noonan Syndrome 12 and Noonan Syndrome 1. Among its related pathways are NGF Pathway and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RRAS.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J014356 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 610.5 | +6.5 | 6497 | 3.6 | SP1 CREB1 TEAD4 PRDM10 ZNF629 IKZF1 POLR2A BACH1 LARP7 ZNF143 | RRAS2 L13714-048 SPON1 | |
GH11J014335 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE dbSUPER | 605 | +25.4 | 25416 | 9.4 | CREB1 GATAD2A TEAD4 ZNF629 LEF1 SOX13 JUND ZNF143 PKNOX1 ZNF24 | RRAS2 COPB1 CYP2R1 L13714-048 SPON1 | |
GH11J014362 | Enhancer | 0.3 | Ensembl | 600.7 | +1.6 | 1605 | 0.6 | HNF4A | RRAS2 L13714-048 SPON1 | |
GH11J014364 | Enhancer | 0.2 | Ensembl | 610.2 | +0.1 | 105 | 0.4 | RRAS2 piR-32214-080 L13714-048 SPON1 | ||
GH11J013461 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 10 | +901.5 | 901517 | 3.2 | BRCA1 ARHGAP35 SP1 GATAD2A PRDM10 REST TFE3 LEF1 SOX13 IKZF1 | BTBD10 ENSG00000287548 lnc-PTH-3 RRAS2 piR-43105-076 ARNTL |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | TAS,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 12620389 |
GO:0005525 | GTP binding | IBA | 21873635 |
GO:0019003 | GDP binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005783 | endoplasmic reticulum | NAS | 10777492 |
GO:0005886 | plasma membrane | NAS,IBA | 21873635 |
GO:0005925 | focal adhesion | HDA | 21423176 |
GO:0016020 | membrane | HDA | 16210410 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
|
2 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Internalin Pathway
.31
|
3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
|
Breast Cancer Regulation by Stathmin1
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
4 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
|
5 | CNTF Signaling |
CNTF Signaling
.50
FLT3 Signaling
.50
IL-3 Pathway
.46
|
OSM Pathway
.46
Nur77-Induced AICD in Macrophage
.45
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001649 | osteoblast differentiation | HDA | 16210410 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007265 | Ras protein signal transduction | IBA | 21873635 |
GO:0009987 | cellular process | IEA | -- |
GO:0030335 | positive regulation of cell migration | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||
SP2: | - | ||||||||||||||
SP3: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RRAS2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RRAS2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RRAS2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RRAS2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rras2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rras2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | RRAS2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RRAS2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RRAS2 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.11640 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.9521 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rras2 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002812 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Ras64B 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | ras-1 30 31 32 |
|
OneToMany | |
ras-2 32 |
|
|
|||
C08F8.7 32 |
|
|
|||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C13387g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAS1 30 31 33 |
|
ManyToMany | |
RAS2 31 |
|
ManyToMany | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL262W 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU08823 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ras1 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2254 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
626910 | Pathogenic: Noonan syndrome | 14,358,797(-) | A/ACGCCGCCCC | INFRAME_INSERTION,INTRON_VARIANT | |
626911 | Pathogenic: Noonan syndrome | 14,358,803(-) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
626912 | Pathogenic: Noonan syndrome; NOONAN SYNDROME 12 | 14,294,851(-) | C/T | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
626913 | Pathogenic: Noonan syndrome; NOONAN SYNDROME 12 | 14,358,792(-) | T/TGCCCACGCC | INFRAME_INSERTION,INTRON_VARIANT | |
rs113954997 | Pathogenic: Neoplasm of ovary; Noonan syndrome; NOONAN SYNDROME 12. Noonan syndrome 12 (NS12) [MIM:618624] | 14,294,844(-) | T/Ap.Gln72Leu | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1660n54 | CNV | gain | 21841781 |
dgv1661n54 | CNV | gain+loss | 21841781 |
esv1753534 | CNV | deletion | 17803354 |
esv25684 | CNV | loss | 19812545 |
esv2744128 | CNV | deletion | 23290073 |
esv3547346 | CNV | deletion | 23714750 |
esv3578250 | CNV | gain | 25503493 |
esv4848 | CNV | loss | 18987735 |
esv6194 | CNV | loss | 19470904 |
esv990130 | CNV | insertion | 20482838 |
esv990812 | CNV | deletion | 20482838 |
nsv1076498 | CNV | deletion | 25765185 |
nsv1122585 | CNV | deletion | 24896259 |
nsv1131021 | CNV | deletion | 24896259 |
nsv1136125 | CNV | deletion | 24896259 |
nsv1146392 | CNV | deletion | 26484159 |
nsv38548 | CNV | deletion | 16902084 |
nsv957175 | CNV | deletion | 24416366 |
nsv975887 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
noonan syndrome 12 |
|
|
noonan syndrome 1 |
|
|
ovarian cancer |
|
|
teratocarcinoma |
|
|
juvenile myelomonocytic leukemia |
|
|