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The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015] See more...
Aliases for RRAS Gene
Aliases for RRAS Gene
External Ids for RRAS Gene
- HGNC: 10447
- Entrez Gene: 6237
- Ensembl: ENSG00000126458
- OMIM: 165090
- UniProtKB: P10301
Previous GeneCards Identifiers for RRAS Gene
- GC19M050796
- GC19M050506
- GC19M054814
- GC19M054830
- GC19M050138
- GC19M046515
Summaries for RRAS Gene
-
The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
GeneCards Summary for RRAS Gene
RRAS (RAS Related) is a Protein Coding gene. Diseases associated with RRAS include Juvenile Myelomonocytic Leukemia and Noonan Syndrome 1. Among its related pathways are NGF Pathway and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RRAS2.
UniProtKB/Swiss-Prot Summary for RRAS Gene
-
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).
Additional gene information for RRAS Gene
- HGNC(10447)
- Entrez Gene(6237)
- Ensembl(ENSG00000126458)
- OMIM(165090)
- UniProtKB(P10301)
- Open Targets Platform(ENSG00000126458)
- Search for RRAS at DataMed
- Search for RRAS at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RRAS Gene
Genomics for RRAS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RRAS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RRAS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RRAS
- Top Transcription factor binding sites by QIAGEN in the RRAS gene promoter:
-
- COUP-TF1
- NF-kappaB
- NF-kappaB1
- p53
- STAT1
Genomic Locations for RRAS Gene
Genomic Locations for RRAS Gene
- chr19:49,635,292-49,640,143
- (GRCh38/hg38)
- Size:
- 4,852 bases
- Orientation:
- Minus strand
- chr19:50,138,549-50,143,458
- (GRCh37/hg19)
- Size:
- 4,910 bases
- Orientation:
- Minus strand
Genomic View for RRAS Gene
Genes around RRAS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
RRAS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RRAS Gene
Proteins for RRAS Gene
-
Protein details for RRAS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10301-RRAS_HUMAN
- Recommended name:
- Ras-related protein R-Ras
- Protein Accession:
- P10301
- Q6FH12
Protein attributes for RRAS Gene
- Size:
- 218 amino acids
- Molecular mass:
- 23480 Da
- Quaternary structure:
-
- Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267, PubMed:16537651, PubMed:20074548) (By similarity). Interacts with ZDHHC19 (PubMed:20074548).
Protein Expression for RRAS Gene
Post-translational modifications for RRAS Gene
- S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RRAS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences RRAS Monoclonal Antibody
- G Biosciences Immunotag™ R-Ras Antibody
- GeneTex Anti-RRAS antibody [N1C3]
- Novus Biologicals Antibodies for RRAS
-
Abcam antibodies for RRAS
- Invitrogen Antibodies for RRAS (AFLGC-RRAS)
- antibodies-online: Show 56 available R-Ras Antibodies ranked by validation data
-
Boster Bio Antibodies for RRAS
-
Santa Cruz Biotechnology (SCBT) Antibodies for RRAS
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RRAS
- Origene Custom Protein Services for RRAS
- ProSpec Recombinant Proteins for RRAS
-
Abcam proteins for RRAS
No data available for DME Specific Peptides for RRAS Gene
Domains & Families for RRAS Gene
Gene Families for RRAS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RRAS Gene
- InterPro:
- Blocks:
-
- Transforming protein P21 RAS signature
- Ras small GTPase, Ras type
- ProtoNet:
Suggested Antigen Peptide Sequences for RRAS Gene
- GenScript: Design optimal peptide antigens:
-
- p23 (RRAS_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P10301- Family:
-
- Belongs to the small GTPase superfamily. Ras family.
Function for RRAS Gene
Molecular function for RRAS Gene
- UniProtKB/Swiss-Prot Function:
- Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).
- GENATLAS Biochemistry:
- Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin activity
Phenotypes From GWAS Catalog for RRAS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | TAS,IMP | 24705357 |
| GO:0005515 | protein binding | IPI | 17474147 |
| GO:0005525 | GTP binding | IBA | 21873635 |
| GO:0019003 | GDP binding | IBA,IMP | 24705357 |
Phenotypes for RRAS Gene
- MGI mutant phenotypes for RRAS:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RRAS:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased viability
- Decreased POU5F1-GFP protein expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), many micronuclei (grape), decreased viability (cell death)
Animal Model Products
-
Taconic Biosciences Mouse Models for RRAS
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RRAS - Select products 50% OFF >
- * RRAS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RRAS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RRAS
-
Santa Cruz Biotechnology (SCBT) CRISPR for RRAS
miRNA for RRAS Gene
- miRTarBase miRNAs that target RRAS
-
- mmu-miR-124-3p (MIRT015662)
- hsa-miR-124-3p (MIRT022156)
- hsa-miR-34a-5p (MIRT025259)
- hsa-miR-449a (MIRT731696)
- hsa-miR-1245b-3p (MIRT736355)
- hsa-miR-1295b-5p (MIRT737192)
- hsa-miR-1304-5p (MIRT737280)
- hsa-miR-1912 (MIRT738484)
- hsa-miR-24-3p (MIRT739231)
- hsa-miR-2467-5p (MIRT739336)
- hsa-miR-3188 (MIRT740940)
- hsa-miR-3915 (MIRT742886)
- hsa-miR-3928-3p (MIRT743050)
- hsa-miR-3975 (MIRT743211)
- hsa-miR-485-5p (MIRT749077)
- hsa-miR-6765-5p (MIRT755075)
- hsa-miR-6884-5p (MIRT758519)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RRAS
- Browse OriGene Inhibitory RNA Products For RRAS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRAS
Clone Products
- Applied Biological Materials (abm): Clones for RRAS - Select products 50% OFF >
- * RRAS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RRAS
- Addgene plasmids for RRAS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RRAS
Cell Line Products
-
Horizon Cell Lines for RRAS
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAS Gene
Localization for RRAS Gene
Subcellular locations from UniProtKB/Swiss-Prot for RRAS Gene
- Cell membrane. Lipid-anchor. Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| nucleus | 4 |
| cytoskeleton | 3 |
| cytosol | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0016020 | membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for RRAS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
|
| 2 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Internalin Pathway
.31
|
| 3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
|
Breast Cancer Regulation by Stathmin1
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
|
| 5 | CNTF Signaling |
CNTF Signaling
.50
FLT3 Signaling
.50
IL-3 Pathway
.46
|
OSM Pathway
.46
Nur77-Induced AICD in Macrophage
.45
|
Pathways by source for RRAS Gene
9 BioSystems pathways for RRAS Gene
12 Reactome pathways for RRAS Gene
3 PharmGKB pathways for RRAS Gene
14 KEGG pathways for RRAS Gene
3 GeneGo (Thomson Reuters) pathways for RRAS Gene
- Development G-Proteins mediated regulation MARK-ERK signaling
- G-protein signaling G-Protein alpha-12 signaling pathway
- G-protein signaling Ras family GTPases in kinase cascades (scheme)
109 Qiagen pathways for RRAS Gene
- 14-3-3 Induced Intracellular Signaling
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Agrin Interactions at Neuromuscular Junction
- Akt Signaling
2 Cell Signaling Technology pathways for RRAS Gene
Interacting Proteins for RRAS Gene
Selected Interacting proteins:
P10301-RRAS_HUMAN
ENSP00000246792
for RRAS Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RRAS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002521 | leukocyte differentiation | IMP | 24705357 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007265 | Ras protein signal transduction | IBA | 21873635 |
| GO:0010595 | positive regulation of endothelial cell migration | IMP | 22825554 |
| GO:0030336 | negative regulation of cell migration | IEA | -- |
Transcripts for RRAS Gene
mRNA/cDNA for RRAS Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000246792 986 nts (view in UCSC)
- ENST00000601532 634 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RRAS - Select products 50% OFF >
- * RRAS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RRAS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RRAS
-
Santa Cruz Biotechnology (SCBT) CRISPR for RRAS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RRAS
- Browse OriGene Inhibitory RNA Products For RRAS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRAS
Clone Products
- Applied Biological Materials (abm): Clones for RRAS - Select products 50% OFF >
- * RRAS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RRAS
- Addgene plasmids for RRAS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RRAS
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: |
Relevant External Links for RRAS Gene
- GeneLoc Exon Structure for
- RRAS
Expression for RRAS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Prostate (10.0) and Urinary Bladder (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRAS Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RRAS
SOURCE GeneReport for Unigene cluster for RRAS Gene:
Hs.515536Evidence on tissue expression from TISSUES for RRAS Gene
- Nervous system(4.6)
- Liver(4.5)
- Heart(3.3)
- Muscle(3.2)
- Kidney(2.9)
- Blood(2.9)
- Lung(2.8)
- Skin(2.8)
- Intestine(2.8)
- Spleen(2.7)
- Lymph node(2.6)
- Adrenal gland(2.5)
- Pancreas(2.5)
- Bone marrow(2.4)
- Thyroid gland(2.4)
- Stomach(2.4)
- Eye(2.2)
Primer Products
-
OriGene qPCR primer pairs for RRAS
-
OriGene qPCR primer pairs and template standards for RRAS
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAS Gene
Orthologs for RRAS Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RRAS 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RRAS 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RRAS 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rras 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rras 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RRAS 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RRAS 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rras 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rras 30 31 |
|
OneToOne | |
| wufb23a02 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ras64B 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ras-1 31 32 |
|
OneToMany | |
| ras-2 32 |
|
|
|||
| C08F8.7 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAS1 31 |
|
ManyToMany | |
| RAS2 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for RRAS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RRAS Gene
- ENSEMBL:
- Gene Tree for RRAS (if available)
- TreeFam:
- Gene Tree for RRAS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RRAS: view image
Paralogs for RRAS Gene
Paralogs for RRAS Gene
(69) SIMAP similar genes for RRAS Gene using alignment to 1 proteins:
- RRAS_HUMAN
- RRAS2
- c-bas/has
- RALA
- MRAS
- RALB
- RAP1B
- RAP2A
- HRAS
- DKFZp547A0616
- RHEB
- NRAS
- DIRAS1
- RIT2
- KRAS
- RIT1
- RASL12
- RAP1A
- RAB17
- RAP2C
- RAB39B
- RAP2B
- RAB4A
- RAB2B
- DKFZp313C1541
- RERG
- RAB15
- RHEBL1
- RASD2
- RAB5B
- RAB4B
- RAB2A
- RANP1
- DIRAS2
- RAB8A
- RAB5C
- RAB30
- RAB23
- RAB10
- RAB7B
- RAB3B
- RAB5A
- RAB37
- RAB8B
- RAB35
- RAB18
- DIRAS3
- RAB9B
- RAB9A
- RAB12
- RAB39A
- RAB26
- RAB11B
- ERAS
- RAB7A
- RAB27A
- REM1
- RAB3D
- RAB3C
- RAB1B
- RAB1A
- RAB3A
- RAB6B
- RAB25
- RAB21
- RAB13
- REM2
- RAB1C
- RAB14
- RAB43
Variants for RRAS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RRAS Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 636997 | Uncertain Significance: not provided | 49,640,038(-) | G/A | MISSENSE_VARIANT | |
| 641321 | Uncertain Significance: Noonan syndrome | 49,635,734(-) | C/T | MISSENSE_VARIANT | |
| 642527 | Uncertain Significance: Noonan syndrome | 49,640,025(-) | G/A | MISSENSE_VARIANT | |
| 645740 | Uncertain Significance: Noonan syndrome | 49,635,849(-) | G/T | MISSENSE_VARIANT | |
| 665777 | Uncertain Significance: Noonan syndrome | 49,636,645(-) | T/A | NONSENSE |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1160655 | CNV | deletion | 26073780 |
| nsv469715 | CNV | gain+loss | 16826518 |
| nsv470150 | CNV | gain | 18288195 |
| nsv817854 | CNV | gain | 17921354 |
| nsv828578 | CNV | loss | 20364138 |
| nsv833864 | CNV | gain | 17160897 |
| nsv833865 | CNV | gain+loss | 17160897 |
| nsv953600 | CNV | deletion | 24416366 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.37;
27.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RRAS Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAS Gene
Disorders for RRAS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| juvenile myelomonocytic leukemia |
|
|
| noonan syndrome 1 |
|
|
| oculoectodermal syndrome |
|
|
| neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux |
|
|
| plantar fascial fibromatosis |
|
|
Search RRAS in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RRAS
No data available for UniProtKB/Swiss-Prot and Genatlas for RRAS Gene
Publications for RRAS Gene
- Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PMID: 3098437) Lowe DG … Goeddel DV (Cell 1987) 2 3 4
- Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. (PMID: 20385769) Sakurai A … Gutkind JS (Molecular and cellular biology 2010) 3 23
- Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. (PMID: 19843518) Tong Y … Buck M (The Journal of biological chemistry 2009) 3 23
- Transcription factor 8 activates R-Ras to regulate angiogenesis. (PMID: 19116136) Inuzuka T … Ohba Y (Biochemical and biophysical research communications 2009) 3 23
- The R-Ras interaction partner ORP3 regulates cell adhesion. (PMID: 18270267) Lehto M … Olkkonen VM (Journal of cell science 2008) 4 23
ExternalLinks
Products for RRAS Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RRAS
- Origene Custom Protein Services for RRAS
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RRAS
- Browse OriGene Inhibitory RNA Products For RRAS
- OriGene qPCR primer pairs for RRAS
- OriGene qPCR primer pairs and template standards for RRAS
- OriGene CRISPR knockouts for RRAS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RRAS
- Sino Biological Human cDNA Clone for RRAS
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RRAS
- Novus Biologicals proteins and lysates for RRAS
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- Abcam proteins for RRAS
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for RRAS
- Taconic Biosciences Mouse Models for RRAS
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RRAS (AFLGC-RRAS)
- VectorBuilder Custom and pre-made DNA vectors for RRAS (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RRAS (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RRAS (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RRAS CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RRAS
- Addgene plasmids for RRAS
- antibodies-online: Show 56 available R-Ras Antibodies ranked by validation data
- antibodies-online: Search results for available R-Ras related products ranked by validation data
- antibodies-online: Search results for available R-Ras related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for RRAS
- Search Santa Cruz Biotechnology (SCBT) for RRAS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RRAS
- Horizon Cell Lines for RRAS
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RRAS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RRAS
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RRAS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRAS
- Boster Bio Antibodies for RRAS
- Browse Boster Bio ELISA Kits
Sources for RRAS Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB