The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015] See more...

Aliases for RRAS Gene

Aliases for RRAS Gene

  • RAS Related 2 3 5
  • Related RAS Viral (R-Ras) Oncogene Homolog 2 3
  • Ras-Related Protein R-Ras 3 4
  • Oncogene RRAS 2 3
  • P23 3 4
  • Ras Family Small GTP Binding Protein R-Ras 3
  • R-Ras 3

External Ids for RRAS Gene

Previous GeneCards Identifiers for RRAS Gene

  • GC19M050796
  • GC19M050506
  • GC19M054814
  • GC19M054830
  • GC19M050138
  • GC19M046515

Summaries for RRAS Gene

Entrez Gene Summary for RRAS Gene

  • The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]

GeneCards Summary for RRAS Gene

RRAS (RAS Related) is a Protein Coding gene. Diseases associated with RRAS include Juvenile Myelomonocytic Leukemia and Noonan Syndrome 1. Among its related pathways are CCR5 Pathway in Macrophages and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RRAS2.

UniProtKB/Swiss-Prot Summary for RRAS Gene

  • Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).

Gene Wiki entry for RRAS Gene

Additional gene information for RRAS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RRAS Gene

Genomics for RRAS Gene

GeneHancer (GH) Regulatory Elements for RRAS Gene

Promoters and enhancers for RRAS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RRAS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RRAS

Top Transcription factor binding sites by QIAGEN in the RRAS gene promoter:
  • COUP-TF1
  • NF-kappaB
  • NF-kappaB1
  • p53
  • STAT1

Genomic Locations for RRAS Gene

Genomic Locations for RRAS Gene
chr19:49,635,292-49,640,143
(GRCh38/hg38)
Size:
4,852 bases
Orientation:
Minus strand
chr19:50,138,549-50,143,458
(GRCh37/hg19)
Size:
4,910 bases
Orientation:
Minus strand

Genomic View for RRAS Gene

Genes around RRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAS Gene

Proteins for RRAS Gene

  • Protein details for RRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10301-RRAS_HUMAN
    Recommended name:
    Ras-related protein R-Ras
    Protein Accession:
    P10301
    Secondary Accessions:
    • Q6FH12

    Protein attributes for RRAS Gene

    Size:
    218 amino acids
    Molecular mass:
    23480 Da
    Quaternary structure:
    • Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267, PubMed:16537651, PubMed:20074548) (By similarity). Interacts with ZDHHC19 (PubMed:20074548).

    Three dimensional structures from OCA and Proteopedia for RRAS Gene

neXtProt entry for RRAS Gene

Post-translational modifications for RRAS Gene

  • S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRAS Gene

Domains & Families for RRAS Gene

Gene Families for RRAS Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRAS Gene

Blocks:
  • Ras small GTPase, Ras type
  • Transforming protein P21 RAS signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RRAS Gene

GenScript: Design optimal peptide antigens:
  • p23 (RRAS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10301

UniProtKB/Swiss-Prot:

RRAS_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RRAS: view

Function for RRAS Gene

Molecular function for RRAS Gene

UniProtKB/Swiss-Prot Function:
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).
GENATLAS Biochemistry:
Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin activity

Phenotypes From GWAS Catalog for RRAS Gene

Gene Ontology (GO) - Molecular Function for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP,TAS 24705357
GO:0005515 protein binding IPI 17474147
GO:0005525 GTP binding IBA 21873635
GO:0019003 GDP binding IBA,IMP 24705357
GO:0044877 protein-containing complex binding IDA 23209302
genes like me logo Genes that share ontologies with RRAS: view
genes like me logo Genes that share phenotypes with RRAS: view

Human Phenotype Ontology for RRAS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for RRAS

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRAS

Clone Products

  • Addgene plasmids for RRAS

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAS Gene

Localization for RRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRAS gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with RRAS: view

Pathways & Interactions for RRAS Gene

PathCards logo

SuperPathways for RRAS Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.51
.49
.48
.47
.44
.43
.36
.35
.34
2 fMLP Pathway
.44
.44
.43
.39
.38
.31
3 GPCR Pathway
.73
.73
.62
.58
.55
.38
4 Apoptotic Pathways in Synovial Fibroblasts
.66
.65
.64
.61
.60
.57
5 CNTF Signaling
.50
.50
.46
.46
.45
genes like me logo Genes that share pathways with RRAS: view

Pathways by source for RRAS Gene

3 GeneGo (Thomson Reuters) pathways for RRAS Gene
  • Development G-Proteins mediated regulation MARK-ERK signaling
  • G-protein signaling G-Protein alpha-12 signaling pathway
  • G-protein signaling Ras family GTPases in kinase cascades (scheme)
109 Qiagen pathways for RRAS Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling
2 Cell Signaling Technology pathways for RRAS Gene

SIGNOR curated interactions for RRAS Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002521 leukocyte differentiation IMP 24705357
GO:0007165 signal transduction IEA --
GO:0007265 Ras protein signal transduction IBA 21873635
GO:0030336 negative regulation of cell migration IEA --
GO:0045766 positive regulation of angiogenesis IMP 21393242
genes like me logo Genes that share ontologies with RRAS: view

Drugs & Compounds for RRAS Gene

(6) Drugs for RRAS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for RRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RRAS: view

Transcripts for RRAS Gene

mRNA/cDNA for RRAS Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RRAS

Clone Products

  • Addgene plasmids for RRAS

Alternative Splicing Database (ASD) splice patterns (SP) for RRAS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for RRAS Gene

GeneLoc Exon Structure for
RRAS

Expression for RRAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRAS Gene

This gene is overexpressed in Prostate (10.0) and Urinary Bladder (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRAS Gene



Protein tissue co-expression partners for RRAS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RRAS

SOURCE GeneReport for Unigene cluster for RRAS Gene:

Hs.515536

Evidence on tissue expression from TISSUES for RRAS Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Heart(2.5)
  • Muscle(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with RRAS: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAS Gene

Orthologs for RRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAS 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RRAS 31 30
  • 91.9 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RRAS 31 30
  • 90.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rras 17 31 30
  • 88.23 (n)
rat
(Rattus norvegicus)
Mammalia Rras 30
  • 88.23 (n)
oppossum
(Monodelphis domestica)
Mammalia RRAS 31
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAS 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rras 30
  • 67.89 (n)
zebrafish
(Danio rerio)
Actinopterygii rras 31 30
  • 67.54 (n)
OneToOne
wufb23a02 30
fruit fly
(Drosophila melanogaster)
Insecta Ras64B 31 32
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ras-1 31 32
  • 56 (a)
OneToMany
ras-2 32
  • 51 (a)
C08F8.7 32
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 31
  • 35 (a)
ManyToMany
RAS2 31
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 60 (a)
OneToMany
Species where no ortholog for RRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAS Gene

ENSEMBL:
Gene Tree for RRAS (if available)
TreeFam:
Gene Tree for RRAS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RRAS: view image

Paralogs for RRAS Gene

genes like me logo Genes that share paralogs with RRAS: view

Variants for RRAS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RRAS Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
565489 Uncertain Significance: Noonan syndrome 49,635,584(-) G/C MISSENSE_VARIANT
569899 Uncertain Significance: Noonan syndrome 49,636,672(-) C/T MISSENSE_VARIANT
572125 Uncertain Significance: Noonan syndrome 49,636,830(-) C/T MISSENSE_VARIANT
573868 Uncertain Significance: Noonan syndrome 49,637,117(-) G/C MISSENSE_VARIANT
575349 Uncertain Significance: Noonan syndrome 49,637,109(-) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for RRAS Gene

Structural Variations from Database of Genomic Variants (DGV) for RRAS Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv470150 CNV gain 18288195
nsv817854 CNV gain 17921354
nsv828578 CNV loss 20364138
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for RRAS Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRAS Gene

Human Gene Mutation Database (HGMD)
RRAS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRAS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAS Gene

Disorders for RRAS Gene

MalaCards: The human disease database

(9) MalaCards diseases for RRAS Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
juvenile myelomonocytic leukemia
  • jmml
noonan syndrome 1
  • ns1
neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux
  • neuropathy, hereditary sensory and autonomic, type ib; hsan1b
plantar fascial fibromatosis
  • dupuytren's contracture of foot
rasopathy
- elite association - COSMIC cancer census association via MalaCards
Search RRAS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RRAS

genes like me logo Genes that share disorders with RRAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRAS Gene

Publications for RRAS Gene

  1. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PMID: 3098437) Lowe DG … Goeddel DV (Cell 1987) 2 3 4 54
  2. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. (PMID: 20385769) Sakurai A … Gutkind JS (Molecular and cellular biology 2010) 3 23 54
  3. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. (PMID: 19843518) Tong Y … Buck M (The Journal of biological chemistry 2009) 3 23 54
  4. Transcription factor 8 activates R-Ras to regulate angiogenesis. (PMID: 19116136) Inuzuka T … Ohba Y (Biochemical and biophysical research communications 2009) 3 23 54
  5. The R-Ras interaction partner ORP3 regulates cell adhesion. (PMID: 18270267) Lehto M … Olkkonen VM (Journal of cell science 2008) 4 23 54

Products for RRAS Gene