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Aliases for RRAGD Gene

Aliases for RRAGD Gene

  • Ras Related GTP Binding D 2 3 5
  • RAGD 3 4
  • Ras-Related GTP-Binding Protein D 3
  • Ras-Related GTP Binding D 2
  • Rag D Protein 3
  • BA11D8.2.1 3
  • Rag D 4

External Ids for RRAGD Gene

Previous GeneCards Identifiers for RRAGD Gene

  • GC06M090024
  • GC06M090070
  • GC06M090073
  • GC06M090131
  • GC06M087291
  • GC06M090074

Summaries for RRAGD Gene

Entrez Gene Summary for RRAGD Gene

  • RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]

GeneCards Summary for RRAGD Gene

RRAGD (Ras Related GTP Binding D) is a Protein Coding gene. Among its related pathways are Gene Expression and RET signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and GTPase activity. An important paralog of this gene is RRAGC.

UniProtKB/Swiss-Prot for RRAGD Gene

  • Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Additional gene information for RRAGD Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAGD Gene

Genomics for RRAGD Gene

GeneHancer (GH) Regulatory Elements for RRAGD Gene

Promoters and enhancers for RRAGD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I089409 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 558.4 +0.7 659 3.9 PKNOX1 SIN3A FEZF1 ZNF121 GLIS2 ZNF207 SP3 REST SREBF1 GLIS1 RRAGD CASP8AP2 LYRM2 MDN1 ANKRD6 PM20D2 SRSF12 ENSG00000237027 GC06M089406 GC06M089255
GH06I089345 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.5 +62.0 62020 8.6 HDGF PKNOX1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B IRF4 SLC30A9 POLR2B UBE2J1 CASP8AP2 SRSF12 RRAGD GABRR2 TUBB3P1 MDN1 PNRC1 ANKRD6 RNGTT
GH06I089371 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.3 +39.7 39733 1.4 HDGF PKNOX1 RB1 ARID4B SIN3A BATF ZNF2 KLF5 IRF4 ZNF48 RRAGD SRSF12 LYRM2 UBE2J1 GC06M089406 GC06M089255 GC06M089256
GH06I089367 Enhancer 0.6 dbSUPER 21.5 +43.6 43629 2.6 CTCF PKNOX1 ZNF654 HLF TRIM22 REST RAD21 ZNF143 SMC3 PRDM10 RRAGD GABRR2 TUBB3P1 LYRM2 SRSF12 MDN1 UBE2J1 GC06M089406 GC06M089255 GC06M089256
GH06I089354 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +54.8 54781 5.1 HDGF PKNOX1 MZF1 IRF4 YY1 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 PM20D2 RRAGD GABRR2 RNGTT UBE2J1 GC06M089406 GC06M089255 GC06M089256
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RRAGD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RRAGD gene promoter:

Genomic Locations for RRAGD Gene

Genomic Locations for RRAGD Gene
chr6:89,364,616-89,412,276
(GRCh38/hg38)
Size:
47,661 bases
Orientation:
Minus strand
chr6:90,074,335-90,121,995
(GRCh37/hg19)

Genomic View for RRAGD Gene

Genes around RRAGD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAGD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAGD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAGD Gene

Proteins for RRAGD Gene

  • Protein details for RRAGD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQL2-RRAGD_HUMAN
    Recommended name:
    Ras-related GTP-binding protein D
    Protein Accession:
    Q9NQL2
    Secondary Accessions:
    • A8K184
    • Q7L8F9
    • Q9NPG0

    Protein attributes for RRAGD Gene

    Size:
    400 amino acids
    Molecular mass:
    45588 Da
    Quaternary structure:
    • Forms a heterodimer with RRAGA in a sequence-independent manner and RRAGB. Heterodimerization stabilizes RRAG proteins. In complex with RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGD and is negatively regulated by amino acids (PubMed:11073942, PubMed:14660641, PubMed:18497260, PubMed:22575674, Ref.14). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with SESN1, SESN2 AND SESN3 (PubMed:25259925).
    SequenceCaution:
    • Sequence=AAH03088.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RRAGD Gene

    Alternative splice isoforms for RRAGD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRAGD Gene

Post-translational modifications for RRAGD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAGD Gene

No data available for DME Specific Peptides for RRAGD Gene

Domains & Families for RRAGD Gene

Gene Families for RRAGD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRAGD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RRAGD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQL2

UniProtKB/Swiss-Prot:

RRAGD_HUMAN :
  • Belongs to the GTR/RAG GTP-binding protein family.
Family:
  • Belongs to the GTR/RAG GTP-binding protein family.
genes like me logo Genes that share domains with RRAGD: view

Function for RRAGD Gene

Molecular function for RRAGD Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Gene Ontology (GO) - Molecular Function for RRAGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 22424946
GO:0005515 protein binding IPI 11073942
GO:0005525 GTP binding IMP 22424946
GO:0019003 GDP binding IMP 22424946
GO:0046982 protein heterodimerization activity IPI,IMP 11073942
genes like me logo Genes that share ontologies with RRAGD: view

Phenotypes for RRAGD Gene

genes like me logo Genes that share phenotypes with RRAGD: view

Animal Model Products

miRNA for RRAGD Gene

miRTarBase miRNAs that target RRAGD

Clone Products

  • Addgene plasmids for RRAGD

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAGD Gene

Localization for RRAGD Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAGD Gene

Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). {ECO:0000269 PubMed:11073942}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRAGD gene
Compartment Confidence
nucleus 5
cytosol 5
lysosome 5
cytoskeleton 4
endosome 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRAGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11073942
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 11073942
GO:0005764 lysosome IEA,IDA 20381137
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with RRAGD: view

Pathways & Interactions for RRAGD Gene

genes like me logo Genes that share pathways with RRAGD: view

Pathways by source for RRAGD Gene

2 KEGG pathways for RRAGD Gene
1 Cell Signaling Technology pathway for RRAGD Gene

SIGNOR curated interactions for RRAGD Gene

Activates:

Gene Ontology (GO) - Biological Process for RRAGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0010506 regulation of autophagy IBA --
GO:0016241 regulation of macroautophagy TAS --
GO:0032008 positive regulation of TOR signaling NAS 20381137
GO:0034613 cellular protein localization ISS --
genes like me logo Genes that share ontologies with RRAGD: view

Drugs & Compounds for RRAGD Gene

(3) Drugs for RRAGD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RRAGD: view

Transcripts for RRAGD Gene

Unigene Clusters for RRAGD Gene

Ras-related GTP binding D:
Representative Sequences:

Clone Products

  • Addgene plasmids for RRAGD

Alternative Splicing Database (ASD) splice patterns (SP) for RRAGD Gene

No ASD Table

Relevant External Links for RRAGD Gene

GeneLoc Exon Structure for
RRAGD
ECgene alternative splicing isoforms for
RRAGD

Expression for RRAGD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRAGD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RRAGD Gene

This gene is overexpressed in Muscle - Skeletal (x6.4).

Protein differential expression in normal tissues from HIPED for RRAGD Gene

This gene is overexpressed in Skin (24.5), Heart (22.2), Spinal cord (8.2), Testis (7.4), and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRAGD Gene



Protein tissue co-expression partners for RRAGD Gene

NURSA nuclear receptor signaling pathways regulating expression of RRAGD Gene:

RRAGD

SOURCE GeneReport for Unigene cluster for RRAGD Gene:

Hs.31712

Evidence on tissue expression from TISSUES for RRAGD Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with RRAGD: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAGD Gene

Orthologs for RRAGD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAGD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAGD 33 34
  • 99.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RRAGD 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRAGD 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRAGD 33 34
  • 92.36 (n)
dog
(Canis familiaris)
Mammalia RRAGD 33 34
  • 91.64 (n)
mouse
(Mus musculus)
Mammalia Rragd 33 16 34
  • 89.06 (n)
rat
(Rattus norvegicus)
Mammalia Rragd 33
  • 87.64 (n)
chicken
(Gallus gallus)
Aves RRAGD 34
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAGD 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rragd 33
  • 78.97 (n)
zebrafish
(Danio rerio)
Actinopterygii rragd 33 34
  • 75.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta RagC 34
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ragc-1 34
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GTR2 34
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9757 34
  • 61 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4891 33
Species where no ortholog for RRAGD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAGD Gene

ENSEMBL:
Gene Tree for RRAGD (if available)
TreeFam:
Gene Tree for RRAGD (if available)

Paralogs for RRAGD Gene

Paralogs for RRAGD Gene

(1) SIMAP similar genes for RRAGD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RRAGD: view

Variants for RRAGD Gene

Sequence variations from dbSNP and Humsavar for RRAGD Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000111903 -- 89,369,918(-) C/A intron_variant
rs1000182784 -- 89,397,421(-) T/C intron_variant
rs1000206787 -- 89,403,621(-) C/A/T intron_variant
rs1000339659 -- 89,393,635(-) G/T intron_variant
rs1000389892 -- 89,401,311(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RRAGD Gene

Variant ID Type Subtype PubMed ID
esv3890901 CNV gain 25118596
nsv1027007 CNV gain 25217958
nsv526829 CNV loss 19592680

Variation tolerance for RRAGD Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRAGD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRAGD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAGD Gene

Disorders for RRAGD Gene

Additional Disease Information for RRAGD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RRAGD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRAGD Gene

Publications for RRAGD Gene

  1. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PMID: 11073942) Sekiguchi T … Nishimoto T (The Journal of biological chemistry 2001) 2 3 4 58
  2. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M … Superti-Furga G (Nature 2015) 3 4 58
  3. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. (PMID: 25259925) Peng M … Li MO (Cell 2014) 3 4 58
  4. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. (PMID: 22575674) Kim YM … Kim DH (Molecular cell 2012) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for RRAGD Gene

  • Addgene plasmids for RRAGD

Sources for RRAGD Gene

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