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Aliases for RRAD Gene

Aliases for RRAD Gene

  • RRAD, Ras Related Glycolysis Inhibitor And Calcium Channel Regulator 2 3 5
  • RRAD, Ras Related Glycolysis Inihibitor And Calcium Channel Regulator 2 3
  • Ras-Related Associated With Diabetes 2 3
  • Ras Associated With Diabetes 3 4
  • RAD1 3 4
  • RAD 3 4
  • RAS (RAD And GEM) Like GTP Binding 3 3
  • GTP-Binding Protein RAD 3
  • REM3 3

External Ids for RRAD Gene

Previous GeneCards Identifiers for RRAD Gene

  • GC16M057650
  • GC16M067333
  • GC16M066691
  • GC16M066731
  • GC16M065513
  • GC16M066955
  • GC16M052829

Summaries for RRAD Gene

GeneCards Summary for RRAD Gene

RRAD (RRAD, Ras Related Glycolysis Inhibitor And Calcium Channel Regulator) is a Protein Coding gene. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is GEM.

UniProtKB/Swiss-Prot for RRAD Gene

  • May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.

Gene Wiki entry for RRAD Gene

Additional gene information for RRAD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAD Gene

Genomics for RRAD Gene

GeneHancer (GH) Regulatory Elements for RRAD Gene

Promoters and enhancers for RRAD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J066924 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 658.1 -1.3 -1328 4.4 HDGF ARID4B ZNF48 ZNF121 ARID2 ZNF207 ZNF143 FOS ATF7 RUNX3 RRAD CENPT EDC4 PLEKHG4 E2F4 CTCF LRRC29 ACD CBFB FHOD1
GH16J066902 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15.4 +21.1 21103 4.1 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 ATF7 CES2 KIAA0895L E2F4 NAE1 RRAD CIAO2B EDC4 CENPT CTCF EXOC3L1
GH16J066879 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 +44.9 44872 2 PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 PDP2 EDC4 CTCF CES2 CENPT E2F4 ENSG00000260465 CDH16 RRAD NAE1
GH16J066899 Enhancer 1.4 Ensembl ENCODE dbSUPER 13.4 +24.9 24917 3.4 HDGF SMAD1 FOXA2 ARNT POLR2B ZNF766 REST ZNF592 KAT8 MEF2D CES2 CTCF E2F4 FBXL8 TRADD ZDHHC1 ENSG00000260465 RRAD CIAO2B ENKD1
GH16J066960 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.6 -35.5 -35476 1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF143 ATF7 DEK CES3 FBXL8 TRADD HSF4 CES2 RRAD CDH16 CIAO2B B3GNT9 CBFB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RRAD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RRAD gene promoter:
  • AML1a

Genomic Locations for RRAD Gene

Genomic Locations for RRAD Gene
chr16:66,921,679-66,925,644
(GRCh38/hg38)
Size:
3,966 bases
Orientation:
Minus strand
chr16:66,955,582-66,959,547
(GRCh37/hg19)
Size:
3,966 bases
Orientation:
Minus strand

Genomic View for RRAD Gene

Genes around RRAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAD Gene

Proteins for RRAD Gene

  • Protein details for RRAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55042-RAD_HUMAN
    Recommended name:
    GTP-binding protein RAD
    Protein Accession:
    P55042
    Secondary Accessions:
    • Q96F39

    Protein attributes for RRAD Gene

    Size:
    308 amino acids
    Molecular mass:
    33245 Da
    Quaternary structure:
    • Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).

    Three dimensional structures from OCA and Proteopedia for RRAD Gene

neXtProt entry for RRAD Gene

Post-translational modifications for RRAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAD Gene

No data available for DME Specific Peptides for RRAD Gene

Domains & Families for RRAD Gene

Gene Families for RRAD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRAD Gene

Suggested Antigen Peptide Sequences for RRAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55042

UniProtKB/Swiss-Prot:

RAD_HUMAN :
  • Belongs to the small GTPase superfamily. RGK family.
Family:
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with RRAD: view

Function for RRAD Gene

Molecular function for RRAD Gene

UniProtKB/Swiss-Prot Function:
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
UniProtKB/Swiss-Prot Induction:
Down-regulated in failing hearts.
GENATLAS Biochemistry:
Ras-GTPase activating protein family member,with high homology to GEM,overexpressed in non-insulin dependent diabetes mellitus (increasing insulin resistant)

Gene Ontology (GO) - Molecular Function for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,TAS --
GO:0005515 protein binding IPI 10359610
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RRAD: view
genes like me logo Genes that share phenotypes with RRAD: view

Animal Models for RRAD Gene

MGI Knock Outs for RRAD:
  • Rrad Rrad<tm1Yec>
  • Rrad Rrad<tm1.1(KOMP)Vlcg>

Animal Model Products

miRNA for RRAD Gene

miRTarBase miRNAs that target RRAD

Clone Products

  • Addgene plasmids for RRAD

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RRAD Gene

Localization for RRAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAD Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRAD gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RRAD: view

Pathways & Interactions for RRAD Gene

genes like me logo Genes that share pathways with RRAD: view

Pathways by source for RRAD Gene

1 BioSystems pathway for RRAD Gene

Gene Ontology (GO) - Biological Process for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction TAS 8248782
GO:1901841 regulation of high voltage-gated calcium channel activity IEA --
GO:1901842 negative regulation of high voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with RRAD: view

No data available for SIGNOR curated interactions for RRAD Gene

Drugs & Compounds for RRAD Gene

(4) Drugs for RRAD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RRAD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RRAD: view

Transcripts for RRAD Gene

mRNA/cDNA for RRAD Gene

Unigene Clusters for RRAD Gene

Ras-related associated with diabetes:
Representative Sequences:

Clone Products

  • Addgene plasmids for RRAD

Alternative Splicing Database (ASD) splice patterns (SP) for RRAD Gene

No ASD Table

Relevant External Links for RRAD Gene

GeneLoc Exon Structure for
RRAD
ECgene alternative splicing isoforms for
RRAD

Expression for RRAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRAD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RRAD Gene

This gene is overexpressed in Muscle - Skeletal (x16.2), Heart - Left Ventricle (x6.8), and Heart - Atrial Appendage (x6.8).

Protein differential expression in normal tissues from HIPED for RRAD Gene

This gene is overexpressed in Gallbladder (23.7) and Fetal heart (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRAD Gene



Protein tissue co-expression partners for RRAD Gene

NURSA nuclear receptor signaling pathways regulating expression of RRAD Gene:

RRAD

SOURCE GeneReport for Unigene cluster for RRAD Gene:

Hs.1027

mRNA Expression by UniProt/SwissProt for RRAD Gene:

P55042-RAD_HUMAN
Tissue specificity: Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.

Evidence on tissue expression from TISSUES for RRAD Gene

  • Muscle(4.7)
  • Eye(4.2)
  • Heart(2.6)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with RRAD: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAD Gene

Orthologs for RRAD Gene

This gene was present in the common ancestor of animals.

Orthologs for RRAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAD 34 33
  • 99.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RRAD 34 33
  • 89.28 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRAD 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAD 34 33
  • 86.64 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rrad 16 34 33
  • 85.8 (n)
rat
(Rattus norvegicus)
Mammalia Rrad 33
  • 85.68 (n)
oppossum
(Monodelphis domestica)
Mammalia RRAD 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRAD 34 33
  • 70.02 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAD 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrad 33
  • 64 (n)
Str.9633 33
zebrafish
(Danio rerio)
Actinopterygii rrad 34 33
  • 68.18 (n)
OneToOne
wufi06a10 33
fruit fly
(Drosophila melanogaster)
Insecta Rgk3 34
  • 19 (a)
ManyToMany
Rgk1 34
  • 18 (a)
ManyToMany
Rgk2 34
  • 12 (a)
ManyToMany
CG42541 34
  • 7 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 34
  • 16 (a)
OneToMany
Species where no ortholog for RRAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAD Gene

ENSEMBL:
Gene Tree for RRAD (if available)
TreeFam:
Gene Tree for RRAD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RRAD: view image

Paralogs for RRAD Gene

(15) SIMAP similar genes for RRAD Gene using alignment to 3 proteins:

  • RAD_HUMAN
  • J3KRG9_HUMAN
  • J3KSM6_HUMAN
genes like me logo Genes that share paralogs with RRAD: view

Variants for RRAD Gene

Sequence variations from dbSNP and Humsavar for RRAD Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000102227 -- 66,925,130(-) C/A coding_sequence_variant, missense_variant
rs1001046979 -- 66,925,280(-) G/C intron_variant
rs1001060859 -- 66,925,086(-) C/G coding_sequence_variant, missense_variant
rs1001097382 -- 66,925,574(-) C/A upstream_transcript_variant
rs1001121002 -- 66,924,659(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RRAD Gene

Variant ID Type Subtype PubMed ID
nsv572904 CNV loss 21841781
nsv827706 CNV loss 20364138

Variation tolerance for RRAD Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRAD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRAD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAD Gene

Disorders for RRAD Gene

Additional Disease Information for RRAD

No disorders were found for RRAD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRAD Gene

Publications for RRAD Gene

  1. Rad GTPase deficiency leads to cardiac hypertrophy. (PMID: 18056528) Chang L … Chen YE (Circulation 2007) 3 4 22 58
  2. Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. (PMID: 9115241) Moyers JS … Kahn CR (The Journal of biological chemistry 1997) 3 4 22 58
  3. RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma. (PMID: 26546438) Shang R … Wang D (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 2 3 58
  4. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. (PMID: 25114038) Zhang C … Feng Z (Oncotarget 2014) 2 3 58
  5. Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split. (PMID: 24992013) Puhl HL … Ikeda SR (PloS one 2014) 2 3 58

Products for RRAD Gene

Sources for RRAD Gene

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