Aliases for RPUSD3 Gene
External Ids for RPUSD3 Gene
Previous GeneCards Identifiers for RPUSD3 Gene
This gene encodes a protein that functions in the assembly of the mitochondrial ribosome by adding a pseudouridine group to 16S rRNA. Loss of this gene results in causes defects in mitochondrial protein production. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
GeneCards Summary for RPUSD3 Gene
RPUSD3 (RNA Pseudouridylate Synthase Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pseudouridine synthase activity. An important paralog of this gene is RPUSD4.
UniProtKB/Swiss-Prot for RPUSD3 Gene
Major enzyme responsible for the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT-CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability.