Aliases for RPUSD2 Gene

Aliases for RPUSD2 Gene

  • RNA Pseudouridine Synthase Domain Containing 2 2 3 5
  • RNA Pseudouridylate Synthase Domain-Containing Protein 2 3 4
  • RNA Pseudouridylate Synthase Domain Containing 2 2 3
  • C15orf19 3 4
  • C18B11 2 3
  • PUS9 2 3
  • Chromosome 15 Open Reading Frame 19 2
  • C18B11 Homolog (44.9kD) 3
  • FLJ31409 2
  • RPUSD2 5

External Ids for RPUSD2 Gene

Previous HGNC Symbols for RPUSD2 Gene

  • C15orf19

Previous GeneCards Identifiers for RPUSD2 Gene

  • GC15P038649
  • GC15P040861
  • GC15P017708

Summaries for RPUSD2 Gene

GeneCards Summary for RPUSD2 Gene

RPUSD2 (RNA Pseudouridine Synthase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pseudouridine synthase activity. An important paralog of this gene is RPUSD4.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPUSD2 Gene

Genomics for RPUSD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPUSD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J040568 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.5 480 2.4 SP1 ZNF207 MYC POLR2A BRCA1 ZBTB10 YY1 MXD4 SMAD5 SIN3A HSALNG0105265 RPUSD2 CCDC32 RMDN3 THBS1 KNL1
GH15J040567 Enhancer 0.7 ENCODE 250.7 -2.0 -1982 0.2 MYC CTCF THAP11 NBN SAP130 RAD21 TEAD3 ZSCAN9 FOXK2 HBP1 RPUSD2 CCDC32
GH15J040592 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11 +25.3 25257 3.3 SP1 ZNF207 ZNF600 SIX5 JUND ZNF580 ZNF592 ATF2 CEBPA POLR3G KNL1 TRS-GCT4-2 piR-34439-002 CCDC32 INO80 DNAJC17 ENSG00000259211 RMDN3 BMF RAD51-AS1
GH15J040742 Promoter/Enhancer 1.3 Ensembl ENCODE 10 +176.6 176625 7.4 ZNF654 MYC NCOR1 IKZF1 ZNF600 ZNF592 ZNF10 NFIC ZIC2 YY1 HSALNG0105282 CCDC32 RAD51 C15orf62 ZFYVE19 DNAJC17 RAD51-AS1 SPINT1 RHOV VPS18
GH15J040791 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.5 +225.3 225302 6 IKZF1 JUND CEBPA ATF3 BRCA1 NFIC YY1 CEBPB FEZF1 HOMEZ ZFYVE19 RMDN3 CCDC32 C15orf62 SPINT1 GCHFR RAD51 RAD51-AS1 RHOV RPUSD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPUSD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPUSD2

Top Transcription factor binding sites by QIAGEN in the RPUSD2 gene promoter:
  • aMEF-2
  • C/EBPbeta
  • E47
  • Egr-3
  • HEN1
  • HFH-1
  • ITF-2
  • MEF-2A
  • Pax-5
  • Tal-1beta

Genomic Locations for RPUSD2 Gene

Latest Assembly
chr15:40,569,299-40,574,949
(GRCh38/hg38)
Size:
5,651 bases
Orientation:
Plus strand

Previous Assembly
chr15:40,861,498-40,867,148
(GRCh37/hg19 by Entrez Gene)
Size:
5,651 bases
Orientation:
Plus strand

chr15:40,861,499-40,866,659
(GRCh37/hg19 by Ensembl)
Size:
5,161 bases
Orientation:
Plus strand

Genomic View for RPUSD2 Gene

Genes around RPUSD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPUSD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPUSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPUSD2 Gene

Proteins for RPUSD2 Gene

  • Protein details for RPUSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ73-RUSD2_HUMAN
    Recommended name:
    RNA pseudouridylate synthase domain-containing protein 2
    Protein Accession:
    Q8IZ73
    Secondary Accessions:
    • B4DDD1
    • Q7L989
    • Q92939
    • Q96IA7
    • Q96N50

    Protein attributes for RPUSD2 Gene

    Size:
    545 amino acids
    Molecular mass:
    61311 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB07777.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for RPUSD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPUSD2 Gene

Post-translational modifications for RPUSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPUSD2 Gene

No data available for DME Specific Peptides for RPUSD2 Gene

Domains & Families for RPUSD2 Gene

Gene Families for RPUSD2 Gene

Protein Domains for RPUSD2 Gene

Suggested Antigen Peptide Sequences for RPUSD2 Gene

GenScript: Design optimal peptide antigens:
  • RNA pseudouridylate synthase domain-containing protein 2 (RUSD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZ73

UniProtKB/Swiss-Prot:

RUSD2_HUMAN :
  • Belongs to the pseudouridine synthase RluA family.
Family:
  • Belongs to the pseudouridine synthase RluA family.
genes like me logo Genes that share domains with RPUSD2: view

Function for RPUSD2 Gene

Phenotypes From GWAS Catalog for RPUSD2 Gene

Gene Ontology (GO) - Molecular Function for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0009982 pseudouridine synthase activity IBA 21873635
genes like me logo Genes that share ontologies with RPUSD2: view
genes like me logo Genes that share phenotypes with RPUSD2: view

Animal Models for RPUSD2 Gene

MGI Knock Outs for RPUSD2:
  • Rpusd2 Rpusd2<tm1b(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPUSD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPUSD2 Gene

Localization for RPUSD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPUSD2 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with RPUSD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPUSD2 Gene

Pathways & Interactions for RPUSD2 Gene

PathCards logo

SuperPathways for RPUSD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000455 enzyme-directed rRNA pseudouridine synthesis IBA 21873635
GO:0001522 pseudouridine synthesis IEA --
GO:0008150 biological_process ND --
GO:0009451 RNA modification IEA --
genes like me logo Genes that share ontologies with RPUSD2: view

No data available for Pathways by source and SIGNOR curated interactions for RPUSD2 Gene

Drugs & Compounds for RPUSD2 Gene

(1) Additional Compounds for RPUSD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • (1S)-1,4-Anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol
  • 5-(beta-D-Ribofuranosyl)uracil
  • beta-Pseudouridine
  • p
  • Psi-uridine
1445-07-4
genes like me logo Genes that share compounds with RPUSD2: view

Transcripts for RPUSD2 Gene

mRNA/cDNA for RPUSD2 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPUSD2

Alternative Splicing Database (ASD) splice patterns (SP) for RPUSD2 Gene

No ASD Table

Relevant External Links for RPUSD2 Gene

GeneLoc Exon Structure for
RPUSD2

Expression for RPUSD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPUSD2 Gene

Protein differential expression in normal tissues from HIPED for RPUSD2 Gene

This gene is overexpressed in CD8 Tcells (13.0), Lymph node (12.2), Peripheral blood mononuclear cells (11.4), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPUSD2 Gene



Protein tissue co-expression partners for RPUSD2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPUSD2

SOURCE GeneReport for Unigene cluster for RPUSD2 Gene:

Hs.173311

Evidence on tissue expression from TISSUES for RPUSD2 Gene

  • Lung(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with RPUSD2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPUSD2 Gene

Orthologs for RPUSD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPUSD2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPUSD2 29 30
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPUSD2 29 30
  • 86.12 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPUSD2 30
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RPUSD2 29 30
  • 84.51 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rpusd2 29 16 30
  • 81.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPUSD2 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RPUSD2 29 30
  • 75.22 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPUSD2 30
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29407 29
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.19049 29
Zebrafish
(Danio rerio)
Actinopterygii LOC565088 29
  • 61.56 (n)
rpusd2 30
  • 48 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta RluA-2 29 30
  • 53.45 (n)
OneToMany
RluA-1 30
  • 31 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea K07E8.7 30
  • 35 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS9 30
  • 34 (a)
OneToMany
RIB2 30 32
  • 28 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 40 (a)
OneToMany
-- 30
  • 27 (a)
OneToMany
Species where no ortholog for RPUSD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RPUSD2 Gene

ENSEMBL:
Gene Tree for RPUSD2 (if available)
TreeFam:
Gene Tree for RPUSD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPUSD2: view image
Alliance of Genome Resources:
Additional Orthologs for RPUSD2

Paralogs for RPUSD2 Gene

Paralogs for RPUSD2 Gene

genes like me logo Genes that share paralogs with RPUSD2: view

Variants for RPUSD2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RPUSD2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RPUSD2 Gene

Variant ID Type Subtype PubMed ID
esv2760026 CNV loss 17122850
esv34145 CNV loss 18971310
nsv832984 CNV loss 17160897

Variation tolerance for RPUSD2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPUSD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPUSD2
Leiden Open Variation Database (LOVD)
RPUSD2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPUSD2 Gene

Disorders for RPUSD2 Gene

Additional Disease Information for RPUSD2

No disorders were found for RPUSD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPUSD2 Gene

Publications for RPUSD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3

Products for RPUSD2 Gene

Sources for RPUSD2 Gene