Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in th... See more...

Aliases for RPS9 Gene

Aliases for RPS9 Gene

  • Ribosomal Protein S9 2 3 5
  • 40S Ribosomal Protein S9 2 3 4
  • Small Ribosomal Subunit Protein US4 3 4
  • S9 2 3
  • RPS9 5

External Ids for RPS9 Gene

Previous GeneCards Identifiers for RPS9 Gene

  • GC19P055568
  • GC19P055129
  • GC19P059380
  • GC19P059396
  • GC19P054795
  • GC19P054800
  • GC19P051020
  • GC19P054806
  • GC19P054813
  • GC19P054820
  • GC19P054828
  • GC19P054842
  • GC19P054851
  • GC19P054866
  • GC19P054357
  • GC19P054370
  • GC19P054480
  • GC19P054519
  • GC19P054557
  • GC19P054603
  • GC19P054380
  • GC19P054389
  • GC19P054396
  • GC19P054403
  • GC19P054443
  • GC19P054453
  • GC19P054463
  • GC19P054472
  • GC19P055552
  • GC19P055928

Summaries for RPS9 Gene

Entrez Gene Summary for RPS9 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS9 Gene

RPS9 (Ribosomal Protein S9) is a Protein Coding gene. Diseases associated with RPS9 include Takayasu Arteritis and Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS9 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS9 Gene

Genomics for RPS9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054199 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 285 +5.0 5032 12.4 BCLAF1 SP1 ZNF207 ZNF600 NCOR1 MYC IKZF1 SSRP1 ZNF580 ZNF592 RPS9 HSALNG0127488 PRPF31 LENG8-AS1 LENG8 CNOT3 ZNF525 ENSG00000235681 ZNF845 ZNF761
GH19J054158 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -39.8 -39756 5.2 SP1 ZNF207 MYC ZNF580 POLR2A ZSCAN16 ZBTB10 YY1 MXD4 CTCF LENG1 lnc-TMC4-1 CNOT3 PRPF31 LENG8-AS1 TMC4 LENG8 ZNF765 ENSG00000269001 ZNF845
GH19J054136 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.6 -62.8 -62820 5.1 SP1 ZNF207 MYC IKZF1 ZNF600 POLR2A ZIC2 YY1 NONO CTCF CNOT3 HSALNG0127476 lnc-TFPT-3 TMC4 ZNF765 LENG8-AS1 PRPF31 ZNF525 ZNF845 LENG8
GH19J054196 Enhancer 0.5 Ensembl 20.4 -3.5 -3456 2.2 YY1 RXRA HNF4A ZBTB33 SP1 piR-52079-098 RPS9 TMC4 LILRB3 LILRA6 ENSG00000249189 LILRB5 ENSG00000223660 TSEN34
GH19J054240 Promoter 0.8 EPDnew Ensembl 6.5 +41.6 41644 2 ZIC2 GLIS1 LILRA6 LILRP1 RPS9 LILRB5 MK280272-001 LILRB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS9

Top Transcription factor binding sites by QIAGEN in the RPS9 gene promoter:
  • AREB6
  • c-Myc
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • NRSF form 1
  • NRSF form 2
  • XBP-1

Genomic Locations for RPS9 Gene

Latest Assembly
chr19:54,200,557-54,249,003
(GRCh38/hg38)
Size:
48,447 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,704,726-54,711,515
(GRCh37/hg19 by Entrez Gene)
Size:
6,790 bases
Orientation:
Plus strand

chr19:54,704,610-54,752,862
(GRCh37/hg19 by Ensembl)
Size:
48,253 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr19(ALT_REF_LOCI_1):175,657-182,446 (+)
  • chr19(ALT_REF_LOCI_2):175,840-182,629 (+)
  • chr19(ALT_REF_LOCI_3):175,840-182,629 (+)
  • chr19(ALT_REF_LOCI_4):175,840-182,629 (+)
  • chr19(ALT_REF_LOCI_5):175,840-182,629 (+)
  • chr19(ALT_REF_LOCI_6):175,840-182,629 (+)
  • chr19(ALT_REF_LOCI_7):175,830-182,618 (+)
  • chr19(ALT_REF_LOCI_8):175,840-182,629 (+)
  • chr19(ALT_REF_LOCI_9):175,840-182,629 (+)

Genomic View for RPS9 Gene

Genes around RPS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS9 Gene

Proteins for RPS9 Gene

  • Protein details for RPS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46781-RS9_HUMAN
    Recommended name:
    40S ribosomal protein S9
    Protein Accession:
    P46781
    Secondary Accessions:
    • A9C4C1
    • Q4QRK7
    • Q9BVZ0

    Protein attributes for RPS9 Gene

    Size:
    194 amino acids
    Molecular mass:
    22591 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS9 Gene

neXtProt entry for RPS9 Gene

Post-translational modifications for RPS9 Gene

  • Ubiquitination at Lys11, Lys30, Lys91, Lys93, Lys116, Lys121, Lys139, and Lys155
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS9 Gene

Domains & Families for RPS9 Gene

Gene Families for RPS9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS9 Gene

InterPro:
Blocks:
  • RNA-binding S4
  • Ribosomal protein S4

Suggested Antigen Peptide Sequences for RPS9 Gene

GenScript: Design optimal peptide antigens:
  • RPS9 protein (A5D904_HUMAN)
  • Ribosomal protein S9, isoform CRA_a (A9C4C1_HUMAN)
  • 40S ribosomal protein S9 (RS9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46781

UniProtKB/Swiss-Prot:

RS9_HUMAN :
  • Belongs to the universal ribosomal protein uS4 family.
Family:
  • Belongs to the universal ribosomal protein uS4 family.
genes like me logo Genes that share domains with RPS9: view

Function for RPS9 Gene

Molecular function for RPS9 Gene

GENATLAS Biochemistry:
40S ribosomal protein S9

Phenotypes From GWAS Catalog for RPS9 Gene

Gene Ontology (GO) - Molecular Function for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
GO:0005515 protein binding IPI 18420587
GO:0019843 rRNA binding IEA,IBA 21873635
GO:0045182 translation regulator activity IMP 18420587
genes like me logo Genes that share ontologies with RPS9: view
genes like me logo Genes that share phenotypes with RPS9: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS9 Gene

Localization for RPS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS9 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS9 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
cytoskeleton 2
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 18420587
GO:0005737 cytoplasm IEA,IDA 18420587
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RPS9 Gene

Pathways & Interactions for RPS9 Gene

PathCards logo

SuperPathways for RPS9 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.53
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 rRNA processing in the nucleus and cytosol
4 Influenza Viral RNA Transcription and Replication
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS9: view

Pathways by source for RPS9 Gene

2 KEGG pathways for RPS9 Gene
1 GeneGo (Thomson Reuters) pathway for RPS9 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,IMP 18420587
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS9: view

No data available for SIGNOR curated interactions for RPS9 Gene

Drugs & Compounds for RPS9 Gene

(1) Drugs for RPS9 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Experimental, Investigational Pharma Target, ligand 123
genes like me logo Genes that share compounds with RPS9: view

Transcripts for RPS9 Gene

mRNA/cDNA for RPS9 Gene

6 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS9

Alternative Splicing Database (ASD) splice patterns (SP) for RPS9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for RPS9 Gene

GeneLoc Exon Structure for
RPS9

Expression for RPS9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS9 Gene

This gene is overexpressed in Tlymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS9 Gene



Protein tissue co-expression partners for RPS9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS9

SOURCE GeneReport for Unigene cluster for RPS9 Gene:

Hs.467284

Evidence on tissue expression from TISSUES for RPS9 Gene

  • Nervous system(5)
  • Skin(4.9)
  • Intestine(4.9)
  • Blood(4.9)
  • Lung(4.8)
  • Liver(4.8)
  • Muscle(4.7)
  • Eye(4.6)
  • Pancreas(4.5)
  • Stomach(3.5)
  • Kidney(3.3)
  • Bone(3.3)
  • Heart(3.2)
  • Spleen(3.2)
  • Lymph node(3.2)
  • Bone marrow(3.1)
  • Thyroid gland(2.9)
  • Adrenal gland(2.8)
  • Gall bladder(2.5)
genes like me logo Genes that share expression patterns with RPS9: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS9 Gene

Orthologs for RPS9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 100 (a)
OneToMany
RPS9 29
  • 99.48 (n)
-- 30
  • 97 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia RPS9 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RPS9 29 30
  • 93.13 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPS9 29 30
  • 91.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rps9 29 16 30
  • 88.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rps9 29
  • 87.46 (n)
Oppossum
(Monodelphis domestica)
Mammalia RPS9 30
  • 86 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPS9 30
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rps9-prov 29
Zebrafish
(Danio rerio)
Actinopterygii rps9 29 30
  • 77.66 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9769 29
Fruit Fly
(Drosophila melanogaster)
Insecta RpS9 29 30 31
  • 77.36 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005061 29
  • 77.18 (n)
Worm
(Caenorhabditis elegans)
Secernentea rps-9 29 30 31
  • 71.96 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AEL255W 29
  • 69.48 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS9A 30
  • 68 (a)
OneToMany
RPS9B 29 30 32
  • 60.87 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23673g 29
  • 65.26 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G15200 29
  • 65.22 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2888 29
Rice
(Oryza sativa)
Liliopsida Os03g0154700 29
  • 68.13 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.23050 29
Corn
(Zea mays)
Liliopsida Zm.7072 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5674 30
  • 90 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU01949 29
  • 73.04 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps901 29
  • 67.27 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2684 29
Species where no ortholog for RPS9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)

Evolution for RPS9 Gene

ENSEMBL:
Gene Tree for RPS9 (if available)
TreeFam:
Gene Tree for RPS9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS9: view image
Alliance of Genome Resources:
Additional Orthologs for RPS9

Paralogs for RPS9 Gene

Pseudogenes.org Pseudogenes for RPS9 Gene

genes like me logo Genes that share paralogs with RPS9: view

No data available for Paralogs for RPS9 Gene

Variants for RPS9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS9 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_036543 A breast cancer sample p.Val137Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RPS9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RPS9 Gene

Variant ID Type Subtype PubMed ID
dgv432n27 CNV loss 19166990
esv2718812 CNV deletion 23290073
esv2756707 CNV loss 18971310
esv2758771 CNV gain+loss 17122850
nsv1066425 CNV gain 25217958
nsv2546 CNV deletion 18451855
nsv428371 CNV gain+loss 18775914
nsv458783 CNV loss 19166990
nsv510774 CNV deletion 20534489
nsv580148 CNV loss 21841781
nsv580149 CNV gain 21841781
nsv580150 CNV loss 21841781

Variation tolerance for RPS9 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS9
Leiden Open Variation Database (LOVD)
RPS9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS9 Gene

Disorders for RPS9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS9 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
takayasu arteritis
  • aortic arch syndrome
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS9

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RPS9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS9 Gene

Publications for RPS9 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4
  2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio JM … Iovanna JL (Biochimica et biophysica acta 1995) 2 3 4
  3. Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation. (PMID: 20221446) Lindström MS … Nistér M (PloS one 2010) 3 22
  4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 40
  5. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. (PMID: 18420587) Lindström MS … Zhang Y (The Journal of biological chemistry 2008) 3 22

Products for RPS9 Gene

Sources for RPS9 Gene