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Aliases for RPS8 Gene

Aliases for RPS8 Gene

  • Ribosomal Protein S8 2 3 5
  • Small Ribosomal Subunit Protein ES8 3 4
  • 40S Ribosomal Protein S8 3
  • OK/SW-Cl.83 3
  • S8 3

External Ids for RPS8 Gene

Previous GeneCards Identifiers for RPS8 Gene

  • GC01P044968
  • GC01P044241
  • GC01P044671
  • GC01P044654
  • GC01P044914
  • GC01P044915
  • GC01P044918
  • GC01P044927
  • GC01P045013
  • GC01P045240

Summaries for RPS8 Gene

Entrez Gene Summary for RPS8 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS8 Gene

RPS8 (Ribosomal Protein S8) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS8 Gene

Additional gene information for RPS8 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS8 Gene

Genomics for RPS8 Gene

GeneHancer (GH) Regulatory Elements for RPS8 Gene

Promoters and enhancers for RPS8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J044774 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 709 +1.0 967 3.7 ZFP64 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 MCM3 SP3 RPS8 ENSG00000225721 GC01P044811 GC01P044823 GC01P044833 GC01P044834 GC01P044835 GC01P044837 SNORD38A SNORD46
GH01J044651 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.1 -123.8 -123753 0.1 RPS8 ARMH1 RNU5F-1 GC01P044661 TMEM53 PIR47647 RNF220
GH01J044729 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 74.8 -43.9 -43877 2.8 CLOCK FEZF1 YBX1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D GC01M044732 RNU5D-1 GPBP1L1 TOE1 RPL7AP16 RPS8 HECTD3 RPS15AP10 NASP MUTYH
GH01J044720 Enhancer 1.5 Ensembl ENCODE dbSUPER 61.6 -52.4 -52447 4.8 MLX ZFP64 FEZF1 YBX1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GC01M044722 RNU5F-1 LOC105378690 TOE1 GPBP1L1 RPL7AP16 MUTYH HECTD3 RPS8 DMAP1
GH01J045684 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 39.4 +911.7 911719 5.1 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GPBP1L1 TMEM69 TOE1 LRRC41 RPS8 RPL7AP16 EFCAB14-AS1 HECTD3 MUTYH MAST2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS8 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • RelA
  • E47
  • Hand1
  • Nkx2-5
  • Gfi-1
  • SRF (504 AA)

Genomic Locations for RPS8 Gene

Genomic Locations for RPS8 Gene
3,529 bases
Plus strand
3,529 bases
Plus strand

Genomic View for RPS8 Gene

Genes around RPS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS8 Gene

Proteins for RPS8 Gene

  • Protein details for RPS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S8
    Protein Accession:
    Secondary Accessions:
    • P09058
    • Q6IRL7

    Protein attributes for RPS8 Gene

    208 amino acids
    Molecular mass:
    24205 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS8 Gene

neXtProt entry for RPS8 Gene

Post-translational modifications for RPS8 Gene

  • Ubiquitination at isoforms=193, isoforms=170, isoforms=98, and isoforms=37
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS8 Gene

Domains & Families for RPS8 Gene

Gene Families for RPS8 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS8 Gene

Suggested Antigen Peptide Sequences for RPS8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS8 family.
  • Belongs to the eukaryotic ribosomal protein eS8 family.
genes like me logo Genes that share domains with RPS8: view

Function for RPS8 Gene

Molecular function for RPS8 Gene

GENATLAS Biochemistry:
40S ribosomal protein S8,24kDa

Phenotypes From GWAS Catalog for RPS8 Gene

Gene Ontology (GO) - Molecular Function for RPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA,IBA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with RPS8: view
genes like me logo Genes that share phenotypes with RPS8: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for RPS8 Gene

Selected GeneGlobe predicted Target genes for RPS8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for RPS8 Gene

Localization for RPS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS8 Gene

Cytoplasm. Membrane; Lipid-anchor. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS8 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endoplasmic reticulum 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with RPS8: view

Pathways & Interactions for RPS8 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS8: view

Gene Ontology (GO) - Biological Process for RPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 8432552
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS8: view

No data available for SIGNOR curated interactions for RPS8 Gene

Drugs & Compounds for RPS8 Gene

(1) Drugs for RPS8 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
genes like me logo Genes that share compounds with RPS8: view

Transcripts for RPS8 Gene

mRNA/cDNA for RPS8 Gene

Unigene Clusters for RPS8 Gene

Ribosomal protein S8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS8 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for RPS8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS8 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS8 Gene

Protein tissue co-expression partners for RPS8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS8 Gene:


SOURCE GeneReport for Unigene cluster for RPS8 Gene:


Evidence on tissue expression from TISSUES for RPS8 Gene

  • Liver(4.9)
  • Pancreas(4.8)
  • Skin(4.7)
  • Nervous system(4.7)
  • Lung(4.6)
  • Eye(4.3)
  • Kidney(4.1)
  • Intestine(3.8)
  • Stomach(3.8)
  • Heart(3.7)
  • Blood(3.6)
  • Bone(3.6)
  • Muscle(3.6)
  • Bone marrow(2.5)
  • Lymph node(2.5)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with RPS8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS8 Gene

Orthologs for RPS8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
RPS8 33
  • 90.54 (n)
(Pan troglodytes)
Mammalia RPS8 34
  • 100 (a)
(Bos Taurus)
Mammalia RPS8 34 33
  • 91.67 (n)
(Rattus norvegicus)
Mammalia Rps8 33
  • 90.71 (n)
(Mus musculus)
Mammalia Rps8 16 34 33
  • 90.06 (n)
(Monodelphis domestica)
Mammalia RPS8 34
  • 78 (a)
(Gallus gallus)
Aves RPS8 34 33
  • 83.17 (n)
(Anolis carolinensis)
Reptilia RPS8 34
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps8 33
  • 80.13 (n)
(Danio rerio)
Actinopterygii rps8b 34 33
  • 78.04 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4092 33
fruit fly
(Drosophila melanogaster)
Insecta CG7808 35
  • 68 (a)
RpS8 34 33
  • 67.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002437 33
  • 66.02 (n)
(Caenorhabditis elegans)
Secernentea rps-8 34 35 33
  • 62.5 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS8B 34
  • 62 (a)
RPS8A 34 33
  • 57 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR375W 33
  • 60.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20461g 33
  • 57.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59240 33
  • 58.62 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11572 33
(Oryza sativa)
Liliopsida Os.11541 33
(Zea mays)
Liliopsida Zm.7012 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5224 34
  • 62 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08500 33
  • 59.63 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps801 33
  • 56.45 (n)
Species where no ortholog for RPS8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS8 Gene

Gene Tree for RPS8 (if available)
Gene Tree for RPS8 (if available)
Evolutionary constrained regions (ECRs) for RPS8: view image

Paralogs for RPS8 Gene

No data available for Paralogs for RPS8 Gene

Variants for RPS8 Gene

Sequence variations from dbSNP and Humsavar for RPS8 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000374451 -- 44,777,152(+) G/C intron_variant
rs1001053651 -- 44,773,624(+) A/G upstream_transcript_variant
rs1001572494 -- 44,778,458(+) A/G intron_variant
rs1002100619 -- 44,776,212(+) C/A intron_variant
rs1002496332 -- 44,774,649(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS8 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV loss 19166990
nsv546145 CNV loss 21841781
nsv945912 CNV duplication 23825009
nsv998871 CNV loss 25217958

Variation tolerance for RPS8 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS8 Gene

Disorders for RPS8 Gene

Additional Disease Information for RPS8

No disorders were found for RPS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS8 Gene

Publications for RPS8 Gene

  1. The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1. (PMID: 8432552) Davies B … Fried M (Genomics 1993) 2 3 4 22 58
  2. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov SN … Otto A (European journal of biochemistry 1996) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RPS8 Gene

Sources for RPS8 Gene

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