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Aliases for RPS6KL1 Gene

Aliases for RPS6KL1 Gene

  • Ribosomal Protein S6 Kinase Like 1 2 3 5
  • Ribosomal Protein S6 Kinase-Like 1 2 3
  • EC 4
  • RSKL2 3

External Ids for RPS6KL1 Gene

Previous GeneCards Identifiers for RPS6KL1 Gene

  • GC14M069189
  • GC14M073362
  • GC14M074442
  • GC14M075372
  • GC14M055540

Summaries for RPS6KL1 Gene

GeneCards Summary for RPS6KL1 Gene

RPS6KL1 (Ribosomal Protein S6 Kinase Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KC1.

Additional gene information for RPS6KL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KL1 Gene

Genomics for RPS6KL1 Gene

GeneHancer (GH) Regulatory Elements for RPS6KL1 Gene

Promoters and enhancers for RPS6KL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I074923 Promoter/Enhancer 1.4 Ensembl ENCODE 573 +0.2 172 1.3 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ATF7 NFYC KAT8 RPS6KL1 GC14M074923 PIR35524 DLST
GH14I074922 Promoter 0.8 EPDnew 550.8 +0.9 867 0.1 NCOA3 BCOR ESRRA ZNF189 ZNF341 NFXL1 GC14M074923 PIR35524 RPS6KL1
GH14I074880 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 24.7 +39.2 39232 6.5 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 DLST ZNF410 RPS6KL1 NEK9 YLPM1 PGF TTLL5 ENSG00000258559 FCF1 MLH3
GH14I074762 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13 +159.2 159158 3.8 HDGF SMAD1 ARNT ZFP64 NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 YLPM1 ZNF410 ELMSAN1 MLH3 TTLL5 RPS6KL1 ENSG00000258559 ENSG00000258891 NEK9 ABCD4
GH14I074898 Enhancer 0.9 ENCODE 25.6 +24.6 24564 1.2 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 RXRA MXD4 MIER2 PPARG RPS6KL1 PGF PROX2 ZC2HC1C ACYP1 MLH3 DLST PIR36863
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS6KL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS6KL1 gene promoter:

Genomic Locations for RPS6KL1 Gene

Genomic Locations for RPS6KL1 Gene
20,548 bases
Minus strand

Genomic View for RPS6KL1 Gene

Genes around RPS6KL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KL1 Gene

Proteins for RPS6KL1 Gene

  • Protein details for RPS6KL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein S6 kinase-like 1
    Protein Accession:
    Secondary Accessions:
    • A6NGM9
    • Q69YT9
    • Q6ZMQ6
    • Q96NR9
    • Q9BSU9

    Protein attributes for RPS6KL1 Gene

    549 amino acids
    Molecular mass:
    60036 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RPS6KL1 Gene


neXtProt entry for RPS6KL1 Gene

Post-translational modifications for RPS6KL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPS6KL1 Gene

Domains & Families for RPS6KL1 Gene

Gene Families for RPS6KL1 Gene

Protein Domains for RPS6KL1 Gene

Suggested Antigen Peptide Sequences for RPS6KL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KL1: view

Function for RPS6KL1 Gene

Molecular function for RPS6KL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for RPS6KL1 Gene

Phenotypes From GWAS Catalog for RPS6KL1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with RPS6KL1: view
genes like me logo Genes that share phenotypes with RPS6KL1: view

Animal Models for RPS6KL1 Gene

MGI Knock Outs for RPS6KL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KL1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KL1 Gene

Localization for RPS6KL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KL1 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPS6KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPS6KL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS6KL1 Gene

Pathways & Interactions for RPS6KL1 Gene

SuperPathways for RPS6KL1 Gene

No Data Available

Interacting Proteins for RPS6KL1 Gene

Gene Ontology (GO) - Biological Process for RPS6KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with RPS6KL1: view

No data available for Pathways by source and SIGNOR curated interactions for RPS6KL1 Gene

Drugs & Compounds for RPS6KL1 Gene

No Compound Related Data Available

Transcripts for RPS6KL1 Gene

Unigene Clusters for RPS6KL1 Gene

Ribosomal protein S6 kinase-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a ·
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - -
SP10: -
SP11: -
SP13: -

ExUns: 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: -
SP9: - -

Relevant External Links for RPS6KL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6KL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS6KL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS6KL1 Gene

This gene is overexpressed in Heart (45.5) and Peripheral blood mononuclear cells (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RPS6KL1 Gene

Protein tissue co-expression partners for RPS6KL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS6KL1 Gene:


SOURCE GeneReport for Unigene cluster for RPS6KL1 Gene:


Evidence on tissue expression from TISSUES for RPS6KL1 Gene

  • Nervous system(4.7)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RPS6KL1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KL1 Gene

Orthologs for RPS6KL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS6KL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS6KL1 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia RPS6KL1 33 34
  • 85.11 (n)
(Rattus norvegicus)
Mammalia Rps6kl1 33
  • 81.19 (n)
(Mus musculus)
Mammalia Rps6kl1 33 16 34
  • 80.82 (n)
(Bos Taurus)
Mammalia RPS6KL1 34
  • 78 (a)
(Monodelphis domestica)
Mammalia RPS6KL1 34
  • 60 (a)
(Gallus gallus)
Aves RPS6KL1 34
  • 51 (a)
(Anolis carolinensis)
Reptilia RPS6KL1 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6kl1 33
  • 59.12 (n)
(Danio rerio)
Actinopterygii LOC101886230 33
  • 64.61 (n)
rps6kl1 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7156 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea rskd-1 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
Species where no ortholog for RPS6KL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KL1 Gene

Gene Tree for RPS6KL1 (if available)
Gene Tree for RPS6KL1 (if available)

Paralogs for RPS6KL1 Gene

Paralogs for RPS6KL1 Gene

(4) SIMAP similar genes for RPS6KL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RPS6KL1: view

Variants for RPS6KL1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KL1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000172409 -- 74,912,338(-) G/A intron_variant
rs1000336096 -- 74,914,735(-) G/A intron_variant
rs1000398446 -- 74,906,650(-) G/A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000629554 -- 74,908,592(-) A/C intron_variant
rs1000650494 -- 74,905,494(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Variation tolerance for RPS6KL1 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.23; 96.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS6KL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPS6KL1 Gene

Disorders for RPS6KL1 Gene

Additional Disease Information for RPS6KL1

No disorders were found for RPS6KL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS6KL1 Gene

Publications for RPS6KL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M … Lindquist S (Cell 2012) 3 58
  5. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C … Stratton MR (Nature 2007) 4 58

Products for RPS6KL1 Gene

Sources for RPS6KL1 Gene

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