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Aliases for RPS6KB2 Gene

Aliases for RPS6KB2 Gene

  • Ribosomal Protein S6 Kinase B2 2 3 5
  • 70 KDa Ribosomal Protein S6 Kinase 2 3 4
  • Serine/Threonine-Protein Kinase 14B 3 4
  • P70 Ribosomal S6 Kinase Beta 3 4
  • S6 Kinase-Related Kinase 3 4
  • P70 S6 Kinase Beta 3 4
  • P70 S6K-Beta 3 4
  • S6K-Beta-2 3 4
  • P70-S6K 2 3 4
  • P70-Beta 3 4
  • S6K-Beta 3 4
  • P70 S6KB 3 4
  • P70S6K2 3 4
  • STK14B 3 4
  • S6K2 3 4
  • SRK 3 4
  • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 3
  • Ribosomal Protein S6 Kinase, 70kD, Polypeptide 2 2
  • Serine/Threonine-Protein Kinase 14 Beta 3
  • Ribosomal Protein S6 Kinase Beta-2 3
  • P70(S6K)-Beta 3
  • EC 4
  • P70-Beta-1 3
  • P70-Beta-2 3
  • S6K-Beta2 3
  • S6KI(2) 3
  • S6Kbeta 3
  • P70S6Kb 3
  • S6KB 3
  • KLS 3

External Ids for RPS6KB2 Gene

Previous GeneCards Identifiers for RPS6KB2 Gene

  • GC11P069692
  • GC11P068892
  • GC11P067445
  • GC11P066971
  • GC11P066932
  • GC11P066952
  • GC11P067195
  • GC11P063523

Summaries for RPS6KB2 Gene

Entrez Gene Summary for RPS6KB2 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

GeneCards Summary for RPS6KB2 Gene

RPS6KB2 (Ribosomal Protein S6 Kinase B2) is a Protein Coding gene. Diseases associated with RPS6KB2 include Kleine-Levin Hibernation Syndrome and Recurrent Hypersomnia. Among its related pathways are Apelin signaling pathway and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KB1.

UniProtKB/Swiss-Prot for RPS6KB2 Gene

  • Phosphorylates specifically ribosomal protein S6.

Gene Wiki entry for RPS6KB2 Gene

Additional gene information for RPS6KB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KB2 Gene

Genomics for RPS6KB2 Gene

GeneHancer (GH) Regulatory Elements for RPS6KB2 Gene

Promoters and enhancers for RPS6KB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J067427 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.1 123 2.5 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 RPS6KB2 PTPRCAP CARNS1 RPS6KB2-AS1
GH11J067116 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.8 -308.8 -308757 5.7 PKNOX1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 ZNF207 SP3 KDM2A ENSG00000258297 RBM14 ENSG00000254461 LOC105369352 RBM4 RAD9A RCE1 ENSG00000245156 BBS1
GH11J067627 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.2 +202.8 202828 8.6 HDGF CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B NUDT8 PPP6R3 ENSG00000260808 DOC2GP ENSG00000255119 ENSG00000258297 KDM2A RAD9A RBM4 RPS6KB2
GH11J066743 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 13.2 -683.8 -683752 2.9 ARID4B SIN3A ZBTB7B YY1 POLR2B ZNF207 ZNF143 FOS SP3 SP5 SPTBN2 GC11M066742 C11orf80 EIF1AD ENSG00000258297 RBM14 KDM2A RBM4 MRPL11 SART1
GH11J068098 Enhancer 1.4 Ensembl ENCODE dbSUPER 20.7 +672.6 672582 4.7 FOXA2 SMAD1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF213 SP5 KMT5B PPP6R3 MRGPRF-AS1 ENSG00000260808 ENSG00000261625 TPCN2 RAD9A MRGPRF KDM2A CORO1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS6KB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS6KB2 gene promoter:
  • Bach2
  • GATA-2
  • Sox9
  • HEN1
  • p53
  • c-Myc
  • Max
  • deltaCREB
  • CREB

Genomic Locations for RPS6KB2 Gene

Genomic Locations for RPS6KB2 Gene
6,949 bases
Plus strand
6,949 bases
Plus strand

Genomic View for RPS6KB2 Gene

Genes around RPS6KB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KB2 Gene

Proteins for RPS6KB2 Gene

  • Protein details for RPS6KB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein S6 kinase beta-2
    Protein Accession:
    Secondary Accessions:
    • B2RMZ9
    • B4DML8
    • O94809
    • Q9UEC1

    Protein attributes for RPS6KB2 Gene

    482 amino acids
    Molecular mass:
    53455 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPS6KB2 Gene


neXtProt entry for RPS6KB2 Gene

Post-translational modifications for RPS6KB2 Gene

  • Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPS6KB2 Gene

Domains & Families for RPS6KB2 Gene

Gene Families for RPS6KB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KB2: view

Function for RPS6KB2 Gene

Molecular function for RPS6KB2 Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates specifically ribosomal protein S6.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
GENATLAS Biochemistry:
ribosomal protein S6 kinase,70kDa,polypeptide 2,widely expressed,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essential regulatory role in protein synthesis during cell proliferation

Enzyme Numbers (IUBMB) for RPS6KB2 Gene

Gene Ontology (GO) - Molecular Function for RPS6KB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS 9804755
GO:0004674 protein serine/threonine kinase activity TAS 9878560
GO:0004711 ribosomal protein S6 kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with RPS6KB2: view
genes like me logo Genes that share phenotypes with RPS6KB2: view

Animal Models for RPS6KB2 Gene

MGI Knock Outs for RPS6KB2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KB2

miRNA for RPS6KB2 Gene

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KB2 Gene

Localization for RPS6KB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KB2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KB2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPS6KB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RPS6KB2: view

Pathways & Interactions for RPS6KB2 Gene

genes like me logo Genes that share pathways with RPS6KB2: view

SIGNOR curated interactions for RPS6KB2 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPS6KB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 9804755
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 9804755
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with RPS6KB2: view

Drugs & Compounds for RPS6KB2 Gene

(9) Drugs for RPS6KB2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
BI-D1870 Pharma P90 RSK inhibitor,ATP-competitive and cell-permeable 0
FMK Pharma RSK inhibitor 0
LY2584702 Pharma p70 S6 kinase inhibitor 0
PF 4708671 Pharma P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor 0

(3) Additional Compounds for RPS6KB2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with RPS6KB2: view

Transcripts for RPS6KB2 Gene

Unigene Clusters for RPS6KB2 Gene

Ribosomal protein S6 kinase, 70kDa, polypeptide 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KB2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: -
SP6: -
SP7: -
SP8: - -
SP9: - -
SP10: - - - - -
SP13: - -
SP14: - - - -
SP15: - - -
SP17: -

ExUns: 16 ^ 17a · 17b

Relevant External Links for RPS6KB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6KB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS6KB2 Gene

Protein differential expression in normal tissues from HIPED for RPS6KB2 Gene

This gene is overexpressed in Adrenal (33.6) and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6KB2 Gene

Protein tissue co-expression partners for RPS6KB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS6KB2 Gene:


SOURCE GeneReport for Unigene cluster for RPS6KB2 Gene:


Evidence on tissue expression from TISSUES for RPS6KB2 Gene

  • Nervous system(4.5)
  • Lung(2.3)
  • Stomach(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RPS6KB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KB2 Gene

Orthologs for RPS6KB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPS6KB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS6KB2 34 33
  • 99.58 (n)
(Canis familiaris)
Mammalia RPS6KB2 34 33
  • 90.35 (n)
(Bos Taurus)
Mammalia RPS6KB2 34 33
  • 89.9 (n)
(Mus musculus)
Mammalia Rps6kb2 16 34 33
  • 88.38 (n)
(Rattus norvegicus)
Mammalia Rps6kb2 33
  • 88.31 (n)
(Monodelphis domestica)
Mammalia RPS6KB2 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia RPS6KB2 34
  • 81 (a)
(Gallus gallus)
Aves RPS6KB2 34
  • 90 (a)
(Anolis carolinensis)
Reptilia RPS6KB2 34
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta S6k 34 35
  • 59 (a)
Pk17E 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea Y47D3A.16 35
  • 57 (a)
R04A9.5 35
  • 51 (a)
rsks-1 34
  • 46 (a)
F28C10.3 35
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL389W 33
  • 54.98 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCH9 34 33
  • 52.72 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03586g 33
  • 50.31 (n)
Species where no ortholog for RPS6KB2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RPS6KB2 Gene

Gene Tree for RPS6KB2 (if available)
Gene Tree for RPS6KB2 (if available)
Evolutionary constrained regions (ECRs) for RPS6KB2: view image

Paralogs for RPS6KB2 Gene

genes like me logo Genes that share paralogs with RPS6KB2: view

Variants for RPS6KB2 Gene

Sequence variations from dbSNP and Humsavar for RPS6KB2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs374535834 An ovarian mucinous carcinoma sample 67,435,048(+) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000277298 -- 67,430,285(+) T/G intron_variant
rs1000306398 -- 67,435,821(+) CTCAGCAGGGCCTCAGCA/CTCAGCA downstream_transcript_variant
rs1000628032 -- 67,430,721(+) A/G intron_variant
rs1000965868 -- 67,434,507(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KB2 Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv524096 CNV loss 19592680

Variation tolerance for RPS6KB2 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.07; 93.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS6KB2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KB2 Gene

Disorders for RPS6KB2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS6KB2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
kleine-levin hibernation syndrome
  • kleine-levin syndrome
recurrent hypersomnia
  • primary recurrent hypersomnia
crouzon syndrome
  • craniofacial dysostosis, type i; cfd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPS6KB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPS6KB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KB2 Gene

Publications for RPS6KB2 Gene

  1. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. (PMID: 9804755) Gout I … Yonezawa K (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. (PMID: 12087098) Park IH … Chen J (The Journal of biological chemistry 2002) 3 4 22 58
  3. Characterization of S6K2, a novel kinase homologous to S6K1. (PMID: 10490847) Lee-Fruman KK … Blenis J (Oncogene 1999) 3 4 22 58
  4. Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases. (PMID: 9878560) Saitoh M … Ichijo H (Biochemical and biophysical research communications 1998) 2 3 4 58
  5. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. (PMID: 21035469) Slattery ML … Wolff RK (Mutation research 2011) 3 44 58

Products for RPS6KB2 Gene

Sources for RPS6KB2 Gene

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