Aliases for RPS6KB2 Gene
Aliases for RPS6KB2 Gene
- Ribosomal Protein S6 Kinase B2 2 3 5
- 70 KDa Ribosomal Protein S6 Kinase 2 3 4
- Serine/Threonine-Protein Kinase 14B 3 4
- P70 Ribosomal S6 Kinase Beta 3 4
- S6 Kinase-Related Kinase 3 4
- P70 S6 Kinase Beta 3 4
- P70 S6K-Beta 3 4
- EC 2.7.11.1 4 56
- S6K-Beta-2 3 4
- P70-S6K 2 3 4
- P70 S6KB 3 4
- P70-Beta 3 4
- S6K-Beta 3 4
- P70S6K2 3 4
- STK14B 3 4
External Ids for RPS6KB2 Gene
- HGNC: 10437
- Entrez Gene: 6199
- Ensembl: ENSG00000175634
- OMIM: 608939
- UniProtKB: Q9UBS0
Previous GeneCards Identifiers for RPS6KB2 Gene
- GC11P069692
- GC11P068892
- GC11P067445
- GC11P066971
- GC11P066932
- GC11P066952
- GC11P067195
- GC11P063523
Summaries for RPS6KB2 Gene
-
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
GeneCards Summary for RPS6KB2 Gene
RPS6KB2 (Ribosomal Protein S6 Kinase B2) is a Protein Coding gene. Diseases associated with RPS6KB2 include Kleine-Levin Hibernation Syndrome and Recurrent Hypersomnia. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and Translation Translation regulation by Alpha-1 adrenergic receptors. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KB1.
UniProtKB/Swiss-Prot for RPS6KB2 Gene
-
Phosphorylates specifically ribosomal protein S6.
Additional gene information for RPS6KB2 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KB2 Gene
Genomics for RPS6KB2 Gene
GeneHancer (GH) Regulatory Elements for RPS6KB2 Gene
Promoters and enhancers for RPS6KB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RPS6KB2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RPS6KB2 Gene
Genomic Locations for RPS6KB2 Gene
- chr11:67,428,460-67,435,408
- (GRCh38/hg38)
- Size:
- 6,949 bases
- Orientation:
- Plus strand
- chr11:67,195,931-67,202,879
- (GRCh37/hg19)
Genomic View for RPS6KB2 Gene
Genes around RPS6KB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.2 by Ensembl
- 11q13.2 by Entrez Gene
- 11q13.2 by HGNC
RPS6KB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPS6KB2 Gene
Proteins for RPS6KB2 Gene
-
Protein details for RPS6KB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBS0-KS6B2_HUMAN
- Recommended name:
- Ribosomal protein S6 kinase beta-2
- Protein Accession:
- Q9UBS0
- B2RMZ9
- B4DML8
- O94809
- Q9UEC1
Protein attributes for RPS6KB2 Gene
- Size:
- 482 amino acids
- Molecular mass:
- 53455 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA34402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for RPS6KB2 Gene
Selected DME Specific Peptides for RPS6KB2 Gene
- Q9UBS0:
-
- YMAPEIL
- GIIYRDLK
- SEEDVSQ
- LQSEEDVSQFD
- KLTDFGLCKESIH
- YAFQTGGKLYLILE
- GGELFTHL
- IKLTDFG
- FLGFTYVAPSVL
- FCGTIEYMAP
- GHNRAVDWWSLGALMYDMLTG
- KGGYGKVF
- EDTACFYLAEI
- LGKGGYG
- KLTDFGL
- AKDTAHT
- RDLKPEN
- FTRQTPVDSPDD
- GHIKLTD
- DFGLCKE
Post-translational modifications for RPS6KB2 Gene
- Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
Other Protein References for RPS6KB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RPS6KB2 (p70 S6 Kinase beta)
- Cell Signaling Technology (CST) Antibodies for RPS6KB2 (P70S6KB)
-
Custom Antibody ServicesOriGene Antibodies for RPS6KB2
- Novus Biologicals Antibodies for RPS6KB2
-
Abcam antibodies for RPS6KB2
-
Cloud-Clone Corp. Antibodies for RPS6KB2
- Invitrogen Antibodies for RPS6KB2
- GeneTex RPS6KB2 antibody for RPS6KB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for RPS6KB2
Protein Products
-
OriGene Purified Proteins for RPS6KB2
- Search Origene for MassSpec and Protein Over-expression Lysates for RPS6KB2
- Origene Custom Protein Services for RPS6KB2
-
Cloud-Clone Corp. Proteins for RPS6KB2
- Search GeneTex for Proteins for RPS6KB2
-
Abcam proteins for RPS6KB2
Assay Products
Domains & Families for RPS6KB2 Gene
Gene Families for RPS6KB2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for RPS6KB2 Gene
Suggested Antigen Peptide Sequences for RPS6KB2 Gene
Graphical View of Domain Structure for InterPro Entry
Q9UBS0UniProtKB/Swiss-Prot:
KS6B2_HUMAN :- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Function for RPS6KB2 Gene
Molecular function for RPS6KB2 Gene
- GENATLAS Biochemistry:
- ribosomal protein S6 kinase,70kDa,polypeptide 2,widely expressed,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essential regulatory role in protein synthesis during cell proliferation
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Phosphorylates specifically ribosomal protein S6.
Enzyme Numbers (IUBMB) for RPS6KB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA,TAS | 9804755 |
| GO:0004674 | protein serine/threonine kinase activity | TAS | 9878560 |
| GO:0004711 | ribosomal protein S6 kinase activity | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for RPS6KB2 Gene
- MGI mutant phenotypes for RPS6KB2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RPS6KB2:
-
- Increased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased viability
- Increased cell viability after pRB stimulation
- Decreased cell proliferation
- Condensed cis-Golgi
- Decreased telomerase activity
- Decreased viability with RAF265
Animal Models for RPS6KB2 Gene
- MGI Knock Outs for RPS6KB2:
-
- Rps6kb2 tm1Gtho
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RPS6KB2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RPS6KB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS6KB2 gene
- Search ViGene Biosciences for RPS6KB2
CRISPR Products
-
OriGene CRISPR knockouts for RPS6KB2
- genomics-online: gRNA clones - Search results for 115 available RPS6KB2 gene related products
- Overview of 115 available RPS6KB2 gene related products
- Applied Biological Materials CRISPR for RPS6KB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS6KB2
- GenScript: Design CRISPR guide RNA sequences for RPS6KB2
miRNA for RPS6KB2 Gene
- miRTarBase miRNAs that target RPS6KB2
miRNA Products
- Search ViGene Biosciences for RPS6KB2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RPS6KB2
- Browse OriGene Inhibitory RNA Products For RPS6KB2
- genomics-online: shRNA clones - Search results for 115 available RPS6KB2 gene related products
- Overview of 115 available RPS6KB2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS6KB2 gene
Clone Products
- Sino Biological Human cDNA Clone for RPS6KB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RPS6KB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RPS6KB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RPS6KB2
- Applied Biological Materials Clones for RPS6KB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RPS6KB2
-
ViGene Biosciences adenoviral particle packaged cDNA for RPS6KB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RPS6KB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS6KB2 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KB2 Gene
Localization for RPS6KB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RPS6KB2 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | -- |
Pathways & Interactions for RPS6KB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 3 | PI3K/AKT activation |
.89
|
|
| 4 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 5 | Gastric cancer |
.62
.62
|
|
Pathways by source for RPS6KB2 Gene
3 Sino Biological pathways for RPS6KB2 Gene
2 Cell Signaling Technology pathways for RPS6KB2 Gene
7 BioSystems pathways for RPS6KB2 Gene
24 Reactome pathways for RPS6KB2 Gene
24 KEGG pathways for RPS6KB2 Gene
8 GeneGo (Thomson Reuters) pathways for RPS6KB2 Gene
4 R&D Systems pathways for RPS6KB2 Gene
2 Qiagen pathways for RPS6KB2 Gene
Interacting Proteins for RPS6KB2 Gene
Selected Interacting proteins:
ENSP00000308413
Q9UBS0-KS6B2_HUMAN
for RPS6KB2 Gene via
STRING
MINT
IID
SIGNOR curated interactions for RPS6KB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | TAS | 9804755 |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007165 | signal transduction | TAS | 9804755 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0035556 | intracellular signal transduction | IBA | -- |
Drugs & Compounds for RPS6KB2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist | 0 | ||
| BI-D1870 | Pharma | P90 RSK inhibitor,ATP-competitive and cell-permeable | 0 | |||
| FMK | Pharma | RSK inhibitor | 0 | |||
| LY2584702 | Pharma | p70 S6 kinase inhibitor | 0 | |||
| PF-4708671 | Pharma | P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(4) ApexBio Compounds for RPS6KB2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BI-D1870 | P90 RSK inhibitor,ATP-competitive and cell-permeable | 501437-28-1 |
| FMK | RSK inhibitor | 821794-92-7 |
| LY2584702 | p70 S6 kinase inhibitor | 1082949-67-4 |
| PF-4708671 | P70 S6K1 isoform inhibitor,cell-permeable | 1255517-76-0 |
Transcripts for RPS6KB2 Gene
mRNA/cDNA for RPS6KB2 Gene
- (8) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (364) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RPS6KB2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RPS6KB2
- genomics-online: gRNA clones - Search results for 115 available RPS6KB2 gene related products
- Overview of 115 available RPS6KB2 gene related products
- Applied Biological Materials CRISPR for RPS6KB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS6KB2
- GenScript: Design CRISPR guide RNA sequences for RPS6KB2
miRNA Products
- Search ViGene Biosciences for RPS6KB2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RPS6KB2
- Browse OriGene Inhibitory RNA Products For RPS6KB2
- genomics-online: shRNA clones - Search results for 115 available RPS6KB2 gene related products
- Overview of 115 available RPS6KB2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS6KB2 gene
Clone Products
- Sino Biological Human cDNA Clone for RPS6KB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RPS6KB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RPS6KB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RPS6KB2
- Applied Biological Materials Clones for RPS6KB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - |
| ExUns: | 16 | ^ | 17a | · | 17b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: | |||||
| SP13: | |||||
| SP14: | |||||
| SP15: | |||||
| SP16: | |||||
| SP17: |
Expression for RPS6KB2 Gene
This gene is overexpressed in Adrenal (33.6) and Placenta (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS6KB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of RPS6KB2 Gene:
RPS6KB2SOURCE GeneReport for Unigene cluster for RPS6KB2 Gene:
Hs.534345Evidence on tissue expression from TISSUES for RPS6KB2 Gene
- Nervous system(4.5)
- Lung(2.3)
- Stomach(2.2)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for RPS6KB2
-
OriGene qPCR primer pairs and template standards for RPS6KB2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KB2 Gene
Orthologs for RPS6KB2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RPS6KB2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RPS6KB2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RPS6KB2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Rps6kb2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rps6kb2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RPS6KB2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RPS6KB2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RPS6KB2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RPS6KB2 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | S6k 35 34 |
|
||
| Pk17E 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | Y47D3A.16 35 |
|
|
|
| R04A9.5 35 |
|
|
|||
| rsks-1 34 |
|
OneToMany | |||
| F28C10.3 35 |
|
|
|||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL389W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SCH9 33 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B03586g 33 |
|
- Species where no ortholog for RPS6KB2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for RPS6KB2 Gene
Paralogs for RPS6KB2 Gene
(65) SIMAP similar genes for RPS6KB2 Gene using alignment to 7 proteins:
- RPS6KB1
- RPS6KA2
- RPS6KA3
- RPS6KA5
- KIN27
- RPS6KA6
- RPS6KA4
- SGK2
- PRKCI
- SGK3
- PRKACA
- PRKACB
- RPS6KA1
- PRKCZ
- PRKG1
- SGKL
- DKFZp781N0293
- PRKACG
- PRKY
- AKT1
- PRKG2
- PRKCA
- AURKA
- PDPK1
- PRKCH
- SGK1
- PNCK
- AKT3
- AKT2
- PRKCQ
- CAMK1D
- CAMK1
- PkB-like 1
- STK32B
- ROCK2
- PKN1
- PRKX
- STK38L
- MAST2
- PRKCB
- ADRBK1
- NUAK1
- PRKAA1
- AURKB
- GRK6
- STK32C
- PKN3
- CIT
- CDC42BPG
- PAK4
- CDK4
- MAST4
- CDC42BPA
- STK38
- CAMK4
- AURKC
- PRKCG
- GRK5
- STK17A
- DAPK3
- STK33
- MYO3A
- MST094
- GRK1
- DAPK1
Variants for RPS6KB2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs374535834 | An ovarian mucinous carcinoma sample | 67,435,048(+) | C/A/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000277298 | -- | 67,430,285(+) | T/G | intron_variant | |
| rs1000306398 | -- | 67,435,821(+) | CTCAGCAGGGCCTCAGCA/CTCAGCA | downstream_transcript_variant | |
| rs1000628032 | -- | 67,430,721(+) | A/G | intron_variant | |
| rs1000965868 | -- | 67,434,507(+) | T/G | intron_variant |
Residual Variation Intolerance Score:
43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.07;
93.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RPS6KB2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KB2 Gene
Disorders for RPS6KB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kleine-levin hibernation syndrome |
|
|
| recurrent hypersomnia |
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Search RPS6KB2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RPS6KB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KB2 Gene
Publications for RPS6KB2 Gene
- Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. (PMID: 9804755) Gout I … Yonezawa K (The Journal of biological chemistry 1998) 2 3 4 22 58
- Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. (PMID: 12087098) Park IH … Chen J (The Journal of biological chemistry 2002) 3 4 22 58
- Characterization of S6K2, a novel kinase homologous to S6K1. (PMID: 10490847) Lee-Fruman KK … Blenis J (Oncogene 1999) 3 4 22 58
- Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases. (PMID: 9878560) Saitoh M … Ichijo H (Biochemical and biophysical research communications 1998) 2 3 4 58
- Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. (PMID: 21035469) Slattery ML … Wolff RK (Mutation research 2011) 3 44 58
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- genomics-online: cdna clones - Search results for 115 available RPS6KB2 gene related products
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Sources for RPS6KB2 Gene
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