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This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
RPS6KB2 (Ribosomal Protein S6 Kinase B2) is a Protein Coding gene. Diseases associated with RPS6KB2 include Esophagus Verrucous Carcinoma and Progressive Myoclonus Epilepsy 7. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA,TAS | 9804755 |
GO:0004674 | protein serine/threonine kinase activity | TAS,IBA | 21873635 |
GO:0004711 | ribosomal protein S6 kinase activity | IBA | -- |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
|
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
|
3 | GAB1 signalosome |
.89
|
|
4 | Endometrial cancer | ||
5 | AMP-activated Protein Kinase (AMPK) Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | TAS | 9804755 |
GO:0006468 | protein phosphorylation | IEA,IBA | 21873635 |
GO:0007165 | signal transduction | TAS | 9804755 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0031929 | TOR signaling | IMP | 29750193 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
BI-D1870 | Pharma | P90 RSK inhibitor,ATP-competitive and cell-permeable | 0 | |||
FMK | Pharma | RSK inhibitor | 0 | |||
LY2584702 | Pharma | p70 S6 kinase inhibitor | 0 | |||
PF 4708671 | Pharma | P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
BI-D1870 | P90 RSK inhibitor,ATP-competitive and cell-permeable | 501437-28-1 |
FMK | RSK inhibitor | 821794-92-7 |
LY2584702 | p70 S6 kinase inhibitor | 1082949-67-4 |
PF-4708671 | P70 S6K1 isoform inhibitor,cell-permeable | 1255517-76-0 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - |
ExUns: | 16 | ^ | 17a | · | 17b |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: | |||||
SP6: | |||||
SP7: | |||||
SP8: | |||||
SP9: | |||||
SP10: | |||||
SP11: | |||||
SP12: | |||||
SP13: | |||||
SP14: | |||||
SP15: | |||||
SP16: | |||||
SP17: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RPS6KB2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RPS6KB2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RPS6KB2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rps6kb2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rps6kb2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | RPS6KB2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RPS6KB2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RPS6KB2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RPS6KB2 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | S6k 31 32 |
|
OneToMany | |
Pk17E 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | Y47D3A.16 32 |
|
|
|
R04A9.5 32 |
|
|
|||
rsks-1 31 |
|
OneToMany | |||
F28C10.3 32 |
|
|
|||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL389W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SCH9 30 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B03586g 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs374535834 | An ovarian mucinous carcinoma sample | p.Thr443Met | |||
rs13859 | - | p.Ala420Val | |||
rs55642995 | - | p.Val368Met | |||
rs55987642 | - | p.Pro267Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
esophagus verrucous carcinoma |
|
|
progressive myoclonus epilepsy 7 |
|
|
kleine-levin hibernation syndrome |
|
|
recurrent hypersomnia |
|
|
kluver-bucy syndrome |
|
|