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This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015] See more...
Aliases for RPS6KB2 Gene
Aliases for RPS6KB2 Gene
- Ribosomal Protein S6 Kinase B2 2 3 5
- STK14B 2 3 4
- 70 KDa Ribosomal Protein S6 Kinase 2 3 4
- Serine/Threonine-Protein Kinase 14B 3 4
- Ribosomal Protein S6 Kinase Beta-2 3 4
- P70 Ribosomal S6 Kinase Beta 3 4
- S6 Kinase-Related Kinase 3 4
- P70 S6 Kinase Beta 3 4
- P70 S6K-Beta 3 4
- EC 2.7.11.1 4 51
- S6K-Beta-2 3 4
- P70-S6K 2 3 4
- P70-Beta 3 4
- S6K-Beta 3 4
- P70 S6KB 3 4
- S6Kbeta 2 3
- P70S6Kb 2 3
External Ids for RPS6KB2 Gene
- HGNC: 10437
- Entrez Gene: 6199
- Ensembl: ENSG00000175634
- OMIM: 608939
- UniProtKB: Q9UBS0
Previous GeneCards Identifiers for RPS6KB2 Gene
- GC11P069692
- GC11P068892
- GC11P067445
- GC11P066971
- GC11P066932
- GC11P066952
- GC11P067195
- GC11P063523
Summaries for RPS6KB2 Gene
-
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
GeneCards Summary for RPS6KB2 Gene
RPS6KB2 (Ribosomal Protein S6 Kinase B2) is a Protein Coding gene. Diseases associated with RPS6KB2 include Esophagus Verrucous Carcinoma and Progressive Myoclonus Epilepsy 7. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KB1.
UniProtKB/Swiss-Prot Summary for RPS6KB2 Gene
-
Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
Additional gene information for RPS6KB2 Gene
- HGNC(10437)
- Entrez Gene(6199)
- Ensembl(ENSG00000175634)
- OMIM(608939)
- UniProtKB(Q9UBS0)
- Open Targets Platform(ENSG00000175634)
- Search for RPS6KB2 at DataMed
- Search for RPS6KB2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS6KB2 Gene
Genomics for RPS6KB2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RPS6KB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RPS6KB2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS6KB2
- Top Transcription factor binding sites by QIAGEN in the RPS6KB2 gene promoter:
-
- Bach2
- c-Myc
- CREB
- deltaCREB
- GATA-2
- HEN1
- Max
- p53
- Sox9
Genomic Locations for RPS6KB2 Gene
Genomic Locations for RPS6KB2 Gene
- chr11:67,428,460-67,435,408
- (GRCh38/hg38)
- Size:
- 6,949 bases
- Orientation:
- Plus strand
- chr11:67,195,931-67,202,879
- (GRCh37/hg19)
- Size:
- 6,949 bases
- Orientation:
- Plus strand
Genomic View for RPS6KB2 Gene
Genes around RPS6KB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.2 by HGNC
- 11q13.2 by Entrez Gene
- 11q13.2 by Ensembl
RPS6KB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPS6KB2 Gene
Proteins for RPS6KB2 Gene
-
Protein details for RPS6KB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBS0-KS6B2_HUMAN
- Recommended name:
- Ribosomal protein S6 kinase beta-2
- Protein Accession:
- Q9UBS0
- B2RMZ9
- B4DML8
- O94809
- Q9UEC1
Protein attributes for RPS6KB2 Gene
- Size:
- 482 amino acids
- Molecular mass:
- 53455 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA34402.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for RPS6KB2 Gene
Selected DME Specific Peptides for RPS6KB2 Gene
- Q9UBS0:
-
- YMAPEIL
- GIIYRDLK
- SEEDVSQ
- LQSEEDVSQFD
- KLTDFGLCKESIH
- YAFQTGGKLYLILE
- GGELFTHL
- IKLTDFG
- FLGFTYVAPSVL
- FCGTIEYMAP
- GHNRAVDWWSLGALMYDMLTG
- KGGYGKVF
- EDTACFYLAEI
- LGKGGYG
- KLTDFGL
- AKDTAHT
- RDLKPEN
- FTRQTPVDSPDD
- GHIKLTD
- DFGLCKE
Post-translational modifications for RPS6KB2 Gene
- Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RPS6KB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents p70 S6 Kinase beta Antibody (RPS6KB2)
-
Custom Antibody ServicesOriGene Antibodies for RPS6KB2
- Novus Biologicals Antibodies for RPS6KB2
- Invitrogen Antibodies for RPS6KB2 (AFLGC-Rps6kb2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RPS6KB2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RPS6KB2
- Origene Custom Protein Services for RPS6KB2
-
Signalway Proteins for RPS6KB2
-
Abcam proteins for RPS6KB2
Assay Products
- antibodies-online: Show 3 available RPS6KB2 Elisa Kits ranked by validation data
- Compare Top RPS6KB2 Elisa Kits
-
Quality Products:
Domains & Families for RPS6KB2 Gene
Gene Families for RPS6KB2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for RPS6KB2 Gene
- InterPro:
- Blocks:
-
- Protein kinase C-terminal domain
- ProtoNet:
Suggested Antigen Peptide Sequences for RPS6KB2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58914, highly similar to Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (B4DML8_HUMAN)
- p70 ribosomal S6 kinase beta (KS6B2_HUMAN)
- Ribosomal protein S6 kinase, 70kDa, polypeptide 2 (Q9BRS0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UBS0UniProtKB/Swiss-Prot:
KS6B2_HUMAN :- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Function for RPS6KB2 Gene
Molecular function for RPS6KB2 Gene
- UniProtKB/Swiss-Prot Function:
- Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- GENATLAS Biochemistry:
- ribosomal protein S6 kinase,70kDa,polypeptide 2,widely expressed,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essential regulatory role in protein synthesis during cell proliferation
Enzyme Numbers (IUBMB) for RPS6KB2 Gene
Phenotypes From GWAS Catalog for RPS6KB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA,TAS | 9804755 |
| GO:0004674 | protein serine/threonine kinase activity | TAS,IBA | 21873635 |
| GO:0004711 | ribosomal protein S6 kinase activity | IBA | -- |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for RPS6KB2 Gene
- MGI mutant phenotypes for RPS6KB2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RPS6KB2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased transferrin (TF) endocytosis
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased cell viability after pRB stimulation
- Decreased viability
- Decreased cell proliferation
- Condensed cis-Golgi, condensed medial Golgi, condensed trans-Golgi
- Decreased viability with RAF265
- Increased telomerase activity
Animal Models for RPS6KB2 Gene
- MGI Knock Outs for RPS6KB2:
-
- Rps6kb2 Rps6kb2<tm1Gtho>
Animal Model Products
-
Taconic Biosciences Mouse Models for RPS6KB2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RPS6KB2 - Select products 50% OFF >
- * RPS6KB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RPS6KB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPS6KB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS6KB2
miRNA for RPS6KB2 Gene
- miRTarBase miRNAs that target RPS6KB2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPS6KB2
- Browse OriGene Inhibitory RNA Products For RPS6KB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6KB2
Clone Products
- Applied Biological Materials (abm): Clones for RPS6KB2 - Select products 50% OFF >
- * RPS6KB2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RPS6KB2
- Addgene plasmids for RPS6KB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPS6KB2
Cell Line Products
-
Horizon Cell Lines for RPS6KB2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KB2 Gene
Localization for RPS6KB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RPS6KB2 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
Pathways & Interactions for RPS6KB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
|
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
|
| 3 | GAB1 signalosome |
.89
|
|
| 4 | Endometrial cancer | ||
| 5 | AMP-activated Protein Kinase (AMPK) Signaling | ||
Pathways by source for RPS6KB2 Gene
3 Sino Biological pathways for RPS6KB2 Gene
7 BioSystems pathways for RPS6KB2 Gene
24 Reactome pathways for RPS6KB2 Gene
30 KEGG pathways for RPS6KB2 Gene
8 GeneGo (Thomson Reuters) pathways for RPS6KB2 Gene
- Apoptosis and survival BAD phosphorylation
- Development CNTF receptor signaling
- Development Endothelin-1/EDNRA transactivation of EGFR
- Regulation of lipid metabolism Insulin signaling-generic cascades
- Transcription Receptor-mediated HIF regulation
3 R&D Systems pathways for RPS6KB2 Gene
2 Qiagen pathways for RPS6KB2 Gene
- 14-3-3 Induced Intracellular Signaling
- FLT3 Signaling
2 Cell Signaling Technology pathways for RPS6KB2 Gene
Interacting Proteins for RPS6KB2 Gene
Selected Interacting proteins:
Q9UBS0-KS6B2_HUMAN
ENSP00000308413
for RPS6KB2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for RPS6KB2
SIGNOR curated interactions for RPS6KB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | TAS | 9804755 |
| GO:0006468 | protein phosphorylation | IEA,IBA | 21873635 |
| GO:0007165 | signal transduction | TAS | 9804755 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0031929 | TOR signaling | IMP | 29750193 |
Drugs & Compounds for RPS6KB2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| BI-D1870 | Pharma | P90 RSK inhibitor,ATP-competitive and cell-permeable | 0 | |||
| FMK | Pharma | RSK inhibitor | 0 | |||
| LY2584702 | Pharma | p70 S6 kinase inhibitor | 0 | |||
| PF 4708671 | Pharma | P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
(4) ApexBio Compounds for RPS6KB2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BI-D1870 | P90 RSK inhibitor,ATP-competitive and cell-permeable | 501437-28-1 |
| FMK | RSK inhibitor | 821794-92-7 |
| LY2584702 | p70 S6 kinase inhibitor | 1082949-67-4 |
| PF-4708671 | P70 S6K1 isoform inhibitor,cell-permeable | 1255517-76-0 |
Transcripts for RPS6KB2 Gene
mRNA/cDNA for RPS6KB2 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000312629 1733 nts (view in UCSC)
- ENST00000420069 461 nts (view in UCSC)
- ENST00000524814 550 nts (view in UCSC)
- ENST00000524934 466 nts (view in UCSC)
- ENST00000525088 5528 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RPS6KB2 - Select products 50% OFF >
- * RPS6KB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RPS6KB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPS6KB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS6KB2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPS6KB2
- Browse OriGene Inhibitory RNA Products For RPS6KB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6KB2
Clone Products
- Applied Biological Materials (abm): Clones for RPS6KB2 - Select products 50% OFF >
- * RPS6KB2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RPS6KB2
- Addgene plasmids for RPS6KB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPS6KB2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - |
| ExUns: | 16 | ^ | 17a | · | 17b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: | |||||
| SP13: | |||||
| SP14: | |||||
| SP15: | |||||
| SP16: | |||||
| SP17: |
Relevant External Links for RPS6KB2 Gene
- GeneLoc Exon Structure for
- RPS6KB2
Expression for RPS6KB2 Gene
This gene is overexpressed in Adrenal (33.6) and Placenta (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6KB2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS6KB2
SOURCE GeneReport for Unigene cluster for RPS6KB2 Gene:
Hs.534345Evidence on tissue expression from TISSUES for RPS6KB2 Gene
- Nervous system(4.6)
- Skin(3)
- Muscle(2.9)
- Bone marrow(2.8)
- Stomach(2.7)
- Lung(2.7)
- Liver(2.6)
- Spleen(2.5)
- Blood(2.5)
- Pancreas(2.4)
- Kidney(2.4)
- Lymph node(2.3)
- Intestine(2.3)
- Heart(2.3)
- Bone(2.2)
Primer Products
-
OriGene qPCR primer pairs for RPS6KB2
-
OriGene qPCR primer pairs and template standards for RPS6KB2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KB2 Gene
Orthologs for RPS6KB2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RPS6KB2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RPS6KB2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RPS6KB2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rps6kb2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rps6kb2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RPS6KB2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RPS6KB2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RPS6KB2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RPS6KB2 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | S6k 31 32 |
|
OneToMany | |
| Pk17E 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | Y47D3A.16 32 |
|
|
|
| R04A9.5 32 |
|
|
|||
| rsks-1 31 |
|
OneToMany | |||
| F28C10.3 32 |
|
|
|||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL389W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SCH9 30 31 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B03586g 30 |
|
- Species where no ortholog for RPS6KB2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for RPS6KB2 Gene
- ENSEMBL:
- Gene Tree for RPS6KB2 (if available)
- TreeFam:
- Gene Tree for RPS6KB2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RPS6KB2: view image
Paralogs for RPS6KB2 Gene
Paralogs for RPS6KB2 Gene
(65) SIMAP similar genes for RPS6KB2 Gene using alignment to 7 proteins:
- KS6B2_HUMAN
- B4DML8_HUMAN
- E9PIP7_HUMAN
- E9PQF6_HUMAN
- G3V2F1_HUMAN
- Q9BRS0_HUMAN
- R4GN47_HUMAN
- RPS6KB1
- RPS6KA2
- RPS6KA3
- RPS6KA5
- KIN27
- RPS6KA6
- RPS6KA4
- SGK2
- PRKCI
- SGK3
- PRKACA
- PRKACB
- RPS6KA1
- PRKCZ
- PRKG1
- SGKL
- DKFZp781N0293
- PRKACG
- PRKY
- AKT1
- PRKG2
- PRKCA
- AURKA
- PDPK1
- PRKCH
- SGK1
- PNCK
- AKT3
- AKT2
- PRKCQ
- CAMK1D
- CAMK1
- PkB-like 1
- STK32B
- ROCK2
- PKN1
- PRKX
- STK38L
- MAST2
- PRKCB
- ADRBK1
- NUAK1
- PRKAA1
- AURKB
- GRK6
- STK32C
- PKN3
- CIT
- CDC42BPG
- PAK4
- CDK4
- MAST4
- CDC42BPA
- STK38
- CAMK4
- AURKC
- PRKCG
- GRK5
- STK17A
- DAPK3
- STK33
- MYO3A
- MST094
- GRK1
- DAPK1
Variants for RPS6KB2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS6KB2 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs374535834 | An ovarian mucinous carcinoma sample | p.Thr443Met | |||
| rs13859 | - | p.Ala420Val | |||
| rs55642995 | - | p.Val368Met | |||
| rs55987642 | - | p.Pro267Leu |
Residual Variation Intolerance Score:
43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.07;
93.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RPS6KB2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KB2 Gene
Disorders for RPS6KB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| esophagus verrucous carcinoma |
|
|
| progressive myoclonus epilepsy 7 |
|
|
| kleine-levin hibernation syndrome |
|
|
| recurrent hypersomnia |
|
|
| kluver-bucy syndrome |
|
|
Search RPS6KB2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RPS6KB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KB2 Gene
Publications for RPS6KB2 Gene
- Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. (PMID: 9804755) Gout I … Yonezawa K (The Journal of biological chemistry 1998) 2 3 4 23
- Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. (PMID: 12087098) Park IH … Chen J (The Journal of biological chemistry 2002) 3 4 23
- Characterization of S6K2, a novel kinase homologous to S6K1. (PMID: 10490847) Lee-Fruman KK … Blenis J (Oncogene 1999) 3 4 23
- Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases. (PMID: 9878560) Saitoh M … Ichijo H (Biochemical and biophysical research communications 1998) 2 3 4
- Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. (PMID: 29750193) Nguyen JT … Krebsbach PH (Science advances 2018) 3 4
ExternalLinks
Products for RPS6KB2 Gene
- Custom Antibody ServicesOriGene Antibodies for RPS6KB2
- Browse OriGene ELISA Kits
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPS6KB2
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- Sino Biological Human cDNA Clone for RPS6KB2
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- Taconic Biosciences Mouse Models for RPS6KB2
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
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- ApexBio compounds for RPS6KB2
- VectorBuilder Custom and pre-made DNA vectors for RPS6KB2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RPS6KB2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RPS6KB2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RPS6KB2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RPS6KB2
- Addgene plasmids for RPS6KB2
- antibodies-online: Show 65 available RPS6KB2 Antibodies ranked by validation data
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- antibodies-online: Show 3 available RPS6KB2 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 11 available RPS6KB2 Proteins ranked by validation data
- Compare Top RPS6KB2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for RPS6KB2
- Search Santa Cruz Biotechnology (SCBT) for RPS6KB2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RPS6KB2
- Horizon Cell Lines for RPS6KB2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPS6KB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPS6KB2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RPS6KB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6KB2
- Signalway Proteins for RPS6KB2
Sources for RPS6KB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (30) HomoloGene
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- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
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- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (110) Genetics Home Reference
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- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
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- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
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- (148) RNACentral
- (149) LncRNADisease
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- (151) miR2Disease
- (152) DiseaseEnhancer
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- (154) Biorbyt
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- (156) Mastermind
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- (178) MirGeneDB