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This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
RPS6KB1 (Ribosomal Protein S6 Kinase B1) is a Protein Coding gene. Diseases associated with RPS6KB1 include Tuberous Sclerosis and Lymphangioleiomyomatosis. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Translation Translation regulation by Alpha-1 adrenergic receptors. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KB2.
Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | TAS,IDA | 17936702 |
GO:0004674 | protein serine/threonine kinase activity | IBA | 21873635 |
GO:0004711 | ribosomal protein S6 kinase activity | IBA | -- |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | IDA | 22797923 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005739 | mitochondrion | IEA,IDA | 17936702 |
GO:0005741 | mitochondrial outer membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
Development Thrombopoietin-regulated cell processes
.38
|
|
2 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF4F activity
.44
|
Development CNTF receptor signaling
.43
Development Growth hormone signaling via PI3K/AKT and MAPK cascades
.34
|
3 | RET signaling | ||
4 | mTOR signalling |
.72
|
.51
|
5 | Development IGF-1 receptor signaling |
Development IGF-1 receptor signaling
.48
Signal transduction AKT signaling
.48
|
Immune response IL-4 signaling pathway
.38
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | IMP | 14673156 |
GO:0006417 | regulation of translation | IEA | -- |
GO:0006468 | protein phosphorylation | IBA | 21873635 |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
XL418 | Investigational | Pharma | inhibitor | 0 | ||
PF 4708671 | Pharma | P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor | 0 | |||
A-443654 | Pharma | Akt inhibitor,potent and selective | 0 | |||
AT7867 | Pharma | Akt1/2/3 and p70S6K/PKA inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
RMM 46 |
|
1307896-46-3 |
|
|
Compound | Action | Cas Number |
---|---|---|
BRD 7389 | Ribosomal S6 kinase inhibitor | 376382-11-5 |
PF 4708671 | S6K1 inhibitor | 1255517-76-0 |
RMM 46 | MSK/RSK family kinase inhibitor | 1307896-46-3 |
SL 0101-1 | Selective ribosomal S6 kinase (RSK) inhibitor | 77307-50-7 |
Compound | Action | Cas Number |
---|---|---|
A-443654 | Akt inhibitor,potent and selective | 552325-16-3 |
AT7867 | Akt1/2/3 and p70S6K/PKA inhibitor | 857531-00-1 |
BI-D1870 | P90 RSK inhibitor,ATP-competitive and cell-permeable | 501437-28-1 |
FMK | RSK inhibitor | 821794-92-7 |
H 89 2HCl | Potent PKA inhibitor | 130964-39-5 |
LY2584702 | p70 S6 kinase inhibitor | 1082949-67-4 |
PF-4708671 | P70 S6K1 isoform inhibitor,cell-permeable | 1255517-76-0 |