Aliases for RPS6KA6 Gene
External Ids for RPS6KA6 Gene
Previous GeneCards Identifiers for RPS6KA6 Gene
This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
GeneCards Summary for RPS6KA6 Gene
RPS6KA6 (Ribosomal Protein S6 Kinase A6) is a Protein Coding gene. Diseases associated with RPS6KA6 include Coffin-Lowry Syndrome and Adrenal Cortical Adenocarcinoma. Among its related pathways are CNTF Signaling and Melanocyte Development and Pigmentation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA3.
UniProtKB/Swiss-Prot Summary for RPS6KA6 Gene
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.