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Aliases for RPS6KA6 Gene

Aliases for RPS6KA6 Gene

  • Ribosomal Protein S6 Kinase A6 2 3 5
  • 90 KDa Ribosomal Protein S6 Kinase 6 3 4
  • Ribosomal S6 Kinase 4 3 4
  • S6K-Alpha-6 3 4
  • P90-RSK 6 3 4
  • P90RSK6 3 4
  • RSK-4 3 4
  • RSK4 3 4
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 6 2
  • Ribosomal Protein S6 Kinase Alpha-6 3
  • S6K-Alpha 6 3
  • EC 4
  • PP90RSK4 3
  • Pp90RSK4 4

External Ids for RPS6KA6 Gene

Previous GeneCards Identifiers for RPS6KA6 Gene

  • GC0XM078698
  • GC0XM080395
  • GC0XM081354
  • GC0XM082090
  • GC0XM083125
  • GC0XM083318
  • GC0XM076885

Summaries for RPS6KA6 Gene

Entrez Gene Summary for RPS6KA6 Gene

  • This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

GeneCards Summary for RPS6KA6 Gene

RPS6KA6 (Ribosomal Protein S6 Kinase A6) is a Protein Coding gene. Diseases associated with RPS6KA6 include Coffin-Lowry Syndrome. Among its related pathways are mTOR Pathway and Melanocyte Development and Pigmentation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA3.

UniProtKB/Swiss-Prot for RPS6KA6 Gene

  • Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.

Tocris Summary for RPS6KA6 Gene

  • Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Additional gene information for RPS6KA6 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA6 Gene

Genomics for RPS6KA6 Gene

GeneHancer (GH) Regulatory Elements for RPS6KA6 Gene

Promoters and enhancers for RPS6KA6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ084186 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 654.6 +0.2 163 2 MXI1 L3MBTL2 ZBED1 ZBTB8A ZNF335 POLR2A PATZ1 PRDM10 ZFX ZBTB26 RPS6KA6 GC0XM083950
GH0XJ084175 Enhancer 0.4 ENCODE 10.4 +11.8 11778 1 SP1 FOXA2 HNF4A RPS6KA6 GC0XM083950
GH0XJ084118 Enhancer 0.4 ENCODE 10.4 +69.1 69120 1.4 SMARCE1 DPF2 RPS6KA6 GC0XM083950 GC0XM084061
GH0XJ084181 Enhancer 0.3 ENCODE 10.6 +5.3 5346 1.5 ZSCAN4 RPS6KA6 GC0XM083950
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS6KA6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS6KA6 gene promoter:
  • IRF-1
  • S8
  • SRY
  • Brachyury
  • CUTL1
  • E2F
  • E2F-1
  • HFH-1
  • AML1a
  • YY1

Genomic Locations for RPS6KA6 Gene

Genomic Locations for RPS6KA6 Gene
129,619 bases
Minus strand
129,590 bases
Minus strand

Genomic View for RPS6KA6 Gene

Genes around RPS6KA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA6 Gene

Proteins for RPS6KA6 Gene

  • Protein details for RPS6KA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein S6 kinase alpha-6
    Protein Accession:
    Secondary Accessions:
    • B2R854
    • B7ZL90
    • Q6FHX2
    • Q8WX28
    • Q9H4S6

    Protein attributes for RPS6KA6 Gene

    745 amino acids
    Molecular mass:
    83872 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with MAPK3/ERK1 but not with MAPK9 or MAPK14 in serum-starved cells.

    Alternative splice isoforms for RPS6KA6 Gene


neXtProt entry for RPS6KA6 Gene

Post-translational modifications for RPS6KA6 Gene

  • Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for RPS6KA6
  • Boster Bio Antibodies for RPS6KA6

No data available for DME Specific Peptides for RPS6KA6 Gene

Domains & Families for RPS6KA6 Gene

Suggested Antigen Peptide Sequences for RPS6KA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA6: view

Function for RPS6KA6 Gene

Molecular function for RPS6KA6 Gene

UniProtKB/Swiss-Prot Function:
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved cells. Does not require growth factor stimulation for significant kinase activity.
GENATLAS Biochemistry:
ribosomal protein S6 kinase 4,abundantly expressed in brain and kidney,involved in neuronal development,member of a family of growth factor related serine threonine kinases,deleted in patients with complex X-linked mental retardation

Enzyme Numbers (IUBMB) for RPS6KA6 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity TAS 10644430
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004711 ribosomal protein S6 kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RPS6KA6: view
genes like me logo Genes that share phenotypes with RPS6KA6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KA6

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6KA6 Gene

Localization for RPS6KA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA6 Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KA6 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS6KA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IBA,IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RPS6KA6: view

Pathways & Interactions for RPS6KA6 Gene

genes like me logo Genes that share pathways with RPS6KA6: view

Gene Ontology (GO) - Biological Process for RPS6KA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP 15042092
GO:0007165 signal transduction TAS 10644430
GO:0007417 central nervous system development TAS 10644430
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with RPS6KA6: view

No data available for SIGNOR curated interactions for RPS6KA6 Gene

Drugs & Compounds for RPS6KA6 Gene

(7) Drugs for RPS6KA6 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
BI-D1870 Pharma P90 RSK inhibitor,ATP-competitive and cell-permeable 0
BRD 7389 Pharma P90 RSK inhibitor, Ribosomal S6 kinase inhibitor 0

(2) Additional Compounds for RPS6KA6 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
RMM 46

(4) Tocris Compounds for RPS6KA6 Gene

Compound Action Cas Number
BRD 7389 Ribosomal S6 kinase inhibitor 376382-11-5
PF 4708671 S6K1 inhibitor 1255517-76-0
RMM 46 MSK/RSK family kinase inhibitor 1307896-46-3
SL 0101-1 Selective ribosomal S6 kinase (RSK) inhibitor 77307-50-7
genes like me logo Genes that share compounds with RPS6KA6: view

Transcripts for RPS6KA6 Gene

mRNA/cDNA for RPS6KA6 Gene

(9) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPS6KA6 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA6 Gene

No ASD Table

Relevant External Links for RPS6KA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6KA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS6KA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6KA6 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS6KA6 Gene:


SOURCE GeneReport for Unigene cluster for RPS6KA6 Gene:


Evidence on tissue expression from TISSUES for RPS6KA6 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RPS6KA6: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KA6 Gene

Orthologs for RPS6KA6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS6KA6 34 33
  • 98.17 (n)
(Bos Taurus)
Mammalia RPS6KA6 34 33
  • 94.18 (n)
(Canis familiaris)
Mammalia RPS6KA6 34 33
  • 93.19 (n)
(Rattus norvegicus)
Mammalia Rps6ka6 33
  • 88.27 (n)
(Ornithorhynchus anatinus)
Mammalia RPS6KA6 34
  • 88 (a)
(Mus musculus)
Mammalia Rps6ka6 16 34 33
  • 87.87 (n)
(Monodelphis domestica)
Mammalia RPS6KA6 34
  • 83 (a)
(Gallus gallus)
Aves RPS6KA6 34 33
  • 82.57 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
-- 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka6 33
  • 78.42 (n)
(Danio rerio)
Actinopterygii rps6kal 33
  • 73.72 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta S6kII 34 35
  • 46 (a)
Pk17E 35
  • 40 (a)
(Caenorhabditis elegans)
Secernentea T01H8.1b 35
  • 60 (a)
rskn-1 34
  • 53 (a)
R04A9.5 35
  • 43 (a)
F28C10.3 35
  • 35 (a)
(Oryza sativa)
Liliopsida Os.13521 33
(Triticum aestivum)
Liliopsida Ta.9084 33
(Zea mays)
Liliopsida Zm.12589 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 67 (a)
Species where no ortholog for RPS6KA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS6KA6 Gene

Gene Tree for RPS6KA6 (if available)
Gene Tree for RPS6KA6 (if available)
Evolutionary constrained regions (ECRs) for RPS6KA6: view image

Paralogs for RPS6KA6 Gene

Variants for RPS6KA6 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
VAR_040637 A lung large cell carcinoma sample p.Tyr140Cys
VAR_040638 A lung adenocarcinoma sample p.Ser258Thr
rs1000054503 -- 84,176,264(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000055760 -- 84,183,915(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000191431 -- 84,088,845(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA6 Gene

Variant ID Type Subtype PubMed ID
esv3367403 CNV insertion 20981092
nsv513613 CNV insertion 21212237
nsv9958 CNV loss 18304495

Variation tolerance for RPS6KA6 Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS6KA6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA6 Gene

Disorders for RPS6KA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS6KA6 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
coffin-lowry syndrome
  • cls
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPS6KA6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPS6KA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KA6 Gene

Publications for RPS6KA6 Gene

  1. A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation. (PMID: 10644430) Yntema HG … van Bokhoven H (Genomics 1999) 2 3 4 22 58
  2. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. (PMID: 15632195) Dümmler BA … Frödin M (The Journal of biological chemistry 2005) 3 4 22 58
  3. X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. (PMID: 19679225) Siddiqui RA … Platzer M (American journal of human genetics 2009) 3 44 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for RPS6KA6 Gene

Sources for RPS6KA6 Gene

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