Aliases for RPS6KA5 Gene

Aliases for RPS6KA5 Gene

  • Ribosomal Protein S6 Kinase A5 2 3 5
  • Nuclear Mitogen- And Stress-Activated Protein Kinase 1 3 4
  • 90 KDa Ribosomal Protein S6 Kinase 5 3 4
  • Ribosomal Protein S6 Kinase Alpha-5 3 4
  • RSK-Like Protein Kinase 3 4
  • S6K-Alpha-5 3 4
  • EC 2.7.11.1 4 52
  • MSK1 3 4
  • RSKL 3 4
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 5 2
  • EC 2.7.11.1'); 52
  • EC 2.7.11 52
  • MSPK1 3
  • RLPK 3

External Ids for RPS6KA5 Gene

Previous GeneCards Identifiers for RPS6KA5 Gene

  • GC14M088842
  • GC14M085153
  • GC14M089327
  • GC14M090406
  • GC14M091337
  • GC14M071512

Summaries for RPS6KA5 Gene

GeneCards Summary for RPS6KA5 Gene

RPS6KA5 (Ribosomal Protein S6 Kinase A5) is a Protein Coding gene. Diseases associated with RPS6KA5 include Septic Myocarditis and Coffin-Lowry Syndrome. Among its related pathways are Nuclear Events (kinase and transcription factor activation) and Signaling mediated by p38-alpha and p38-beta. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA4.

UniProtKB/Swiss-Prot Summary for RPS6KA5 Gene

  • Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).

Gene Wiki entry for RPS6KA5 Gene

Additional gene information for RPS6KA5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS6KA5 Gene

Genomics for RPS6KA5 Gene

GeneHancer (GH) Regulatory Elements for RPS6KA5 Gene

Promoters and enhancers for RPS6KA5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS6KA5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS6KA5

Top Transcription factor binding sites by QIAGEN in the RPS6KA5 gene promoter:
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for RPS6KA5 Gene

Genomic Locations for RPS6KA5 Gene
chr14:90,847,861-91,060,649
(GRCh38/hg38)
Size:
212,789 bases
Orientation:
Minus strand
chr14:91,336,799-91,526,993
(GRCh37/hg19)
Size:
190,195 bases
Orientation:
Minus strand

Genomic View for RPS6KA5 Gene

Genes around RPS6KA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA5 Gene

Proteins for RPS6KA5 Gene

  • Protein details for RPS6KA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75582-KS6A5_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-5
    Protein Accession:
    O75582
    Secondary Accessions:
    • B7Z2Y5
    • O95316
    • Q96AF7

    Protein attributes for RPS6KA5 Gene

    Size:
    802 amino acids
    Molecular mass:
    89865 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA. Interacts with CREBBP and EP300.
    Miscellaneous:
    • Enzyme activity requires the presence of both kinase domains.
    SequenceCaution:
    • Sequence=AAC69577.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS6KA5 Gene

    Alternative splice isoforms for RPS6KA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA5 Gene

Selected DME Specific Peptides for RPS6KA5 Gene

O75582:
  • VVHRDLK
  • WSLGVILY
  • ARSAMMKDSPF
  • RDIKLEN
  • GEIVLALEHLHKLGIIYRD
  • TSTSTETRSSSSESS
  • LMYELLTG
  • LTDFGLSK
  • GHDKAVDWWS
  • SPFTVDG
  • LIQGLLTVDPNKR
  • HFSETEAS
  • NFAEEFT
  • EIMKKIKKG
  • LGSSGAAVHT
  • LVSAVSHMHDVGVVHRDLKPENLLFTDE
  • LYAMKVL
  • EITALKLCEGHPN
  • LKPENLL
  • LRYNEWLQDGSQLSSNPLMTPD
  • LGIIYRD
  • RDLKPEN
  • LHYAFQT
  • KLENILLD
  • DLWSLGV
  • AVKIISKRMEANTQ
  • KRLGCGP
  • GKVFLVRK
  • GGELFTHL
  • FELLKVLG
  • KPLGEGSFSICRKC
  • FQGYSFVAPSILFKRNAA
  • FSFEGEAWKNVS
  • VHRDLKP
  • KLHLILDY
  • FCGTIEYMAP
  • GELFERI

Post-translational modifications for RPS6KA5 Gene

  • Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain.
  • Ubiquitinated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for RPS6KA5
  • Santa Cruz Biotechnology (SCBT) Antibodies for RPS6KA5

Domains & Families for RPS6KA5 Gene

Gene Families for RPS6KA5 Gene

Protein Domains for RPS6KA5 Gene

Suggested Antigen Peptide Sequences for RPS6KA5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54679, highly similar to Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (B7Z2Y5_HUMAN)
  • RSK-like protein kinase (KS6A5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75582

UniProtKB/Swiss-Prot:

KS6A5_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA5: view

Function for RPS6KA5 Gene

Molecular function for RPS6KA5 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269 PubMed:12628924, ECO:0000269 PubMed:9687510, ECO:0000269 PubMed:9873047};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269 PubMed:12628924, ECO:0000269 PubMed:9687510, ECO:0000269 PubMed:9873047};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha, and by further autophosphorylation of Ser-212, Ser-376 and Ser-381 by the activated C-terminal kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as Ser-750, Ser-752 and Ser-758 in its own C-terminal region.

Enzyme Numbers (IUBMB) for RPS6KA5 Gene

Phenotypes From GWAS Catalog for RPS6KA5 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA,IDA 9873047
GO:0004674 protein serine/threonine kinase activity TAS,IEA --
GO:0005515 protein binding IPI 12628924
GO:0005524 ATP binding IDA,IEA 9687510
genes like me logo Genes that share ontologies with RPS6KA5: view
genes like me logo Genes that share phenotypes with RPS6KA5: view

Animal Models for RPS6KA5 Gene

MGI Knock Outs for RPS6KA5:

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KA5

CRISPR Products

miRNA for RPS6KA5 Gene

miRTarBase miRNAs that target RPS6KA5

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KA5 Gene

Localization for RPS6KA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA5 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KA5 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPS6KA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP,IBA 12628924
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IDA 18511904
genes like me logo Genes that share ontologies with RPS6KA5: view

Pathways & Interactions for RPS6KA5 Gene

genes like me logo Genes that share pathways with RPS6KA5: view

Pathways by source for RPS6KA5 Gene

3 Sino Biological pathways for RPS6KA5 Gene
4 GeneGo (Thomson Reuters) pathways for RPS6KA5 Gene
  • Development EPO-induced Jak-STAT pathway
  • Development_TGF-beta receptor signaling
  • Transcription CREB pathway
  • Translation Regulation of EIF4F activity
15 Qiagen pathways for RPS6KA5 Gene
  • 14-3-3 Induced Intracellular Signaling
  • BAD Phosphorylation
  • Cellular Apoptosis Pathway
  • CNTF Signaling
  • ERK Signaling
1 Cell Signaling Technology pathway for RPS6KA5 Gene
1 GeneTex pathway for RPS6KA5 Gene

SIGNOR curated interactions for RPS6KA5 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPS6KA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production TAS 18508628
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated IEA,IMP 12763138
GO:0006468 protein phosphorylation IDA,IEA 9687510
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with RPS6KA5: view

Drugs & Compounds for RPS6KA5 Gene

(11) Drugs for RPS6KA5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
cyclic amp Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(3) Additional Compounds for RPS6KA5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with RPS6KA5: view

Transcripts for RPS6KA5 Gene

mRNA/cDNA for RPS6KA5 Gene

14 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2:

Relevant External Links for RPS6KA5 Gene

GeneLoc Exon Structure for
RPS6KA5

Expression for RPS6KA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS6KA5 Gene

Protein differential expression in normal tissues from HIPED for RPS6KA5 Gene

This gene is overexpressed in Urine (14.7), Lung (13.1), and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6KA5 Gene



Protein tissue co-expression partners for RPS6KA5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS6KA5

SOURCE GeneReport for Unigene cluster for RPS6KA5 Gene:

Hs.510225

mRNA Expression by UniProt/SwissProt for RPS6KA5 Gene:

O75582-KS6A5_HUMAN
Tissue specificity: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.

Evidence on tissue expression from TISSUES for RPS6KA5 Gene

  • Nervous system(4.6)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with RPS6KA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KA5 Gene

Orthologs for RPS6KA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS6KA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA5 31 30
  • 99.49 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS6KA5 31
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KA5 31
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA5 31 30
  • 90.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka5 17 31 30
  • 89.43 (n)
cow
(Bos Taurus)
Mammalia RPS6KA5 31 30
  • 87.86 (n)
OneToOne
chicken
(Gallus gallus)
Aves RPS6KA5 31 30
  • 82.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS6KA5 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka5 30
  • 77.33 (n)
zebrafish
(Danio rerio)
Actinopterygii RPS6KA5 31
  • 76 (a)
OneToOne
LOC565173 30
  • 71.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta JIL-1 31 30
  • 50.89 (n)
OneToMany
Pk17E 32
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea rskn-2 31 30
  • 56.5 (n)
OneToMany
C54G4.1 32
  • 46 (a)
R04A9.5 32
  • 46 (a)
F28C10.3 32
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToMany
Species where no ortholog for RPS6KA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA5 Gene

ENSEMBL:
Gene Tree for RPS6KA5 (if available)
TreeFam:
Gene Tree for RPS6KA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS6KA5: view image

Paralogs for RPS6KA5 Gene

genes like me logo Genes that share paralogs with RPS6KA5: view

Variants for RPS6KA5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS6KA5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs34604933 - p.Pro574Leu
rs34699345 - p.His190Arg
rs55911249 - p.Asp554Asn
rs55968863 - p.Tyr599Cys

Additional dbSNP identifiers (rs#s) for RPS6KA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA5 Gene

Variant ID Type Subtype PubMed ID
dgv1122n106 CNV deletion 24896259
esv2749012 CNV deletion 23290073
esv2749013 CNV deletion 23290073
esv2749014 CNV deletion 23290073
esv3635320 CNV loss 21293372
nsv1046924 CNV gain 25217958
nsv832855 CNV loss 17160897
nsv832856 CNV loss 17160897

Variation tolerance for RPS6KA5 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS6KA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS6KA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA5 Gene

Disorders for RPS6KA5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS6KA5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
septic myocarditis
coffin-lowry syndrome
  • cls
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPS6KA5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPS6KA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KA5 Gene

Publications for RPS6KA5 Gene

  1. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. (PMID: 9687510) Deak M … Alessi DR (The EMBO journal 1998) 2 3 4 23 54
  2. Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. (PMID: 18511904) Beck IM … De Bosscher K (The EMBO journal 2008) 3 4 23 54
  3. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. (PMID: 17117922) McCoy CE … Arthur JS (The Biochemical journal 2007) 3 4 23 54
  4. MSK1 activity is controlled by multiple phosphorylation sites. (PMID: 15568999) McCoy CE … Arthur JS (The Biochemical journal 2005) 3 4 23 54
  5. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PMID: 15010469) Zhang Y … Parvin JD (The Journal of biological chemistry 2004) 3 4 23 54

Products for RPS6KA5 Gene