This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have be... See more...

Aliases for RPS6KA4 Gene

Aliases for RPS6KA4 Gene

  • Ribosomal Protein S6 Kinase A4 2 3 5
  • Nuclear Mitogen- And Stress-Activated Protein Kinase 2 3 4
  • 90 KDa Ribosomal Protein S6 Kinase 4 3 4
  • Ribosomal Protein S6 Kinase Alpha-4 3 4
  • Ribosomal Protein Kinase B 3 4
  • S6K-Alpha-4 3 4
  • EC 2.7.11.1 4 52
  • MSK2 3 4
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 4 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 4 2
  • Mitogen- And Stress-Activated Protein Kinase 2 3
  • EC 2.7.11 52
  • RSK-B 3
  • RSKB 4

External Ids for RPS6KA4 Gene

Previous GeneCards Identifiers for RPS6KA4 Gene

  • GC11P066642
  • GC11P065808
  • GC11P064377
  • GC11P063902
  • GC11P063884
  • GC11P064126
  • GC11P060454

Summaries for RPS6KA4 Gene

Entrez Gene Summary for RPS6KA4 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for RPS6KA4 Gene

RPS6KA4 (Ribosomal Protein S6 Kinase A4) is a Protein Coding gene. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA5.

UniProtKB/Swiss-Prot Summary for RPS6KA4 Gene

  • Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

Tocris Summary for RPS6KA4 Gene

  • Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Gene Wiki entry for RPS6KA4 Gene

Additional gene information for RPS6KA4 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS6KA4 Gene

Genomics for RPS6KA4 Gene

GeneHancer (GH) Regulatory Elements for RPS6KA4 Gene

Promoters and enhancers for RPS6KA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064354 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 509.6 -1.2 -1174 6.6 ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G PHF8 JUND FOS PHB2 RPS6KA4 ENSG00000236935 PLCB3 LINC02723 TRPT1 MARK2 PPP1R14B ESRRA PRDX5 TRMT112
GH11J064405 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 13.6 +47.3 47253 3.6 USF1 FOXA1 TSC22D4 GATAD2B MCM3 NR2F2 HES1 ZNF207 POLR2A NONO PLCB3 NAALADL1 POLA2 ZFPL1 RPS6KA4 LINC02723 SF1 ATL3 FAU ENSG00000257086
GH11J064394 Enhancer 0.7 ENCODE CraniofacialAtlas 13.8 +36.9 36945 1.7 ZIC2 GABPA HINFP NR2F2 ZNF335 SIN3A SMARCA4 ZNF148 ZBTB20 RBBP5 LINC02723 RPS6KA4 MIR1237 LINC02724 NRXN2 TRMT112 CCDC88B lnc-TRMT112-3
GH11J064444 Enhancer 0.7 Ensembl 10.1 +86.4 86353 1.4 ZNF217 USF1 RBAK SIX5 REST USF2 MYC NFYB HCFC1 CREB3L1 TRMT112 RPS6KA4 LINC02723 LINC02724 RF00017-941
GH11J064390 Enhancer 0.3 ENCODE 17 +32.1 32097 0.6 REST POLR2A RF00017-939 RPS6KA4 LINC02723 LINC02724 NRXN2 HSALNG0084783
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS6KA4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS6KA4

Top Transcription factor binding sites by QIAGEN in the RPS6KA4 gene promoter:
  • CREB
  • deltaCREB

Genomic Locations for RPS6KA4 Gene

Genomic Locations for RPS6KA4 Gene
chr11:64,359,148-64,372,215
(GRCh38/hg38)
Size:
13,068 bases
Orientation:
Plus strand
chr11:64,126,620-64,139,687
(GRCh37/hg19)
Size:
13,068 bases
Orientation:
Plus strand

Genomic View for RPS6KA4 Gene

Genes around RPS6KA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA4 Gene

Proteins for RPS6KA4 Gene

  • Protein details for RPS6KA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75676-KS6A4_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-4
    Protein Accession:
    O75676
    Secondary Accessions:
    • A8K7Z8
    • O75585
    • Q53ES8

    Protein attributes for RPS6KA4 Gene

    Size:
    772 amino acids
    Molecular mass:
    85606 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA4 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.
    Miscellaneous:
    • Enzyme activity requires the presence of both kinase domains.

    Alternative splice isoforms for RPS6KA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA4 Gene

Selected DME Specific Peptides for RPS6KA4 Gene

O75676:
  • GIIYRDLK
  • VVHRDLK
  • WSLGVILY
  • GEIVLALEHLHKLGIIYRD
  • LTDFGLSK
  • NFAEEFT
  • LYAMKVL
  • RDLKPEN
  • LGIIYRD
  • LHYAFQT
  • DLWSLGV
  • GKVFLVRK
  • FELLKVLG
  • RDLKLEN
  • VHRDLKP
  • FCGTIEYMAP
  • KLHLILDY

Post-translational modifications for RPS6KA4 Gene

  • Ser-343 and Thr-568 phosphorylation is required for kinase activity. Ser-343 and Ser-196 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-737 and Ser-745 by the N-terminal kinase domain (By similarity).
  • Ubiquitination at Lys37 and Lys440
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Boster Bio Antibodies for RPS6KA4

Domains & Families for RPS6KA4 Gene

Gene Families for RPS6KA4 Gene

Protein Domains for RPS6KA4 Gene

Suggested Antigen Peptide Sequences for RPS6KA4 Gene

GenScript: Design optimal peptide antigens:
  • RPS6KA4 protein (A0PJF8_HUMAN)
  • Ribosomal protein kinase B (KS6A4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75676

UniProtKB/Swiss-Prot:

KS6A4_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA4: view

Function for RPS6KA4 Gene

Molecular function for RPS6KA4 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha, and by further autophosphorylation of Ser-196, Ser-360 and Ser-365 by the activated C-terminal kinase domain.

Enzyme Numbers (IUBMB) for RPS6KA4 Gene

Phenotypes From GWAS Catalog for RPS6KA4 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IMP 12773393
GO:0004711 ribosomal protein S6 kinase activity NAS 11035004
GO:0005515 protein binding IPI 9792677
genes like me logo Genes that share ontologies with RPS6KA4: view
genes like me logo Genes that share phenotypes with RPS6KA4: view

Animal Models for RPS6KA4 Gene

MGI Knock Outs for RPS6KA4:

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KA4

CRISPR Products

miRNA for RPS6KA4 Gene

miRTarBase miRNAs that target RPS6KA4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6KA4

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KA4 Gene

Localization for RPS6KA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KA4 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS6KA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 9792677
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RPS6KA4: view

Pathways & Interactions for RPS6KA4 Gene

PathCards logo

SuperPathways for RPS6KA4 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.61
2 ERK Signaling
.61
.58
.49
3 Type I Interferon Signaling Pathways
.33
4 GDNF-Family Ligands and Receptor Interactions
.41
.39
5 CNTF Signaling
.50
.50
genes like me logo Genes that share pathways with RPS6KA4: view

Pathways by source for RPS6KA4 Gene

2 KEGG pathways for RPS6KA4 Gene
1 GeneGo (Thomson Reuters) pathway for RPS6KA4 Gene
  • Transcription CREB pathway
18 Qiagen pathways for RPS6KA4 Gene
  • 14-3-3 Induced Intracellular Signaling
  • BAD Phosphorylation
  • BDNF Pathway
  • Cellular Apoptosis Pathway
  • CNTF Signaling
1 Cell Signaling Technology pathway for RPS6KA4 Gene
1 GeneTex pathway for RPS6KA4 Gene

SIGNOR curated interactions for RPS6KA4 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPS6KA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production TAS 18508628
GO:0006355 regulation of transcription, DNA-templated IDA 9792677
GO:0006468 protein phosphorylation IDA,IEA 9792677
GO:0006954 inflammatory response IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with RPS6KA4: view

Drugs & Compounds for RPS6KA4 Gene

(7) Drugs for RPS6KA4 Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flavin Mononucleotide Approved, Investigational Pharma Target 11
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
PF 4708671 Pharma P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor 0
BI-D1870 Pharma P90 RSK inhibitor,ATP-competitive and cell-permeable 0

(2) Additional Compounds for RPS6KA4 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
RMM 46
1307896-46-3

(4) Tocris Compounds for RPS6KA4 Gene

Compound Action Cas Number
BRD 7389 Ribosomal S6 kinase inhibitor 376382-11-5
PF 4708671 S6K1 inhibitor 1255517-76-0
RMM 46 MSK/RSK family kinase inhibitor 1307896-46-3
SL 0101-1 Selective ribosomal S6 kinase (RSK) inhibitor 77307-50-7

(2) ApexBio Compounds for RPS6KA4 Gene

Compound Action Cas Number
BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable 501437-28-1
PF-4708671 P70 S6K1 isoform inhibitor,cell-permeable 1255517-76-0
genes like me logo Genes that share compounds with RPS6KA4: view

Drug Products

Transcripts for RPS6KA4 Gene

mRNA/cDNA for RPS6KA4 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6KA4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for RPS6KA4 Gene

GeneLoc Exon Structure for
RPS6KA4

Expression for RPS6KA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS6KA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS6KA4 Gene

This gene is overexpressed in Lung (45.1) and Breast (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6KA4 Gene



Protein tissue co-expression partners for RPS6KA4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS6KA4

SOURCE GeneReport for Unigene cluster for RPS6KA4 Gene:

Hs.105584

Evidence on tissue expression from TISSUES for RPS6KA4 Gene

  • Nervous system(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RPS6KA4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KA4 Gene

Orthologs for RPS6KA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA4 31 30
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA4 31 30
  • 91.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPS6KA4 31 30
  • 90.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka4 17 31 30
  • 88.17 (n)
rat
(Rattus norvegicus)
Mammalia Rps6ka4 30
  • 88.17 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS6KA4 31
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KA4 31
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS6KA4 31
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486973 30
  • 62.98 (n)
zebrafish
(Danio rerio)
Actinopterygii rps6ka4 31 30
  • 67.72 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006094 30
  • 56.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta JIL-1 31
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rskn-2 31
  • 47 (a)
OneToMany
C54G4.1 32
  • 47 (a)
R04A9.5 32
  • 44 (a)
corn
(Zea mays)
Liliopsida Zm.10489 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToMany
Species where no ortholog for RPS6KA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA4 Gene

ENSEMBL:
Gene Tree for RPS6KA4 (if available)
TreeFam:
Gene Tree for RPS6KA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS6KA4: view image

Paralogs for RPS6KA4 Gene

genes like me logo Genes that share paralogs with RPS6KA4: view

Variants for RPS6KA4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS6KA4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
776621 Benign: not provided 64,369,866(+) C/T SYNONYMOUS_VARIANT
787911 Benign: not provided 64,361,956(+) C/T MISSENSE_VARIANT
rs746466314 A breast infiltrating ductal carcinoma sample p.Ser236Leu
rs17857342 - p.Ser758Ala

Additional dbSNP identifiers (rs#s) for RPS6KA4 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA4 Gene

Variant ID Type Subtype PubMed ID
dgv13n64 CNV loss 17921354
nsv358 CNV insertion 18451855
nsv832186 CNV loss 17160897
nsv832187 CNV loss 17160897

Variation tolerance for RPS6KA4 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS6KA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS6KA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA4 Gene

Disorders for RPS6KA4 Gene

Additional Disease Information for RPS6KA4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RPS6KA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS6KA4 Gene

Publications for RPS6KA4 Gene

  1. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. (PMID: 9687510) Deak M … Alessi DR (The EMBO journal 1998) 2 3 4 54
  2. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). (PMID: 9792677) Pierrat B … Lesslauer W (The Journal of biological chemistry 1998) 2 3 4 54
  3. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PMID: 22019778) Zhang F … Zhang X (Nature genetics 2011) 3 41 54
  4. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells GF … Anderson CA (Nature genetics 2011) 3 41 54
  5. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PMID: 20805296) Coulthard LR … McDermott MF (Annals of the rheumatic diseases 2011) 3 41 54

Products for RPS6KA4 Gene

  • Boster Bio Antibodies for RPS6KA4
  • Boster Bio ELISA Kits for RPS6KA4

Sources for RPS6KA4 Gene