RPS6KA3 Gene (Protein Coding)

Ribosomal Protein S6 Kinase A3

GC0XM020149
GIFtS:
52
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations... See more...

Aliases for RPS6KA3 Gene

Aliases for RPS6KA3 Gene

  • Ribosomal Protein S6 Kinase A3 2 3 5
  • RSK2 2 3 4
  • MAP Kinase-Activated Protein Kinase 1b 3 4
  • Ribosomal Protein S6 Kinase Alpha-3 3 4
  • Insulin-Stimulated Protein Kinase 1 3 4
  • MAPK-Activated Protein Kinase 1b 3 4
  • Ribosomal S6 Kinase 2 3 4
  • MAPKAP Kinase 1b 3 4
  • S6K-Alpha-3 3 4
  • EC 2.7.11.1 4 51
  • MAPKAPK-1b 3 4
  • MAPKAPK1B 3 4
  • P90-RSK 3 3 4
  • Pp90RSK2 3 4
  • ISPK-1 3 4
  • RSK-2 3 4
  • HU-3 2 3
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 3 2
  • Epididymis Secretory Sperm Binding Protein 3
  • 90 KDa Ribosomal Protein S6 Kinase 3 4
  • S6K-Alpha3 3
  • EC 2.7.11 51
  • P90-RSK2 3
  • RPS6KA3 5
  • P90RSK3 4
  • MRX19 3
  • ISPK1 4
  • CLS 3
  • RSK 3

External Ids for RPS6KA3 Gene

Previous HGNC Symbols for RPS6KA3 Gene

  • MRX19
  • CLS

Previous GeneCards Identifiers for RPS6KA3 Gene

  • GC0XU990207
  • GC0XM018839
  • GC0XM019371
  • GC0XM019534
  • GC0XM019933
  • GC0XM020077
  • GC0XM020168
  • GC0XM017910

Summaries for RPS6KA3 Gene

Entrez Gene Summary for RPS6KA3 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6KA3 Gene

RPS6KA3 (Ribosomal Protein S6 Kinase A3) is a Protein Coding gene. Diseases associated with RPS6KA3 include Coffin-Lowry Syndrome and Symptomatic Form Of Coffin-Lowry Syndrome In Female Carriers. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Nuclear Events (kinase and transcription factor activation). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA2.

UniProtKB/Swiss-Prot Summary for RPS6KA3 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:9770464, PubMed:16223362, PubMed:17360704, PubMed:16213824). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:9770464, PubMed:10436156). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity).

Tocris Summary for RPS6KA3 Gene

  • Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Gene Wiki entry for RPS6KA3 Gene

Additional gene information for RPS6KA3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS6KA3 Gene

Genomics for RPS6KA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RPS6KA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ020262 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 606 +1.7 1749 6.5 HNRNPL PRDM10 ZNF629 TFE3 SIX5 IKZF1 ZNF692 POLR2A JUND PRDM1 RPS6KA3 BCLAF3 SH3KBP1 hsa-miR-5096-189 RF00017-8214 EIF1AX
GH0XJ020360 Enhancer 1 ENCODE dbSUPER 16.3 -94.7 -94704 4 CEBPG GATAD2A PRDM10 ZNF629 TFE3 NFKBIZ FOXA1 PRDM1 RBFOX2 IRF2 RPS6KA3 BCLAF3 piR-33303-190 RF00017-8214 piR-37026-629
GH0XJ020374 Enhancer 0.7 ENCODE 17.8 -107.5 -107533 1.8 GATAD2A RCOR2 JUND FOXA1 CEBPA SOX13 ZNF316 FOXA2 MAFF MAFK RPS6KA3 BCLAF3 RF00017-8214 piR-33422-466 CNKSR2
GH0XJ020378 Enhancer 0.8 Ensembl ENCODE 15 -110.9 -110882 2 RFX1 YY1 SCRT2 SP1 CEBPB ESRRA NFYB FOSL2 PRDM1 RFX5 RF00017-8214 RPS6KA3 piR-41525-711 CNKSR2
GH0XJ020442 Enhancer 0.8 ENCODE 13.5 -175.3 -175344 0.8 GATAD2A CTCF RCOR2 ZNF143 ZNF24 RXRB REST RAD21 TRIM22 GABPA ENSG00000283400 RPS6KA3 piR-39858-671 CNKSR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS6KA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS6KA3

Top Transcription factor binding sites by QIAGEN in the RPS6KA3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • SRF
  • SRF (504 AA)

Genomic Locations for RPS6KA3 Gene

Genomic Locations for RPS6KA3 Gene
chrX:20,149,911-20,267,519
(GRCh38/hg38)
Size:
117,609 bases
Orientation:
Minus strand
chrX:20,168,029-20,285,523
(GRCh37/hg19)
Size:
117,495 bases
Orientation:
Minus strand

Genomic View for RPS6KA3 Gene

Genes around RPS6KA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RPS6KA3 Gene

Proteins for RPS6KA3 Gene

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  • Protein details for RPS6KA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51812-KS6A3_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-3
    Protein Accession:
    P51812
    Secondary Accessions:
    • B2R9V4
    • Q4VAP3
    • Q59H26
    • Q5JPK8
    • Q7Z3Z7

    Protein attributes for RPS6KA3 Gene

    Size:
    740 amino acids
    Molecular mass:
    83736 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4, ETV1/ER81 and FGFR1.
    SequenceCaution:
    • Sequence=BAD92170.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS6KA3 Gene

neXtProt entry for RPS6KA3 Gene

Protein Expression for RPS6KA3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for RPS6KA3 Gene

P51812:
  • DVKFYLAEL
  • GIIYRDLK
  • DKILRQK
  • FTRLSKEV
  • LVKGAMAATYSALN
  • VSKMLHVDPHQRLTA
  • LDHLHSLGIIYRDLKPENILLDEEGHIK
  • YSFCGTVEYMAPEV
  • LYAMKVL
  • LHYAFQT
  • GVEEIKRH
  • QGVVHRDLKPSNILY
  • HKATNME
  • GHIKLTDFGLSK
  • ILKAKLGMPQFLS
  • HRDLKPSNIL
  • IKLTDFG
  • IGVGSYS
  • LKVRDRVRTKMERDIL
  • GVLMFEMLTG
  • VVHRDLK
  • LTDFGLSK
  • CDIWSLG
  • KLTDFGL
  • GSYSVCKRC
  • TPFANGP
  • IDKSKRDP
  • EYMAPEVV
  • FRGFSFV
  • LGIIYRD
  • RDLKPEN
  • GHIKLTD
  • RYGQHPNII
  • FELLKVLG
  • TPCYTANFVAPEVL
  • FFSTIDWNKL
  • LPFQGKDR
  • VHRDLKP
  • ILRQKFFSEREA
  • KPENILLD

Post-translational modifications for RPS6KA3 Gene

  • Activated by phosphorylation at Ser-227 by PDPK1. Autophosphorylated on Ser-386, as part of the activation process. May be phosphorylated at Thr-365 and Ser-369 by MAPK1/ERK2 and MAPK3/ERK1. Can also be activated via phosphorylation at Ser-386 by MAPKAPK2.
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Ubiquitination at Lys72 and Lys81
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS6KA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RPS6KA3 Gene

Gene Families for RPS6KA3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RPS6KA3 Gene

InterPro:
Blocks:
  • Protein kinase C-terminal domain
ProtoNet:

Suggested Antigen Peptide Sequences for RPS6KA3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56618, highly similar to Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (B4DG22_HUMAN)
  • cDNA, FLJ79381, highly similar to Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (B7ZB17_HUMAN)
  • pp90RSK2 (KS6A3_HUMAN)
  • RPS6KA3 protein (Q7Z2E2_HUMAN)
  • RPS6KA3 protein (Q7Z2J3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51812

UniProtKB/Swiss-Prot:

KS6A3_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA3: view

Function for RPS6KA3 Gene

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Molecular function for RPS6KA3 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:9770464, PubMed:16223362, PubMed:17360704, PubMed:16213824). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:9770464, PubMed:10436156). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:17213202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.56 uM for NFATC4 {ECO:0000269|PubMed:17213202}; Vmax=11.5 umol/min/ug enzyme toward ATP {ECO:0000269|PubMed:17213202};
UniProtKB/Swiss-Prot EnzymeRegulation:
Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-577 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-386, allowing binding of PDPK1, which in turn phosphorylates Ser-227 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
GENATLAS Biochemistry:
ribosomal S6 kinase,polypeptide 3,growth factor regulated serine /threonine kinase family,responsive for the activation of glycogen synthesis,involved in cell proliferation and differentiation but not in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation,required for epidermal growth factor activated phosphorylation of histone H3

Enzyme Numbers (IUBMB) for RPS6KA3 Gene

Phenotypes From GWAS Catalog for RPS6KA3 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA,TAS 10436156
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004711 ribosomal protein S6 kinase activity IBA 21873635
genes like me logo Genes that share ontologies with RPS6KA3: view
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Human Phenotype Ontology for RPS6KA3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RPS6KA3 Gene

MGI Knock Outs for RPS6KA3:

Animal Model Products

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Inhibitory RNA Products

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No data available for Transcription Factor Targets and HOMER Transcription for RPS6KA3 Gene

Localization for RPS6KA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KA3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS6KA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS6KA3: view

Pathways & Interactions for RPS6KA3 Gene

PathCards logo

SuperPathways for RPS6KA3 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
2 Post NMDA receptor activation events
Activation of NMDA receptor upon glutamate binding and postsynaptic events
.90
Post NMDA receptor activation events
.90
CREB phosphorylation through the activation of Ras
.78
RSK activation
.01
3 Nuclear Events (kinase and transcription factor activation)
ERK/MAPK targets
.88
Nuclear Events (kinase and transcription factor activation)
.88
MAPK targets/ Nuclear events mediated by MAP kinases
.81
CREB phosphorylation
.01
4 GDNF-Family Ligands and Receptor Interactions
GDNF-Family Ligands and Receptor Interactions
.41
Development GDNF family signaling
.41
BDNF Pathway
.39
5 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
ERK5 Signaling
.61
genes like me logo Genes that share pathways with RPS6KA3: view

Pathways by source for RPS6KA3 Gene

8 GeneGo (Thomson Reuters) pathways for RPS6KA3 Gene
  • Apoptosis and survival BAD phosphorylation
  • Development A2A receptor signaling
  • Development EDNRB signaling
  • Development Flt3 signaling
  • Development GDNF family signaling
19 Qiagen pathways for RPS6KA3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • BAD Phosphorylation
  • BDNF Pathway
  • Cellular Apoptosis Pathway
  • CNTF Signaling
1 Cell Signaling Technology pathway for RPS6KA3 Gene
1 GeneTex pathway for RPS6KA3 Gene

SIGNOR curated interactions for RPS6KA3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPS6KA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8955270
GO:0002224 toll-like receptor signaling pathway ISS --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with RPS6KA3: view

Drugs & Compounds for RPS6KA3 Gene

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(21) Drugs for RPS6KA3 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, inhibitor 1512
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
AT9283 Investigational Pharma inhibitor Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0

(5) Additional Compounds for RPS6KA3 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
RMM 46
1307896-46-3

(4) Tocris Compounds for RPS6KA3 Gene

Compound Action Cas Number
BRD 7389 Ribosomal S6 kinase inhibitor 376382-11-5
PF 4708671 S6K1 inhibitor 1255517-76-0
RMM 46 MSK/RSK family kinase inhibitor 1307896-46-3
SL 0101-1 Selective ribosomal S6 kinase (RSK) inhibitor 77307-50-7

(6) ApexBio Compounds for RPS6KA3 Gene

Compound Action Cas Number
BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable 501437-28-1
BIX 02565 RSK2 inhibitor 1311367-27-7
BRD 7389 P90 RSK inhibitor 376382-11-5
CMK RSK2 kinase inhibitor 821794-90-5
PF-4708671 P70 S6K1 isoform inhibitor,cell-permeable 1255517-76-0
SL 0101-1 77307-50-7
genes like me logo Genes that share compounds with RPS6KA3: view

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Transcripts for RPS6KA3 Gene

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mRNA/cDNA for RPS6KA3 Gene

1 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6KA3

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: - - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for RPS6KA3 Gene

GeneLoc Exon Structure for
RPS6KA3

Expression for RPS6KA3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS6KA3 Gene

mRNA expression in normal human tissues for RPS6KA3 Gene
mRNA expression by BioGPS for RPS6KA3 GenemRNA expression by GTEx for RPS6KA3 Gene

mRNA differential expression in normal tissues according to GTEx for RPS6KA3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.0).

Protein differential expression in normal tissues from HIPED for RPS6KA3 Gene

This gene is overexpressed in Lymph node (16.4) and Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6KA3 Gene



Protein tissue co-expression partners for RPS6KA3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS6KA3

SOURCE GeneReport for Unigene cluster for RPS6KA3 Gene:

Hs.445387

mRNA Expression by UniProt/SwissProt for RPS6KA3 Gene:

P51812-KS6A3_HUMAN
Tissue specificity: Expressed in many tissues, highest levels in skeletal muscle.

Evidence on tissue expression from TISSUES for RPS6KA3 Gene

  • Muscle(4.6)
  • Nervous system(4.6)
  • Liver(4.6)
  • Blood(4.5)
  • Kidney(2.9)
  • Intestine(2.9)
  • Heart(2.8)
  • Lung(2.8)
  • Skin(2.8)
  • Spleen(2.7)
  • Adrenal gland(2.5)
  • Lymph node(2.5)
  • Pancreas(2.2)
  • Thyroid gland(2.2)
  • Stomach(2.2)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KA3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
Thorax:
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • intestine
Pelvis:
  • anus
  • pelvis
  • rectum
  • testicle
  • urinary bladder
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with RPS6KA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RPS6KA3 Gene

Orthologs for RPS6KA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA3 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
 Mammalia RPS6KA3 31
  • 99 (a)
 OneToOne
Chimpanzee
(Pan troglodytes)
 Mammalia RPS6KA3 30
  • 96.66 (n)
Dog
(Canis familiaris)
 Mammalia RPS6KA3 30 31
  • 95.93 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia RPS6KA3 30 31
  • 95.77 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Rps6ka3 30
  • 94.95 (n)
Mouse
(Mus musculus)
 Mammalia Rps6ka3 30 17 31
  • 94.41 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia RPS6KA3 31
  • 67 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves RPS6KA3 30 31
  • 86.43 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia RPS6KA3 31
  • 97 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100496161 30
  • 79.63 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.33175 30
Zebrafish
(Danio rerio)
 Actinopterygii rps6ka3a 31
  • 86 (a)
 OneToMany
rps6ka3b 30 31
  • 73.83 (n)
 OneToMany
Dr.21039 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003040 30
  • 59.08 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta S6kII 30 31 32
  • 57.85 (n)
 OneToMany
Pk17E 32
  • 42 (a)
Worm
(Caenorhabditis elegans)
 Secernentea T01H8.1b 32
  • 62 (a)
rskn-1 31
  • 56 (a)
 OneToMany
R04A9.5 32
  • 41 (a)
F28C10.3 32
  • 36 (a)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.5313 30
Soybean
(Glycine max)
 eudicotyledons Gma.3835 30
Barley
(Hordeum vulgare)
 Liliopsida Hv.12219 30
Rice
(Oryza sativa)
 Liliopsida Os.11068 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 71 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.8096 30
Species where no ortholog for RPS6KA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RPS6KA3 Gene

ENSEMBL:
Gene Tree for RPS6KA3 (if available)
TreeFam:
Gene Tree for RPS6KA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS6KA3: view image

Paralogs for RPS6KA3 Gene

Paralogs for RPS6KA3 Gene

(150) SIMAP similar genes for RPS6KA3 Gene using alignment to 10 proteins:

  • KS6A3_HUMAN
  • B1AXG1_HUMAN
  • B1AXG2_HUMAN
  • B4DG22_HUMAN
  • B7ZB17_HUMAN
  • F5GYC4_HUMAN
  • Q7Z2E2_HUMAN
  • Q7Z2J3_HUMAN
  • Q7Z2J4_HUMAN
  • Q8TDJ4_HUMAN
genes like me logo Genes that share paralogs with RPS6KA3: view

Variants for RPS6KA3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS6KA3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
11656 Pathogenic: Coffin-Lowry syndrome 20,194,222(-) CCT/C FRAMESHIFT_VARIANT
11661 Pathogenic: Coffin-Lowry syndrome 20,194,186(-) T/C INTRON_VARIANT
11663 Pathogenic: Coffin-Lowry syndrome 20,155,476(-) TG/T FRAMESHIFT_VARIANT
11667 Pathogenic: Coffin-Lowry syndrome 20,169,414(-) GATA/G INFRAME_DELETION
635336 Pathogenic: Coffin-Lowry syndrome 20,155,424(-) TA/T FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for RPS6KA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA3 Gene

Variant ID Type Subtype PubMed ID
esv2672797 CNV deletion 23128226
esv3558672 CNV deletion 23714750
esv3576795 CNV gain 25503493
nsv478641 CNV novel sequence insertion 20440878
nsv520690 CNV gain 19592680
nsv526033 CNV gain 19592680

Variation tolerance for RPS6KA3 Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS6KA3 Gene

Human Gene Mutation Database (HGMD)
RPS6KA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS6KA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA3 Gene

Disorders for RPS6KA3 Gene

MalaCards: The human disease database

(12) MalaCards diseases for RPS6KA3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coffin-lowry syndrome
  • cls
symptomatic form of coffin-lowry syndrome in female carriers
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
learning disability
  • academic skill disorder
specific learning disability
  • specific learning difficulty
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

KS6A3_HUMAN
  • Coffin-Lowry syndrome (CLS) [MIM:303600]: An X-linked mental retardation associated with facial and digital dysmorphisms, progressive skeletal malformations, growth retardation, hearing deficit and paroxysmal movement disorders. {ECO:0000269 PubMed:10094187, ECO:0000269 PubMed:10528858, ECO:0000269 PubMed:14986828, ECO:0000269 PubMed:15214012, ECO:0000269 PubMed:8955270, ECO:0000269 PubMed:9837815}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Mental retardation, X-linked 19 (MRX19) [MIM:300844]: A non-syndromic form of mild to moderate mental retardation. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. {ECO:0000269 PubMed:10319851, ECO:0000269 PubMed:17100996}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RPS6KA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RPS6KA3: view

No data available for Genatlas for RPS6KA3 Gene

Publications for RPS6KA3 Gene

  1. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. (PMID: 8955270) Trivier E … Hanauer A (Nature 1996) 3 4 23 41
  2. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PMID: 8141249) Moller DE … Jakubowski M (The American journal of physiology 1994) 2 3 4 23
  3. RSK2 mediates muscle cell differentiation through regulation of NFAT3. (PMID: 17213202) Cho YY … Dong Z (The Journal of biological chemistry 2007) 3 4 23
  4. Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. (PMID: 16223362) Wingate AD … Arthur JS (The Biochemical journal 2006) 3 4 23
  5. Identification of novel mutations in the RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome. (PMID: 16879200) Delaunoy JP … Hanauer A (Clinical genetics 2006) 2 3 23

ExternalLinks

View latest publications for RPS6KA3 gene in Mastermind

Products for RPS6KA3 Gene

Sources for RPS6KA3 Gene