Aliases for RPS6KA2 Gene
- Ribosomal Protein S6 Kinase A2 2 3 5
- MAP Kinase-Activated Protein Kinase 1c 3 4
- Ribosomal Protein S6 Kinase Alpha-2 3 4
- MAPK-Activated Protein Kinase 1c 3 4
- Ribosomal S6 Kinase 3 3 4
- EC 188.8.131.52 4 52
- MAPKAPK1C 3 4
- Pp90RSK3 3 4
- P90RSK2 3 4
- RSK3 3 4
- Mitogen-Activated Protein Kinase-Activated Protein Kinase 1C 3
- Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 3
- Ribosomal Protein S6 Kinase, 90kD, Polypeptide 2 2
External Ids for RPS6KA2 Gene
Previous GeneCards Identifiers for RPS6KA2 Gene
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
GeneCards Summary for RPS6KA2 Gene
RPS6KA2 (Ribosomal Protein S6 Kinase A2) is a Protein Coding gene. Diseases associated with RPS6KA2 include Coffin-Lowry Syndrome and Dyskeratosis Congenita, Autosomal Dominant 3. Among its related pathways are Oocyte meiosis and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA3.
UniProtKB/Swiss-Prot Summary for RPS6KA2 Gene
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.