Aliases for RPS6KA2 Gene
- Ribosomal Protein S6 Kinase A2 2 3 5
- RSK3 2 3 4
- MAP Kinase-Activated Protein Kinase 1c 3 4
- Ribosomal Protein S6 Kinase Alpha-2 3 4
- MAPK-Activated Protein Kinase 1c 3 4
- Ribosomal S6 Kinase 3 3 4
- EC 188.8.131.52 4 51
- MAPKAPK1C 3 4
- Pp90RSK3 3 4
- P90RSK2 3 4
- HU-2 2 3
- Mitogen-Activated Protein Kinase-Activated Protein Kinase 1C 3
- Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 3
External Ids for RPS6KA2 Gene
Previous GeneCards Identifiers for RPS6KA2 Gene
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
GeneCards Summary for RPS6KA2 Gene
RPS6KA2 (Ribosomal Protein S6 Kinase A2) is a Protein Coding gene. Diseases associated with RPS6KA2 include Coffin-Lowry Syndrome and Dyskeratosis Congenita, Autosomal Dominant 3. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Nuclear Events (kinase and transcription factor activation). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA3.
UniProtKB/Swiss-Prot Summary for RPS6KA2 Gene
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.