This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate ... See more...

Aliases for RPS6KA1 Gene

Aliases for RPS6KA1 Gene

  • Ribosomal Protein S6 Kinase A1 2 3 5
  • MAP Kinase-Activated Protein Kinase 1a 3 4
  • 90 KDa Ribosomal Protein S6 Kinase 1 3 4
  • Ribosomal Protein S6 Kinase Alpha-1 3 4
  • MAPK-Activated Protein Kinase 1a 3 4
  • Ribosomal S6 Kinase 1 3 4
  • MAPKAP Kinase 1a 3 4
  • EC 2.7.11.1 4 54
  • MAPKAPK-1a 3 4
  • MAPKAPK1A 3 4
  • P90-RSK 1 3 4
  • P90RSK1 3 4
  • P90S6K 3 4
  • RSK-1 3 4
  • RSK1 3 4
  • DJ590P13.1 (Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1) 3
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1 2
  • S6K-Alpha 1 3
  • S6K-Alpha-1 4
  • EC 2.7.11 54
  • MAPKAPK1 3
  • P90Rsk 3
  • HU-1 3
  • RSK 3

External Ids for RPS6KA1 Gene

Previous GeneCards Identifiers for RPS6KA1 Gene

  • GC01P028654
  • GC01P025888
  • GC01P026089
  • GC01P026460
  • GC01P026728
  • GC01P026856
  • GC01P025110

Summaries for RPS6KA1 Gene

Entrez Gene Summary for RPS6KA1 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6KA1 Gene

RPS6KA1 (Ribosomal Protein S6 Kinase A1) is a Protein Coding gene. Diseases associated with RPS6KA1 include Coffin-Lowry Syndrome and Adrenal Cortical Adenocarcinoma. Among its related pathways are Cellular Senescence (REACTOME) and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA3.

UniProtKB/Swiss-Prot Summary for RPS6KA1 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).

Tocris Summary for RPS6KA1 Gene

  • Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Gene Wiki entry for RPS6KA1 Gene

Additional gene information for RPS6KA1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS6KA1 Gene

Genomics for RPS6KA1 Gene

GeneHancer (GH) Regulatory Elements for RPS6KA1 Gene

Promoters and enhancers for RPS6KA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS6KA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS6KA1 gene promoter:
  • C/EBPbeta
  • Elk-1
  • HNF-4alpha1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for RPS6KA1 Gene

Genomic Locations for RPS6KA1 Gene
chr1:26,529,758-26,575,030
(GRCh38/hg38)
Size:
45,273 bases
Orientation:
Plus strand
chr1:26,856,249-26,901,521
(GRCh37/hg19)
Size:
45,273 bases
Orientation:
Plus strand

Genomic View for RPS6KA1 Gene

Genes around RPS6KA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA1 Gene

Proteins for RPS6KA1 Gene

  • Protein details for RPS6KA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15418-KS6A1_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-1
    Protein Accession:
    Q15418
    Secondary Accessions:
    • A6NGG4
    • A8K9K7
    • B2RDY8
    • B7Z5J0
    • E9PRI4
    • Q5SVM5
    • Q5SVM8
    • Q5SVM9
    • Q96C05
    • Q9BQK2

    Protein attributes for RPS6KA1 Gene

    Size:
    735 amino acids
    Molecular mass:
    82723 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1.

    Three dimensional structures from OCA and Proteopedia for RPS6KA1 Gene

    Alternative splice isoforms for RPS6KA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA1 Gene

Selected DME Specific Peptides for RPS6KA1 Gene

Q15418:
  • DVKFYLAEL
  • ELMRGGELLD
  • GIIYRDLK
  • DKILRQK
  • FTRLSKEV
  • LVKGAMAATYSALN
  • VSKMLHVDPHQRLTA
  • EAQSLLRALFKRNPANRLGSGPDGAEEIKRH
  • LDHLHSLGIIYRDLKPENILLDEEGHIK
  • PFVVKLH
  • YSFCGTVEYMAPEV
  • LYAMKVL
  • LHYAFQT
  • TNMEYAVKVIDK
  • QGVVHRDLKPSNILY
  • HKATNME
  • PLHSVVQQLHGKN
  • RLTAKQVL
  • GHIKLTDFGLSK
  • ILKAKLGMPQFLS
  • HRDLKPSNIL
  • FYSTIDWNKLYRREIKPPFKPAV
  • IKLTDFG
  • AVKVIDK
  • IGVGSYS
  • LKVRDRVRTKMERDIL
  • GVLMFEMLTG
  • EYAVKVID
  • VVHRDLK
  • LTDFGLSK
  • CDIWSLG
  • KLTDFGL
  • KRDPSEEIEIL
  • TPFANGP
  • IDKSKRDP
  • FRGFSFV
  • EYMAPEVV
  • LGIIYRD
  • RDLKPEN
  • GHIKLTD
  • RYGQHPNII
  • GKVFLVRK
  • FELLKVLG
  • TPCYTANFVAPEVL
  • QVLQHPW
  • LPFQGKDR
  • SSILAQRRV
  • VHRDLKP
  • ILRQKFFSEREA
  • KPENILLD

Post-translational modifications for RPS6KA1 Gene

  • Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1.
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Ubiquitination at Lys66, Lys278, and Lys316
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for RPS6KA1 Gene

Gene Families for RPS6KA1 Gene

Suggested Antigen Peptide Sequences for RPS6KA1 Gene

GenScript: Design optimal peptide antigens:
  • Ribosomal S6 kinase 1 (KS6A1_HUMAN)
  • Ribosomal protein S6 kinase, 90kDa, polypeptide 1 (Q5SVM6_HUMAN)
  • Ribosomal protein S6 kinase, 90kDa, polypeptide 1 (Q5SVM7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15418

UniProtKB/Swiss-Prot:

KS6A1_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA1: view

Function for RPS6KA1 Gene

Molecular function for RPS6KA1 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
GENATLAS Biochemistry:
ribosomal protein S6 kinase,polypeptide 1,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation

Enzyme Numbers (IUBMB) for RPS6KA1 Gene

Phenotypes From GWAS Catalog for RPS6KA1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 10679322
GO:0004711 ribosomal protein S6 kinase activity IBA 21873635
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
genes like me logo Genes that share ontologies with RPS6KA1: view
genes like me logo Genes that share phenotypes with RPS6KA1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6KA1 Gene

Localization for RPS6KA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KA1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with RPS6KA1: view

Pathways & Interactions for RPS6KA1 Gene

PathCards logo

SuperPathways for RPS6KA1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Post NMDA receptor activation events
3 Nuclear Events (kinase and transcription factor activation)
4 GDNF-Family Ligands and Receptor Interactions
.41
.39
5 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.61
genes like me logo Genes that share pathways with RPS6KA1: view

SIGNOR curated interactions for RPS6KA1 Gene

Gene Ontology (GO) - Biological Process for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction TAS 8141249
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with RPS6KA1: view

Drugs & Compounds for RPS6KA1 Gene

(15) Drugs for RPS6KA1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
Purvalanol A Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
BRD 7389 Pharma P90 RSK inhibitor, Ribosomal S6 kinase inhibitor 0

(8) Additional Compounds for RPS6KA1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
RMM 46
1307896-46-3

(4) Tocris Compounds for RPS6KA1 Gene

Compound Action Cas Number
BRD 7389 Ribosomal S6 kinase inhibitor 376382-11-5
PF 4708671 S6K1 inhibitor 1255517-76-0
RMM 46 MSK/RSK family kinase inhibitor 1307896-46-3
SL 0101-1 Selective ribosomal S6 kinase (RSK) inhibitor 77307-50-7

(4) ApexBio Compounds for RPS6KA1 Gene

Compound Action Cas Number
BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable 501437-28-1
BRD 7389 P90 RSK inhibitor 376382-11-5
PF-4708671 P70 S6K1 isoform inhibitor,cell-permeable 1255517-76-0
SL 0101-1 77307-50-7
genes like me logo Genes that share compounds with RPS6KA1: view

Transcripts for RPS6KA1 Gene

mRNA/cDNA for RPS6KA1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for RPS6KA1 Gene

GeneLoc Exon Structure for
RPS6KA1
ECgene alternative splicing isoforms for
RPS6KA1

Expression for RPS6KA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS6KA1 Gene

mRNA differential expression in normal tissues according to GTEx for RPS6KA1 Gene

This gene is overexpressed in Whole Blood (x21.5).

Protein differential expression in normal tissues from HIPED for RPS6KA1 Gene

This gene is overexpressed in Lymph node (11.8), Stomach (7.0), Peripheral blood mononuclear cells (7.0), and Salivary gland (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6KA1 Gene



Protein tissue co-expression partners for RPS6KA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS6KA1 Gene:

RPS6KA1

SOURCE GeneReport for Unigene cluster for RPS6KA1 Gene:

Hs.149957

Evidence on tissue expression from TISSUES for RPS6KA1 Gene

  • Intestine(4.5)
  • Liver(4.4)
  • Thyroid gland(4.3)
  • Lung(2.6)
  • Blood(2.5)
  • Nervous system(2.5)
  • Heart(2.2)
  • Kidney(2.2)
  • Muscle(2.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with RPS6KA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KA1 Gene

Orthologs for RPS6KA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPS6KA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA1 33 32
  • 99.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPS6KA1 33 32
  • 92.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA1 33