Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is t... See more...

Aliases for RPS6 Gene

Aliases for RPS6 Gene

  • Ribosomal Protein S6 2 3 5
  • 40S Ribosomal Protein S6 2 3 4
  • Phosphoprotein NP33 2 3 4
  • Small Ribosomal Subunit Protein ES6 3 4
  • S6 2 3
  • RPS6 5

External Ids for RPS6 Gene

Previous GeneCards Identifiers for RPS6 Gene

  • GC09M019706
  • GC09M019565
  • GC09M019190
  • GC09M019366

Summaries for RPS6 Gene

Entrez Gene Summary for RPS6 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

CIViC Summary for RPS6 Gene

GeneCards Summary for RPS6 Gene

RPS6 (Ribosomal Protein S6) is a Protein Coding gene. Diseases associated with RPS6 include Tuberous Sclerosis and Hemimegalencephaly. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot Summary for RPS6 Gene

  • May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS6 Gene

Genomics for RPS6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS6

Top Transcription factor binding sites by QIAGEN in the RPS6 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Pbx1a
  • USF-1
  • USF1

Genomic Locations for RPS6 Gene

Genomic Locations for RPS6 Gene
chr9:19,375,715-19,380,236
(GRCh38/hg38)
Size:
4,522 bases
Orientation:
Minus strand
chr9:19,375,713-19,380,252
(GRCh37/hg19)
Size:
4,540 bases
Orientation:
Minus strand

Genomic View for RPS6 Gene

Genes around RPS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6 Gene

Proteins for RPS6 Gene

  • Protein details for RPS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62753-RS6_HUMAN
    Recommended name:
    40S ribosomal protein S6
    Protein Accession:
    P62753
    Secondary Accessions:
    • P08227
    • P10660
    • Q4VBY7
    • Q8N6Z7

    Protein attributes for RPS6 Gene

    Size:
    249 amino acids
    Molecular mass:
    28681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS6 Gene

neXtProt entry for RPS6 Gene

Post-translational modifications for RPS6 Gene

  • Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.
  • Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.
  • Ubiquitination at Lys14, Lys46, Lys58, Lys64, Lys116, Lys143, Lys149, Lys203, and Lys211
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS6 Gene

Antibody Products

  • Abcam antibodies for RPS6

No data available for DME Specific Peptides for RPS6 Gene

Domains & Families for RPS6 Gene

Gene Families for RPS6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS6 Gene

Suggested Antigen Peptide Sequences for RPS6 Gene

GenScript: Design optimal peptide antigens:
  • 40S ribosomal protein S6 (A2A3R5_HUMAN)
  • 40S ribosomal protein S6 (A2A3R6_HUMAN)
  • Ribosomal protein S6, isoform CRA_d (D3DRJ5_HUMAN)
  • 40S ribosomal protein S6 (Q96DV6_HUMAN)
  • Phosphoprotein NP33 (RS6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62753

UniProtKB/Swiss-Prot:

RS6_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS6 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS6 family.
genes like me logo Genes that share domains with RPS6: view

Function for RPS6 Gene

Molecular function for RPS6 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
GENATLAS Biochemistry:
40S ribosomal protein S6,28kDa,housekeeping gene

Phenotypes From GWAS Catalog for RPS6 Gene

Gene Ontology (GO) - Molecular Function for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 16314389
GO:0019901 protein kinase binding IPI 21418524
genes like me logo Genes that share ontologies with RPS6: view
genes like me logo Genes that share phenotypes with RPS6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6 Gene

Localization for RPS6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 2334893
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 8590812
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with RPS6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS6 Gene

Pathways & Interactions for RPS6 Gene

PathCards logo

SuperPathways for RPS6 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.53
2 RET signaling
3 Regulation of lipid metabolism Insulin signaling-generic cascades
.59
.59
.51
4 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
5 rRNA processing in the nucleus and cytosol
genes like me logo Genes that share pathways with RPS6: view

Pathways by source for RPS6 Gene

2 Sino Biological pathways for RPS6 Gene
6 GeneGo (Thomson Reuters) pathways for RPS6 Gene
  • CFTR translational fidelity (class I mutations)
  • Development IGF-1 receptor signaling
  • Regulation of lipid metabolism Insulin signaling-generic cascades
  • Signal transduction AKT signaling
  • Transcription Receptor-mediated HIF regulation
2 R&D Systems pathways for RPS6 Gene
5 Qiagen pathways for RPS6 Gene
  • IGF1R Signaling
  • Insulin Receptor Pathway
  • Interferon Pathway
  • mTOR Pathway
  • Regulation of eIF4 and p70S6K
1 Cell Signaling Technology pathway for RPS6 Gene
1 GeneTex pathway for RPS6 Gene

SIGNOR curated interactions for RPS6 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS6: view

Drugs & Compounds for RPS6 Gene

(23) Drugs for RPS6 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 115
PX-866 Pharma Inhibition, inhibitor Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0

(8) Additional Compounds for RPS6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS6: view

Transcripts for RPS6 Gene

mRNA/cDNA for RPS6 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS6

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:
SP8: - -

Relevant External Links for RPS6 Gene

GeneLoc Exon Structure for
RPS6

Expression for RPS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS6 Gene

Protein differential expression in normal tissues from HIPED for RPS6 Gene

This gene is overexpressed in Nasal epithelium (7.0) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6 Gene



Protein tissue co-expression partners for RPS6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS6

SOURCE GeneReport for Unigene cluster for RPS6 Gene:

Hs.408073

Evidence on tissue expression from TISSUES for RPS6 Gene

  • Pancreas(5)
  • Intestine(5)
  • Skin(5)
  • Liver(5)
  • Muscle(4.9)
  • Nervous system(4.9)
  • Lung(4.9)
  • Blood(4.8)
  • Eye(4.8)
  • Kidney(4.7)
  • Bone(4.7)
  • Heart(4.5)
  • Stomach(4.5)
  • Lymph node(3.8)
  • Thyroid gland(3.8)
  • Bone marrow(3.7)
  • Spleen(3.7)
  • Adrenal gland(3.4)
  • Gall bladder(2.7)
genes like me logo Genes that share expression patterns with RPS6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6 Gene

Orthologs for RPS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPS6 30 31
  • 99.73 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPS6 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
OneToMany
RPS6 30 31
  • 90.5 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 96 (a)
OneToMany
RPS6 30 31 31
  • 92.1 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Rps6 30
  • 88.89 (n)
Mouse
(Mus musculus)
Mammalia Rps6 30 17 31
  • 87.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPS6 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RPS6 30 31
  • 82.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 98 (a)
OneToMany
-- 31
  • 94 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rps6 30
  • 80.86 (n)
MGC76307 30
Zebrafish
(Danio rerio)
Actinopterygii rps6 30 31
  • 78.58 (n)
OneToOne
-- 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4344 30
Fruit Fly
(Drosophila melanogaster)
Insecta RpS6 30 31 32
  • 65.86 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002919 30
  • 60.88 (n)
Worm
(Caenorhabditis elegans)
Secernentea rps-6 30 31 32
  • 57.99 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS6B 31 33
  • 63 (a)
OneToMany
RPS6A 30 31 33
  • 61.72 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24047g 30
  • 61.58 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR197C 30
  • 59.46 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EMB3010 30
  • 60.5 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6719 30
Rice
(Oryza sativa)
Liliopsida Os07g0622100 30
  • 61.86 (n)
Barley
(Hordeum vulgare)
Liliopsida Hv.2106 30
Wheat
(Triticum aestivum)
Liliopsida Ta.28703 30
Corn
(Zea mays)
Liliopsida Zm.516 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11154 31
  • 76 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU08502 30
  • 63.98 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps601 30
  • 62.71 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5356 30
Species where no ortholog for RPS6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS6 Gene

ENSEMBL:
Gene Tree for RPS6 (if available)
TreeFam:
Gene Tree for RPS6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS6: view image

Paralogs for RPS6 Gene

No data available for Paralogs for RPS6 Gene

Variants for RPS6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS6 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
631553 Uncertain Significance: Hemimegalencephaly 19,376,348(-) C/T MISSENSE_VARIANT
708362 Benign: not provided 19,378,522(-) G/C INTRON_VARIANT
714421 Benign: not provided 19,376,395(-) A/G INTRON_VARIANT
rs17852447 - p.Lys221Arg

Additional dbSNP identifiers (rs#s) for RPS6 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS6 Gene

Variant ID Type Subtype PubMed ID
esv3619907 CNV gain 21293372
esv3619911 CNV gain 21293372
nsv1030736 CNV gain 25217958
nsv466286 CNV gain 19166990
nsv613730 CNV gain 21841781
nsv982199 CNV duplication 23825009

Variation tolerance for RPS6 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6 Gene

Disorders for RPS6 Gene

MalaCards: The human disease database

(12) MalaCards diseases for RPS6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis
  • tuberous sclerosis 1
hemimegalencephaly
  • macrencephaly
lymphangioleiomyomatosis
  • lam
rett syndrome
  • rtt
subependymal glioma
  • mixed subependymoma-ependymoma
- elite association - COSMIC cancer census association via MalaCards
Search RPS6 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RPS6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6 Gene

Publications for RPS6 Gene

  1. JMJD5 is a human arginyl C-3 hydroxylase. (PMID: 29563586) Wilkins SE … Chowdhury R (Nature communications 2018) 3 4
  2. Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. (PMID: 21418524) Schläfli P … Wenger RH (The FEBS journal 2011) 3 4
  3. Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men. (PMID: 18565837) Glover EI … Phillips SM (American journal of physiology. Regulatory, integrative and comparative physiology 2008) 3 23
  4. Anti-peptide antibodies for examining the conformation, molecular assembly and localization of an intracellular protein, ribosomal protein S6, in vivo. (PMID: 18039684) Nakagawa M … Azuma T (Journal of biochemistry 2008) 3 23
  5. Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy. (PMID: 18157089) Iwenofu OH … Brooks JS (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008) 3 23

Products for RPS6 Gene

  • Addgene plasmids for RPS6

Sources for RPS6 Gene