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Aliases for RPS6 Gene

Aliases for RPS6 Gene

  • Ribosomal Protein S6 2 3 5
  • Phosphoprotein NP33 2 3 4
  • Small Ribosomal Subunit Protein ES6 3 4
  • 40S Ribosomal Protein S6 2 3
  • S6 3

External Ids for RPS6 Gene

Previous GeneCards Identifiers for RPS6 Gene

  • GC09M019706
  • GC09M019565
  • GC09M019190

Summaries for RPS6 Gene

Entrez Gene Summary for RPS6 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

CIViC summary for RPS6 Gene

GeneCards Summary for RPS6 Gene

RPS6 (Ribosomal Protein S6) is a Protein Coding gene. Diseases associated with RPS6 include Tuberous Sclerosis and Rett Syndrome. Among its related pathways are Apelin signaling pathway and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS6 Gene

  • May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

Additional gene information for RPS6 Gene

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6 Gene

Genomics for RPS6 Gene

GeneHancer (GH) Regulatory Elements for RPS6 Gene

Promoters and enhancers for RPS6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J019377 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 677.6 +0.7 731 4.2 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 RPS6 GC09M019380 GC09M019381 DENND4C SCARNA8 ENSG00000273226 HAUS6
GH09J018975 Enhancer 1.2 Ensembl ENCODE 26.4 +403.6 403603 1.7 PKNOX1 ARNT FEZF1 ZNF2 YY1 ZNF213 KLF13 SP3 ZNF662 REST ENSG00000273226 DENND4C RPS6 HAUS6 RPS6P10 ENSG00000272842 ENSG00000227167 ENSG00000270712 SCARNA8 RRAGA
GH09J019101 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 +277.8 277801 2.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 HAUS6 RPS6 DENND4C PLIN2 ENSG00000201118
GH09J019173 Enhancer 1.4 Ensembl ENCODE dbSUPER 12 +206.0 205987 1.3 HDGF FOXA2 SMAD1 ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B IRF4 DENND4C SCARNA8 ENSG00000273226 ENSG00000272842 HAUS6 PLIN2 RPS6 SAXO1 PSMC3P1 RPS6P10
GH09J019441 Enhancer 0.7 Ensembl ENCODE 18.5 -61.5 -61533 1.2 IKZF1 ATF7 MLLT1 BCLAF1 MAFK RPS6 NDUFA5P3 HAUS6 ENSG00000260912 PIR51132 ACER2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS6 gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • USF1
  • USF-1
  • Pbx1a

Genomic Locations for RPS6 Gene

Genomic Locations for RPS6 Gene
4,540 bases
Minus strand
4,540 bases
Minus strand

Genomic View for RPS6 Gene

Genes around RPS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6 Gene

Proteins for RPS6 Gene

  • Protein details for RPS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S6
    Protein Accession:
    Secondary Accessions:
    • P08227
    • P10660
    • Q4VBY7
    • Q8N6Z7

    Protein attributes for RPS6 Gene

    249 amino acids
    Molecular mass:
    28681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS6 Gene

neXtProt entry for RPS6 Gene

Post-translational modifications for RPS6 Gene

  • Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.
  • Ubiquitination at posLast=211211, isoforms=203, posLast=149149, isoforms=143, isoforms=116, posLast=6464, isoforms=58, posLast=4646, and posLast=1414
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS6 Gene

Antibody Products

  • R&D Systems Antibodies for RPS6 (Ribosomal Protein S6/RPS6)
  • Abcam antibodies for RPS6

No data available for DME Specific Peptides for RPS6 Gene

Domains & Families for RPS6 Gene

Gene Families for RPS6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS6 family.
  • Belongs to the eukaryotic ribosomal protein eS6 family.
genes like me logo Genes that share domains with RPS6: view

Function for RPS6 Gene

Molecular function for RPS6 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
GENATLAS Biochemistry:
40S ribosomal protein S6,28kDa,housekeeping gene

Gene Ontology (GO) - Molecular Function for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 16314389
GO:0019901 protein kinase binding IPI 21418524
genes like me logo Genes that share ontologies with RPS6: view
genes like me logo Genes that share phenotypes with RPS6: view

Animal Model Products

Clone Products

  • Addgene plasmids for RPS6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6 Gene

Localization for RPS6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 2334893
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 8590812
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RPS6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS6 Gene

Pathways & Interactions for RPS6 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 RET signaling
3 Regulation of lipid metabolism Insulin signaling-generic cascades
4 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
5 rRNA processing in the nucleus and cytosol
genes like me logo Genes that share pathways with RPS6: view

Pathways by source for RPS6 Gene

SIGNOR curated interactions for RPS6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000278 mitotic cell cycle IEA --
GO:0001890 placenta development IEA --
GO:0002309 T cell proliferation involved in immune response IEA --
genes like me logo Genes that share ontologies with RPS6: view

Drugs & Compounds for RPS6 Gene

(24) Drugs for RPS6 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
PX-866 Pharma Inhibition, inhibitor Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0

(7) Additional Compounds for RPS6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS6: view

Transcripts for RPS6 Gene

mRNA/cDNA for RPS6 Gene

Unigene Clusters for RPS6 Gene

Ribosomal protein S6:
Representative Sequences:

Clone Products

  • Addgene plasmids for RPS6

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP8: - -

Relevant External Links for RPS6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS6 Gene

Protein differential expression in normal tissues from HIPED for RPS6 Gene

This gene is overexpressed in Nasal epithelium (7.0) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS6 Gene

Protein tissue co-expression partners for RPS6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS6 Gene:


SOURCE GeneReport for Unigene cluster for RPS6 Gene:


Evidence on tissue expression from TISSUES for RPS6 Gene

  • Intestine(5)
  • Liver(5)
  • Pancreas(5)
  • Skin(5)
  • Lung(4.9)
  • Muscle(4.9)
  • Nervous system(4.9)
  • Blood(4.8)
  • Eye(4.8)
  • Kidney(4.6)
  • Bone(4.5)
  • Heart(4.4)
  • Stomach(4.3)
  • Thyroid gland(3.3)
  • Lymph node(3.1)
  • Spleen(3.1)
  • Bone marrow(3)
  • Adrenal gland(2.8)
  • Gall bladder(2.7)
genes like me logo Genes that share expression patterns with RPS6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6 Gene

Orthologs for RPS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS6 34 33
  • 99.73 (n)
(Ornithorhynchus anatinus)
Mammalia RPS6 34
  • 99 (a)
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
RPS6 34 33
  • 90.5 (n)
(Bos Taurus)
Mammalia -- 34
  • 96 (a)
RPS6 34 34 33
  • 92.1 (n)
(Rattus norvegicus)
Mammalia LOC100911372 33
  • 88.89 (n)
(Mus musculus)
Mammalia Rps6 16 34 33
  • 87.82 (n)
(Monodelphis domestica)
Mammalia RPS6 34
  • 72 (a)
(Gallus gallus)
Aves RPS6 34 33
  • 82.46 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 98 (a)
-- 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6 33
  • 80.86 (n)
MGC76307 33
(Danio rerio)
Actinopterygii rps6 34 33
  • 78.58 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4344 33
fruit fly
(Drosophila melanogaster)
Insecta RpS6 34 35 33
  • 65.86 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002919 33
  • 60.88 (n)
(Caenorhabditis elegans)
Secernentea rps-6 34 35 33
  • 57.99 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS6B 36 34
  • 63 (a)
RPS6A 34 33
  • 61.72 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24047g 33
  • 61.58 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR197C 33
  • 59.46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB3010 33
  • 60.5 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6719 33
(Oryza sativa)
Liliopsida Os07g0622100 33
  • 61.86 (n)
(Hordeum vulgare)
Liliopsida Hv.2106 33
(Triticum aestivum)
Liliopsida Ta.28703 33
(Zea mays)
Liliopsida Zm.516 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11154 34
  • 76 (a)
Cin.5356 33
bread mold
(Neurospora crassa)
Ascomycetes NCU08502 33
  • 63.98 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps601 33
  • 62.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5356 33
Species where no ortholog for RPS6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS6 Gene

Gene Tree for RPS6 (if available)
Gene Tree for RPS6 (if available)
Evolutionary constrained regions (ECRs) for RPS6: view image

Paralogs for RPS6 Gene

No data available for Paralogs for RPS6 Gene

Variants for RPS6 Gene

Sequence variations from dbSNP and Humsavar for RPS6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000379757 -- 19,378,547(-) A/C intron_variant
rs1000883711 -- 19,381,193(-) A/G upstream_transcript_variant
rs1001249707 -- 19,379,251(-) C/T intron_variant
rs1001303668 -- 19,379,343(-) C/G intron_variant
rs1002505438 -- 19,382,235(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6 Gene

Variant ID Type Subtype PubMed ID
esv3619907 CNV gain 21293372
esv3619911 CNV gain 21293372
nsv1030736 CNV gain 25217958
nsv466286 CNV gain 19166990
nsv613730 CNV gain 21841781
nsv982199 CNV duplication 23825009

Variation tolerance for RPS6 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6 Gene

Disorders for RPS6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis
  • tuberous sclerosis 1
rett syndrome
  • rtt
aplastic anemia
  • aa
subcorneal pustular dermatosis
  • sneddon-wilkinson disease or syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS6

genes like me logo Genes that share disorders with RPS6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6 Gene

Publications for RPS6 Gene

  1. Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. (PMID: 21418524) Schläfli P … Wenger RH (The FEBS journal 2011) 3 4 58
  2. Anti-peptide antibodies for examining the conformation, molecular assembly and localization of an intracellular protein, ribosomal protein S6, in vivo. (PMID: 18039684) Nakagawa M … Azuma T (Journal of biochemistry 2008) 3 22 58
  3. Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy. (PMID: 18157089) Iwenofu OH … Brooks JS (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008) 3 22 58
  4. Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men. (PMID: 18565837) Glover EI … Phillips SM (American journal of physiology. Regulatory, integrative and comparative physiology 2008) 3 22 58
  5. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. (PMID: 17360704) Roux PP … Blenis J (The Journal of biological chemistry 2007) 4 22 58

Products for RPS6 Gene

  • Addgene plasmids for RPS6

Sources for RPS6 Gene

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