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Aliases for RPS4Y1 Gene

Aliases for RPS4Y1 Gene

  • Ribosomal Protein S4 Y-Linked 1 2 3
  • Small Ribosomal Subunit Protein ES4 3 4
  • Ribosomal Protein S4, Y-Linked 2 3
  • 40S Ribosomal Protein S4, Y 2 3
  • Ribosomal Protein S4Y 2 3
  • RPS4Y 3 4
  • 40S Ribosomal Protein S4, Y Isoform 1 3
  • Ribosomal Protein S4, Y-Linked 1 5
  • S4 3

External Ids for RPS4Y1 Gene

Previous HGNC Symbols for RPS4Y1 Gene

  • RPS4Y

Previous GeneCards Identifiers for RPS4Y1 Gene

  • GC0YP002356
  • GC0YP002753
  • GC0YP002769
  • GC0YP002709
  • GC0YP000062

Summaries for RPS4Y1 Gene

Entrez Gene Summary for RPS4Y1 Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS4Y1 Gene

RPS4Y1 (Ribosomal Protein S4 Y-Linked 1) is a Protein Coding gene. Diseases associated with RPS4Y1 include Turner Syndrome. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include RNA binding and rRNA binding. An important paralog of this gene is RPS4Y2.

Gene Wiki entry for RPS4Y1 Gene

Additional gene information for RPS4Y1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4Y1 Gene

Genomics for RPS4Y1 Gene

GeneHancer (GH) Regulatory Elements for RPS4Y1 Gene

Promoters and enhancers for RPS4Y1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YJ002840 Enhancer 0.6 ENCODE 650.7 +0.4 390 1.8 MXI1 POLR2A HCFC1 USF2 SIN3A ZBTB40 SIN3B NR2C2 RPS4Y1 GC0YP002808 HSFY3P
GH0YJ002999 Enhancer 0.6 FANTOM5 ENCODE 2.5 +163.4 163407 10.4 HLF LINC00278 ZFY RPS4Y1 ZFY-AS1 PIR33109
GH0YJ002837 Enhancer 0.4 ENCODE 0.7 -3.6 -3592 1.2 FOXA2 CEBPB RPS4Y1 TOMM22P2 GC0YP002808
GH0YJ002836 Enhancer 0.2 ENCODE 0.7 -4.6 -4577 0.4 RPS4Y1 TOMM22P2 GC0YP002808
GH0YJ002913 Enhancer 0.5 ENCODE 0.2 +71.8 71809 0.1 CTCF JUND ZNF384 RAD21 GC0YM002926 HSFY3P RPS4Y1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS4Y1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS4Y1 gene promoter:
  • Tal-1beta
  • ITF-2
  • Pax-4a
  • Pax-6
  • GATA-1
  • Evi-1
  • Elk-1
  • STAT3
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)

Genomic Locations for RPS4Y1 Gene

Genomic Locations for RPS4Y1 Gene
90,515 bases
Plus strand
90,515 bases
Plus strand

Genomic View for RPS4Y1 Gene

Genes around RPS4Y1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS4Y1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS4Y1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS4Y1 Gene

Proteins for RPS4Y1 Gene

  • Protein details for RPS4Y1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S4, Y isoform 1
    Protein Accession:
    Secondary Accessions:
    • A8K9V4

    Protein attributes for RPS4Y1 Gene

    263 amino acids
    Molecular mass:
    29456 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS4Y1 Gene

neXtProt entry for RPS4Y1 Gene

Post-translational modifications for RPS4Y1 Gene

  • Ubiquitination at isoforms=168 and posLast=134134
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS4Y1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS4Y1 Gene

Domains & Families for RPS4Y1 Gene

Gene Families for RPS4Y1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPS4Y1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS4 family.
  • Belongs to the eukaryotic ribosomal protein eS4 family.
genes like me logo Genes that share domains with RPS4Y1: view

Function for RPS4Y1 Gene

Gene Ontology (GO) - Molecular Function for RPS4Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IEA 2124517
GO:0003735 structural constituent of ribosome IEA,IMP 8358435
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS4Y1: view
genes like me logo Genes that share phenotypes with RPS4Y1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS4Y1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS4Y1 Gene

Localization for RPS4Y1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS4Y1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS4Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS4Y1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPS4Y1 Gene

Pathways & Interactions for RPS4Y1 Gene

SuperPathways for RPS4Y1 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS4Y1: view

Pathways by source for RPS4Y1 Gene

Gene Ontology (GO) - Biological Process for RPS4Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IMP,IEA 8358435
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS4Y1: view

No data available for SIGNOR curated interactions for RPS4Y1 Gene

Drugs & Compounds for RPS4Y1 Gene

No Compound Related Data Available

Transcripts for RPS4Y1 Gene

mRNA/cDNA for RPS4Y1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(558) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPS4Y1 Gene

Ribosomal protein S4, Y-linked 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS4Y1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS4Y1 Gene

No ASD Table

Relevant External Links for RPS4Y1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS4Y1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS4Y1 Gene

Protein differential expression in normal tissues from HIPED for RPS4Y1 Gene

This gene is overexpressed in Heart (21.4) and Testis (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS4Y1 Gene

Protein tissue co-expression partners for RPS4Y1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS4Y1 Gene:


SOURCE GeneReport for Unigene cluster for RPS4Y1 Gene:


Evidence on tissue expression from TISSUES for RPS4Y1 Gene

  • Lung(3.6)
  • Stomach(3.4)
  • Nervous system(3.1)
  • Skin(2.4)
  • Spleen(2.4)
  • Liver(2.3)
  • Eye(2.1)
  • Blood(2)
  • Bone marrow(2)
  • Gall bladder(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with RPS4Y1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS4Y1 Gene

Orthologs for RPS4Y1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS4Y1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS4Y1 34 33
  • 99.24 (n)
(Monodelphis domestica)
Mammalia RPS4Y1 34
  • 93 (a)
(Mus musculus)
Mammalia Rps4y2 34
  • 89 (a)
Rps4x 16 33
  • 80.99 (n)
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Rps4x 33
  • 80.35 (n)
(Bos Taurus)
Mammalia LOC100850611 33
  • 79.72 (n)
-- 34
  • 74 (a)
(Danio rerio)
Actinopterygii rps4x 34
  • 88 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS4 34
  • 74 (a)
(Caenorhabditis elegans)
Secernentea rps-4 34
  • 63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS4B 34
  • 70 (a)
RPS4A 34
  • 70 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2819 33
(Oryza sativa)
Liliopsida Os.12238 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5094 34
  • 75 (a)
Species where no ortholog for RPS4Y1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPS4Y1 Gene

Gene Tree for RPS4Y1 (if available)
Gene Tree for RPS4Y1 (if available)
Evolutionary constrained regions (ECRs) for RPS4Y1: view image

Paralogs for RPS4Y1 Gene

Paralogs for RPS4Y1 Gene

(2) SIMAP similar genes for RPS4Y1 Gene using alignment to 4 proteins:

  • A4FU11_HUMAN
  • Q496E4_HUMAN Pseudogenes for RPS4Y1 Gene

genes like me logo Genes that share paralogs with RPS4Y1: view

Variants for RPS4Y1 Gene

Sequence variations from dbSNP and Humsavar for RPS4Y1 Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs1002030689 -- 2,855,552(+) G/A intron_variant
rs1003297610 -- 2,848,527(+) G/T intron_variant
rs1003861355 -- 2,850,115(+) G/A intron_variant
rs1004859766 -- 2,848,606(+) A/G intron_variant
rs1006086311 -- 2,840,734(+) C/T upstream_transcript_variant

Additional Variant Information for RPS4Y1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RPS4Y1 Gene

Disorders for RPS4Y1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS4Y1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
turner syndrome
  • bonnevie-ullrich syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPS4Y1

genes like me logo Genes that share disorders with RPS4Y1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS4Y1 Gene

Publications for RPS4Y1 Gene

  1. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. (PMID: 2124517) Fisher EM … Page DC (Cell 1990) 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs. (PMID: 8808278) Omoe K … Endo A (Genomics 1996) 3 22 58
  4. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. (PMID: 8139551) Zinn AR … Page DC (Molecular and cellular biology 1994) 3 22 58
  5. Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome. (PMID: 8358435) Watanabe M … Nishimoto T (Nature genetics 1993) 3 22 58

Products for RPS4Y1 Gene

Sources for RPS4Y1 Gene

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