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Aliases for RPS4X Gene

Aliases for RPS4X Gene

  • Ribosomal Protein S4 X-Linked 2 3
  • Small Ribosomal Subunit Protein ES4 3 4
  • 40S Ribosomal Protein S4, X Isoform 2 3
  • Single Copy Abundant MRNA Protein 3 4
  • Ribosomal Protein S4X Isoform 2 3
  • Single-Copy Abundant MRNA 2 3
  • Cell Cycle Gene 2 2 3
  • SCR10 3 4
  • CCG2 3 4
  • RPS4 3 4
  • SCAR 3 4
  • Ribosomal Protein S4, X-Linked 5
  • DXS306 3
  • S4 3

External Ids for RPS4X Gene

Previous GeneCards Identifiers for RPS4X Gene

  • GC0XM067219
  • GC0XM068727
  • GC0XM069725
  • GC0XM070359
  • GC0XM071275
  • GC0XM071408
  • GC0XM071475
  • GC0XM065247

Summaries for RPS4X Gene

Entrez Gene Summary for RPS4X Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS4X Gene

RPS4X (Ribosomal Protein S4 X-Linked) is a Protein Coding gene. Diseases associated with RPS4X include Turner Syndrome. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPS4Y1.

Gene Wiki entry for RPS4X Gene

Additional gene information for RPS4X Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4X Gene

Genomics for RPS4X Gene

GeneHancer (GH) Regulatory Elements for RPS4X Gene

Promoters and enhancers for RPS4X Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ072271 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 663.6 +2.4 2395 6 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B RPS4X TAF1 NONO LOC100420758 ERCC6L OGT RTL5 LOC392489 ENSG00000229601 TOMM20P4
GH0XJ071282 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.9 +993.0 992991 4.2 PKNOX1 SMAD1 ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF213 NONO MED12 OGT TAF1 ENSG00000229601 ERCC6L LOC100420758 LOC392489 RPS26P11 RPS4X
GH0XJ072257 Enhancer 0.8 ENCODE 0.4 +19.0 18986 0.9 FOXA2 NFIB SAP130 TEAD4 RARA ZEB1 TEAD3 GLIS2 ZBTB48 PATZ1 PIN4 ERCC6L RPS4X
GH0XJ072267 Enhancer 0.7 ENCODE 0.4 +7.8 7821 3 JUN ZNF140 ZNF384 ZNF2 ZNF121 FOSL1 EGR1 POLR2A FOS CREM TAF1 NONO RPS4X ERCC6L PIN4
GH0XJ072272 Enhancer 0.4 ENCODE 0.4 +6.0 5994 0.2 ZNF362 POLR2A ZNF384 RPS4X ERCC6L PIN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS4X on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS4X gene promoter:
  • p53
  • FAC1
  • CUTL1
  • NRF-2
  • FOXO1
  • FOXO1a
  • POU2F1a
  • POU2F1
  • Pax-5
  • Oct-B1

Genomic Locations for RPS4X Gene

Genomic Locations for RPS4X Gene
21,622 bases
Minus strand
21,622 bases
Minus strand

Genomic View for RPS4X Gene

Genes around RPS4X on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS4X Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS4X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS4X Gene

Proteins for RPS4X Gene

  • Protein details for RPS4X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S4, X isoform
    Protein Accession:
    Secondary Accessions:
    • P12631
    • P12750
    • P27576
    • P55831
    • Q14727
    • Q6IPY4

    Protein attributes for RPS4X Gene

    263 amino acids
    Molecular mass:
    29598 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS4X Gene

neXtProt entry for RPS4X Gene

Post-translational modifications for RPS4X Gene

  • Ubiquitination at isoforms=134 and posLast=9494
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS4X Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS4X Gene

Domains & Families for RPS4X Gene

Gene Families for RPS4X Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS4 family.
  • Belongs to the eukaryotic ribosomal protein eS4 family.
genes like me logo Genes that share domains with RPS4X: view

Function for RPS4X Gene

Molecular function for RPS4X Gene

GENATLAS Biochemistry:
40S ribosomal protein S4,29kDa,X-linked isoform,escaping inactivation

Gene Ontology (GO) - Molecular Function for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IMP 8358435
GO:0005515 protein binding IPI 24965446
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS4X: view
genes like me logo Genes that share phenotypes with RPS4X: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS4X

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS4X Gene

Localization for RPS4X Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS4X Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS4X gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome HDA 15883184
genes like me logo Genes that share ontologies with RPS4X: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RPS4X Gene

Pathways & Interactions for RPS4X Gene

SuperPathways for RPS4X Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS4X: view

Gene Ontology (GO) - Biological Process for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IMP 8358435
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS4X: view

No data available for SIGNOR curated interactions for RPS4X Gene

Drugs & Compounds for RPS4X Gene

No Compound Related Data Available

Transcripts for RPS4X Gene

mRNA/cDNA for RPS4X Gene

Unigene Clusters for RPS4X Gene

Ribosomal protein S4, X-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS4X

Alternative Splicing Database (ASD) splice patterns (SP) for RPS4X Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - -
SP7: - -

Relevant External Links for RPS4X Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS4X Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS4X Gene

Protein differential expression in normal tissues from HIPED for RPS4X Gene

This gene is overexpressed in Nasal epithelium (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS4X Gene

Protein tissue co-expression partners for RPS4X Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS4X Gene:


SOURCE GeneReport for Unigene cluster for RPS4X Gene:


Evidence on tissue expression from TISSUES for RPS4X Gene

  • Nervous system(5)
  • Liver(4.9)
  • Pancreas(4.9)
  • Intestine(4.8)
  • Lung(4.8)
  • Muscle(4.8)
  • Kidney(4.7)
  • Skin(4.7)
  • Eye(4.6)
  • Stomach(4.2)
  • Blood(4.1)
  • Heart(3.6)
  • Bone(3.5)
  • Spleen(3.1)
  • Lymph node(2.6)
  • Bone marrow(2.5)
  • Thyroid gland(2.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPS4X: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS4X Gene

Orthologs for RPS4X Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS4X Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rps4x 34
  • 100 (a)
(Bos Taurus)
Mammalia RPS4 34
  • 100 (a)
RPS4Y1 34
  • 99 (a)
-- 34
  • 98 (a)
RPS4X 33
  • 90.24 (n)
(Canis familiaris)
Mammalia RPS4 34
  • 100 (a)
LOC102154781 33
  • 90.49 (n)
(Pan troglodytes)
Mammalia RPS4X 34 33
  • 99.87 (n)
(Ornithorhynchus anatinus)
Mammalia RPS4X 34
  • 97 (a)
(Monodelphis domestica)
Mammalia RPS4X 34
  • 95 (a)
(Gallus gallus)
Aves RPS4 34
  • 98 (a)
RPS4X 33
  • 83.9 (n)
(Anolis carolinensis)
Reptilia RPS4X 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps4x 33
  • 83.78 (n)
(Danio rerio)
Actinopterygii rps4x 34 33
  • 83.33 (n)
hmzehn2185 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11979 33
fruit fly
(Drosophila melanogaster)
Insecta RpS4 34 35 33
  • 69.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006871 33
  • 64.89 (n)
(Caenorhabditis elegans)
Secernentea Y43B11AR.4 35
  • 64 (a)
rps-4 34 33
  • 62.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS4A 36 34
  • 72 (a)
RPS4B 34 33
  • 65.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL391C 33
  • 66.92 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03652g 33
  • 65.89 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G17360 33
  • 63.47 (n)
(Oryza sativa)
Liliopsida Os05g0368300 33
  • 64.2 (n)
Os.8466 33
(Triticum aestivum)
Liliopsida Ta.1924 33
(Hordeum vulgare)
Liliopsida Hv.8478 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5094 34
  • 76 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02181 33
  • 68.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps403 33
  • 65.12 (n)
Species where no ortholog for RPS4X was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS4X Gene

Gene Tree for RPS4X (if available)
Gene Tree for RPS4X (if available)
Evolutionary constrained regions (ECRs) for RPS4X: view image

Paralogs for RPS4X Gene

Variants for RPS4X Gene

Sequence variations from dbSNP and Humsavar for RPS4X Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000214249 -- 72,276,733(-) C/A intron_variant
rs1000554984 -- 72,278,199(-) G/A upstream_transcript_variant
rs1000646820 -- 72,277,881(-) T/A upstream_transcript_variant
rs1000825369 -- 72,273,162(-) G/A intron_variant
rs1001101562 -- 72,272,851(-) TCACTT/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS4X Gene

Variant ID Type Subtype PubMed ID
esv2740221 CNV deletion 23290073
esv2740222 CNV deletion 23290073

Variation tolerance for RPS4X Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS4X Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS4X Gene

Disorders for RPS4X Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS4X Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
turner syndrome
  • bonnevie-ullrich syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS4X in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS4X

genes like me logo Genes that share disorders with RPS4X: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS4X Gene

Publications for RPS4X Gene

  1. Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene. (PMID: 1795030) Watanabe M … Nishimito T (Journal of cell science 1991) 2 3 4 22 58
  2. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. (PMID: 8139551) Zinn AR … Page DC (Molecular and cellular biology 1994) 2 3 22 58
  3. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. (PMID: 2124517) Fisher EM … Page DC (Cell 1990) 3 4 22 58
  4. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RPS4X Gene

Sources for RPS4X Gene

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