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Aliases for RPS3A Gene

Aliases for RPS3A Gene

  • Ribosomal Protein S3A 2 3 5
  • Small Ribosomal Subunit Protein ES1 3 4
  • Fte-1 3 4
  • MFTL 3 4
  • FTE1 3 4
  • V-Fos Transformation Effector Protein 1 3
  • V-Fos Transformation Effector Protein 4
  • 40S Ribosomal Protein S3a 3
  • S3A 3

External Ids for RPS3A Gene

Previous HGNC Symbols for RPS3A Gene

  • MFTL

Previous GeneCards Identifiers for RPS3A Gene

  • GC04P152874
  • GC04P152409
  • GC04P152486
  • GC04P152598
  • GC04P152593
  • GC04P152378
  • GC04P152240
  • GC04P152020

Summaries for RPS3A Gene

Entrez Gene Summary for RPS3A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for RPS3A Gene

RPS3A (Ribosomal Protein S3A) is a Protein Coding gene. Diseases associated with RPS3A include Spherocytosis, Type 4 and Spherocytosis, Type 1. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS3A Gene

  • May play a role during erythropoiesis through regulation of transcription factor DDIT3.

Gene Wiki entry for RPS3A Gene

Additional gene information for RPS3A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS3A Gene

Genomics for RPS3A Gene

GeneHancer (GH) Regulatory Elements for RPS3A Gene

Promoters and enhancers for RPS3A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J151097 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 658.2 +0.5 477 4.5 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RPS3A SNORD73B GC04P151107 GC04P151106 GC04P151105 GC04P151100 ENSG00000249708 ENSG00000249818 FAM160A1 SH3D19
GH04J151760 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.2 +661.3 661324 1.7 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 GATB RPS3A MIR4453HG GC04P151731
GH04J151029 Enhancer 1 ENCODE dbSUPER 11.9 -69.5 -69545 0.8 HDGF TAF9B NFRKB BMI1 BATF IRF4 ATF7 IKZF2 RUNX3 CREM RPS3A SNORD73B AK4P6 GC04M151092
GH04J151225 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 6.1 +127.7 127652 4 JUND RXRA POLR2A JUN FOSL2 FOS SH3D19 ENSG00000270681 RPS3A FAM160A1 ENSG00000249012 GC04M151175
GH04J150577 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.4 -516.2 -516170 11.1 SIN3A FEZF1 KLF14 ZNF2 RAD21 YY1 CHAMP1 ZNF335 GLIS2 ZNF366 MAB21L2 LRBA ENSG00000270681 FAM160A1 RPS3A ENSG00000249690 GC04P150691
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS3A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS3A gene promoter:
  • NRF-2
  • Ik-3
  • STAT5B
  • C/EBPalpha
  • COMP1
  • PPAR-gamma1
  • PPAR-gamma2
  • GATA-1
  • HEN1
  • E2F-5

Genomic Locations for RPS3A Gene

Genomic Locations for RPS3A Gene
5,080 bases
Plus strand
5,080 bases
Plus strand

Genomic View for RPS3A Gene

Genes around RPS3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS3A Gene

Proteins for RPS3A Gene

  • Protein details for RPS3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S3a
    Protein Accession:
    Secondary Accessions:
    • B2R4D4
    • D3DP05
    • P33443
    • P49241

    Protein attributes for RPS3A Gene

    264 amino acids
    Molecular mass:
    29945 Da
    Quaternary structure:
    • Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.

    Three dimensional structures from OCA and Proteopedia for RPS3A Gene

neXtProt entry for RPS3A Gene

Post-translational modifications for RPS3A Gene

  • Ubiquitination at posLast=249249, posLast=240240, isoforms=227, isoforms=199, isoforms=187, posLast=182182, posLast=167167, posLast=9494, posLast=6363, isoforms=46, and posLast=3434
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS3A Gene

Domains & Families for RPS3A Gene

Gene Families for RPS3A Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS3A Gene

Suggested Antigen Peptide Sequences for RPS3A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS1 family.
  • Belongs to the eukaryotic ribosomal protein eS1 family.
genes like me logo Genes that share domains with RPS3A: view

Function for RPS3A Gene

Molecular function for RPS3A Gene

UniProtKB/Swiss-Prot Function:
May play a role during erythropoiesis through regulation of transcription factor DDIT3.
GENATLAS Biochemistry:
40S ribosomal protein S3,pseudogene

Gene Ontology (GO) - Molecular Function for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 1398113
GO:0003735 structural constituent of ribosome IEA,IBA --
GO:0005515 protein binding IPI 11823430
GO:0048027 mRNA 5-UTR binding IDA 16213212
genes like me logo Genes that share ontologies with RPS3A: view
genes like me logo Genes that share phenotypes with RPS3A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS3A Gene

Localization for RPS3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS3A Gene

Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS3A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endoplasmic reticulum 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus ISS,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 15572026
GO:0005737 cytoplasm IEA,IDA 11823430
genes like me logo Genes that share ontologies with RPS3A: view

Pathways & Interactions for RPS3A Gene

SuperPathways for RPS3A Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS3A: view

Gene Ontology (GO) - Biological Process for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 1398113
GO:0006413 translational initiation TAS 9566973
genes like me logo Genes that share ontologies with RPS3A: view

No data available for SIGNOR curated interactions for RPS3A Gene

Drugs & Compounds for RPS3A Gene

No Compound Related Data Available

Transcripts for RPS3A Gene

mRNA/cDNA for RPS3A Gene

Unigene Clusters for RPS3A Gene

Ribosomal protein S3A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS3A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - - - - - -

Relevant External Links for RPS3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS3A Gene

Protein differential expression in normal tissues from HIPED for RPS3A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS3A Gene

Protein tissue co-expression partners for RPS3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS3A Gene:


SOURCE GeneReport for Unigene cluster for RPS3A Gene:


Evidence on tissue expression from TISSUES for RPS3A Gene

  • Eye(5)
  • Liver(5)
  • Skin(5)
  • Nervous system(5)
  • Lung(4.9)
  • Muscle(4.9)
  • Pancreas(4.9)
  • Intestine(4.8)
  • Stomach(4.6)
  • Blood(4.4)
  • Bone(4.4)
  • Kidney(4.2)
  • Heart(3.8)
  • Bone marrow(2.9)
  • Lymph node(2.8)
  • Spleen(2.6)
  • Thyroid gland(2.4)
  • Adrenal gland(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with RPS3A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS3A Gene

Orthologs for RPS3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS3A 34 33
  • 100 (n)
(Mus musculus)
Mammalia Rps3a1 34
  • 99 (a)
Rps3a2 34
  • 99 (a)
Rps3a3 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPS3A 34
  • 98 (a)
(Monodelphis domestica)
Mammalia RPS3A 34
  • 98 (a)
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
RPS3A 34 33
  • 92.8 (n)
-- 34
  • 72 (a)
(Canis familiaris)
Mammalia RPS3A 34 33
  • 93.56 (n)
(Rattus norvegicus)
Mammalia LOC100365839 33
  • 89.14 (n)
(Gallus gallus)
Aves RPS3A 34
  • 97 (a)
(Anolis carolinensis)
Reptilia RPS3A 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6700 33
African clawed frog
(Xenopus laevis)
Amphibia rps3a-prov 33
(Danio rerio)
Actinopterygii rps3a 34
  • 93 (a)
wufb02h01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8315 33
fruit fly
(Drosophila melanogaster)
Insecta RpS3A 34 35
  • 68 (a)
(Caenorhabditis elegans)
Secernentea rps-1 34 35 33
  • 63.42 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS1B 36 34
  • 52 (a)
RPS1A 34
  • 51 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7235 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4971 34
  • 73 (a)
Species where no ortholog for RPS3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS3A Gene

Gene Tree for RPS3A (if available)
Gene Tree for RPS3A (if available)
Evolutionary constrained regions (ECRs) for RPS3A: view image

Paralogs for RPS3A Gene

(1) SIMAP similar genes for RPS3A Gene using alignment to 16 proteins:

  • A8K4W0_HUMAN
  • B7Z3M5_HUMAN
  • D6R9B6_HUMAN
  • D6RB09_HUMAN
  • D6RG13_HUMAN
  • D6RI02_HUMAN
  • F5H4F9_HUMAN
  • H0Y8L7_HUMAN
  • H0Y9Y4_HUMAN
genes like me logo Genes that share paralogs with RPS3A: view

No data available for Paralogs for RPS3A Gene

Variants for RPS3A Gene

Sequence variations from dbSNP and Humsavar for RPS3A Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000025259 -- 151,097,643(+) T/C upstream_transcript_variant
rs1000120214 -- 151,103,814(+) A/G 3_prime_UTR_variant, intron_variant
rs1000223231 -- 151,097,869(+) A/G upstream_transcript_variant
rs1000407038 -- 151,104,037(+) T/G 3_prime_UTR_variant, intron_variant
rs1000873413 -- 151,104,163(+) T/G 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS3A Gene

Variant ID Type Subtype PubMed ID
dgv5436n100 CNV gain 25217958
esv2763837 CNV gain+loss 21179565
esv3602674 CNV gain 21293372
nsv1028814 CNV gain 25217958
nsv526976 CNV gain 19592680
nsv595690 CNV gain 21841781
nsv964104 CNV duplication 23825009

Variation tolerance for RPS3A Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS3A Gene

Disorders for RPS3A Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS3A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spherocytosis, type 4
  • sph4
spherocytosis, type 1
  • sph1
diamond-blackfan anemia
  • diamond-blackfan anemia 1
hereditary spherocytosis
  • spherocytosis, type 1
- elite association - COSMIC cancer census association via MalaCards
Search RPS3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS3A

genes like me logo Genes that share disorders with RPS3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS3A Gene

Publications for RPS3A Gene

  1. The human S3a ribosomal protein: sequence, location and cell-free transcription of the functional gene. (PMID: 8647443) Nolte D … Seifart KH (Gene 1996) 2 3 4 22 58
  2. Human ribosomal protein S3a: cloning of the cDNA and primary structure of the protein. (PMID: 1398113) Metspalu A … Kruppa J (Gene 1992) 2 3 4 22 58
  3. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for RPS3A Gene

Sources for RPS3A Gene

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