Aliases for RPS3A Gene
External Ids for RPS3A Gene
Previous HGNC Symbols for RPS3A Gene
Previous GeneCards Identifiers for RPS3A Gene
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for RPS3A Gene
RPS3A (Ribosomal Protein S3A) is a Protein Coding gene. Diseases associated with RPS3A include Spherocytosis, Type 4 and Spherocytosis, Type 1. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
UniProtKB/Swiss-Prot for RPS3A Gene
May play a role during erythropoiesis through regulation of transcription factor DDIT3.