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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
RPS28 (Ribosomal Protein S28) is a Protein Coding gene. Diseases associated with RPS28 include Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis and Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003735 | structural constituent of ribosome | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005791 | rough endoplasmic reticulum | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
CFTR translational fidelity (class I mutations)
.79
.77
.53
|
|
2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
3 | Influenza Viral RNA Transcription and Replication | ||
4 | rRNA processing in the nucleus and cytosol |
.89
|
|
5 | HIV Life Cycle |
.45
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000028 | ribosomal small subunit assembly | IBA | 21873635 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
GO:0002181 | cytoplasmic translation | IDA | 25957688 |
GO:0006364 | rRNA processing | IMP | 18697920 |
GO:0006412 | translation | IC | 8706699 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 115 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RPS28 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RPS28 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RPS28 30 |
|
||
Cow (Bos Taurus) |
Mammalia | RPS28 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rps28 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rps28 30 |
|
||
Chicken (Gallus gallus) |
Aves | RPS28 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rps28p9 30 |
|
||
Str.17156 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | rps28 30 31 |
|
OneToOne | |
Dr.24923 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.827 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | RpS28a 31 |
|
OneToMany | |
RpS28b 30 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003412 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | rps-28 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPS28B 31 |
|
OneToMany | |
RPS28A 30 31 |
|
OneToMany | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR261W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F20383g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RPS28 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os10g0411700 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.2070 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.16049 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU05599 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rps2802 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
668538 | Likely Benign: not provided | 8,321,709(+) | C/T | INTRON_VARIANT | |
rs786203997 | Pathogenic: Diamond-Blackfan anemia 15 with mandibulofacial dysostosis | 8,321,531(+) | A/G | INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
diamond-blackfan anemia 15 with mandibulofacial dysostosis |
|
|
diamond-blackfan anemia |
|
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dysostosis |
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|
macrocytic anemia |
|
|
chromosome 5q deletion syndrome |
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