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This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]
RPS27L (Ribosomal Protein S27 Like) is a Protein Coding gene. Diseases associated with RPS27L include Retinitis Pigmentosa 27 and Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is RPS27.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0003735 | structural constituent of ribosome | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 21170087 |
GO:0008494 | translation activator activity | IDA | 18056458 |
GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | IDA | 17057733 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 18056458 |
GO:0005840 | ribosome | IEA | -- |
GO:0022627 | cytosolic small ribosomal subunit | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
.77
.53
|
|
2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
3 | Influenza Viral RNA Transcription and Replication | ||
4 | rRNA processing in the nucleus and cytosol |
.89
|
|
5 | HIV Life Cycle |
.45
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000028 | ribosomal small subunit assembly | IBA | 21873635 |
GO:0006412 | translation | IEA | -- |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | 17057733 |
GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | IDA | 18056458 |
GO:0031571 | mitotic G1 DNA damage checkpoint | IMP | 18056458 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RPS27L 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RPS27L 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RPS27L 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RPS27L 30 31 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Rps27l 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RPS27L 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rps27l 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RPS27L 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rps27.2 31 |
|
OneToOne | |
zgc:136826 30 |
|
||||
Dr.7787 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10423 32 |
|
|
|
RpS27 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | rps-27 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPS27B 31 |
|
ManyToMany | |
RPS27A 31 |
|
ManyToMany | |||
Soybean (Glycine max) |
eudicotyledons | Gma.6612 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.8049 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10862 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv27033 | CNV | gain+loss | 19812545 |
esv3636712 | CNV | gain | 21293372 |
nsv1035441 | CNV | gain | 25217958 |
nsv428305 | CNV | gain | 18775914 |
Disorder | Aliases | PubMed IDs |
---|---|---|
retinitis pigmentosa 27 |
|
|
diamond-blackfan anemia |
|
|