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This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008] See more...
Aliases for RPS27L Gene
Aliases for RPS27L Gene
External Ids for RPS27L Gene
- HGNC: 18476
- Entrez Gene: 51065
- Ensembl: ENSG00000185088
- OMIM: 612055
- UniProtKB: Q71UM5
Previous GeneCards Identifiers for RPS27L Gene
- GC15M059232
- GC15M056493
- GC15M060996
- GC15M061161
- GC15M061233
- GC15M063445
- GC15M040268
- GC15M063128
- GC15M064075
- GC15M064202
- GC15M064246
- GC15M063134
- GC15M063368
- GC15M063414
- GC15M063536
- GC15M063656
- GC15M063773
- GC15M063899
- GC15M063992
Summaries for RPS27L Gene
-
This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for RPS27L Gene
RPS27L (Ribosomal Protein S27 Like) is a Protein Coding gene. Diseases associated with RPS27L include Retinitis Pigmentosa 27 and Diamond-Blackfan Anemia. Among its related pathways are Direct p53 effectors and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is RPS27.
Additional gene information for RPS27L Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS27L Gene
Genomics for RPS27L Gene
GeneHancer (GH) Regulatory Elements for RPS27L Gene
Promoters and enhancers for RPS27L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RPS27L on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS27L
- Top Transcription factor binding sites by QIAGEN in the RPS27L gene promoter:
-
- FOXO1
- FOXO1a
- Gfi-1
- GR
- GR-alpha
- NF-1
- Pbx1a
- SREBP-1a
- STAT3
Genomic Locations for RPS27L Gene
Genomic Locations for RPS27L Gene
- chr15:63,125,872-63,158,021
- (GRCh38/hg38)
- Size:
- 32,150 bases
- Orientation:
- Minus strand
- chr15:63,418,071-63,450,220
- (GRCh37/hg19)
- Size:
- 32,150 bases
- Orientation:
- Minus strand
Genomic View for RPS27L Gene
Genes around RPS27L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.2 by HGNC
- 15q22.2 by Entrez Gene
- 15q22.2 by Ensembl
RPS27L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPS27L Gene
Proteins for RPS27L Gene
-
Protein details for RPS27L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q71UM5-RS27L_HUMAN
- Recommended name:
- 40S ribosomal protein S27-like
- Protein Accession:
- Q71UM5
- Q9BTJ1
Protein attributes for RPS27L Gene
- Size:
- 84 amino acids
- Molecular mass:
- 9477 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for RPS27L Gene
Post-translational modifications for RPS27L Gene
Other Protein References for RPS27L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RPS27L Antibody
- Creative Diagnostics Anti-RPS27L (aa 1-50) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for RPS27L
- Novus Biologicals Antibodies for RPS27L
- Invitrogen Antibodies for RPS27L (AFLGC-RPS27L)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RPS27L
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-
Signalway Proteins for RPS27L
Assay Products
- antibodies-online: Show 13 available RPS27L Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for RPS27L Gene
Domains & Families for RPS27L Gene
Gene Families for RPS27L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for RPS27L Gene
- Blocks:
-
- Ribosomal protein S27E
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RPS27L Gene
- GenScript: Design optimal peptide antigens:
-
- Ribosomal protein S27 (C9J1C5_HUMAN)
- Ribosomal protein S27 (C9JLI6_HUMAN)
- 40S ribosomal protein S27-like (RS27L_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q71UM5- Family:
-
- Belongs to the eukaryotic ribosomal protein eS27 family.
Function for RPS27L Gene
Phenotypes From GWAS Catalog for RPS27L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0003735 | structural constituent of ribosome | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 21170087 |
| GO:0008494 | translation activator activity | IDA | 18056458 |
| GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | IDA | 17057733 |
Phenotypes for RPS27L Gene
- MGI mutant phenotypes for RPS27L:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RPS27L:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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-
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- Overview of 81 available RPS27L gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS27L
miRNA for RPS27L Gene
- miRTarBase miRNAs that target RPS27L
miRNA Products
Inhibitory RNA Products
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Clone Products
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- Sino Biological Human cDNA Clone for RPS27L
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- Overview of 81 available RPS27L gene related products
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- Overview of 81 available RPS27L gene related products
Cell Line Products
-
Horizon Cell Lines for RPS27L
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27L Gene
Localization for RPS27L Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Cytosol (3)
- Endoplasmic reticulum (3)
- Nucleoli (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA | 18056458 |
| GO:0005840 | ribosome | IEA | -- |
| GO:0022627 | cytosolic small ribosomal subunit | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS27L Gene
Pathways & Interactions for RPS27L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
.55
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | Influenza Viral RNA Transcription and Replication | ||
| 4 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for RPS27L Gene
1 BioSystems pathway for RPS27L Gene
1 KEGG pathway for RPS27L Gene
Interacting Proteins for RPS27L Gene
Selected Interacting proteins:
Q71UM5-RS27L_HUMAN
ENSP00000331019
for RPS27L Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RPS27L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000028 | ribosomal small subunit assembly | IBA | 21873635 |
| GO:0006412 | translation | IEA | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | 17057733 |
| GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | IDA | 18056458 |
| GO:0031571 | mitotic G1 DNA damage checkpoint | IMP | 18056458 |
No data available for SIGNOR curated interactions for RPS27L Gene
Transcripts for RPS27L Gene
mRNA/cDNA for RPS27L Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000330964 6110 bps (ENST00000330964.10)
- ENST00000411926 528 bps (ENST00000411926.1)
- ENST00000439025 970 bps (ENST00000439025.1)
- ENST00000455271 923 bps (ENST00000455271.5)
- ENST00000462430 681 bps (ENST00000462430.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RPS27L - Select products 50% OFF >
- * RPS27L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RPS27L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPS27L
- genomics-online: gRNA clones - Search for available RPS27L gRNA products
- Overview of 81 available RPS27L gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS27L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPS27L
- Browse OriGene Inhibitory RNA Products For RPS27L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS27L
- genomics-online: shRNA clones - Search for available RPS27L shRNA products
- Overview of 81 available RPS27L gene related products
Clone Products
- Applied Biological Materials (abm): Clones for RPS27L - Select products 50% OFF >
- * RPS27L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RPS27L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPS27L
- genomics-online: cdna clones - Search for available RPS27L CDNA products
- Overview of 81 available RPS27L gene related products
- orf clones - Search for available RPS27L ORF products
- Overview of 81 available RPS27L gene related products
Relevant External Links for RPS27L Gene
- GeneLoc Exon Structure for
- RPS27L
Expression for RPS27L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Islet of Langerhans (7.8) and Amniocyte (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS27L Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS27L
SOURCE GeneReport for Unigene cluster for RPS27L Gene:
Hs.108957Evidence on tissue expression from TISSUES for RPS27L Gene
- Liver(4.5)
- Skin(2.6)
- Nervous system(2.4)
- Lung(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for RPS27L
-
OriGene qPCR primer pairs and template standards for RPS27L
- genomics-online: primer clones - Search for available RPS27L Primer products
- Overview of 81 available RPS27L gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS27L Gene
Orthologs for RPS27L Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RPS27L 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | RPS27L 31 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RPS27L 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RPS27L 31 31 30 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Rps27l 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RPS27L 31 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rps27l 17 31 30 |
|
||
| chicken (Gallus gallus) |
Aves | RPS27L 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rps27.2 31 |
|
OneToOne | |
| zgc:136826 30 |
|
||||
| Dr.7787 30 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10423 32 |
|
|
|
| RpS27 31 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rps-27 31 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPS27B 31 |
|
ManyToMany | |
| RPS27A 31 |
|
ManyToMany | |||
| soybean (Glycine max) |
eudicotyledons | Gma.6612 30 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.8049 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10862 31 |
|
OneToMany |
- Species where no ortholog for RPS27L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for RPS27L Gene
- ENSEMBL:
- Gene Tree for RPS27L (if available)
- TreeFam:
- Gene Tree for RPS27L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RPS27L: view image
Paralogs for RPS27L Gene
(2) SIMAP similar genes for RPS27L Gene using alignment to 4 proteins:
- RS27L_HUMAN
- C9J1C5_HUMAN
- C9JLI6_HUMAN
- H0YMV8_HUMAN
Pseudogenes.org Pseudogenes for RPS27L Gene
Variants for RPS27L Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv27033 | CNV | gain+loss | 19812545 |
| esv3636712 | CNV | gain | 21293372 |
| nsv1035441 | CNV | gain | 25217958 |
| nsv428305 | CNV | gain | 18775914 |
Residual Variation Intolerance Score:
49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.74;
15.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RPS27L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RPS27L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS27L Gene
Disorders for RPS27L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 27 |
|
|
| diamond-blackfan anemia |
|
|
Search RPS27L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RPS27L
No data available for UniProtKB/Swiss-Prot and Genatlas for RPS27L Gene
Publications for RPS27L Gene
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 54
- Ribosomal protein S27L is a direct p53 target that regulates apoptosis. (PMID: 17057733) He H … Sun Y (Oncogene 2007) 3 23 54
- Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (PMID: 18056458) Li J … Yu Q (Cancer research 2007) 3 23 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
- BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion. (PMID: 31519766) Chan CJ … Melançon P (Molecular & cellular proteomics : MCP 2019) 3 54
ExternalLinks
Products for RPS27L Gene
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- antibodies-online: Show 24 available RPS27L Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) CRISPR for RPS27L
- Horizon Cell Lines for RPS27L
- genomics-online: cdna clones - Search for available RPS27L CDNA products
- Overview of 81 available RPS27L gene related products
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- Signalway Proteins for RPS27L
Sources for RPS27L Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
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