This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008] See more...

Aliases for RPS27L Gene

Aliases for RPS27L Gene

  • Ribosomal Protein S27 Like 2 3 5
  • Small Ribosomal Subunit Protein ES27-Like 3 4
  • 40S Ribosomal Protein S27-Like 3 4
  • Ribosomal Protein S27-Like 2
  • RPS27L 5

External Ids for RPS27L Gene

Previous GeneCards Identifiers for RPS27L Gene

  • GC15M059232
  • GC15M056493
  • GC15M060996
  • GC15M061161
  • GC15M061233
  • GC15M063445
  • GC15M040268
  • GC15M063128
  • GC15M064075
  • GC15M064202
  • GC15M064246
  • GC15M064544
  • GC15M063134
  • GC15M063368
  • GC15M063414
  • GC15M063536
  • GC15M063656
  • GC15M063773
  • GC15M063899
  • GC15M063992

Summaries for RPS27L Gene

Entrez Gene Summary for RPS27L Gene

  • This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS27L Gene

RPS27L (Ribosomal Protein S27 Like) is a Protein Coding gene. Diseases associated with RPS27L include Retinitis Pigmentosa 27 and Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is RPS27.

Additional gene information for RPS27L Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS27L Gene

Genomics for RPS27L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS27L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS27L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS27L

Top Transcription factor binding sites by QIAGEN in the RPS27L gene promoter:
  • FOXO1
  • FOXO1a
  • Gfi-1
  • GR
  • GR-alpha
  • NF-1
  • Pbx1a
  • SREBP-1a
  • STAT3

Genomic Locations for RPS27L Gene

Genomic Locations for RPS27L Gene
chr15:63,125,872-63,158,021
(GRCh38/hg38)
Size:
32,150 bases
Orientation:
Minus strand
chr15:63,418,071-63,450,220
(GRCh37/hg19)
Size:
32,150 bases
Orientation:
Minus strand

Genomic View for RPS27L Gene

Genes around RPS27L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS27L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS27L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27L Gene

Proteins for RPS27L Gene

  • Protein details for RPS27L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71UM5-RS27L_HUMAN
    Recommended name:
    40S ribosomal protein S27-like
    Protein Accession:
    Q71UM5
    Secondary Accessions:
    • Q9BTJ1

    Protein attributes for RPS27L Gene

    Size:
    84 amino acids
    Molecular mass:
    9477 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for RPS27L Gene

Post-translational modifications for RPS27L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS27L Gene

No data available for DME Specific Peptides for RPS27L Gene

Domains & Families for RPS27L Gene

Gene Families for RPS27L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS27L Gene

InterPro:
Blocks:
  • Ribosomal protein S27E
ProtoNet:

Suggested Antigen Peptide Sequences for RPS27L Gene

GenScript: Design optimal peptide antigens:
  • Ribosomal protein S27 (C9J1C5_HUMAN)
  • Ribosomal protein S27 (C9JLI6_HUMAN)
  • 40S ribosomal protein S27-like (RS27L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q71UM5

UniProtKB/Swiss-Prot:

RS27L_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS27 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS27 family.
genes like me logo Genes that share domains with RPS27L: view

Function for RPS27L Gene

Phenotypes From GWAS Catalog for RPS27L Gene

Gene Ontology (GO) - Molecular Function for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA 21873635
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
GO:0005515 protein binding IPI 21170087
GO:0008494 translation activator activity IDA 18056458
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA 17057733
genes like me logo Genes that share ontologies with RPS27L: view
genes like me logo Genes that share phenotypes with RPS27L: view

Animal Model Products

CRISPR Products

miRNA for RPS27L Gene

miRTarBase miRNAs that target RPS27L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS27L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27L Gene

Localization for RPS27L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS27L gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18056458
GO:0005840 ribosome IEA --
GO:0022627 cytosolic small ribosomal subunit IBA 21873635
genes like me logo Genes that share ontologies with RPS27L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS27L Gene

Pathways & Interactions for RPS27L Gene

PathCards logo

SuperPathways for RPS27L Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.53
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS27L: view

Gene Ontology (GO) - Biological Process for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA 21873635
GO:0006412 translation IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 17057733
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA 18056458
GO:0031571 mitotic G1 DNA damage checkpoint IMP 18056458
genes like me logo Genes that share ontologies with RPS27L: view

No data available for SIGNOR curated interactions for RPS27L Gene

Drugs & Compounds for RPS27L Gene

No Compound Related Data Available

Transcripts for RPS27L Gene

mRNA/cDNA for RPS27L Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS27L

Alternative Splicing Database (ASD) splice patterns (SP) for RPS27L Gene

No ASD Table

Relevant External Links for RPS27L Gene

GeneLoc Exon Structure for
RPS27L

Expression for RPS27L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS27L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS27L Gene

This gene is overexpressed in Islet of Langerhans (7.8) and Amniocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS27L Gene



Protein tissue co-expression partners for RPS27L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS27L

SOURCE GeneReport for Unigene cluster for RPS27L Gene:

Hs.108957

Evidence on tissue expression from TISSUES for RPS27L Gene

  • Liver(4.6)
  • Skin(3.3)
  • Nervous system(2.9)
  • Intestine(2.5)
  • Lung(2.4)
  • Kidney(2.4)
  • Blood(2.3)
  • Stomach(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with RPS27L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS27L Gene

Orthologs for RPS27L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS27L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPS27L 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPS27L 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RPS27L 30 31
  • 93.65 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RPS27L 30 31 31
  • 92.86 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Rps27l 30
  • 90.48 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RPS27L 31
  • 90 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Rps27l 30 17 31
  • 88.89 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RPS27L 30
  • 79.76 (n)
Zebrafish
(Danio rerio)
Actinopterygii rps27.2 31
  • 89 (a)
OneToOne
zgc:136826 30
  • 79.37 (n)
Dr.7787 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG10423 32
  • 81 (a)
RpS27 31
  • 79 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rps-27 31
  • 76 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS27B 31
  • 70 (a)
ManyToMany
RPS27A 31
  • 68 (a)
ManyToMany
Soybean
(Glycine max)
eudicotyledons Gma.6612 30
Barley
(Hordeum vulgare)
Liliopsida Hv.8049 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10862 31
  • 94 (a)
OneToMany
Species where no ortholog for RPS27L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RPS27L Gene

ENSEMBL:
Gene Tree for RPS27L (if available)
TreeFam:
Gene Tree for RPS27L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS27L: view image

Paralogs for RPS27L Gene

Paralogs for RPS27L Gene

(2) SIMAP similar genes for RPS27L Gene using alignment to 4 proteins:

  • RS27L_HUMAN
  • C9J1C5_HUMAN
  • C9JLI6_HUMAN
  • H0YMV8_HUMAN
genes like me logo Genes that share paralogs with RPS27L: view

Variants for RPS27L Gene

Additional dbSNP identifiers (rs#s) for RPS27L Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS27L Gene

Variant ID Type Subtype PubMed ID
esv27033 CNV gain+loss 19812545
esv3636712 CNV gain 21293372
nsv1035441 CNV gain 25217958
nsv428305 CNV gain 18775914

Variation tolerance for RPS27L Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS27L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS27L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS27L Gene

Disorders for RPS27L Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS27L Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 27
  • rp27
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with RPS27L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS27L Gene

Publications for RPS27L Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
  2. Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (PMID: 18056458) Li J … Yu Q (Cancer research 2007) 3 23
  3. Ribosomal protein S27L is a direct p53 target that regulates apoptosis. (PMID: 17057733) He H … Sun Y (Oncogene 2007) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion. (PMID: 31519766) Chan CJ … Melançon P (Molecular & cellular proteomics : MCP 2019) 3

Products for RPS27L Gene

  • Signalway Proteins for RPS27L

Sources for RPS27L Gene