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Aliases for RPS27L Gene

Aliases for RPS27L Gene

  • Ribosomal Protein S27 Like 2 3 5
  • Small Ribosomal Subunit Protein ES27-Like 4
  • Ribosomal Protein S27-Like 2

External Ids for RPS27L Gene

Previous GeneCards Identifiers for RPS27L Gene

  • GC15M059232
  • GC15M056493
  • GC15M060996
  • GC15M061161
  • GC15M061233
  • GC15M063445
  • GC15M040268
  • GC15M063128
  • GC15M063134
  • GC15M063368
  • GC15M063414
  • GC15M063536
  • GC15M063656

Summaries for RPS27L Gene

Entrez Gene Summary for RPS27L Gene

  • This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS27L Gene

RPS27L (Ribosomal Protein S27 Like) is a Protein Coding gene. Diseases associated with RPS27L include Shwachman-Diamond Syndrome. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is RPS27.

Additional gene information for RPS27L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27L Gene

Genomics for RPS27L Gene

GeneHancer (GH) Regulatory Elements for RPS27L Gene

Promoters and enhancers for RPS27L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I063155 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 583.6 +0.9 918 3.3 HDGF FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 RPS27L LACTB USP3-AS1 TPM1-AS
GH15I063188 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.7 -34.9 -34864 8.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A YBX1 ZBTB7B IRF4 YY1 ZNF143 RAB8B RPS27L USP3 LACTB APH1B SNX1 USP3-AS1 LOC101928972
GH15I063037 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.1 +110.6 110614 20.2 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A MEF2D TPM1 TPM1-AS GC15P068650 GC15P069319 RPS27L VPS13C USP3 RAB8B LACTB GC15P069490
GH15I063231 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 25.5 -75.3 -75342 4.1 SOX13 FOXA2 JUN ZNF133 ZNF384 RFX5 FOS HOMEZ RUNX3 TCF7L2 RPS27L RAB8B USP3 LACTB APH1B CA12 FBXL22 TPM1-AS
GH15I063209 Enhancer 1.3 Ensembl ENCODE dbSUPER 25.3 -54.6 -54566 5.2 PKNOX1 FEZF1 TCF12 ATF7 FOS RUNX3 JUNB REST ATF4 GMEB1 RPS27L RAB8B APH1B LACTB FBXL22 CA12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS27L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS27L gene promoter:

Genomic Locations for RPS27L Gene

Genomic Locations for RPS27L Gene
chr15:63,125,872-63,158,021
(GRCh38/hg38)
Size:
32,150 bases
Orientation:
Minus strand
chr15:63,418,071-63,450,220
(GRCh37/hg19)

Genomic View for RPS27L Gene

Genes around RPS27L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS27L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS27L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27L Gene

Proteins for RPS27L Gene

  • Protein details for RPS27L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71UM5-RS27L_HUMAN
    Recommended name:
    40S ribosomal protein S27-like
    Protein Accession:
    Q71UM5
    Secondary Accessions:
    • Q9BTJ1

    Protein attributes for RPS27L Gene

    Size:
    84 amino acids
    Molecular mass:
    9477 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for RPS27L Gene

Post-translational modifications for RPS27L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS27L Gene

No data available for DME Specific Peptides for RPS27L Gene

Domains & Families for RPS27L Gene

Gene Families for RPS27L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for RPS27L Gene

Suggested Antigen Peptide Sequences for RPS27L Gene

Graphical View of Domain Structure for InterPro Entry

Q71UM5

UniProtKB/Swiss-Prot:

RS27L_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS27 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS27 family.
genes like me logo Genes that share domains with RPS27L: view

Function for RPS27L Gene

Phenotypes From GWAS Catalog for RPS27L Gene

Gene Ontology (GO) - Molecular Function for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22681889
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI 21170087
GO:0008494 translation activator activity IDA 18056458
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA 17057733
genes like me logo Genes that share ontologies with RPS27L: view
genes like me logo Genes that share phenotypes with RPS27L: view

miRNA for RPS27L Gene

miRTarBase miRNAs that target RPS27L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27L Gene

Localization for RPS27L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS27L gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 18056458
GO:0005840 ribosome IEA --
GO:0022627 cytosolic small ribosomal subunit IBA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPS27L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS27L Gene

Pathways & Interactions for RPS27L Gene

SuperPathways for RPS27L Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS27L: view

Gene Ontology (GO) - Biological Process for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0006281 DNA repair IMP --
GO:0006412 translation IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 17057733
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA 18056458
genes like me logo Genes that share ontologies with RPS27L: view

No data available for SIGNOR curated interactions for RPS27L Gene

Drugs & Compounds for RPS27L Gene

No Compound Related Data Available

Transcripts for RPS27L Gene

Unigene Clusters for RPS27L Gene

Ribosomal protein S27-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS27L Gene

No ASD Table

Relevant External Links for RPS27L Gene

GeneLoc Exon Structure for
RPS27L
ECgene alternative splicing isoforms for
RPS27L

Expression for RPS27L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS27L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS27L Gene

This gene is overexpressed in Islet of Langerhans (7.8) and Amniocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS27L Gene



Protein tissue co-expression partners for RPS27L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS27L Gene:

RPS27L

SOURCE GeneReport for Unigene cluster for RPS27L Gene:

Hs.108957

Evidence on tissue expression from TISSUES for RPS27L Gene

  • Liver(4.5)
  • Skin(2.6)
  • Nervous system(2.4)
  • Lung(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with RPS27L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS27L Gene

Orthologs for RPS27L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS27L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS27L 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS27L 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS27L 33 34
  • 93.65 (n)
cow
(Bos Taurus)
Mammalia RPS27L 33 34 34
  • 92.86 (n)
rat
(Rattus norvegicus)
Mammalia Rps27l 33
  • 90.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPS27L 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps27l 33 16 34
  • 88.89 (n)
chicken
(Gallus gallus)
Aves RPS27L 33
  • 79.76 (n)
zebrafish
(Danio rerio)
Actinopterygii rps27.2 34
  • 89 (a)
OneToOne
zgc:136826 33
  • 79.37 (n)
Dr.7787 33
fruit fly
(Drosophila melanogaster)
Insecta CG10423 35
  • 81 (a)
RpS27 34
  • 79 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rps-27 34
  • 76 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS27B 34
  • 70 (a)
ManyToMany
RPS27A 34
  • 68 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.6612 33
barley
(Hordeum vulgare)
Liliopsida Hv.8049 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10862 34
  • 94 (a)
OneToMany
Species where no ortholog for RPS27L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPS27L Gene

ENSEMBL:
Gene Tree for RPS27L (if available)
TreeFam:
Gene Tree for RPS27L (if available)

Paralogs for RPS27L Gene

Paralogs for RPS27L Gene

(2) SIMAP similar genes for RPS27L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RPS27L: view

Variants for RPS27L Gene

Sequence variations from dbSNP and Humsavar for RPS27L Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000263127 -- 63,153,702(-) G/C 3_prime_UTR_variant
rs1000303088 -- 63,159,325(-) G/A upstream_transcript_variant
rs1000576820 -- 63,157,659(-) T/G upstream_transcript_variant
rs1000629049 -- 63,157,842(-) G/A upstream_transcript_variant
rs1000635827 -- 63,158,129(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS27L Gene

Variant ID Type Subtype PubMed ID
esv27033 CNV gain+loss 19812545
esv3636712 CNV gain 21293372
nsv1035441 CNV gain 25217958
nsv428305 CNV gain 18775914

Variation tolerance for RPS27L Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS27L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS27L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS27L Gene

Disorders for RPS27L Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS27L Gene - From: DISEASES

Disorder Aliases PubMed IDs
shwachman-diamond syndrome
  • sds
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPS27L

genes like me logo Genes that share disorders with RPS27L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS27L Gene

Publications for RPS27L Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. Ribosomal protein S27L is a direct p53 target that regulates apoptosis. (PMID: 17057733) He H … Sun Y (Oncogene 2007) 3 22 58
  3. Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (PMID: 18056458) Li J … Yu Q (Cancer research 2007) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for RPS27L Gene

Sources for RPS27L Gene

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