Aliases for RPS27L Gene
Aliases for RPS27L Gene
External Ids for RPS27L Gene
- HGNC: 18476
- Entrez Gene: 51065
- Ensembl: ENSG00000185088
- OMIM: 612055
- UniProtKB: Q71UM5
Previous GeneCards Identifiers for RPS27L Gene
- GC15M059232
- GC15M056493
- GC15M060996
- GC15M061161
- GC15M061233
- GC15M063445
- GC15M040268
- GC15M063128
- GC15M063134
- GC15M063368
- GC15M063414
- GC15M063536
- GC15M063656
Summaries for RPS27L Gene
-
This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for RPS27L Gene
RPS27L (Ribosomal Protein S27 Like) is a Protein Coding gene. Diseases associated with RPS27L include Shwachman-Diamond Syndrome. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is RPS27.
Additional gene information for RPS27L Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27L Gene
Genomics for RPS27L Gene
GeneHancer (GH) Regulatory Elements for RPS27L Gene
Promoters and enhancers for RPS27L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RPS27L on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RPS27L Gene
Genomic Locations for RPS27L Gene
- chr15:63,125,872-63,158,021
- (GRCh38/hg38)
- Size:
- 32,150 bases
- Orientation:
- Minus strand
- chr15:63,418,071-63,450,220
- (GRCh37/hg19)
Genomic View for RPS27L Gene
Genes around RPS27L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.2 by Ensembl
- 15q22.2 by Entrez Gene
- 15q22.2 by HGNC
RPS27L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPS27L Gene
Proteins for RPS27L Gene
-
Protein details for RPS27L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q71UM5-RS27L_HUMAN
- Recommended name:
- 40S ribosomal protein S27-like
- Protein Accession:
- Q71UM5
- Q9BTJ1
Protein attributes for RPS27L Gene
- Size:
- 84 amino acids
- Molecular mass:
- 9477 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for RPS27L Gene
Post-translational modifications for RPS27L Gene
Other Protein References for RPS27L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RPS27L
- Novus Biologicals Antibodies for RPS27L
- Invitrogen Antibodies for RPS27L
- Search GeneTex for Antibodies for RPS27L
Protein Products
-
OriGene Purified Proteins for RPS27L
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- Search GeneTex for Proteins for RPS27L
Assay Products
No data available for DME Specific Peptides for RPS27L Gene
Domains & Families for RPS27L Gene
Gene Families for RPS27L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
- Ribosomal proteins
Protein Domains for RPS27L Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RPS27L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q71UM5- Family:
-
- Belongs to the eukaryotic ribosomal protein eS27 family.
Function for RPS27L Gene
Phenotypes From GWAS Catalog for RPS27L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA,HDA | 22681889 |
| GO:0003735 | structural constituent of ribosome | IBA,IEA | -- |
| GO:0005515 | protein binding | IPI | 21170087 |
| GO:0008494 | translation activator activity | IDA | 18056458 |
| GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | IDA | 17057733 |
Phenotypes for RPS27L Gene
- MGI mutant phenotypes for RPS27L:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RPS27L:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for RPS27L gene
-
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- Search ViGene Biosciences for RPS27L
CRISPR Products
-
OriGene CRISPR knockouts for RPS27L
- genomics-online: gRNA clones - Search results for 66 available RPS27L gene related products
- Overview of 66 available RPS27L gene related products
- Applied Biological Materials CRISPR for RPS27L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS27L
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miRNA for RPS27L Gene
- miRTarBase miRNAs that target RPS27L
miRNA Products
- Search ViGene Biosciences for RPS27L
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RPS27L
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- genomics-online: shRNA clones - Search results for 66 available RPS27L gene related products
- Overview of 66 available RPS27L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS27L gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RPS27L
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RPS27L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RPS27L
-
ViGene Biosciences adenoviral particle packaged cDNA for RPS27L gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RPS27L gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS27L gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27L Gene
Localization for RPS27L Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 3 |
- Cytosol (3)
- Endoplasmic reticulum (3)
- Nucleoli (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA | 18056458 |
| GO:0005840 | ribosome | IEA | -- |
| GO:0022627 | cytosolic small ribosomal subunit | IBA | -- |
| GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS27L Gene
Pathways & Interactions for RPS27L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
.55
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | Influenza Viral RNA Transcription and Replication | ||
| 4 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for RPS27L Gene
1 BioSystems pathway for RPS27L Gene
1 KEGG pathway for RPS27L Gene
Interacting Proteins for RPS27L Gene
Selected Interacting proteins:
Q71UM5-RS27L_HUMAN
ENSP00000331019
for RPS27L Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000028 | ribosomal small subunit assembly | IBA | -- |
| GO:0006281 | DNA repair | IMP | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | 17057733 |
| GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | IDA | 18056458 |
No data available for SIGNOR curated interactions for RPS27L Gene
Transcripts for RPS27L Gene
mRNA/cDNA for RPS27L Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (431) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RPS27L Gene
CRISPR Products
-
OriGene CRISPR knockouts for RPS27L
- genomics-online: gRNA clones - Search results for 66 available RPS27L gene related products
- Overview of 66 available RPS27L gene related products
- Applied Biological Materials CRISPR for RPS27L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS27L
- GenScript: Design CRISPR guide RNA sequences for RPS27L
miRNA Products
- Search ViGene Biosciences for RPS27L
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RPS27L
- Browse OriGene Inhibitory RNA Products For RPS27L
- genomics-online: shRNA clones - Search results for 66 available RPS27L gene related products
- Overview of 66 available RPS27L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS27L gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RPS27L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RPS27L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RPS27L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RPS27L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Islet of Langerhans (7.8) and Amniocyte (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS27L Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RPS27L Gene:
RPS27LSOURCE GeneReport for Unigene cluster for RPS27L Gene:
Hs.108957Evidence on tissue expression from TISSUES for RPS27L Gene
- Liver(4.5)
- Skin(2.6)
- Nervous system(2.4)
- Lung(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for RPS27L
-
OriGene qPCR primer pairs and template standards for RPS27L
- genomics-online: primer clones - Search results for 66 available RPS27L gene related products
- Overview of 66 available RPS27L gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS27L Gene
Orthologs for RPS27L Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RPS27L 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RPS27L 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RPS27L 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RPS27L 33 34 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rps27l 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RPS27L 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rps27l 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | RPS27L 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rps27.2 34 |
|
OneToOne | |
| zgc:136826 33 |
|
||||
| Dr.7787 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10423 35 |
|
|
|
| RpS27 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rps-27 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPS27B 34 |
|
ManyToMany | |
| RPS27A 34 |
|
ManyToMany | |||
| soybean (Glycine max) |
eudicotyledons | Gma.6612 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.8049 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10862 34 |
|
OneToMany |
- Species where no ortholog for RPS27L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for RPS27L Gene
(2) SIMAP similar genes for RPS27L Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for RPS27L Gene
Variants for RPS27L Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000263127 | -- | 63,153,702(-) | G/C | 3_prime_UTR_variant | |
| rs1000303088 | -- | 63,159,325(-) | G/A | upstream_transcript_variant | |
| rs1000576820 | -- | 63,157,659(-) | T/G | upstream_transcript_variant | |
| rs1000629049 | -- | 63,157,842(-) | G/A | upstream_transcript_variant | |
| rs1000635827 | -- | 63,158,129(-) | G/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv27033 | CNV | gain+loss | 19812545 |
| esv3636712 | CNV | gain | 21293372 |
| nsv1035441 | CNV | gain | 25217958 |
| nsv428305 | CNV | gain | 18775914 |
Residual Variation Intolerance Score:
49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.74;
15.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RPS27L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RPS27L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS27L Gene
Disorders for RPS27L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| shwachman-diamond syndrome |
|
|
Search RPS27L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RPS27L
No data available for UniProtKB/Swiss-Prot and Genatlas for RPS27L Gene
Publications for RPS27L Gene
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
- Ribosomal protein S27L is a direct p53 target that regulates apoptosis. (PMID: 17057733) He H … Sun Y (Oncogene 2007) 3 22 58
- Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (PMID: 18056458) Li J … Yu Q (Cancer research 2007) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58
Products for RPS27L Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RPS27L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 21 available RPS27L Antibodies ranked by validation data
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- antibodies-online: Search results for 5 available RPS27L Proteins ranked by validation data
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- Search GeneTex for Antibodies for RPS27L
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- ViGene Biosciences adenoviral particle packaged cDNA for RPS27L gene
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- Overview of 66 available RPS27L gene related products
Sources for RPS27L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
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