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Aliases for RPS27A Gene

Aliases for RPS27A Gene

  • Ribosomal Protein S27a 2 3 5
  • Ubiquitin Carboxyl Extension Protein 80 2 3 4
  • UBCEP1 3 4
  • UBA80 3 4
  • Ubiquitin And Ribosomal Protein S27a 3
  • Ubiquitin-40S Ribosomal Protein S27a 3
  • Epididymis Luminal Protein 112 3
  • 40S Ribosomal Protein S27a 3
  • Ubiquitin-CEP80 3
  • Ubiquitin C 3
  • UBCEP80 3
  • HEL112 3
  • CEP80 3
  • S27A 3
  • UBC 3

External Ids for RPS27A Gene

Previous GeneCards Identifiers for RPS27A Gene

  • GC02P055497
  • GC02P055646
  • GC02P055417
  • GC02P055434
  • GC02P055371
  • GC02P055313
  • GC02P055459
  • GC02P055193

Summaries for RPS27A Gene

Entrez Gene Summary for RPS27A Gene

  • Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]

GeneCards Summary for RPS27A Gene

RPS27A (Ribosomal Protein S27a) is a Protein Coding gene. Diseases associated with RPS27A include Neuronal Intranuclear Inclusion Disease and Oculopharyngeal Muscular Dystrophy. Among its related pathways are Diseases of carbohydrate metabolism and Gene Expression. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is ENSG00000231767.

UniProtKB/Swiss-Prot for RPS27A Gene

  • Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

  • 40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.

Gene Wiki entry for RPS27A Gene

Additional gene information for RPS27A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27A Gene

Genomics for RPS27A Gene

GeneHancer (GH) Regulatory Elements for RPS27A Gene

Promoters and enhancers for RPS27A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J055231 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 671.6 +1.1 1082 3.7 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B CLHC1 RPS27A RTN4 GC02P055233 PRORSD1P
GH02J055268 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37.4 +37.3 37305 2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 MTIF2 GC02P055270 RPS27A CLHC1 PRORSD1P GC02P055233
GH02J055045 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.8 -182.5 -182463 8.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 RTN4 RPS27A PRORSD1P RNU6-433P ENSG00000272156 CLHC1 EML6 GC02P055039 LOC105374662
GH02J055614 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 +385.4 385434 5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ENSG00000272606 PPP4R3B GC02P055618 RPS27A PNPT1 PRORSD1P CLHC1 GC02P055601
GH02J054554 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -672.7 -672698 8.8 ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 NFYC ZNF610 RCOR2 NBN SPTBN1 LOC105374640 EML6 ENSG00000203327 RPS27A RTN4 GC02M054620 PIR49112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS27A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS27A gene promoter:

Genomic Locations for RPS27A Gene

Genomic Locations for RPS27A Gene
chr2:55,231,903-55,235,853
(GRCh38/hg38)
Size:
3,951 bases
Orientation:
Plus strand
chr2:55,459,039-55,462,989
(GRCh37/hg19)

Genomic View for RPS27A Gene

Genes around RPS27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27A Gene

Proteins for RPS27A Gene

  • Protein details for RPS27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62979-RS27A_HUMAN
    Recommended name:
    Ubiquitin-40S ribosomal protein S27a
    Protein Accession:
    P62979
    Secondary Accessions:
    • P02248
    • P02249
    • P02250
    • P14798
    • P62988
    • Q29120
    • Q6LBL4
    • Q6LDU5
    • Q8WYN8
    • Q91887
    • Q91888
    • Q9BQ77
    • Q9BWD6
    • Q9BX98
    • Q9UEF2
    • Q9UEG1
    • Q9UEK8
    • Q9UPK7

    Protein attributes for RPS27A Gene

    Size:
    156 amino acids
    Molecular mass:
    17965 Da
    Quaternary structure:
    • Ribosomal protein S27a is part of the 40S ribosomal subunit.
    Miscellaneous:
    • Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
    • For a better understanding, features related to ubiquitin are only indicated for the first chain.

    Three dimensional structures from OCA and Proteopedia for RPS27A Gene

neXtProt entry for RPS27A Gene

Post-translational modifications for RPS27A Gene

  • Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
  • Ubiquitination at isoforms=143, isoforms=113, isoforms=163, posLast=4848, posLast=3333, posLast=2929, isoforms=27, posLast=1111, and posLast=66
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS27A Gene

No data available for DME Specific Peptides for RPS27A Gene

Domains & Families for RPS27A Gene

Gene Families for RPS27A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry

P62979

UniProtKB/Swiss-Prot:

RS27A_HUMAN :
  • In the N-terminal section; belongs to the ubiquitin family.
Family:
  • In the N-terminal section; belongs to the ubiquitin family.
  • In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
genes like me logo Genes that share domains with RPS27A: view

Function for RPS27A Gene

Molecular function for RPS27A Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
UniProtKB/Swiss-Prot Function:
40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.
GENATLAS Biochemistry:
60S ribosomal protein S27A

Phenotypes From GWAS Catalog for RPS27A Gene

Gene Ontology (GO) - Molecular Function for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA,HDA --
GO:0003735 structural constituent of ribosome IBA,HDA --
GO:0005515 protein binding IEA,IPI 15936278
GO:0031386 protein tag IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with RPS27A: view
genes like me logo Genes that share phenotypes with RPS27A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27A Gene

Localization for RPS27A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS27A Gene

Ubiquitin: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS27A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 4
endoplasmic reticulum 4
endosome 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus HDA 16791210
GO:0005737 cytoplasm IEA,IBA --
genes like me logo Genes that share ontologies with RPS27A: view

Pathways & Interactions for RPS27A Gene

SuperPathways for RPS27A Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Activated TLR4 signalling
4 Viral mRNA Translation
.55
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS27A: view

Pathways by source for RPS27A Gene

Gene Ontology (GO) - Biological Process for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0000165 MAPK cascade TAS --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000187 activation of MAPK activity TAS --
genes like me logo Genes that share ontologies with RPS27A: view

No data available for SIGNOR curated interactions for RPS27A Gene

Drugs & Compounds for RPS27A Gene

(55) Drugs for RPS27A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(60) Additional Compounds for RPS27A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS27A: view

Transcripts for RPS27A Gene

mRNA/cDNA for RPS27A Gene

Unigene Clusters for RPS27A Gene

Ribosomal protein S27a:
Representative Sequences: