This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Aug 2017] See more...

Aliases for RPS26 Gene

Aliases for RPS26 Gene

  • Ribosomal Protein S26 2 3 5
  • 40S Ribosomal Protein S26 2 3 4
  • Small Ribosomal Subunit Protein ES26 3 4
  • ES26 2 3
  • S26 2 3
  • DBA10 3
  • RPS26 5

External Ids for RPS26 Gene

Previous GeneCards Identifiers for RPS26 Gene

  • GC13M099552
  • GC12P056999
  • GC12P056152
  • GC12P054721
  • GC12P054722
  • GC12P056438
  • GC07P121716

Summaries for RPS26 Gene

Entrez Gene Summary for RPS26 Gene

  • This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Aug 2017]

GeneCards Summary for RPS26 Gene

RPS26 (Ribosomal Protein S26) is a Protein Coding gene. Diseases associated with RPS26 include Diamond-Blackfan Anemia 10 and Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include mRNA binding.

Gene Wiki entry for RPS26 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS26 Gene

Genomics for RPS26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS26

Top Transcription factor binding sites by QIAGEN in the RPS26 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • FOXD1
  • GATA-3
  • MAZR
  • Nkx2-5
  • STAT5A

Genomic Locations for RPS26 Gene

Genomic Locations for RPS26 Gene
chr12:56,041,351-56,044,697
(GRCh38/hg38)
Size:
3,347 bases
Orientation:
Plus strand
chr12:56,435,637-56,438,116
(GRCh37/hg19)
Size:
2,480 bases
Orientation:
Plus strand

Genomic View for RPS26 Gene

Genes around RPS26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS26 Gene

Proteins for RPS26 Gene

  • Protein details for RPS26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62854-RS26_HUMAN
    Recommended name:
    40S ribosomal protein S26
    Protein Accession:
    P62854
    Secondary Accessions:
    • P02383
    • P70394
    • Q06722
    • Q3MHD8
    • Q6IRY4

    Protein attributes for RPS26 Gene

    Size:
    115 amino acids
    Molecular mass:
    13015 Da
    Quaternary structure:
    • Component of the 40S small ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPS26 Gene

neXtProt entry for RPS26 Gene

Post-translational modifications for RPS26 Gene

  • Ubiquitination at Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS26 Gene

Domains & Families for RPS26 Gene

Gene Families for RPS26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS26 Gene

Suggested Antigen Peptide Sequences for RPS26 Gene

GenScript: Design optimal peptide antigens:
  • Similar to 40S ribosomal protein S26 (Q75MH1_HUMAN)
  • 40S ribosomal protein S26 (RS26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62854

UniProtKB/Swiss-Prot:

RS26_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS26 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS26 family.
genes like me logo Genes that share domains with RPS26: view

Function for RPS26 Gene

Molecular function for RPS26 Gene

GENATLAS Biochemistry:
40S ribosomal protein S26,12kDa

Phenotypes From GWAS Catalog for RPS26 Gene

Gene Ontology (GO) - Molecular Function for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003729 mRNA binding IBA,IDA 15716004
GO:0003735 structural constituent of ribosome IBA 21873635
GO:0005515 protein binding IPI 16189514
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with RPS26: view
genes like me logo Genes that share phenotypes with RPS26: view

Human Phenotype Ontology for RPS26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RPS26 Gene

MGI Knock Outs for RPS26:
  • Rps26 Rps26<tm2b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS26

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RPS26 Gene

Localization for RPS26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS26 Gene

Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250 UniProtKB:P49171, ECO:0000269 PubMed:25957688}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS26 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
endoplasmic reticulum 4
mitochondrion 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS26: view

Pathways & Interactions for RPS26 Gene

PathCards logo

SuperPathways for RPS26 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.53
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS26: view

Pathways by source for RPS26 Gene

1 KEGG pathway for RPS26 Gene
1 GeneGo (Thomson Reuters) pathway for RPS26 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006412 translation IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS26: view

No data available for SIGNOR curated interactions for RPS26 Gene

Drugs & Compounds for RPS26 Gene

No Compound Related Data Available

Transcripts for RPS26 Gene

mRNA/cDNA for RPS26 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS26

Alternative Splicing Database (ASD) splice patterns (SP) for RPS26 Gene

No ASD Table

Relevant External Links for RPS26 Gene

GeneLoc Exon Structure for
RPS26

Expression for RPS26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS26 Gene

Protein differential expression in normal tissues from HIPED for RPS26 Gene

This gene is overexpressed in Pancreas (14.8) and Lung (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS26 Gene



Protein tissue co-expression partners for RPS26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS26

SOURCE GeneReport for Unigene cluster for RPS26 Gene:

Hs.447562

Evidence on tissue expression from TISSUES for RPS26 Gene

  • Nervous system(4.8)
  • Liver(4.7)
  • Muscle(3.5)
  • Blood(3.3)
  • Kidney(3.2)
  • Heart(3.2)
  • Intestine(3.1)
  • Lung(2.9)
  • Spleen(2.9)
  • Skin(2.9)
  • Pancreas(2.9)
  • Bone marrow(2.8)
  • Thyroid gland(2.7)
  • Stomach(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.5)
  • Eye(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS26 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
Thorax:
  • aorta
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • kidney
  • large intestine
Pelvis:
  • pelvis
  • penis
  • ureter
  • urethra
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with RPS26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS26 Gene

Orthologs for RPS26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS26 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Rps26-ps1 31
  • 100 (a)
OneToMany
Rps26 30 17 31
  • 86.09 (n)
OneToMany
Chimpanzee
(Pan troglodytes)
Mammalia RPS26 30 31 31
  • 99.71 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia RPS26 30 31
  • 93.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPS26 30 31
  • 89.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rps26 30
  • 87.54 (n)
Oppossum
(Monodelphis domestica)
Mammalia RPS26 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RPS26 30 31
  • 82.32 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPS26 31
  • 98 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rps26 30
  • 79.54 (n)
Str.403 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8381 30
Zebrafish
(Danio rerio)
Actinopterygii rps26 31
  • 93 (a)
OneToMany
rps26l 30 31
  • 81.19 (n)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta RpS26 30 31 32
  • 71.67 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RS26_ANOGA 30
  • 66.67 (n)
Worm
(Caenorhabditis elegans)
Secernentea rps-26 30 31
  • 66.67 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS26B 30 31
  • 63.7 (n)
OneToMany
RPS26A 31 33
  • 62 (a)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR194W 30
  • 63.67 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05115g 30
  • 63.04 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G40510 30
  • 62.71 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU04552 30
  • 69.33 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2602 30
  • 62.33 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 57 (a)
OneToOne
Species where no ortholog for RPS26 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RPS26 Gene

ENSEMBL:
Gene Tree for RPS26 (if available)
TreeFam:
Gene Tree for RPS26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS26: view image

Paralogs for RPS26 Gene

(1) SIMAP similar genes for RPS26 Gene using alignment to 2 proteins:

  • RS26_HUMAN
  • Q75MH1_HUMAN
genes like me logo Genes that share paralogs with RPS26: view

No data available for Paralogs for RPS26 Gene

Variants for RPS26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS26 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
651454 Uncertain Significance: Diamond-Blackfan anemia 10 56,043,493(+) G/A SYNONYMOUS_VARIANT
702675 Likely Benign: not provided 56,042,439(+) G/A SYNONYMOUS_VARIANT
703119 Likely Benign: not provided 56,042,484(+) T/A SYNONYMOUS_VARIANT
812897 Likely Pathogenic: Anemia; Pure red cell aplasia 56,043,495(+) T/A SPLICE_DONOR_VARIANT
881904 Uncertain Significance: Diamond-Blackfan anemia 10 56,042,037(+) T/G FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for RPS26 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS26 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832424 CNV loss 17160897
nsv832427 CNV loss 17160897
nsv973074 CNV duplication 23825009

Variation tolerance for RPS26 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS26 Gene

Human Gene Mutation Database (HGMD)
RPS26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS26 Gene

Disorders for RPS26 Gene

MalaCards: The human disease database

(13) MalaCards diseases for RPS26 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 10
  • dba10
diamond-blackfan anemia 15 with mandibulofacial dysostosis
  • dba15
diamond-blackfan anemia
  • diamond-blackfan anemia 1
pure red-cell aplasia
  • primary red cell aplasia
macrocytic anemia
  • anemia macrocytic
- elite association - COSMIC cancer census association via MalaCards
Search RPS26 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RS26_HUMAN
  • Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:20116044, ECO:0000269 PubMed:24942156}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RPS26

genes like me logo Genes that share disorders with RPS26: view

No data available for Genatlas for RPS26 Gene

Publications for RPS26 Gene

  1. Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26. (PMID: 9602156) Filipenko ML … Amaldi F (Gene 1998) 3 4 23
  2. [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]. (PMID: 8670309) Filipenko ML … Mertvetsov NP (Bioorganicheskaia khimiia 1995) 2 3 23
  3. [Cloning cDNA of human S26 ribosomal protein and determination of its primary structure]. (PMID: 7945460) Filipenko ML … Mertvetsov NP (Bioorganicheskaia khimiia 1994) 3 4 23
  4. Structural snapshots of actively translating human ribosomes. (PMID: 25957688) Behrmann E … Spahn CM (Cell 2015) 3 4
  5. A new system for naming ribosomal proteins. (PMID: 24524803) Ban N … Yusupov M (Current opinion in structural biology 2014) 3 4

Products for RPS26 Gene

Sources for RPS26 Gene