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Aliases for RPS25 Gene

Aliases for RPS25 Gene

  • Ribosomal Protein S25 2 3 5
  • Small Ribosomal Subunit Protein ES25 3 4
  • 40S Ribosomal Protein S25 3
  • S25 3

External Ids for RPS25 Gene

Previous GeneCards Identifiers for RPS25 Gene

  • GC11M134077
  • GC11M120398
  • GC11M118917
  • GC11M118424
  • GC11M118391
  • GC11M114826
  • GC11M118886

Summaries for RPS25 Gene

Entrez Gene Summary for RPS25 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS25 Gene

RPS25 (Ribosomal Protein S25) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS25 Gene

Additional gene information for RPS25 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS25 Gene

Genomics for RPS25 Gene

GeneHancer (GH) Regulatory Elements for RPS25 Gene

Promoters and enhancers for RPS25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I119015 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.6 630 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 TRAPPC4 GC11P119045 PIR32149 RPS25 PIR60932 MIR3656 BCL9L ARCN1 ENSG00000254909 UBE4A
GH11I119090 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 30.4 -75.0 -74981 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GC11M119097 H2AFX KMT2A HINFP UBE4A ARCN1 BCL9L RPL5P30 ENSG00000254909 CCDC84
GH11I118906 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 +99.9 99898 24.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 BCL9L DPAGT1 UBE4A ENSG00000254909 RPL23AP64 ARCN1 ENSG00000254428 RNF26 CCDC84 KMT2A
GH11I119066 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.3 -49.0 -48995 2.2 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 VPS11 ENSG00000272186 DPAGT1 HMBS ARCN1 H2AFX C2CD2L KMT2A ENSG00000254909 SLC37A4
GH11I119106 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 -89.3 -89288 3.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 POLR2B DPAGT1 C2CD2L HINFP ENSG00000254909 UBE4A ARCN1 RPL23AP64 ENSG00000254428 BCL9L RPS25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS25 gene promoter:

Genomic Locations for RPS25 Gene

Genomic Locations for RPS25 Gene
2,980 bases
Minus strand

Genomic View for RPS25 Gene

Genes around RPS25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS25 Gene

Proteins for RPS25 Gene

  • Protein details for RPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S25
    Protein Accession:
    Secondary Accessions:
    • B2R4M7
    • P25111

    Protein attributes for RPS25 Gene

    125 amino acids
    Molecular mass:
    13742 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS25 Gene

neXtProt entry for RPS25 Gene

Post-translational modifications for RPS25 Gene

  • Ubiquitination at isoforms=43, isoforms=52, posLast=6060, isoforms=94, isoforms=98, and posLast=114114
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS25 Gene

Domains & Families for RPS25 Gene

Gene Families for RPS25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS25 Gene


Suggested Antigen Peptide Sequences for RPS25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS25 family.
  • Belongs to the eukaryotic ribosomal protein eS25 family.
genes like me logo Genes that share domains with RPS25: view

Function for RPS25 Gene

Molecular function for RPS25 Gene

GENATLAS Biochemistry:
40S ribosomal protein S25,13kDa

Phenotypes From GWAS Catalog for RPS25 Gene

Gene Ontology (GO) - Molecular Function for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 10050887
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with RPS25: view
genes like me logo Genes that share phenotypes with RPS25: view

miRNA for RPS25 Gene

miRTarBase miRNAs that target RPS25

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS25 Gene

Localization for RPS25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS25 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 10050887
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8020948
genes like me logo Genes that share ontologies with RPS25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS25 Gene

Pathways & Interactions for RPS25 Gene

SuperPathways for RPS25 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS25: view

Gene Ontology (GO) - Biological Process for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 8020948
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS25: view

No data available for SIGNOR curated interactions for RPS25 Gene

Drugs & Compounds for RPS25 Gene

No Compound Related Data Available

Transcripts for RPS25 Gene

Unigene Clusters for RPS25 Gene

Ribosomal protein S25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS25 Gene

No ASD Table

Relevant External Links for RPS25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS25 Gene

This gene is overexpressed in Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS25 Gene

Protein tissue co-expression partners for RPS25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS25 Gene:


SOURCE GeneReport for Unigene cluster for RPS25 Gene:


Evidence on tissue expression from TISSUES for RPS25 Gene

  • Skin(4.8)
  • Pancreas(4.6)
  • Muscle(4.5)
  • Lung(4.4)
  • Nervous system(4.2)
  • Liver(4.1)
  • Eye(4)
  • Heart(4)
  • Intestine(3.5)
  • Bone(2.8)
  • Blood(2.7)
  • Stomach(2.7)
  • Thyroid gland(2.7)
  • Lymph node(2.6)
  • Bone marrow(2.5)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.3)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with RPS25: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS25 Gene

Orthologs for RPS25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS25 33 34
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia RPS25 34
  • 98 (a)
(Monodelphis domestica)
Mammalia RPS25 34
  • 96 (a)
(Bos Taurus)
Mammalia RPS25 33 34 34
  • 93.6 (n)
-- 34
  • 80 (a)
-- 34
  • 76 (a)
(Canis familiaris)
Mammalia RPS25 33 34
  • 92.8 (n)
(Rattus norvegicus)
Mammalia Rps25 33
  • 91.47 (n)
(Mus musculus)
Mammalia Rps25 33 16 34
  • 88.53 (n)
(Gallus gallus)
Aves RPS25 33 34
  • 82.13 (n)
(Anolis carolinensis)
Reptilia RPS25 34
  • 98 (a)
(Danio rerio)
Actinopterygii rps25 33 34
  • 78.82 (n)
zgc73391 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.787 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004462 33
  • 69.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpS25 33 34
  • 69.77 (n)
(Caenorhabditis elegans)
Secernentea rps-25 33 34
  • 65.1 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS25A 34
  • 45 (a)
RPS25B 34
  • 44 (a)
(Oryza sativa)
Liliopsida Os.22978 33
(Zea mays)
Liliopsida Zm.12378 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 72 (a)
Species where no ortholog for RPS25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPS25 Gene

Gene Tree for RPS25 (if available)
Gene Tree for RPS25 (if available)

Paralogs for RPS25 Gene

No data available for Paralogs for RPS25 Gene

Variants for RPS25 Gene

Sequence variations from dbSNP and Humsavar for RPS25 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs386352288 uncertain-significance, not provided 119,015,316(-) A/G downstream_transcript_variant
rs1000121364 -- 119,015,770(-) A/G intron_variant
rs1000708180 -- 119,019,907(-) A/G upstream_transcript_variant
rs1000730956 -- 119,017,219(-) G/A intron_variant
rs1001022384 -- 119,018,706(-) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS25 Gene

Variant ID Type Subtype PubMed ID
nsv826101 CNV gain 20364138
nsv983067 CNV duplication 23825009

Variation tolerance for RPS25 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS25 Gene

Disorders for RPS25 Gene

Additional Disease Information for RPS25

No disorders were found for RPS25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS25 Gene

Publications for RPS25 Gene

  1. Cloning and sequencing a cDNA encoding human ribosomal protein S25. (PMID: 1748303) Li ML … Center MS (Gene 1991) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 58
  4. Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins. (PMID: 10050887) Kubota S … Pomerantz RJ (Oncogene 1999) 3 22 58
  5. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov SN … Otto A (European journal of biochemistry 1996) 3 4 58

Products for RPS25 Gene

Sources for RPS25 Gene

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