Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in t... See more...

Aliases for RPS25 Gene

Aliases for RPS25 Gene

  • Ribosomal Protein S25 2 3 5
  • Small Ribosomal Subunit Protein ES25 3 4
  • 40S Ribosomal Protein S25 3 4
  • S25 2 3
  • RPS25 5

External Ids for RPS25 Gene

Previous GeneCards Identifiers for RPS25 Gene

  • GC11M134077
  • GC11M120398
  • GC11M118917
  • GC11M118424
  • GC11M118391
  • GC11M114826
  • GC11M118886

Summaries for RPS25 Gene

Entrez Gene Summary for RPS25 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS25 Gene

RPS25 (Ribosomal Protein S25) is a Protein Coding gene. Diseases associated with RPS25 include Chromosome 5Q Deletion Syndrome and Hermansky-Pudlak Syndrome 3. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS25 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS25 Gene

Genomics for RPS25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS25 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS25

Top Transcription factor binding sites by QIAGEN in the RPS25 gene promoter:
  • AML1a
  • Gfi-1
  • HNF-4alpha1
  • Ik-2
  • ITF-2
  • NF-1
  • NF-1/L
  • Nkx6-1
  • S8
  • Tal-1beta

Genomic Locations for RPS25 Gene

Latest Assembly
chr11:119,015,712-119,018,691
(GRCh38/hg38)
Size:
2,980 bases
Orientation:
Minus strand

Previous Assembly
chr11:118,886,427-118,889,053
(GRCh37/hg19 by Entrez Gene)
Size:
2,627 bases
Orientation:
Minus strand

chr11:118,886,422-118,889,401
(GRCh37/hg19 by Ensembl)
Size:
2,980 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr11(PATCHES):37,317-39,943 (-)

Genomic View for RPS25 Gene

Genes around RPS25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS25 Gene

Proteins for RPS25 Gene

  • Protein details for RPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62851-RS25_HUMAN
    Recommended name:
    40S ribosomal protein S25
    Protein Accession:
    P62851
    Secondary Accessions:
    • B2R4M7
    • P25111

    Protein attributes for RPS25 Gene

    Size:
    125 amino acids
    Molecular mass:
    13742 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS25 Gene

neXtProt entry for RPS25 Gene

Post-translational modifications for RPS25 Gene

  • Ubiquitination at Lys43, Lys52, Lys60, Lys66, Lys94, Lys98, and Lys114
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS25 Gene

No data available for DME Specific Peptides for RPS25 Gene

Domains & Families for RPS25 Gene

Gene Families for RPS25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS25 Gene

Suggested Antigen Peptide Sequences for RPS25 Gene

GenScript: Design optimal peptide antigens:
  • 40S ribosomal protein S25 (RS25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62851

UniProtKB/Swiss-Prot:

RS25_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS25 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS25 family.
genes like me logo Genes that share domains with RPS25: view

Function for RPS25 Gene

Molecular function for RPS25 Gene

GENATLAS Biochemistry:
40S ribosomal protein S25,13kDa

Phenotypes From GWAS Catalog for RPS25 Gene

Gene Ontology (GO) - Molecular Function for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 10050887
GO:0003735 structural constituent of ribosome IMP 18697920
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with RPS25: view
genes like me logo Genes that share phenotypes with RPS25: view

miRNA for RPS25 Gene

miRTarBase miRNAs that target RPS25

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS25 Gene

Localization for RPS25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS25 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 10050887
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8020948
genes like me logo Genes that share ontologies with RPS25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS25 Gene

Pathways & Interactions for RPS25 Gene

PathCards logo

SuperPathways for RPS25 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.53
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS25: view

Pathways by source for RPS25 Gene

2 KEGG pathways for RPS25 Gene
1 GeneGo (Thomson Reuters) pathway for RPS25 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation NAS 8020948
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS25: view

No data available for SIGNOR curated interactions for RPS25 Gene

Drugs & Compounds for RPS25 Gene

No Compound Related Data Available

Transcripts for RPS25 Gene

mRNA/cDNA for RPS25 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS25

Alternative Splicing Database (ASD) splice patterns (SP) for RPS25 Gene

No ASD Table

Relevant External Links for RPS25 Gene

GeneLoc Exon Structure for
RPS25

Expression for RPS25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS25 Gene

This gene is overexpressed in Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS25 Gene



Protein tissue co-expression partners for RPS25 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS25

SOURCE GeneReport for Unigene cluster for RPS25 Gene:

Hs.512676

Evidence on tissue expression from TISSUES for RPS25 Gene

  • Skin(4.9)
  • Pancreas(4.6)
  • Blood(4.6)
  • Muscle(4.6)
  • Lung(4.4)
  • Nervous system(4.4)
  • Liver(4.3)
  • Heart(4.2)
  • Eye(4.1)
  • Intestine(3.8)
  • Lymph node(2.8)
  • Kidney(2.8)
  • Spleen(2.8)
  • Bone(2.8)
  • Bone marrow(2.7)
  • Stomach(2.7)
  • Adrenal gland(2.4)
  • Thyroid gland(2.4)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPS25: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS25 Gene

Orthologs for RPS25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPS25 29 30
  • 100 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPS25 30
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPS25 30
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RPS25 29 30 30
  • 93.6 (n)
OneToMany
-- 30
  • 80 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia RPS25 29 30
  • 92.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rps25 29
  • 91.47 (n)
Mouse
(Mus musculus)
Mammalia Rps25 29 16 30
  • 88.53 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RPS25 29 30
  • 82.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPS25 30
  • 98 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii rps25 29 30
  • 78.82 (n)
OneToOne
zgc73391 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.787 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004462 29
  • 69.8 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta RpS25 29 30
  • 69.77 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea rps-25 29 30
  • 65.1 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS25A 30
  • 45 (a)
OneToMany
RPS25B 30
  • 44 (a)
OneToMany
Rice
(Oryza sativa)
Liliopsida Os.22978 29
Corn
(Zea mays)
Liliopsida Zm.12378 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 72 (a)
OneToOne
Species where no ortholog for RPS25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RPS25 Gene

ENSEMBL:
Gene Tree for RPS25 (if available)
TreeFam:
Gene Tree for RPS25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS25: view image
Alliance of Genome Resources:
Additional Orthologs for RPS25

Paralogs for RPS25 Gene

No data available for Paralogs for RPS25 Gene

Variants for RPS25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS25 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs149825323 Benign: not provided 119,015,893(-) G/A
NM_001028.3(RPS25):c.330C>T (p.Thr110=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RPS25 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RPS25 Gene

Variant ID Type Subtype PubMed ID
nsv826101 CNV gain 20364138
nsv983067 CNV duplication 23825009

Variation tolerance for RPS25 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS25
Leiden Open Variation Database (LOVD)
RPS25

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS25 Gene

Disorders for RPS25 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RPS25 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search RPS25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS25

genes like me logo Genes that share disorders with RPS25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS25 Gene

Publications for RPS25 Gene

  1. Cloning and sequencing a cDNA encoding human ribosomal protein S25. (PMID: 1748303) Li ML … Center MS (Gene 1991) 2 3 4 22
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4
  4. Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins. (PMID: 10050887) Kubota S … Pomerantz RJ (Oncogene 1999) 3 22
  5. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov SN … Otto A (European journal of biochemistry 1996) 3 4

Products for RPS25 Gene

Sources for RPS25 Gene