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Aliases for RPS21 Gene

Aliases for RPS21 Gene

  • Ribosomal Protein S21 2 3 5
  • Small Ribosomal Subunit Protein ES21 3 4
  • 8.2 KDa Differentiation Factor 2 3
  • Human Leukemia Differentiation Factor 3
  • 40S Ribosomal Protein S21 3
  • HLDF 3
  • S21 3

External Ids for RPS21 Gene

Previous GeneCards Identifiers for RPS21 Gene

  • GC20P060725
  • GC20P061600
  • GC20P061647
  • GC20P060395
  • GC20P060962

Summaries for RPS21 Gene

Entrez Gene Summary for RPS21 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS21 Gene

RPS21 (Ribosomal Protein S21) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.

Gene Wiki entry for RPS21 Gene

Additional gene information for RPS21 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS21 Gene

Genomics for RPS21 Gene

GeneHancer (GH) Regulatory Elements for RPS21 Gene

Promoters and enhancers for RPS21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J062385 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 674.4 +0.3 261 3.9 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 RPS21 LAMA5 ENSG00000273619 DIDO1 LINC00029 CABLES2 TAF4 LSM14B LINC01056 YTHDF1
GH20J062300 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.2 -83.3 -83275 5.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ADRM1 DIDO1 TAF4 MRGBP ENSG00000226332 GID8 RPS21 YTHDF1 LAMA5 LAMA5-AS1
GH20J062935 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.1 +550.7 550688 4.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 DIDO1 GID8 LINC00029 GMEB2 LOC105372725 RPS21 ENSG00000226332 LINC01056 TAF4 SLC17A9
GH20J062500 Enhancer 1.6 FANTOM5 Ensembl ENCODE 23.8 +114.6 114558 2.8 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A YBX1 ZNF2 ZBTB7B DIDO1 TAF4 ENSG00000226332 MRGBP RPS21 LAMA5 HAR1A MTG2 YTHDF1 DPH3P1
GH20J062793 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.3 +408.8 408761 5 HDGF CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B MRGBP LOC105372716 DIDO1 OGFR YTHDF1 RPS21 LSM14B LAMA5 TAF4 RTEL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS21 gene promoter:
  • HFH-3
  • FOXI1
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • MyoD
  • Pax-2b
  • Pax-2a
  • Pax-2

Genomic Locations for RPS21 Gene

Genomic Locations for RPS21 Gene
1,456 bases
Plus strand
1,456 bases
Plus strand

Genomic View for RPS21 Gene

Genes around RPS21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS21 Gene

Proteins for RPS21 Gene

  • Protein details for RPS21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S21
    Protein Accession:
    Secondary Accessions:
    • P35265

    Protein attributes for RPS21 Gene

    83 amino acids
    Molecular mass:
    9111 Da
    Quaternary structure:
    • Component of the 40S small ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPS21 Gene

neXtProt entry for RPS21 Gene

Post-translational modifications for RPS21 Gene

  • Ubiquitination at isoforms=74, isoforms=51, and isoforms=27
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS21 Gene

No data available for DME Specific Peptides for RPS21 Gene

Domains & Families for RPS21 Gene

Gene Families for RPS21 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS21 family.
  • Belongs to the eukaryotic ribosomal protein eS21 family.
genes like me logo Genes that share domains with RPS21: view

Function for RPS21 Gene

Molecular function for RPS21 Gene

GENATLAS Biochemistry:
40S ribosomal protein S21,9kDa

Phenotypes From GWAS Catalog for RPS21 Gene

Gene Ontology (GO) - Molecular Function for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI --
GO:0047485 protein N-terminus binding IPI 10079194
genes like me logo Genes that share ontologies with RPS21: view
genes like me logo Genes that share phenotypes with RPS21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS21 Gene

Localization for RPS21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS21 Gene

Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250 UniProtKB:P63221, ECO:0000269 PubMed:25957688}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS21 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005791 rough endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RPS21: view

Pathways & Interactions for RPS21 Gene

SuperPathways for RPS21 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS21: view

Gene Ontology (GO) - Biological Process for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000461 endonucleolytic cleavage to generate mature 3-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPS21: view

No data available for SIGNOR curated interactions for RPS21 Gene

Drugs & Compounds for RPS21 Gene

No Compound Related Data Available

Transcripts for RPS21 Gene

mRNA/cDNA for RPS21 Gene

Unigene Clusters for RPS21 Gene

Ribosomal protein S21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS21

Alternative Splicing Database (ASD) splice patterns (SP) for RPS21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: - -

Relevant External Links for RPS21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS21 Gene

This gene is overexpressed in Nasal epithelium (10.2) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS21 Gene

Protein tissue co-expression partners for RPS21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS21 Gene:


SOURCE GeneReport for Unigene cluster for RPS21 Gene:


Evidence on tissue expression from TISSUES for RPS21 Gene

  • Liver(4.7)
  • Blood(4.6)
  • Nervous system(4.2)
  • Muscle(3.5)
  • Pancreas(3.4)
  • Lung(3.3)
  • Lymph node(3)
  • Heart(2.9)
  • Skin(2.9)
  • Bone marrow(2.8)
  • Spleen(2.7)
  • Thyroid gland(2.7)
  • Adrenal gland(2.6)
  • Gall bladder(2.6)
  • Intestine(2.6)
  • Stomach(2.6)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with RPS21: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS21 Gene

Orthologs for RPS21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS21 34
  • 100 (a)
LOC458388 33
  • 100 (n)
(Bos Taurus)
Mammalia RPS21 34 33
  • 91.97 (n)
(Mus musculus)
Mammalia Rps21 16 34 33
  • 91.57 (n)
(Canis familiaris)
Mammalia RPS21 34 33
  • 90.76 (n)
(Rattus norvegicus)
Mammalia Rps21 33
  • 89.96 (n)
(Ornithorhynchus anatinus)
Mammalia RPS21 34
  • 76 (a)
(Monodelphis domestica)
Mammalia RPS21 34
  • 76 (a)
(Gallus gallus)
Aves RPS21 34 33
  • 82.88 (n)
(Anolis carolinensis)
Reptilia RPS21 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps21 33
  • 79.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29265 33
(Danio rerio)
Actinopterygii rps21 34 33
  • 79.84 (n)
zgc56642 33
fruit fly
(Drosophila melanogaster)
Insecta RpS21 34 33
  • 67.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009431 33
  • 67.87 (n)
(Caenorhabditis elegans)
Secernentea rps-21 34 33
  • 63.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS21A 36 34 33
  • 60.34 (n)
RPS21B 34
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR255C 33
  • 57.81 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05700g 33
  • 56.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G53890 33
  • 56.25 (n)
(Oryza sativa)
Liliopsida Os03g0345200 33
  • 62.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08627 33
  • 63.71 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps21 33
  • 61.6 (n)
Species where no ortholog for RPS21 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS21 Gene

Gene Tree for RPS21 (if available)
Gene Tree for RPS21 (if available)
Evolutionary constrained regions (ECRs) for RPS21: view image

Paralogs for RPS21 Gene

No data available for Paralogs for RPS21 Gene

Variants for RPS21 Gene

Sequence variations from dbSNP and Humsavar for RPS21 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000089780 -- 62,386,927(+) C/A upstream_transcript_variant
rs1000833913 -- 62,385,652(+) A/T upstream_transcript_variant
rs1000983455 -- 62,385,343(+) C/G upstream_transcript_variant
rs1002038455 -- 62,385,633(+) C/A upstream_transcript_variant
rs1002291159 -- 62,388,758(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS21 Gene

Variant ID Type Subtype PubMed ID
dgv518n27 CNV loss 19166990
dgv7650n54 CNV loss 21841781
dgv7651n54 CNV loss 21841781
esv2422398 CNV duplication 17116639
nsv459065 CNV gain 19166990
nsv459067 CNV loss 19166990
nsv470556 CNV loss 18288195
nsv470557 CNV gain 18288195
nsv518296 CNV loss 19592680
nsv520024 CNV loss 19592680
nsv586496 CNV gain 21841781
nsv586497 CNV loss 21841781
nsv586498 CNV loss 21841781
nsv828774 CNV loss 20364138
nsv834024 CNV gain 17160897
nsv953302 CNV deletion 24416366

Variation tolerance for RPS21 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS21 Gene

Disorders for RPS21 Gene

Additional Disease Information for RPS21

No disorders were found for RPS21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS21 Gene

Publications for RPS21 Gene

  1. Primary structure of human ribosomal protein S21. (PMID: 8332502) Bhat KS … Morrison SG (Nucleic acids research 1993) 2 3 4 22 58
  2. Cloning and characterization of the human ribosomal protein S21 gene [. (PMID: 10900511) Smirnova EV … Lipkin VM (Bioorganicheskaia khimiia 2000) 3 4 22 58
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  4. Structural snapshots of actively translating human ribosomes. (PMID: 25957688) Behrmann E … Spahn CM (Cell 2015) 3 4 58
  5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 58

Products for RPS21 Gene

Sources for RPS21 Gene

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