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Aliases for RPS20 Gene

Aliases for RPS20 Gene

  • Ribosomal Protein S20 2 3 5
  • Small Ribosomal Subunit Protein US10 3 4
  • 40S Ribosomal Protein S20 3
  • US10 3
  • S20 3

External Ids for RPS20 Gene

Previous GeneCards Identifiers for RPS20 Gene

  • GC08M056164
  • GC08M056924
  • GC08M056704
  • GC08M057035
  • GC08M057148
  • GC08M056982

Summaries for RPS20 Gene

Entrez Gene Summary for RPS20 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for RPS20 Gene

RPS20 (Ribosomal Protein S20) is a Protein Coding gene. Diseases associated with RPS20 include Familial Colorectal Cancer Type X. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS20 Gene

Additional gene information for RPS20 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS20 Gene

Genomics for RPS20 Gene

GeneHancer (GH) Regulatory Elements for RPS20 Gene

Promoters and enhancers for RPS20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J056072 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 670.2 +0.5 461 2.7 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RPS20 CERNA3 SNORD54 PIR49149 GC08M056077 GC08M056076 GC08M056075 TGS1 RNA5SP265 PSMC6P1
GH08J055771 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.2 +301.2 301212 4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 TGS1 TMEM68 RPS20 LYN
GH08J056209 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7 -136.6 -136556 3.7 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 POLR2B ZNF207 ZNF143 FOS CHCHD7 PLAG1 TGS1 RPS20 GC08M056160
GH08J055987 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.4 +83.2 83237 7.1 HDGF PKNOX1 FOXA2 SMAD1 SIN3A IRF4 ZNF207 ATF7 FOS RUNX3 LYN TGS1 TMEM68 RPS20 PSMC6P1 RN7SL798P GC08P056003
GH08J055970 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +101.1 101062 6.2 HDGF PKNOX1 BATF IRF4 RAD21 ZNF143 ZNF207 ATF7 FOS RCOR1 LYN TGS1 RPS20 PSMC6P1 RN7SL798P GC08P055943
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS20 gene promoter:
  • p53
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • ISGF-3
  • c-Ets-1
  • RORalpha2
  • Ik-3
  • AP-1

Genomic Locations for RPS20 Gene

Genomic Locations for RPS20 Gene
chr8:56,067,295-56,074,581
(GRCh38/hg38)
Size:
7,287 bases
Orientation:
Minus strand
chr8:56,979,854-56,987,140
(GRCh37/hg19)
Size:
7,287 bases
Orientation:
Minus strand

Genomic View for RPS20 Gene

Genes around RPS20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS20 Gene

Proteins for RPS20 Gene

  • Protein details for RPS20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60866-RS20_HUMAN
    Recommended name:
    40S ribosomal protein S20
    Protein Accession:
    P60866
    Secondary Accessions:
    • B2R4F4
    • B4DW28
    • P17075
    • Q5M8S9

    Protein attributes for RPS20 Gene

    Size:
    119 amino acids
    Molecular mass:
    13373 Da
    Quaternary structure:
    • Component of the 40S small ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPS20 Gene

    Alternative splice isoforms for RPS20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS20 Gene

Post-translational modifications for RPS20 Gene

  • Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).
  • Ubiquitination at isoforms=275, isoforms=267, isoforms=234, and posLast=3030
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS20 Gene

Domains & Families for RPS20 Gene

Gene Families for RPS20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPS20 Gene

Graphical View of Domain Structure for InterPro Entry

P60866

UniProtKB/Swiss-Prot:

RS20_HUMAN :
  • Belongs to the universal ribosomal protein uS10 family.
Family:
  • Belongs to the universal ribosomal protein uS10 family.
genes like me logo Genes that share domains with RPS20: view

Function for RPS20 Gene

Molecular function for RPS20 Gene

GENATLAS Biochemistry:
40S ribosomal protein S20

Gene Ontology (GO) - Molecular Function for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome NAS 8479924
GO:0005515 protein binding IPI 18274552
genes like me logo Genes that share ontologies with RPS20: view
genes like me logo Genes that share phenotypes with RPS20: view

Animal Model Products

CRISPR Products

miRNA for RPS20 Gene

miRTarBase miRNAs that target RPS20

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS20

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS20 Gene

Localization for RPS20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS20 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS20: view

Pathways & Interactions for RPS20 Gene

SuperPathways for RPS20 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS20: view

Gene Ontology (GO) - Biological Process for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 8479924
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS20: view

No data available for SIGNOR curated interactions for RPS20 Gene

Drugs & Compounds for RPS20 Gene

No Compound Related Data Available

Transcripts for RPS20 Gene

mRNA/cDNA for RPS20 Gene

Unigene Clusters for RPS20 Gene

Ribosomal protein S20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS20

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6: - - - -

Relevant External Links for RPS20 Gene

GeneLoc Exon Structure for
RPS20
ECgene alternative splicing isoforms for
RPS20

Expression for RPS20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS20 Gene



Protein tissue co-expression partners for RPS20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS20 Gene:

RPS20

SOURCE GeneReport for Unigene cluster for RPS20 Gene:

Hs.8102

Evidence on tissue expression from TISSUES for RPS20 Gene

  • Liver(5)
  • Lung(4.7)
  • Nervous system(4.7)
  • Intestine(4.6)
  • Muscle(4.5)
  • Eye(4.4)
  • Blood(4.2)
  • Skin(4.2)
  • Pancreas(4.1)
  • Heart(3.8)
  • Bone(3.6)
  • Kidney(3.4)
  • Stomach(3.3)
  • Lymph node(2.9)
  • Bone marrow(2.8)
  • Spleen(2.7)
  • Thyroid gland(2.7)
  • Adrenal gland(2.6)
  • Gall bladder(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS20 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • nervous
  • reproductive
  • urinary
Regions:
Abdomen:
  • biliary tract
  • gallbladder
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • stomach
Pelvis:
  • anus
  • ovary
  • rectum
  • uterus
General:
  • blood
  • red blood cell
genes like me logo Genes that share expression patterns with RPS20: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS20 Gene

Orthologs for RPS20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS20 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
OneToMany
RPS20 33
  • 90.48 (n)
-- 34
  • 77 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPS20 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS20 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps20 16 34 33
  • 89.64 (n)
rat
(Rattus norvegicus)
Mammalia Rps20 33
  • 89.64 (n)
cow
(Bos Taurus)
Mammalia RPS20 34 33
  • 88.8 (n)
OneToOne
chicken
(Gallus gallus)
Aves RPS20 34 33
  • 82.63 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm6 33
  • 79.27 (n)
Str.17075 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1787 33
zebrafish
(Danio rerio)
Actinopterygii rps20 33
  • 79.83 (n)
Dr.280 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10529 33
fruit fly
(Drosophila melanogaster)
Insecta RpS20 34 35 33
  • 69.23 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010591 33
  • 67.52 (n)
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.16 35
  • 80 (a)
rps-20 34 33
  • 66.01 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS20 36 34 33
  • 64.03 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25542g 33
  • 61.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR041C 33
  • 58.79 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G62300 33
  • 68.21 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.767 33
rice
(Oryza sativa)
Liliopsida Os06g0134000 33
  • 66.67 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.3696 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps20 33
  • 71.57 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06892 33
  • 65.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.6589 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6589 33
Species where no ortholog for RPS20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS20 Gene

ENSEMBL:
Gene Tree for RPS20 (if available)
TreeFam:
Gene Tree for RPS20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS20: view image

Paralogs for RPS20 Gene

No data available for Paralogs for RPS20 Gene

Variants for RPS20 Gene

Sequence variations from dbSNP and Humsavar for RPS20 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs863223400 uncertain-significance, not provided 56,073,725(-) TTT/TTTT coding_sequence_variant, frameshift
rs1000023575 -- 56,071,777(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000287653 -- 56,073,500(-) A/C intron_variant
rs1000722790 -- 56,070,128(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000882533 -- 56,074,469(-) A/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS20 Gene

Variant ID Type Subtype PubMed ID
nsv524526 CNV loss 19592680
nsv525972 CNV loss 19592680
nsv831319 CNV gain 17160897
nsv967592 CNV duplication 23825009

Variation tolerance for RPS20 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS20 Gene

Human Gene Mutation Database (HGMD)
RPS20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS20 Gene

Disorders for RPS20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS20 Gene - From: Orphanet

Disorder Aliases PubMed IDs
familial colorectal cancer type x
  • fcctx
- elite association - COSMIC cancer census association via MalaCards
Search RPS20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPS20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS20 Gene

Publications for RPS20 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  2. Human ribosomal protein S20 cDNA sequence. (PMID: 8479924) Chu W … Burns DK (Nucleic acids research 1993) 2 3 4 58
  3. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. (PMID: 28065601) Juszkiewicz S … Hegde RS (Molecular cell 2017) 3 4 58
  4. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. (PMID: 28132843) Sundaramoorthy E … Bennett EJ (Molecular cell 2017) 3 4 58
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58

Products for RPS20 Gene

Sources for RPS20 Gene

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