Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in th... See more...

Aliases for RPS2 Gene

Aliases for RPS2 Gene

  • Ribosomal Protein S2 2 3 5
  • Small Ribosomal Subunit Protein US5 3 4
  • 40S Ribosomal Protein S2 3 4
  • 40S Ribosomal Protein S4 3 4
  • Protein LLRep3 3 4
  • LLREP3 2 3
  • S2 2 3
  • OK/KNS-Cl.6 3
  • RPS2 5
  • RPS4 4

External Ids for RPS2 Gene

Previous GeneCards Identifiers for RPS2 Gene

  • GC16M002029
  • GC16M001952
  • GC16M002012
  • GC16M001967
  • GC16M001975
  • GC16M002104
  • GC16M002118
  • GC16M001966
  • GC16M002160
  • GC16M001983
  • GC16M002007
  • GC16M002045
  • GC16M002056
  • GC16M002066
  • GC16M002072
  • GC16M002077
  • GC16M002087

Summaries for RPS2 Gene

Entrez Gene Summary for RPS2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS2 Gene

RPS2 (Ribosomal Protein S2) is a Protein Coding gene. Diseases associated with RPS2 include Diamond-Blackfan Anemia and Cardiac Valvular Dysplasia, X-Linked. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is MRPS5.

Gene Wiki entry for RPS2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS2 Gene

Genomics for RPS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS2

Top Transcription factor binding sites by QIAGEN in the RPS2 gene promoter:
  • AML1a
  • AP-4
  • MAZR
  • NF-1
  • NF-1/L
  • Pax-5
  • SRF
  • SRF (504 AA)
  • STAT3
  • YY1

Genomic Locations for RPS2 Gene

Genomic Locations for RPS2 Gene
chr16:1,962,058-1,964,841
(GRCh38/hg38)
Size:
2,784 bases
Orientation:
Minus strand
chr16:2,012,053-2,014,861
(GRCh37/hg19)
Size:
2,809 bases
Orientation:
Minus strand

Genomic View for RPS2 Gene

Genes around RPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS2 Gene

Proteins for RPS2 Gene

  • Protein details for RPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15880-RS2_HUMAN
    Recommended name:
    40S ribosomal protein S2
    Protein Accession:
    P15880
    Secondary Accessions:
    • B2R5G0
    • D3DU82
    • Q3MIB1

    Protein attributes for RPS2 Gene

    Size:
    293 amino acids
    Molecular mass:
    31324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA35078.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS2 Gene

neXtProt entry for RPS2 Gene

Post-translational modifications for RPS2 Gene

  • Citrullinated by PADI4 in the Arg/Gly-rich region.
  • Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.
  • Ubiquitination at Lys58, Lys65, Lys76, Lys108, Lys114, Lys145, Lys212, Lys238, Lys246, Lys257, and Lys263
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS2 Gene

Domains & Families for RPS2 Gene

Gene Families for RPS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS2 Gene

InterPro:
Blocks:
  • Ribosomal protein S5
  • Globular protein, non-globular alpha/beta subunit
ProtoNet:

Suggested Antigen Peptide Sequences for RPS2 Gene

GenScript: Design optimal peptide antigens:
  • Ribosomal protein S2 (Q3KQT6_HUMAN)
  • Ribosomal protein S2 (Q6IPX5_HUMAN)
  • Ribosomal protein S2 (Q8J014_HUMAN)
  • Ribosomal protein S2 (Q8N5L9_HUMAN)
  • Ribosomal protein S2 (Q8NI62_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15880

UniProtKB/Swiss-Prot:

RS2_HUMAN :
  • Belongs to the universal ribosomal protein uS5 family.
Family:
  • Belongs to the universal ribosomal protein uS5 family.
genes like me logo Genes that share domains with RPS2: view

Function for RPS2 Gene

Molecular function for RPS2 Gene

GENATLAS Biochemistry:
60S ribosomal protein S2

Phenotypes From GWAS Catalog for RPS2 Gene

Gene Ontology (GO) - Molecular Function for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
GO:0005515 protein binding IPI 15473865
GO:0017134 fibroblast growth factor binding IPI 16263090
genes like me logo Genes that share ontologies with RPS2: view
genes like me logo Genes that share phenotypes with RPS2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS2

Clone Products

  • Addgene plasmids for RPS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS2 Gene

Localization for RPS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 3
plasma membrane 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 16061210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS2 Gene

Pathways & Interactions for RPS2 Gene

PathCards logo

SuperPathways for RPS2 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.53
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 rRNA processing in the nucleus and cytosol
4 Influenza Viral RNA Transcription and Replication
5 Chromatin organization
genes like me logo Genes that share pathways with RPS2: view

Pathways by source for RPS2 Gene

1 KEGG pathway for RPS2 Gene
1 GeneGo (Thomson Reuters) pathway for RPS2 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS2: view

No data available for SIGNOR curated interactions for RPS2 Gene

Drugs & Compounds for RPS2 Gene

(2) Drugs for RPS2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 249
genes like me logo Genes that share compounds with RPS2: view

Transcripts for RPS2 Gene

mRNA/cDNA for RPS2 Gene

1 REFSEQ mRNAs :
36 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS2

Clone Products

  • Addgene plasmids for RPS2

Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: - - - - - -
SP11: -
SP12: -

Relevant External Links for RPS2 Gene

GeneLoc Exon Structure for
RPS2

Expression for RPS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS2 Gene

This gene is overexpressed in Nasal epithelium (6.9) and Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS2 Gene



Protein tissue co-expression partners for RPS2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS2

SOURCE GeneReport for Unigene cluster for RPS2 Gene:

Hs.356366

Evidence on tissue expression from TISSUES for RPS2 Gene

  • Nervous system(5)
  • Intestine(5)
  • Lung(5)
  • Skin(5)
  • Liver(5)
  • Pancreas(5)
  • Eye(5)
  • Kidney(4.9)
  • Blood(4.9)
  • Muscle(4.9)
  • Bone(4.9)
  • Stomach(4.9)
  • Heart(3.5)
  • Spleen(3.4)
  • Bone marrow(3)
  • Lymph node(2.9)
  • Thyroid gland(2.7)
  • Gall bladder(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with RPS2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS2 Gene

Orthologs for RPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPS2 30
  • 99.09 (n)
Mouse
(Mus musculus)
Mammalia Rps2-ps6 31
  • 99 (a)
OneToOne
Rps2 30 17
  • 87.6 (n)
Cow
(Bos Taurus)
Mammalia RPS2 30 31
  • 89.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPS2 30 31
  • 88.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rps2 30
  • 88.17 (n)
Oppossum
(Monodelphis domestica)
Mammalia RPS2 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPS2 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RPS2 30 31
  • 83.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPS2 31
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rps2 30
  • 85 (n)
Str.6712 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.29155 30
Zebrafish
(Danio rerio)
Actinopterygii rps2 30 31
  • 83.48 (n)
OneToOne
wufb65c08 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9009 30
Fruit Fly
(Drosophila melanogaster)
Insecta sop 32
  • 83 (a)
RpS2 30 31
  • 77.09 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003768 30
  • 75.6 (n)
Worm
(Caenorhabditis elegans)
Secernentea rps-2 30 31 32
  • 70.61 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAR177W 30
  • 64.44 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09812g 30
  • 62.19 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS2 30 31 33
  • 60.19 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons XW6 30
  • 66.82 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7153 30
Rice
(Oryza sativa)
Liliopsida Os03g0807800 30
  • 72.4 (n)
Os.11049 30
Barley
(Hordeum vulgare)
Liliopsida Hv.4103 30
Wheat
(Triticum aestivum)
Liliopsida Ta.28855 30
Corn
(Zea mays)
Liliopsida Zm.7140 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10600 31
  • 81 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU06047 30
  • 70.32 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2 30
  • 65.33 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4371 30
Species where no ortholog for RPS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS2 Gene

ENSEMBL:
Gene Tree for RPS2 (if available)
TreeFam:
Gene Tree for RPS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS2: view image

Paralogs for RPS2 Gene

Paralogs for RPS2 Gene

(4) SIMAP similar genes for RPS2 Gene using alignment to 14 proteins:

  • RS2_HUMAN
  • D3DU83_HUMAN
  • E9PM36_HUMAN
  • E9PMM9_HUMAN
  • E9PPT0_HUMAN
  • E9PQD7_HUMAN
  • H0YE27_HUMAN
  • H0YEN5_HUMAN
  • H3BNG3_HUMAN
  • I3L404_HUMAN
  • Q3KQT6_HUMAN
  • Q6IPX5_HUMAN
  • Q8N5L9_HUMAN
  • Q9BSW5_HUMAN
genes like me logo Genes that share paralogs with RPS2: view

Variants for RPS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
768738 Benign: not provided 1,964,488(-) T/C SYNONYMOUS_VARIANT
781179 Benign: not provided 1,964,288(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RPS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS2 Gene

Variant ID Type Subtype PubMed ID
dgv4858n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv471070 CNV gain 18288195
nsv571179 CNV loss 21841781
nsv833120 CNV loss 17160897
nsv952901 CNV deletion 24416366
nsv984249 CNV duplication 23825009

Variation tolerance for RPS2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS2 Gene

Disorders for RPS2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • diamond-blackfan anemia 1
cardiac valvular dysplasia, x-linked
  • cvd1
cataract 37
  • ctrct37
atrial septal defect 4
  • asd4
- elite association - COSMIC cancer census association via MalaCards
Search RPS2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS2 Gene

Publications for RPS2 Gene

  1. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PMID: 15473865) Swiercz R … Bedford MT (The Biochemical journal 2005) 3 4 23
  2. Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. (PMID: 21584310) Guo Q … Fast W (Molecular bioSystems 2011) 3 4
  3. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PMID: 18573314) Choi S … Im DS (Biochimica et biophysica acta 2008) 3 23
  4. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PMID: 16263090) Antoine M … Kiefer P (Biochemical and biophysical research communications 2005) 3 23
  5. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PMID: 16061210) Antoine M … Kiefer P (Biochemical and biophysical research communications 2005) 3 23

Products for RPS2 Gene

Sources for RPS2 Gene