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Aliases for RPS2 Gene

Aliases for RPS2 Gene

  • Ribosomal Protein S2 2 3 5
  • Small Ribosomal Subunit Protein US5 3 4
  • 40S Ribosomal Protein S4 3 4
  • Protein LLRep3 3 4
  • 40S Ribosomal Protein S2 3
  • OK/KNS-Cl.6 3
  • LLREP3 3
  • RPS4 4
  • S2 3

External Ids for RPS2 Gene

Previous GeneCards Identifiers for RPS2 Gene

  • GC16M002029
  • GC16M001952
  • GC16M002012
  • GC16M001967
  • GC16M001975
  • GC16M001983
  • GC16M002007
  • GC16M002045
  • GC16M002056
  • GC16M002066

Summaries for RPS2 Gene

Entrez Gene Summary for RPS2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS2 Gene

RPS2 (Ribosomal Protein S2) is a Protein Coding gene. Diseases associated with RPS2 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include enzyme binding.

Gene Wiki entry for RPS2 Gene

Additional gene information for RPS2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS2 Gene

Genomics for RPS2 Gene

GeneHancer (GH) Regulatory Elements for RPS2 Gene

Promoters and enhancers for RPS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I001962 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 556.7 +0.6 638 4.1 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000255513 SNORA64 SNHG9 RPS2 GC16M001962 GC16M001963 GC16M001965 GC16M001966 GC16P001995 GC16P002197
GH16I001966 Promoter 0.6 EPDnew 550.8 -2.0 -1977 0.1 ZNF121 GC16P001995 GC16P002197 RNF151 RPS2 SNHG9 SNORA78 SYNGR3 ENSG00000277602
GH16I001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.3 +654.1 654106 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 TELO2 ENSG00000261505 E4F1 TSC2 ENSG00000260051 IFT140
GH16I001825 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +136.2 136245 6.9 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 FAHD1 HAGH GC16M001827 GC16M001829 ENSG00000261505 SRRM2 TELO2 ENSG00000260051 CRAMP1 ENSG00000260954
GH16I002679 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -716.7 -716691 4.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ENSG00000279901 KCTD5 PIR43814 PIR61225 PIR38297 ENSG00000261613 TBL3 ZNF597 E4F1 ENSG00000261207
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS2 gene promoter:

Genomic Locations for RPS2 Gene

Genomic Locations for RPS2 Gene
2,809 bases
Minus strand

Genomic View for RPS2 Gene

Genes around RPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS2 Gene

Proteins for RPS2 Gene

  • Protein details for RPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S2
    Protein Accession:
    Secondary Accessions:
    • B2R5G0
    • D3DU82
    • Q3MIB1

    Protein attributes for RPS2 Gene

    293 amino acids
    Molecular mass:
    31324 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS2 Gene

neXtProt entry for RPS2 Gene

Post-translational modifications for RPS2 Gene

  • Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.
  • Citrullinated by PADI4 in the Arg/Gly-rich region.
  • Ubiquitination at isoforms=58, isoforms=65, posLast=114114, isoforms=145, posLast=212212, isoforms=238, posLast=246246, posLast=257257, isoforms=263, and posLast=275275
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS2 Gene

Domains & Families for RPS2 Gene

Gene Families for RPS2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS5 family.
  • Belongs to the universal ribosomal protein uS5 family.
genes like me logo Genes that share domains with RPS2: view

Function for RPS2 Gene

Molecular function for RPS2 Gene

GENATLAS Biochemistry:
60S ribosomal protein S2

Gene Ontology (GO) - Molecular Function for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome HDA,IEA 15883184
GO:0005515 protein binding IPI 15473865
GO:0017134 fibroblast growth factor binding IPI 16263090
genes like me logo Genes that share ontologies with RPS2: view
genes like me logo Genes that share phenotypes with RPS2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS2 Gene

Localization for RPS2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 16061210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS2 Gene

Pathways & Interactions for RPS2 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 rRNA processing in the nucleus and cytosol
4 Influenza Viral RNA Transcription and Replication
5 Chromatin organization
genes like me logo Genes that share pathways with RPS2: view

Pathways by source for RPS2 Gene

Gene Ontology (GO) - Biological Process for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006479 protein methylation TAS --
genes like me logo Genes that share ontologies with RPS2: view

No data available for SIGNOR curated interactions for RPS2 Gene

Drugs & Compounds for RPS2 Gene

(2) Drugs for RPS2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
genes like me logo Genes that share compounds with RPS2: view

Transcripts for RPS2 Gene

Unigene Clusters for RPS2 Gene

Ribosomal protein S2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP9: -
SP10: - - - - - -
SP11: -
SP12: -

Relevant External Links for RPS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS2 Gene

This gene is overexpressed in Nasal epithelium (6.9) and Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS2 Gene

Protein tissue co-expression partners for RPS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS2 Gene:


SOURCE GeneReport for Unigene cluster for RPS2 Gene:


Evidence on tissue expression from TISSUES for RPS2 Gene

  • Eye(5)
  • Intestine(5)
  • Liver(5)
  • Lung(5)
  • Pancreas(5)
  • Skin(5)
  • Nervous system(5)
  • Kidney(4.9)
  • Bone(4.8)
  • Muscle(4.8)
  • Stomach(4.8)
  • Blood(4.5)
  • Heart(3)
  • Spleen(3)
  • Lymph node(2.5)
  • Bone marrow(2.4)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with RPS2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS2 Gene

Orthologs for RPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS2 33
  • 99.09 (n)
(Mus musculus)
Mammalia Rps2-ps6 34
  • 99 (a)
Rps2 16 33
  • 87.6 (n)
(Bos Taurus)
Mammalia RPS2 34 33
  • 89.65 (n)
(Canis familiaris)
Mammalia RPS2 33 34
  • 88.85 (n)
(Rattus norvegicus)
Mammalia Rps2 33
  • 88.17 (n)
(Monodelphis domestica)
Mammalia RPS2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RPS2 34
  • 81 (a)
(Gallus gallus)
Aves RPS2 34 33
  • 83.75 (n)
(Anolis carolinensis)
Reptilia RPS2 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps2 33
  • 85 (n)
Str.6712 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29155 33
(Danio rerio)
Actinopterygii rps2 34 33
  • 83.48 (n)
wufb65c08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9009 33
fruit fly
(Drosophila melanogaster)
Insecta sop 35
  • 83 (a)
RpS2 34 33
  • 77.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003768 33
  • 75.6 (n)
(Caenorhabditis elegans)
Secernentea rps-2 35 33 34
  • 70.61 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR177W 33
  • 64.44 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09812g 33
  • 62.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS2 33 34 36
  • 60.19 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons XW6 33
  • 66.82 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7153 33
(Oryza sativa)
Liliopsida Os03g0807800 33
  • 72.4 (n)
Os.11049 33
(Hordeum vulgare)
Liliopsida Hv.4103 33
(Triticum aestivum)
Liliopsida Ta.28855 33
(Zea mays)
Liliopsida Zm.7140 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10600 34
  • 81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06047 33
  • 70.32 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2 33
  • 65.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4371 33
Species where no ortholog for RPS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS2 Gene

Gene Tree for RPS2 (if available)
Gene Tree for RPS2 (if available)

Paralogs for RPS2 Gene

genes like me logo Genes that share paralogs with RPS2: view

No data available for Paralogs for RPS2 Gene

Variants for RPS2 Gene

Sequence variations from dbSNP and Humsavar for RPS2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000994330 -- 1,963,995(-) G/A intron_variant
rs1001008825 -- 1,961,652(-) A/C downstream_transcript_variant
rs1001274604 -- 1,963,822(-) C/G/T intron_variant
rs1001537032 -- 1,961,599(-) G/A downstream_transcript_variant
rs1001591131 -- 1,966,634(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS2 Gene

Variant ID Type Subtype PubMed ID
dgv4858n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv471070 CNV gain 18288195
nsv571179 CNV loss 21841781
nsv833120 CNV loss 17160897
nsv952901 CNV deletion 24416366
nsv984249 CNV duplication 23825009

Variation tolerance for RPS2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS2 Gene

Disorders for RPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS2

genes like me logo Genes that share disorders with RPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS2 Gene

Publications for RPS2 Gene

  1. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PMID: 15473865) Swiercz R … Bedford MT (The Biochemical journal 2005) 3 4 22 58
  2. Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. (PMID: 21584310) Guo Q … Fast W (Molecular bioSystems 2011) 3 4 58
  3. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PMID: 18573314) Choi S … Im DS (Biochimica et biophysica acta 2008) 3 22 58
  4. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PMID: 16061210) Antoine M … Kiefer P (Biochemical and biophysical research communications 2005) 3 22 58
  5. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PMID: 16263090) Antoine M … Kiefer P (Biochemical and biophysical research communications 2005) 3 22 58

Products for RPS2 Gene

Sources for RPS2 Gene