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Aliases for RPS19BP1 Gene

Aliases for RPS19BP1 Gene

  • Ribosomal Protein S19 Binding Protein 1 2 3 5
  • 40S Ribosomal Protein S19-Binding Protein 1 3 4
  • RPS19-Binding Protein 1 3 4
  • S19BP 3 4
  • AROS 3 4
  • Homolog Of Mouse S19 Binding Protein 3
  • Active Regulator Of SIRT1 3

External Ids for RPS19BP1 Gene

Previous GeneCards Identifiers for RPS19BP1 Gene

  • GC22M038255
  • GC22M039925
  • GC22M022889
  • GC22M039563
  • GC22M039839
  • GC22M039851
  • GC22M039946
  • GC22M040637
  • GC22M041082
  • GC22M041480

Summaries for RPS19BP1 Gene

GeneCards Summary for RPS19BP1 Gene

RPS19BP1 (Ribosomal Protein S19 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include enzyme binding.

UniProtKB/Swiss-Prot for RPS19BP1 Gene

  • Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Additional gene information for RPS19BP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS19BP1 Gene

Genomics for RPS19BP1 Gene

GeneHancer (GH) Regulatory Elements for RPS19BP1 Gene

Promoters and enhancers for RPS19BP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I039530 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 555.4 +0.7 724 2.7 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 RPS19BP1 PIR58856 ATF4 RPL3 TNRC6B ENSG00000228274 GC22P039523 PIR62526
GH22I039533 Enhancer 0.3 ENCODE 550.8 -1.0 -996 0.2 TGIF2 RPS19BP1 PIR58856 CACNA1I FAM83F MGAT3 TNRC6B RPL3
GH22I039500 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12 +30.4 30420 3.8 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF143 LOC105373035 GC22P039502 GC22P039503 GC22P039504 GC22P039505 GC22P039506 GC22P039507 GC22P039509 MIEF1 ATF4
GH22I039462 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +63.6 63582 14.4 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 ZNF143 SP5 REST MGAT3 SYNGR1 ENSG00000230912 MIEF1 RPS19BP1 TAB1 MGAT3-AS1 DDX17
GH22I039518 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.1 +8.5 8472 12.3 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ATF4 ENSG00000272834 ENSG00000230912 RPL3 TAB1 CBY1 SNORD83B ENSG00000228274 CBX6 CBX7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS19BP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS19BP1 gene promoter:

Genomic Locations for RPS19BP1 Gene

Genomic Locations for RPS19BP1 Gene
3,763 bases
Minus strand

Genomic View for RPS19BP1 Gene

Genes around RPS19BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS19BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS19BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS19BP1 Gene

Proteins for RPS19BP1 Gene

  • Protein details for RPS19BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Active regulator of SIRT1
    Protein Accession:
    Secondary Accessions:
    • B0QY96
    • Q5JZA1

    Protein attributes for RPS19BP1 Gene

    136 amino acids
    Molecular mass:
    15434 Da
    Quaternary structure:
    • Interacts with RPS19 (By similarity). Interacts with SIRT1.

neXtProt entry for RPS19BP1 Gene

Post-translational modifications for RPS19BP1 Gene

Other Protein References for RPS19BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS19BP1 Gene

Domains & Families for RPS19BP1 Gene

Gene Families for RPS19BP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RPS19BP1 Gene


Suggested Antigen Peptide Sequences for RPS19BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AROS family.
  • Belongs to the AROS family.
genes like me logo Genes that share domains with RPS19BP1: view

Function for RPS19BP1 Gene

Molecular function for RPS19BP1 Gene

UniProtKB/Swiss-Prot Function:
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Phenotypes From GWAS Catalog for RPS19BP1 Gene

Gene Ontology (GO) - Molecular Function for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 17964266
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with RPS19BP1: view
genes like me logo Genes that share phenotypes with RPS19BP1: view

Animal Models for RPS19BP1 Gene

MGI Knock Outs for RPS19BP1:

Animal Model Products

miRNA for RPS19BP1 Gene

miRTarBase miRNAs that target RPS19BP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS19BP1 Gene

Localization for RPS19BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS19BP1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm ISS,IEA 16289379
GO:0005730 nucleolus ISS 16289379
GO:0005829 cytosol IDA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS19BP1: view

Pathways & Interactions for RPS19BP1 Gene

genes like me logo Genes that share pathways with RPS19BP1: view

Pathways by source for RPS19BP1 Gene

Gene Ontology (GO) - Biological Process for RPS19BP1 Gene


No data available for SIGNOR curated interactions for RPS19BP1 Gene

Drugs & Compounds for RPS19BP1 Gene

No Compound Related Data Available

Transcripts for RPS19BP1 Gene

Unigene Clusters for RPS19BP1 Gene

Ribosomal protein S19 binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS19BP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: - - -
SP5: - - -

Relevant External Links for RPS19BP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS19BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS19BP1 Gene

Protein differential expression in normal tissues from HIPED for RPS19BP1 Gene

This gene is overexpressed in Lung (28.3) and Breast (25.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS19BP1 Gene

Protein tissue co-expression partners for RPS19BP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS19BP1 Gene:


SOURCE GeneReport for Unigene cluster for RPS19BP1 Gene:


mRNA Expression by UniProt/SwissProt for RPS19BP1 Gene:

Tissue specificity: Widely expressed (at protein level).

Evidence on tissue expression from TISSUES for RPS19BP1 Gene

  • Skin(4.2)
  • Nervous system(3.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RPS19BP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS19BP1 Gene

Orthologs for RPS19BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPS19BP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS19BP1 33 34
  • 99.75 (n)
(Canis familiaris)
Mammalia RPS19BP1 33 34
  • 87.25 (n)
(Bos Taurus)
Mammalia RPS19BP1 33 34
  • 84.07 (n)
(Mus musculus)
Mammalia Rps19bp1 33 16 34
  • 81.37 (n)
(Monodelphis domestica)
Mammalia RPS19BP1 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia RPS19BP1 34
  • 39 (a)
(Gallus gallus)
Aves RPS19BP1 33 34
  • 58.4 (n)
(Anolis carolinensis)
Reptilia RPS19BP1 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps19bp1 33
  • 47.65 (n)
(Danio rerio)
Actinopterygii rps19bp1 34
  • 35 (a)
Species where no ortholog for RPS19BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPS19BP1 Gene

Gene Tree for RPS19BP1 (if available)
Gene Tree for RPS19BP1 (if available)

Paralogs for RPS19BP1 Gene

No data available for Paralogs for RPS19BP1 Gene

Variants for RPS19BP1 Gene

Sequence variations from dbSNP and Humsavar for RPS19BP1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000258840 -- 39,533,220(-) A/T upstream_transcript_variant
rs1000596569 -- 39,534,577(-) T/A upstream_transcript_variant
rs1000822683 -- 39,529,237(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000962710 -- 39,530,995(-) C/T intron_variant
rs1001081913 -- 39,530,816(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS19BP1 Gene

Variant ID Type Subtype PubMed ID
nsv3629 CNV insertion 18451855
nsv834199 CNV loss 17160897

Variation tolerance for RPS19BP1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS19BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Disorders for RPS19BP1 Gene

Additional Disease Information for RPS19BP1

No disorders were found for RPS19BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS19BP1 Gene

Publications for RPS19BP1 Gene

  1. A novel nucleolar protein interacts with ribosomal protein S19. (PMID: 16289379) Maeda N … Tanaka T (Biochemical and biophysical research communications 2006) 2 3 22 58
  2. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. (PMID: 17964266) Kim EJ … Um SJ (Molecular cell 2007) 3 4 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58

Products for RPS19BP1 Gene

Sources for RPS19BP1 Gene

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