Aliases for RPS19BP1 Gene

Aliases for RPS19BP1 Gene

  • Ribosomal Protein S19 Binding Protein 1 2 3 5
  • 40S Ribosomal Protein S19-Binding Protein 1 3 4
  • Active Regulator Of SIRT1 3 4
  • RPS19-Binding Protein 1 3 4
  • S19BP 3 4
  • AROS 3 4
  • Homolog Of Mouse S19 Binding Protein 3
  • RPS19BP1 5
  • MGC52010 2
  • FLJ21770 2

External Ids for RPS19BP1 Gene

Previous GeneCards Identifiers for RPS19BP1 Gene

  • GC22M038255
  • GC22M039925
  • GC22M022889
  • GC22M039563
  • GC22M039839
  • GC22M042779
  • GC22M042891
  • GC22M042949
  • GC22M044559
  • GC22M039851
  • GC22M039946
  • GC22M040637
  • GC22M041082
  • GC22M041480
  • GC22M041890
  • GC22M042317
  • GC22M042669

Summaries for RPS19BP1 Gene

GeneCards Summary for RPS19BP1 Gene

RPS19BP1 (Ribosomal Protein S19 Binding Protein 1) is a Protein Coding gene. Diseases associated with RPS19BP1 include Inhibited Female Orgasm and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include enzyme binding.

UniProtKB/Swiss-Prot Summary for RPS19BP1 Gene

  • Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Additional gene information for RPS19BP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS19BP1 Gene

Genomics for RPS19BP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS19BP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS19BP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS19BP1

Top Transcription factor binding sites by QIAGEN in the RPS19BP1 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Meis-1b
  • ZIC2

Genomic Locations for RPS19BP1 Gene

Genomic Locations for RPS19BP1 Gene
chr22:39,529,093-39,532,761
(GRCh38/hg38)
Size:
3,669 bases
Orientation:
Minus strand
chr22:39,925,098-39,928,860
(GRCh37/hg19)
Size:
3,763 bases
Orientation:
Minus strand

Genomic View for RPS19BP1 Gene

Genes around RPS19BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS19BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS19BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS19BP1 Gene

Proteins for RPS19BP1 Gene

  • Protein details for RPS19BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WX3-AROS_HUMAN
    Recommended name:
    Active regulator of SIRT1
    Protein Accession:
    Q86WX3
    Secondary Accessions:
    • B0QY96
    • Q5JZA1

    Protein attributes for RPS19BP1 Gene

    Size:
    136 amino acids
    Molecular mass:
    15434 Da
    Quaternary structure:
    • Interacts with RPS19 (By similarity). Interacts with SIRT1.

neXtProt entry for RPS19BP1 Gene

Post-translational modifications for RPS19BP1 Gene

Other Protein References for RPS19BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS19BP1 Gene

Domains & Families for RPS19BP1 Gene

Gene Families for RPS19BP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RPS19BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS19BP1 Gene

GenScript: Design optimal peptide antigens:
  • 40S ribosomal protein S19-binding protein 1 (AROS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WX3

UniProtKB/Swiss-Prot:

AROS_HUMAN :
  • Belongs to the AROS family.
Family:
  • Belongs to the AROS family.
genes like me logo Genes that share domains with RPS19BP1: view

Function for RPS19BP1 Gene

Molecular function for RPS19BP1 Gene

UniProtKB/Swiss-Prot Function:
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Phenotypes From GWAS Catalog for RPS19BP1 Gene

Gene Ontology (GO) - Molecular Function for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 17964266
GO:0019899 enzyme binding IBA,IPI 23382074
genes like me logo Genes that share ontologies with RPS19BP1: view
genes like me logo Genes that share phenotypes with RPS19BP1: view

Animal Models for RPS19BP1 Gene

MGI Knock Outs for RPS19BP1:

Animal Model Products

CRISPR Products

miRNA for RPS19BP1 Gene

miRTarBase miRNAs that target RPS19BP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS19BP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS19BP1 Gene

Localization for RPS19BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS19BP1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm ISS 16289379
GO:0005730 nucleolus ISS 16289379
GO:0005829 cytosol IDA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS19BP1: view

Pathways & Interactions for RPS19BP1 Gene

genes like me logo Genes that share pathways with RPS19BP1: view

Pathways by source for RPS19BP1 Gene

Gene Ontology (GO) - Biological Process for RPS19BP1 Gene

None

No data available for SIGNOR curated interactions for RPS19BP1 Gene

Drugs & Compounds for RPS19BP1 Gene

No Compound Related Data Available

Transcripts for RPS19BP1 Gene

mRNA/cDNA for RPS19BP1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS19BP1

Alternative Splicing Database (ASD) splice patterns (SP) for RPS19BP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5: - - -
SP6:

Relevant External Links for RPS19BP1 Gene

GeneLoc Exon Structure for
RPS19BP1

Expression for RPS19BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS19BP1 Gene

Protein differential expression in normal tissues from HIPED for RPS19BP1 Gene

This gene is overexpressed in Lung (28.3) and Breast (25.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS19BP1 Gene



Protein tissue co-expression partners for RPS19BP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS19BP1

SOURCE GeneReport for Unigene cluster for RPS19BP1 Gene:

Hs.526933

mRNA Expression by UniProt/SwissProt for RPS19BP1 Gene:

Q86WX3-AROS_HUMAN
Tissue specificity: Widely expressed (at protein level).

Evidence on tissue expression from TISSUES for RPS19BP1 Gene

  • Skin(4.5)
  • Nervous system(3.8)
  • Muscle(2.9)
  • Liver(2.5)
  • Intestine(2.3)
  • Kidney(2.3)
  • Heart(2.3)
  • Pancreas(2.1)
  • Blood(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RPS19BP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS19BP1 Gene

Orthologs for RPS19BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPS19BP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPS19BP1 30 31
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPS19BP1 30 31
  • 87.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RPS19BP1 30 31
  • 84.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rps19bp1 30 17 31
  • 81.37 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPS19BP1 31
  • 54 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPS19BP1 31
  • 39 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RPS19BP1 30 31
  • 58.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPS19BP1 31
  • 42 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rps19bp1 30
  • 47.65 (n)
Zebrafish
(Danio rerio)
Actinopterygii rps19bp1 31
  • 35 (a)
OneToOne
Species where no ortholog for RPS19BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RPS19BP1 Gene

ENSEMBL:
Gene Tree for RPS19BP1 (if available)
TreeFam:
Gene Tree for RPS19BP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS19BP1: view image

Paralogs for RPS19BP1 Gene

No data available for Paralogs for RPS19BP1 Gene

Variants for RPS19BP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS19BP1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs17001278 - p.Glu124Ala

Additional dbSNP identifiers (rs#s) for RPS19BP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS19BP1 Gene

Variant ID Type Subtype PubMed ID
nsv3629 CNV insertion 18451855
nsv834199 CNV loss 17160897

Variation tolerance for RPS19BP1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS19BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS19BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Disorders for RPS19BP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS19BP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inhibited female orgasm
  • female orgasmic disorder
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with RPS19BP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS19BP1 Gene

Publications for RPS19BP1 Gene

  1. A novel nucleolar protein interacts with ribosomal protein S19. (PMID: 16289379) Maeda N … Tanaka T (Biochemical and biophysical research communications 2006) 2 3 23
  2. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. (PMID: 17964266) Kim EJ … Um SJ (Molecular cell 2007) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4

Products for RPS19BP1 Gene

  • Signalway Proteins for RPS19BP1

Sources for RPS19BP1 Gene