Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in th... See more...

Aliases for RPS16 Gene

Aliases for RPS16 Gene

  • Ribosomal Protein S16 2 3 5
  • 40S Ribosomal Protein S16 2 3 4
  • Small Ribosomal Subunit Protein US9 3 4
  • S16 3

External Ids for RPS16 Gene

Previous GeneCards Identifiers for RPS16 Gene

  • GC19M040561
  • GC19M040315
  • GC19M044596
  • GC19M044615
  • GC19M039923
  • GC19M036370

Summaries for RPS16 Gene

Entrez Gene Summary for RPS16 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS16 Gene

RPS16 (Ribosomal Protein S16) is a Protein Coding gene. Diseases associated with RPS16 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is MRPS9.

Gene Wiki entry for RPS16 Gene

Additional gene information for RPS16 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS16 Gene

Genomics for RPS16 Gene

GeneHancer (GH) Regulatory Elements for RPS16 Gene

Promoters and enhancers for RPS16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS16 gene promoter:
  • GATA-1
  • GATA-2
  • HSF2
  • Ik-2
  • ISGF-3
  • p53
  • Pax-4a
  • YY1
  • ZIC2

Genomic Locations for RPS16 Gene

Genomic Locations for RPS16 Gene
chr19:39,433,137-39,436,020
(GRCh38/hg38)
Size:
2,884 bases
Orientation:
Minus strand
chr19:39,923,847-39,926,618
(GRCh37/hg19)
Size:
2,772 bases
Orientation:
Minus strand

Genomic View for RPS16 Gene

Genes around RPS16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS16 Gene

Proteins for RPS16 Gene

  • Protein details for RPS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62249-RS16_HUMAN
    Recommended name:
    40S ribosomal protein S16
    Protein Accession:
    P62249
    Secondary Accessions:
    • B2RDD5
    • P17008

    Protein attributes for RPS16 Gene

    Size:
    146 amino acids
    Molecular mass:
    16445 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS16 Gene

neXtProt entry for RPS16 Gene

Post-translational modifications for RPS16 Gene

  • Ubiquitination at Lys4, Lys33, Lys50, Lys60, Lys73, Lys90, Lys98, and Lys109
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS16 Gene

Domains & Families for RPS16 Gene

Gene Families for RPS16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPS16 Gene

GenScript: Design optimal peptide antigens:
  • 40S ribosomal protein S16 (RS16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62249

UniProtKB/Swiss-Prot:

RS16_HUMAN :
  • Belongs to the universal ribosomal protein uS9 family.
Family:
  • Belongs to the universal ribosomal protein uS9 family.
genes like me logo Genes that share domains with RPS16: view

Function for RPS16 Gene

Molecular function for RPS16 Gene

GENATLAS Biochemistry:
40S ribosomal protein S16,16kDa

Phenotypes From GWAS Catalog for RPS16 Gene

Gene Ontology (GO) - Molecular Function for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IBA 17881366
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
GO:0005515 protein binding IPI 24725412
genes like me logo Genes that share ontologies with RPS16: view
genes like me logo Genes that share phenotypes with RPS16: view

Animal Model Products

CRISPR Products

miRNA for RPS16 Gene

miRTarBase miRNAs that target RPS16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS16 Gene

Localization for RPS16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS16 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0015935 small ribosomal subunit HDA 15883184
genes like me logo Genes that share ontologies with RPS16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS16 Gene

Pathways & Interactions for RPS16 Gene

PathCards logo

SuperPathways for RPS16 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS16: view

Gene Ontology (GO) - Biological Process for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation NAS,IEA 12082018
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS16: view

No data available for SIGNOR curated interactions for RPS16 Gene

Drugs & Compounds for RPS16 Gene

No Compound Related Data Available

Transcripts for RPS16 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: -
SP8:

Relevant External Links for RPS16 Gene

GeneLoc Exon Structure for
RPS16
ECgene alternative splicing isoforms for
RPS16

Expression for RPS16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS16 Gene

This gene is overexpressed in Nasal epithelium (14.2) and Bone marrow mesenchymal stem cell (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS16 Gene



Protein tissue co-expression partners for RPS16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS16 Gene:

RPS16

SOURCE GeneReport for Unigene cluster for RPS16 Gene:

Hs.397609

Evidence on tissue expression from TISSUES for RPS16 Gene

  • Pancreas(4.9)
  • Nervous system(4.9)
  • Liver(4.8)
  • Kidney(4.6)
  • Lung(4.3)
  • Skin(4.3)
  • Intestine(4.2)
  • Muscle(4.2)
  • Eye(3.9)
  • Heart(3.7)
  • Stomach(3.5)
  • Lymph node(2.9)
  • Bone marrow(2.7)
  • Gall bladder(2.7)
  • Spleen(2.7)
  • Thyroid gland(2.7)
  • Adrenal gland(2.5)
  • Blood(2.4)
  • Bone(2)
genes like me logo Genes that share expression patterns with RPS16: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS16 Gene

Orthologs for RPS16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS16 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RPS16 33
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS16 33 32
  • 99.32 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS16 33
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS16 33 32
  • 91.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPS16 33 32
  • 90.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rps16 17 33 32
  • 89.5 (n)
rat
(Rattus norvegicus)
Mammalia Rps16 32
  • 89.04 (n)
chicken
(Gallus gallus)
Aves RPS16 33 32
  • 79.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS16 33
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps16 32
  • 79 (n)
Str.1030 32
zebrafish
(Danio rerio)
Actinopterygii rps16 33 32
  • 82.65 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4046 34
  • 88 (a)
RpS16 33 32
  • 78.49 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011424 32
  • 74.36 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-16 33 34 32
  • 71.43 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS16B 33
  • 63 (a)
OneToMany
RPS16A 35 33 32
  • 57.97 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR258W 32
  • 61.35 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21979g 32
  • 57.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18380 32
  • 68.26 (n)
rice
(Oryza sativa)
Liliopsida Os11g0127900 32
  • 66.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 76 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08620 32
  • 66.67 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1601 32
  • 65 (n)
Species where no ortholog for RPS16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS16 Gene

ENSEMBL:
Gene Tree for RPS16 (if available)
TreeFam:
Gene Tree for RPS16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS16: view image

Paralogs for RPS16 Gene

Variants for RPS16 Gene

Sequence variations from dbSNP and Humsavar for RPS16 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000541073 -- 39,432,704(-) G/T downstream_transcript_variant
rs1000701357 -- 39,435,118(-) G/A/C intron_variant
rs1002093885 -- 39,434,961(-) A/C intron_variant
rs1002549601 -- 39,435,256(-) G/A intron_variant
rs1003326876 -- 39,436,280(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS16 Gene

Variant ID Type Subtype PubMed ID
nsv523856 CNV loss 19592680

Variation tolerance for RPS16 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS16 Gene

Disorders for RPS16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPS16 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPS16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS16 Gene

Publications for RPS16 Gene

  1. Molecular cloning and sequence analysis of the human ribosomal protein S16. (PMID: 2016298) Batra SK … Hollingsworth MA (The Journal of biological chemistry 1991) 2 3 4 23 56
  2. Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations. (PMID: 19773262) Quarello P … Ramenghi U (Haematologica 2010) 3 43 56
  3. [Human ribosomal protein S16 inhibites excision of the first intron from its own]. (PMID: 20198863) Ivanov AV … Karpova GG (Molekuliarnaia biologiia 2010) 3 23 56
  4. Interactions of human ribosomal proteins S16 and S5 with an 18S rRNA fragment containing their binding sites. (PMID: 19559069) Malygin AA … Karpova GG (Biochimie 2009) 3 23 56
  5. [Binding of human ribosomal protein S16 with the 18S rRNA fragment 1203-1236/1521-1698]. (PMID: 18318121) Ian'shina DD … Karpova GG (Molekuliarnaia biologiia 2007) 3 23 56

Products for RPS16 Gene