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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
RPS16 (Ribosomal Protein S16) is a Protein Coding gene. Diseases associated with RPS16 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is MRPS9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IDA,IBA | 17881366 |
GO:0003735 | structural constituent of ribosome | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 24725412 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005840 | ribosome | IEA | -- |
GO:0005925 | focal adhesion | HDA | 21423176 |
GO:0015935 | small ribosomal subunit | HDA | 15883184 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
.77
.55
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2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
3 | Influenza Viral RNA Transcription and Replication | ||
4 | rRNA processing in the nucleus and cytosol |
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5 | HIV Life Cycle |
.45
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | 21873635 |
GO:0006364 | rRNA processing | IMP | 18697920 |
GO:0006412 | translation | NAS,IEA | 12082018 |
GO:0006413 | translational initiation | TAS | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
oppossum (Monodelphis domestica) |
Mammalia | RPS16 33 |
|
OneToOne | |
chimpanzee (Pan troglodytes) |
Mammalia | RPS16 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | RPS16 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | RPS16 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | RPS16 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Rps16 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Rps16 32 |
|
||
chicken (Gallus gallus) |
Aves | RPS16 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | RPS16 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rps16 32 |
|
||
Str.1030 32 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | rps16 33 32 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | CG4046 34 |
|
|
|
RpS16 33 32 |
|
OneToOne | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011424 32 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | rps-16 33 34 32 |
|
OneToOne | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPS16B 33 |
|
OneToMany | |
RPS16A 35 33 32 |
|
||||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR258W 32 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E21979g 32 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G18380 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os11g0127900 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU08620 32 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rps1601 32 |
|
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000541073 | -- | 39,432,704(-) | G/T | downstream_transcript_variant | |
rs1000701357 | -- | 39,435,118(-) | G/A/C | intron_variant | |
rs1002093885 | -- | 39,434,961(-) | A/C | intron_variant | |
rs1002549601 | -- | 39,435,256(-) | G/A | intron_variant | |
rs1003326876 | -- | 39,436,280(-) | C/T | upstream_transcript_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
diamond-blackfan anemia |
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|