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Aliases for RPS15A Gene

Aliases for RPS15A Gene

  • Ribosomal Protein S15a 2 3 5
  • Small Ribosomal Subunit Protein US8 3 4
  • Up-Regulated By HBV X Protein 3
  • 40S Ribosomal Protein S15a 3
  • S15a 3

External Ids for RPS15A Gene

Previous GeneCards Identifiers for RPS15A Gene

  • GC16M018285
  • GC16M018721
  • GC16M018760
  • GC16M017336

Summaries for RPS15A Gene

Entrez Gene Summary for RPS15A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS15A Gene

RPS15A (Ribosomal Protein S15a) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is ARL6IP1.

Gene Wiki entry for RPS15A Gene

Additional gene information for RPS15A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS15A Gene

Genomics for RPS15A Gene

GeneHancer (GH) Regulatory Elements for RPS15A Gene

Promoters and enhancers for RPS15A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J018786 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 663.3 +1.4 1406 5 MLX ZFP64 YBX1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RPS15A ARL6IP1 CCP110 COQ7 ENSG00000205746 GC16M018782 ENSG00000260342
GH16J018794 Promoter 0.5 EPDnew 650.7 -4.3 -4274 0.1 RPS15A COQ7 ENSG00000260342 ARL6IP1
GH16J019554 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.6 -765.2 -765243 2.6 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 VPS35L RPS15A CCP110 ENSG00000263253 ENSG00000260017 ENSG00000263237 COQ7 TMC5 KNOP1 GDE1
GH16J019715 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.6 -927.3 -927296 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 E2F8 KNOP1 IQCK RPS15A
GH16J018797 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -11.9 -11938 9.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 ENSG00000260017 ARL6IP1 ENSG00000260342 SMG1 ENSG00000205746 ENSG00000262974 ENSG00000260242 NPIPA8 PKD1P5 RPS15A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS15A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS15A gene promoter:
  • E2F-1
  • E2F
  • YY1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • STAT3
  • POU2F1
  • POU2F1a

Genomic Locations for RPS15A Gene

Genomic Locations for RPS15A Gene
chr16:18,781,295-18,790,383
(GRCh38/hg38)
Size:
9,089 bases
Orientation:
Minus strand
chr16:18,792,617-18,801,705
(GRCh37/hg19)
Size:
9,089 bases
Orientation:
Minus strand

Genomic View for RPS15A Gene

Genes around RPS15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS15A Gene

Proteins for RPS15A Gene

  • Protein details for RPS15A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62244-RS15A_HUMAN
    Recommended name:
    40S ribosomal protein S15a
    Protein Accession:
    P62244
    Secondary Accessions:
    • P39027
    • P39031
    • Q3MHD9
    • Q8C023
    • Q9BV24

    Protein attributes for RPS15A Gene

    Size:
    130 amino acids
    Molecular mass:
    14840 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA44568.1; Type=Frameshift; Positions=24, 37; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS15A Gene

neXtProt entry for RPS15A Gene

Post-translational modifications for RPS15A Gene

  • Ubiquitination at isoforms=124, isoforms=88, posLast=8484, posLast=7171, posLast=6060, posLast=3232, and posLast=1212
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS15A Gene

Domains & Families for RPS15A Gene

Gene Families for RPS15A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Ribosomal proteins

Protein Domains for RPS15A Gene

Suggested Antigen Peptide Sequences for RPS15A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62244

UniProtKB/Swiss-Prot:

RS15A_HUMAN :
  • Belongs to the universal ribosomal protein uS8 family.
Family:
  • Belongs to the universal ribosomal protein uS8 family.
genes like me logo Genes that share domains with RPS15A: view

Function for RPS15A Gene

Molecular function for RPS15A Gene

GENATLAS Biochemistry:
60S ribosomal protein S15A

Gene Ontology (GO) - Molecular Function for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 9582194
GO:0003735 structural constituent of ribosome IEA,NAS 9582194
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPS15A: view
genes like me logo Genes that share phenotypes with RPS15A: view

Animal Model Products

CRISPR Products

miRNA for RPS15A Gene

miRTarBase miRNAs that target RPS15A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS15A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS15A Gene

Localization for RPS15A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS15A gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15108328
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS15A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPS15A Gene

Pathways & Interactions for RPS15A Gene

SuperPathways for RPS15A Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS15A: view

Pathways by source for RPS15A Gene

Gene Ontology (GO) - Biological Process for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 9582194
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS15A: view

No data available for SIGNOR curated interactions for RPS15A Gene

Drugs & Compounds for RPS15A Gene

No Compound Related Data Available

Transcripts for RPS15A Gene

mRNA/cDNA for RPS15A Gene

Unigene Clusters for RPS15A Gene

Ribosomal protein S15a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS15A

Alternative Splicing Database (ASD) splice patterns (SP) for RPS15A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3:

Relevant External Links for RPS15A Gene

GeneLoc Exon Structure for
RPS15A
ECgene alternative splicing isoforms for
RPS15A

Expression for RPS15A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS15A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS15A Gene

This gene is overexpressed in Nasal epithelium (8.1) and Hair follicle (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS15A Gene



Protein tissue co-expression partners for RPS15A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS15A Gene:

RPS15A

SOURCE GeneReport for Unigene cluster for RPS15A Gene:

Hs.370504

Evidence on tissue expression from TISSUES for RPS15A Gene

  • Eye(4.7)
  • Lung(4.7)
  • Skin(4.5)
  • Liver(4.4)
  • Nervous system(4.1)
  • Stomach(3.5)
  • Muscle(3.2)
  • Pancreas(2.9)
  • Intestine(2.8)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Thyroid gland(2.6)
  • Blood(2.4)
  • Bone marrow(2.4)
  • Heart(2.4)
  • Kidney(2.4)
  • Gall bladder(2.3)
  • Adrenal gland(2.2)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with RPS15A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS15A Gene

Orthologs for RPS15A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS15A Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RPS15A 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS15A 34 33
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPS15A 33
  • 94.87 (n)
-- 34
  • 94 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPS15A 34 33
  • 94.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps15a 33
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Rps15a 16 34 33
  • 87.69 (n)
chicken
(Gallus gallus)
Aves RPS15A 34 33
  • 86.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps15a 33
  • 83.85 (n)
Str.10134 33
zebrafish
(Danio rerio)
Actinopterygii rps15a 34 33
  • 83.08 (n)
OneToOne
wufb04b07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9200 33
fruit fly
(Drosophila melanogaster)
Insecta RpS15Ab 34
  • 88 (a)
OneToMany
RpS15A 35
  • 88 (a)
CG12324 35
  • 87 (a)
RpS15Aa 34 33
  • 74.1 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009572 33
  • 68.97 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-22 34 35 33
  • 69.49 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS22B 34
  • 76 (a)
OneToMany
RPS22A 36 34 33
  • 67.18 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR579W 33
  • 67.95 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07931g 33
  • 66.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39590 33
  • 68.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11200 34
  • 88 (a)
OneToOne
Cin.5168 33
bread mold
(Neurospora crassa)
Ascomycetes NCU06431 33
  • 66.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2202 33
  • 64.1 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5168 33
Species where no ortholog for RPS15A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS15A Gene

ENSEMBL:
Gene Tree for RPS15A (if available)
TreeFam:
Gene Tree for RPS15A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS15A: view image

Paralogs for RPS15A Gene

Paralogs for RPS15A Gene

(1) SIMAP similar genes for RPS15A Gene using alignment to 7 proteins:

  • RS15A_HUMAN
  • H3BT37_HUMAN
  • H3BV27_HUMAN
  • H3BVC7_HUMAN
  • I3L246_HUMAN
  • I3L303_HUMAN
  • I3L3P7_HUMAN
genes like me logo Genes that share paralogs with RPS15A: view

Variants for RPS15A Gene

Sequence variations from dbSNP and Humsavar for RPS15A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000112108 -- 18,786,938(-) C/G intron_variant
rs1000274400 -- 18,786,686(-) G/A intron_variant
rs1000835621 -- 18,790,275(-) G/A/T 5_prime_UTR_variant, intron_variant
rs1001022854 -- 18,791,364(-) C/T upstream_transcript_variant
rs1002044306 -- 18,783,850(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS15A Gene

Variant ID Type Subtype PubMed ID
esv2758634 CNV gain+loss 17122850
esv34419 CNV gain 17911159
esv3570409 CNV gain 25503493
nsv1044846 CNV gain 25217958
nsv428320 CNV loss 18775914
nsv469598 CNV gain 16826518
nsv833161 CNV loss 17160897
nsv974777 CNV duplication 23825009
nsv984284 CNV duplication 23825009

Variation tolerance for RPS15A Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS15A Gene

Human Gene Mutation Database (HGMD)
RPS15A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS15A Gene

Disorders for RPS15A Gene

Additional Disease Information for RPS15A

No disorders were found for RPS15A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS15A Gene

Publications for RPS15A Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human S15a expression is upregulated by hepatitis B virus X protein. (PMID: 15108328) Lian Z … Feitelson MA (Molecular carcinogenesis 2004) 3 22 58
  4. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov SN … Otto A (European journal of biochemistry 1996) 3 4 58
  5. The primary structure of rat ribosomal protein S15a. (PMID: 8185605) Chan YL … Wool IG (Biochemical and biophysical research communications 1994) 3 4 58

Products for RPS15A Gene

Sources for RPS15A Gene

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