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Aliases for RPS15 Gene

Aliases for RPS15 Gene

  • Ribosomal Protein S15 2 3 5
  • Small Ribosomal Subunit Protein US19 3 4
  • 40S Ribosomal Protein S15 2 3
  • Homolog Of Rat Insulinoma 2 3
  • Insulinoma Protein 2 3
  • RIG 3 4
  • RIG Protein 4
  • S15 3

External Ids for RPS15 Gene

Previous GeneCards Identifiers for RPS15 Gene

  • GC19M001605
  • GC19P001507
  • GC19P001379
  • GC19P001390
  • GC19P001392
  • GC19P001393
  • GC19P001212

Summaries for RPS15 Gene

Entrez Gene Summary for RPS15 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for RPS15 Gene

RPS15 (Ribosomal Protein S15) is a Protein Coding gene. Diseases associated with RPS15 include Leukemia, Chronic Lymphocytic and Insulinoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS15 Gene

Additional gene information for RPS15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS15 Gene

Genomics for RPS15 Gene

GeneHancer (GH) Regulatory Elements for RPS15 Gene

Promoters and enhancers for RPS15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J001437 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 669.7 +1.1 1125 4.3 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RPS15 ENSG00000268798 SF3A2 TCF3 TMEM259 LOC100288123 PTBP1 DAZAP1 MED16 GRIN3B
GH19J001436 Enhancer 0.8 dbSUPER 650.7 -1.7 -1725 0.9 HDGF MEIS2 PKNOX1 ZNF133 KLF17 ZNF384 ZIC2 BCL11B ZFHX2 GLIS2 RPS15 GC19P001426
GH19J001236 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.1 -181.5 -181499 41.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 CIRBP C19orf24 MIDN CBARP ATP5F1D SF3A2 TCF3 TMEM259 LOC100288123 MIER2
GH19J001406 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.7 -25.5 -25528 13.5 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D DAZAP1 TCF3 SF3A2 TMEM259 LOC100288123 PTBP1 RPS15 MED16 GRIN3B ENSG00000267317
GH19J001019 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 20.6 -417.2 -417151 4.4 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 TMEM259 GC19P001025 RNU6-2 DAZAP1 LOC100288123 TCF3 GRIN3B PTBP1 MED16 CIRBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS15 gene promoter:
  • p53
  • NRSF form 2
  • NRSF form 1
  • C/EBPalpha
  • NF-1

Genomic Locations for RPS15 Gene

Genomic Locations for RPS15 Gene
chr19:1,438,358-1,440,494
(GRCh38/hg38)
Size:
2,137 bases
Orientation:
Plus strand
chr19:1,438,358-1,440,583
(GRCh37/hg19)
Size:
2,226 bases
Orientation:
Plus strand

Genomic View for RPS15 Gene

Genes around RPS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS15 Gene

Proteins for RPS15 Gene

  • Protein details for RPS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62841-RS15_HUMAN
    Recommended name:
    40S ribosomal protein S15
    Protein Accession:
    P62841
    Secondary Accessions:
    • A5D8V9
    • P11174
    • Q3KRA1
    • Q9UDC2

    Protein attributes for RPS15 Gene

    Size:
    145 amino acids
    Molecular mass:
    17040 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS15 Gene

neXtProt entry for RPS15 Gene

Post-translational modifications for RPS15 Gene

  • Ubiquitination at posLast=7777 and posLast=6565
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS15 Gene

Domains & Families for RPS15 Gene

Gene Families for RPS15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS15 Gene

Suggested Antigen Peptide Sequences for RPS15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62841

UniProtKB/Swiss-Prot:

RS15_HUMAN :
  • Belongs to the universal ribosomal protein uS19 family.
Family:
  • Belongs to the universal ribosomal protein uS19 family.
genes like me logo Genes that share domains with RPS15: view

Function for RPS15 Gene

Molecular function for RPS15 Gene

GENATLAS Biochemistry:
40S ribosomal protein S15,16kDa,homolog to rig (rat insulinoma gene)

Phenotypes From GWAS Catalog for RPS15 Gene

Gene Ontology (GO) - Molecular Function for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 2159154
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003735 structural constituent of ribosome IEA,IBA --
GO:0005515 protein binding IPI 24725412
genes like me logo Genes that share ontologies with RPS15: view
genes like me logo Genes that share phenotypes with RPS15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS15 Gene

Localization for RPS15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS15 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 2159154
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with RPS15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS15 Gene

Pathways & Interactions for RPS15 Gene

SuperPathways for RPS15 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS15: view

Gene Ontology (GO) - Biological Process for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000056 ribosomal small subunit export from nucleus IMP 16037817
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001649 osteoblast differentiation HDA 16210410
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPS15: view

No data available for SIGNOR curated interactions for RPS15 Gene

Drugs & Compounds for RPS15 Gene

(1) Additional Compounds for RPS15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS15: view

Transcripts for RPS15 Gene

mRNA/cDNA for RPS15 Gene

Unigene Clusters for RPS15 Gene

Ribosomal protein S15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS15 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2:
SP3: - -

Relevant External Links for RPS15 Gene

GeneLoc Exon Structure for
RPS15
ECgene alternative splicing isoforms for
RPS15

Expression for RPS15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS15 Gene



Protein tissue co-expression partners for RPS15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS15 Gene:

RPS15

SOURCE GeneReport for Unigene cluster for RPS15 Gene:

Hs.406683

Evidence on tissue expression from TISSUES for RPS15 Gene

  • Pancreas(4.9)
  • Nervous system(4.9)
  • Liver(4.6)
  • Intestine(3.9)
  • Muscle(3.8)
  • Skin(3.8)
  • Blood(3.7)
  • Eye(3.7)
  • Lung(3.3)
  • Kidney(2.8)
  • Spleen(2.8)
  • Thyroid gland(2.7)
  • Heart(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.4)
  • Bone marrow(2.4)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with RPS15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS15 Gene

Orthologs for RPS15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
RPS15 33
  • 99.08 (n)
-- 34
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPS15 34 33
  • 94.94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPS15 34 33
  • 93.33 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps15 33
  • 90.8 (n)
mouse
(Mus musculus)
Mammalia Rps15 16 34 33
  • 90.34 (n)
Gm4775 34
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPS15 34
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS15 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS15 34 33
  • 90.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS15 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17045 33
zebrafish
(Danio rerio)
Actinopterygii rps15 34
  • 97 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11968 33
fruit fly
(Drosophila melanogaster)
Insecta CG8332 35
  • 77 (a)
RpS15 34
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rps-15 34 35
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL343C 33
  • 59.62 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07843g 33
  • 57.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS15 34 33
  • 56.81 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G43640 33
  • 66.67 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.925 33
rice
(Oryza sativa)
Liliopsida Os03g0798600 33
  • 74.02 (n)
corn
(Zea mays)
Liliopsida Zm.6569 33
barley
(Hordeum vulgare)
Liliopsida Hv.7206 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3293 34
  • 81 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00971 33
  • 71.6 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1502 33
  • 67.61 (n)
Species where no ortholog for RPS15 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS15 Gene

ENSEMBL:
Gene Tree for RPS15 (if available)
TreeFam:
Gene Tree for RPS15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS15: view image

Paralogs for RPS15 Gene

No data available for Paralogs for RPS15 Gene

Variants for RPS15 Gene

Sequence variations from dbSNP and Humsavar for RPS15 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs201657403 benign, not specified 1,440,069(+) G/A/C coding_sequence_variant, missense_variant
rs7251165 benign, not specified 1,438,866(+) C/T coding_sequence_variant, synonymous_variant
rs1000457377 -- 1,439,409(+) C/T intron_variant
rs1000807244 -- 1,439,159(+) G/A intron_variant
rs1001194964 -- 1,439,483(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS15 Gene

Variant ID Type Subtype PubMed ID
esv2758743 CNV gain+loss 17122850
esv32942 CNV gain+loss 17666407
nsv578278 CNV loss 21841781
nsv578279 CNV gain 21841781
nsv828377 CNV loss 20364138
nsv833705 CNV loss 17160897
nsv953942 CNV deletion 24416366

Variation tolerance for RPS15 Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS15 Gene

Human Gene Mutation Database (HGMD)
RPS15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS15 Gene

Disorders for RPS15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPS15 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
insulinoma
  • islet cell tumor
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPS15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS15

genes like me logo Genes that share disorders with RPS15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS15 Gene

Publications for RPS15 Gene

  1. Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes. (PMID: 2159154) Shiga K … Okamoto H (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov SN … Otto A (European journal of biochemistry 1996) 3 4 58
  4. Evolutionary conservation of the insulinoma gene rig and its possible function. (PMID: 2821540) Inoue C … Okamoto H (Proceedings of the National Academy of Sciences of the United States of America 1987) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RPS15 Gene

Sources for RPS15 Gene