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Aliases for RPS14 Gene

Aliases for RPS14 Gene

  • Ribosomal Protein S14 2 3 5
  • Small Ribosomal Subunit Protein US11 3 4
  • 40S Ribosomal Protein S14 2 3
  • Emetine Resistance 2 3
  • EMTB 3
  • S14 3

External Ids for RPS14 Gene

Previous GeneCards Identifiers for RPS14 Gene

  • GC05M149892
  • GC05M150420
  • GC05M149805
  • GC05M149852
  • GC05M149803
  • GC05M144971

Summaries for RPS14 Gene

Entrez Gene Summary for RPS14 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS14 Gene

RPS14 (Ribosomal Protein S14) is a Protein Coding gene. Diseases associated with RPS14 include Chromosome 5Q Deletion Syndrome and Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS14 Gene

Additional gene information for RPS14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS14 Gene

Genomics for RPS14 Gene

GeneHancer (GH) Regulatory Elements for RPS14 Gene

Promoters and enhancers for RPS14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J150447 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 671.4 +0.8 803 3.4 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 RPS14 GC05P150449 HMGXB3 TCOF1 RBM22 ZNF300 RPL7P1 TIGD6 GC05M150442
GH05J150404 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.3 +39.0 39045 13.3 HDGF PKNOX1 SMAD1 MLX YBX1 IRF4 YY1 ZNF207 ZNF143 FOS CD74 GC05M150410 TCOF1 RPS14 HMGXB3 CAMK2A ZNF300P1 RBM22 SYNPO DCTN4
GH05J150496 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 18 -58.3 -58303 24.1 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 NDST1 TCOF1 NDST1-AS1 RPS14 HMGXB3 SYNPO ENSG00000253852 RBM22 MYOZ3 ENSG00000250309
GH05J149449 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +996.3 996289 8.5 MLX ZFP64 YBX1 DMAP1 SLC30A9 ZNF213 E2F8 MCM3 ZC3H11A MEF2D HMGXB3 TCOF1 TIGD6 RPL7P1 CARMN CSNK1A1 PDGFRB RPS14 RPS20P4 ARHGEF37
GH05J149956 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +490.1 490107 6.7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 SLC26A2 PDE6A HMGXB3 TCOF1 TIGD6 ZNF300 RPL7P1 CSNK1A1 ZNF300P1 PDGFRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS14 gene promoter:
  • TBP
  • Nkx2-5
  • ER-alpha
  • Nkx5-1
  • MyoD
  • deltaCREB
  • CREB
  • Egr-1
  • HOXA9
  • HOXA9B

Genomic Locations for RPS14 Gene

Genomic Locations for RPS14 Gene
7,122 bases
Minus strand
6,567 bases
Minus strand

Genomic View for RPS14 Gene

Genes around RPS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS14 Gene

Proteins for RPS14 Gene

  • Protein details for RPS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S14
    Protein Accession:
    Secondary Accessions:
    • B2R5G5
    • D3DQG5
    • P06366
    • Q5BJI0

    Protein attributes for RPS14 Gene

    151 amino acids
    Molecular mass:
    16273 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS14 Gene

neXtProt entry for RPS14 Gene

Post-translational modifications for RPS14 Gene

  • Ubiquitination at isoforms=106, isoforms=96, isoforms=86, and posLast=6363
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS14 Gene

Domains & Families for RPS14 Gene

Gene Families for RPS14 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS14 Gene

Suggested Antigen Peptide Sequences for RPS14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS11 family.
  • Belongs to the universal ribosomal protein uS11 family.
genes like me logo Genes that share domains with RPS14: view

Function for RPS14 Gene

Molecular function for RPS14 Gene

GENATLAS Biochemistry:
40S ribosomal protein S14,16kDa

Phenotypes From GWAS Catalog for RPS14 Gene

Gene Ontology (GO) - Molecular Function for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0003735 structural constituent of ribosome IEA,IBA --
GO:0005515 protein binding IPI 24965446
GO:0045182 translation regulator activity IMP 3683397
GO:0048027 mRNA 5-UTR binding IDA 7867928
genes like me logo Genes that share ontologies with RPS14: view
genes like me logo Genes that share phenotypes with RPS14: view

Human Phenotype Ontology for RPS14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS14 Gene

Localization for RPS14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS14 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 9152021
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS14 Gene

Pathways & Interactions for RPS14 Gene

SuperPathways for RPS14 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 rRNA processing in the nucleus and cytosol
4 Influenza Viral RNA Transcription and Replication
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS14: view

Gene Ontology (GO) - Biological Process for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly ISS --
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 7867928
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPS14: view

No data available for SIGNOR curated interactions for RPS14 Gene

Drugs & Compounds for RPS14 Gene

(1) Additional Compounds for RPS14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS14: view

Transcripts for RPS14 Gene

mRNA/cDNA for RPS14 Gene

Unigene Clusters for RPS14 Gene

Ribosomal protein S14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS14 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for RPS14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS14 Gene

Protein differential expression in normal tissues from HIPED for RPS14 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS14 Gene

Protein tissue co-expression partners for RPS14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS14 Gene:


SOURCE GeneReport for Unigene cluster for RPS14 Gene:


Evidence on tissue expression from TISSUES for RPS14 Gene

  • Blood(4.8)
  • Liver(4.8)
  • Skin(4.8)
  • Lung(4.7)
  • Nervous system(4.6)
  • Pancreas(4.3)
  • Eye(4.2)
  • Intestine(4.2)
  • Muscle(3.6)
  • Bone marrow(3.4)
  • Bone(3.1)
  • Heart(3)
  • Kidney(2.9)
  • Lymph node(2.8)
  • Spleen(2.6)
  • Stomach(2.6)
  • Thyroid gland(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS14 Gene

Germ Layers:
  • mesoderm
  • cardiovascular
  • blood
  • bone marrow
  • coagulation system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with RPS14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS14 Gene

Orthologs for RPS14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS14 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia RPS14 34
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPS14 34
  • 100 (a)
(Pan troglodytes)
Mammalia RPS14 34 33
  • 99.78 (n)
(Bos Taurus)
Mammalia RPS14 34 33
  • 93.02 (n)
-- 34
  • 86 (a)
(Canis familiaris)
Mammalia RPS14 34 33
  • 92.72 (n)
-- 34
  • 88 (a)
-- 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Rps14 33
  • 92.27 (n)
(Mus musculus)
Mammalia Rps14 16 34 33
  • 92.05 (n)
(Gallus gallus)
Aves RPS14 34 33
  • 86.98 (n)
(Anolis carolinensis)
Reptilia RPS14 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549476 33
  • 84.55 (n)
Str.5998 33
African clawed frog
(Xenopus laevis)
Amphibia rps14-prov 33
(Danio rerio)
Actinopterygii rps14 34
  • 99 (a)
wufa92e08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4262 33
fruit fly
(Drosophila melanogaster)
Insecta RpS14a 34 35
  • 87 (a)
RpS14b 34 35
  • 87 (a)
(Caenorhabditis elegans)
Secernentea rps-14 34 35 33
  • 71.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS14B 36 34
  • 79 (a)
RPS14A 34 33
  • 70.25 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07623g 33
  • 69.15 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL152W 33
  • 68.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11510 33
  • 73.86 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.965 33
(Oryza sativa)
Liliopsida Os02g0162500 33
  • 74.1 (n)
Os.7876 33
(Zea mays)
Liliopsida Zm.6030 33
(Hordeum vulgare)
Liliopsida Hv.3897 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4503 34
  • 89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07830 33
  • 72.66 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1402 33
  • 71.2 (n)
Species where no ortholog for RPS14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS14 Gene

Gene Tree for RPS14 (if available)
Gene Tree for RPS14 (if available)
Evolutionary constrained regions (ECRs) for RPS14: view image

Paralogs for RPS14 Gene

(1) SIMAP similar genes for RPS14 Gene using alignment to 4 proteins:

  • RS14_HUMAN
  • E5RH77_HUMAN
  • H0YB22_HUMAN
  • Q15372_HUMAN
genes like me logo Genes that share paralogs with RPS14: view

No data available for Paralogs for RPS14 Gene

Variants for RPS14 Gene

Sequence variations from dbSNP and Humsavar for RPS14 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000272958 -- 150,445,806(-) A/G intron_variant
rs1000775775 -- 150,449,969(-) C/G upstream_transcript_variant
rs1001394383 -- 150,444,788(-) G/C 3_prime_UTR_variant, intron_variant
rs1001708048 -- 150,449,242(-) T/C intron_variant
rs1001976021 -- 150,450,601(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS14 Gene

Variant ID Type Subtype PubMed ID
esv2759386 CNV loss 17122850
nsv980744 CNV duplication 23825009

Variation tolerance for RPS14 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS14 Gene

Disorders for RPS14 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPS14 Gene - From: OMIM, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chromosome 5q deletion syndrome
  • 5q- syndrome
diamond-blackfan anemia
  • diamond-blackfan anemia 1
retinitis pigmentosa 14
  • rp14
myelodysplastic syndrome
  • mds
shwachman-diamond syndrome 1
  • sds1
- elite association - COSMIC cancer census association via MalaCards
Search RPS14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS14

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPS14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS14 Gene

Publications for RPS14 Gene

  1. Fine-structure map of the human ribosomal protein gene RPS14. (PMID: 1549121) Diaz JJ … Roufa DJ (Molecular and cellular biology 1992) 2 3 4 22 58
  2. Primary structure of human ribosomal protein S14 and the gene that encodes it. (PMID: 3785212) Rhoads DD … Roufa DJ (Molecular and cellular biology 1986) 2 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations. (PMID: 19773262) Quarello P … Ramenghi U (Haematologica 2010) 3 44 58
  5. Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival. (PMID: 19794090) Czibere A … Germing U (Haematologica 2009) 3 22 58

Products for RPS14 Gene

Sources for RPS14 Gene