Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in t... See more...

Aliases for RPS13 Gene

Aliases for RPS13 Gene

  • Ribosomal Protein S13 2 3 5
  • 40S Ribosomal Protein S13 2 3 4
  • Small Ribosomal Subunit Protein US15 3 4
  • S13 2 3
  • RPS13 5

External Ids for RPS13 Gene

Previous GeneCards Identifiers for RPS13 Gene

  • GC11M018166
  • GC11M018039
  • GC11M017135
  • GC11M017060
  • GC11M017054
  • GC11M017055
  • GC11M016780
  • GC11M017095
  • GC11M017080
  • GC11M017085
  • GC11M017132
  • GC11M017138
  • GC11M017145
  • GC11M017173
  • GC11M017091
  • GC11M017103
  • GC11M017107
  • GC11M017111
  • GC11M017116
  • GC11M017120
  • GC11M017124
  • GC11M017128
  • GC11M017179

Summaries for RPS13 Gene

Entrez Gene Summary for RPS13 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS13 Gene

RPS13 (Ribosomal Protein S13) is a Protein Coding gene. Diseases associated with RPS13 include Hypertensive Encephalopathy and Neuroblastoma. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include mRNA binding.

Gene Wiki entry for RPS13 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS13 Gene

Genomics for RPS13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS13

Top Transcription factor binding sites by QIAGEN in the RPS13 gene promoter:
  • AP-1
  • AP-2rep
  • GATA-1
  • Ik-2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • p53
  • YY1

Genomic Locations for RPS13 Gene

Latest Assembly
chr11:17,074,388-17,077,715
(GRCh38/hg38)
Size:
3,328 bases
Orientation:
Minus strand

Previous Assembly
chr11:17,095,935-17,099,214
(GRCh37/hg19 by Entrez Gene)
Size:
3,280 bases
Orientation:
Minus strand

chr11:17,095,936-17,099,334
(GRCh37/hg19 by Ensembl)
Size:
3,399 bases
Orientation:
Minus strand

Genomic View for RPS13 Gene

Genes around RPS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS13 Gene

Proteins for RPS13 Gene

  • Protein details for RPS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62277-RS13_HUMAN
    Recommended name:
    40S ribosomal protein S13
    Protein Accession:
    P62277
    Secondary Accessions:
    • B2R549
    • P19116
    • Q02546
    • Q29200
    • Q498Y0

    Protein attributes for RPS13 Gene

    Size:
    151 amino acids
    Molecular mass:
    17222 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS13 Gene

neXtProt entry for RPS13 Gene

Post-translational modifications for RPS13 Gene

  • Ubiquitination at Lys9, Lys27, Lys34, Lys39, Lys43, Lys70, and Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS13 Gene

Antibodies for research

  • Abcam antibodies for RPS13

No data available for DME Specific Peptides for RPS13 Gene

Domains & Families for RPS13 Gene

Gene Families for RPS13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS13 Gene

InterPro:
Blocks:
  • Ribosomal S13S15 N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for RPS13 Gene

GenScript: Design optimal peptide antigens:
  • 40S ribosomal protein S13 (RS13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62277

UniProtKB/Swiss-Prot:

RS13_HUMAN :
  • Belongs to the universal ribosomal protein uS15 family.
Family:
  • Belongs to the universal ribosomal protein uS15 family.
genes like me logo Genes that share domains with RPS13: view

Function for RPS13 Gene

Molecular function for RPS13 Gene

GENATLAS Biochemistry:
60S ribosomal protein S13

Phenotypes From GWAS Catalog for RPS13 Gene

Gene Ontology (GO) - Molecular Function for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003729 mRNA binding IDA 17881366
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
GO:0005515 protein binding IPI 12054647
GO:0048027 mRNA 5'-UTR binding IDA 16213212
genes like me logo Genes that share ontologies with RPS13: view
genes like me logo Genes that share phenotypes with RPS13: view

miRNA for RPS13 Gene

miRTarBase miRNAs that target RPS13

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS13 Gene

Localization for RPS13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS13 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
golgi apparatus 2
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17881366
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA,IDA 17881366
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA,NAS 8332508
genes like me logo Genes that share ontologies with RPS13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS13 Gene

Pathways & Interactions for RPS13 Gene

PathCards logo

SuperPathways for RPS13 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.53
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS13: view

Pathways by source for RPS13 Gene

2 KEGG pathways for RPS13 Gene
1 GeneGo (Thomson Reuters) pathway for RPS13 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0019083 viral transcription TAS --
genes like me logo Genes that share ontologies with RPS13: view

No data available for SIGNOR curated interactions for RPS13 Gene

Drugs & Compounds for RPS13 Gene

(1) Drugs for RPS13 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 119
genes like me logo Genes that share compounds with RPS13: view

Transcripts for RPS13 Gene

mRNA/cDNA for RPS13 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS13

Alternative Splicing Database (ASD) splice patterns (SP) for RPS13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6
SP1:
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for RPS13 Gene

GeneLoc Exon Structure for
RPS13

Expression for RPS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS13 Gene

This gene is overexpressed in Nasal epithelium (11.8) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS13 Gene



Protein tissue co-expression partners for RPS13 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS13

SOURCE GeneReport for Unigene cluster for RPS13 Gene:

Hs.446588

Evidence on tissue expression from TISSUES for RPS13 Gene

  • Nervous system(4.9)
  • Muscle(4.8)
  • Liver(4.8)
  • Pancreas(4.7)
  • Bone(4.5)
  • Intestine(4.1)
  • Lung(4.1)
  • Blood(4.1)
  • Heart(3.7)
  • Spleen(3.4)
  • Skin(3.3)
  • Lymph node(3.1)
  • Stomach(3.1)
  • Kidney(3.1)
  • Bone marrow(3.1)
  • Eye(2.8)
  • Thyroid gland(2.6)
  • Adrenal gland(2.6)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with RPS13: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS13 Gene

Orthologs for RPS13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPS13 30
  • 99.78 (n)
Oppossum
(Monodelphis domestica)
Mammalia RPS13 31
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPS13 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 98 (a)
OneToMany
RPS13 30 31
  • 90.51 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia RPS13 30
  • 91.39 (n)
Mouse
(Mus musculus)
Mammalia Rps13 30 17 31
  • 86.98 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RPS13 30 31
  • 81.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPS13 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rps13 30
  • 80.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia rps13-prov 30
Zebrafish
(Danio rerio)
Actinopterygii rps13 30 31
  • 78.15 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13839 30
Fruit Fly
(Drosophila melanogaster)
Insecta RpS13 30 31 32
  • 71.08 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RS13_ANOGA 30
  • 68.21 (n)
Worm
(Caenorhabditis elegans)
Secernentea rps-13 30 31 32
  • 68.43 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F18040g 30
  • 67.11 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGL030W 30
  • 66.44 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS13 30 31 33
  • 66.22 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RPS13A 30
  • 66 (n)
Rice
(Oryza sativa)
Liliopsida Os08g0117300 30
  • 62.69 (n)
Os.15168 30
Wheat
(Triticum aestivum)
Liliopsida Ta.14203 30
Corn
(Zea mays)
Liliopsida Zm.3223 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11176 31
  • 88 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU03038 30
  • 68.21 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps13 30
  • 65.56 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.14352 30
Species where no ortholog for RPS13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS13 Gene

ENSEMBL:
Gene Tree for RPS13 (if available)
TreeFam:
Gene Tree for RPS13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS13: view image

Paralogs for RPS13 Gene

No data available for Paralogs for RPS13 Gene

Variants for RPS13 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RPS13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RPS13 Gene

Variant ID Type Subtype PubMed ID
nsv467711 CNV gain 19166990
nsv553567 CNV gain 21841781
nsv553568 CNV gain 21841781

Variation tolerance for RPS13 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS13 Gene

Disorders for RPS13 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPS13 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hypertensive encephalopathy
neuroblastoma
  • nb
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
diamond-blackfan anemia
  • blackfan - diamond syndrome
autosomal dominant non-syndromic intellectual disability
  • autosomal dominant mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search RPS13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS13

genes like me logo Genes that share disorders with RPS13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS13 Gene

Publications for RPS13 Gene

  1. Cloning and analysis of the human S13 ribosomal protein cDNA. (PMID: 8332508) Chadéneau C … Denis MG (Nucleic acids research 1993) 2 3 4
  2. Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism. (PMID: 17881366) Malygin AA … Karpova GG (Nucleic acids research 2007) 3 23
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4
  4. Human ribosomal protein S13: cloning, expression, refolding, and structural stability. (PMID: 15680243) Malygin A … Karpova G (Biochimica et biophysica acta 2005) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RPS13 Gene

Sources for RPS13 Gene