Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in t... See more...

Aliases for RPS12 Gene

Aliases for RPS12 Gene

  • Ribosomal Protein S12 2 3 5
  • Small Ribosomal Subunit Protein ES12 3 4
  • 40S Ribosomal Protein S12 3 4
  • S12 3

External Ids for RPS12 Gene

Previous GeneCards Identifiers for RPS12 Gene

  • GC06P132758
  • GC06P132982
  • GC06P133116
  • GC06P133177
  • GC06P130710
  • GC06P133136

Summaries for RPS12 Gene

Entrez Gene Summary for RPS12 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS12 Gene

RPS12 (Ribosomal Protein S12) is a Protein Coding gene. Diseases associated with RPS12 include Mycobacterium Tuberculosis 1 and Multidrug-Resistant Tuberculosis. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS12 Gene

Additional gene information for RPS12 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS12 Gene

Genomics for RPS12 Gene

GeneHancer (GH) Regulatory Elements for RPS12 Gene

Promoters and enhancers for RPS12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS12 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS12

Top Transcription factor binding sites by QIAGEN in the RPS12 gene promoter:
  • Brachyury
  • c-Myb
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GR
  • GR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for RPS12 Gene

Genomic Locations for RPS12 Gene
chr6:132,814,569-132,817,564
(GRCh38/hg38)
Size:
2,996 bases
Orientation:
Plus strand
chr6:133,135,580-133,138,703
(GRCh37/hg19)
Size:
3,124 bases
Orientation:
Plus strand

Genomic View for RPS12 Gene

Genes around RPS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS12 Gene

Proteins for RPS12 Gene

  • Protein details for RPS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25398-RS12_HUMAN
    Recommended name:
    40S ribosomal protein S12
    Protein Accession:
    P25398
    Secondary Accessions:
    • Q76M58

    Protein attributes for RPS12 Gene

    Size:
    132 amino acids
    Molecular mass:
    14515 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS12 Gene

neXtProt entry for RPS12 Gene

Post-translational modifications for RPS12 Gene

  • Ubiquitination at Lys93, Lys112, and Lys129
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS12 Gene

Domains & Families for RPS12 Gene

Gene Families for RPS12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS12 Gene

Blocks:
  • Ribosomal protein L7Ae/L30e/S12e/Gadd45
  • Ribosomal protein S12E
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS12 Gene

GenScript: Design optimal peptide antigens:
  • 40S ribosomal protein S12 (RS12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25398

UniProtKB/Swiss-Prot:

RS12_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS12 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS12 family.
genes like me logo Genes that share domains with RPS12: view

Function for RPS12 Gene

Molecular function for RPS12 Gene

GENATLAS Biochemistry:
60S ribosomal protein S12

Phenotypes From GWAS Catalog for RPS12 Gene

Gene Ontology (GO) - Molecular Function for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA 21873635
genes like me logo Genes that share ontologies with RPS12: view
genes like me logo Genes that share phenotypes with RPS12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS12 Gene

Localization for RPS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS12 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS12 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 4
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS12: view

Pathways & Interactions for RPS12 Gene

PathCards logo

SuperPathways for RPS12 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS12: view

Pathways by source for RPS12 Gene

1 KEGG pathway for RPS12 Gene
1 GeneGo (Thomson Reuters) pathway for RPS12 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation NAS,IEA 1861993
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0019083 viral transcription TAS --
genes like me logo Genes that share ontologies with RPS12: view

No data available for SIGNOR curated interactions for RPS12 Gene

Drugs & Compounds for RPS12 Gene

(3) Drugs for RPS12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RPS12 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS12: view

Transcripts for RPS12 Gene

mRNA/cDNA for RPS12 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS12

Alternative Splicing Database (ASD) splice patterns (SP) for RPS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for RPS12 Gene

GeneLoc Exon Structure for
RPS12

Expression for RPS12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS12 Gene

Protein differential expression in normal tissues from HIPED for RPS12 Gene

This gene is overexpressed in Amniocyte (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS12 Gene



Protein tissue co-expression partners for RPS12 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS12

SOURCE GeneReport for Unigene cluster for RPS12 Gene:

Hs.546289

Evidence on tissue expression from TISSUES for RPS12 Gene

  • Liver(4.9)
  • Skin(4.7)
  • Nervous system(4.3)
  • Intestine(3.2)
  • Heart(2.9)
  • Pancreas(2.8)
  • Muscle(2.7)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Bone marrow(2.5)
  • Eye(2.5)
  • Lung(2.5)
  • Stomach(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
  • Thyroid gland(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RPS12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS12 Gene

Orthologs for RPS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS12 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia RPS12 31
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS12 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS12 31 30
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPS12 31 30
  • 95.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPS12 30
  • 94.44 (n)
-- 31
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rps12 17 31 30
  • 91.41 (n)
rat
(Rattus norvegicus)
Mammalia Rps12 30
  • 91.41 (n)
chicken
(Gallus gallus)
Aves RPS12 31 30
  • 83.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS12 31
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps12 30
  • 86.87 (n)
Str.17155 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68529 30
zebrafish
(Danio rerio)
Actinopterygii rps12 31 30
  • 81.31 (n)
OneToOne
wufa95a02 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8526 30
fruit fly
(Drosophila melanogaster)
Insecta RpS12 31 32
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rps-12 31 32 30
  • 58.06 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS12 33 31 30
  • 55.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR412C 30
  • 55.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00352g 30
  • 53.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G15930 30
  • 58.69 (n)
rice
(Oryza sativa)
Liliopsida Os07g0150200 30
  • 62.81 (n)
Os.22993 30
corn
(Zea mays)
Liliopsida Zm.6239 30
wheat
(Triticum aestivum)
Liliopsida Ta.22961 30
barley
(Hordeum vulgare)
Liliopsida Hv.7997 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4620 31
  • 66 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1201 30
  • 62.06 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06432 30
  • 56.35 (n)
Species where no ortholog for RPS12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS12 Gene

ENSEMBL:
Gene Tree for RPS12 (if available)
TreeFam:
Gene Tree for RPS12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS12: view image

Paralogs for RPS12 Gene

No data available for Paralogs for RPS12 Gene

Variants for RPS12 Gene

Additional dbSNP identifiers (rs#s) for RPS12 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS12 Gene

Variant ID Type Subtype PubMed ID
dgv1830e212 CNV loss 25503493
nsv970166 CNV duplication 23825009
nsv970167 CNV duplication 23825009

Variation tolerance for RPS12 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS12

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS12 Gene

Disorders for RPS12 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS12 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
mycobacterium tuberculosis 1
  • mycobacterium tuberculosis, susceptibility to, 1
multidrug-resistant tuberculosis
  • tuberculosis multidrug-resistant
- elite association - COSMIC cancer census association via MalaCards
Search RPS12 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS12

genes like me logo Genes that share disorders with RPS12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS12 Gene

Publications for RPS12 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 54
  2. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Hérault Y … Brun G (Nucleic acids research 1991) 2 3 4 54
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 54
  4. Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. (PMID: 11870519) Cheng Q … Hui KM (British journal of cancer 2002) 3 23 54
  5. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov SN … Otto A (European journal of biochemistry 1996) 3 4 54

Products for RPS12 Gene

Sources for RPS12 Gene