Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleol... See more...

Aliases for RPS11 Gene

Aliases for RPS11 Gene

  • Ribosomal Protein S11 2 3 5
  • 40S Ribosomal Protein S11 2 3 4
  • Small Ribosomal Subunit Protein US17 3 4
  • S11 2 3
  • RPS11 5

External Ids for RPS11 Gene

Previous GeneCards Identifiers for RPS11 Gene

  • GC19P050657
  • GC19P050367
  • GC19P054675
  • GC19P054692
  • GC19P054693
  • GC19P054695
  • GC19P054710
  • GC19P054719
  • GC19P054720
  • GC19P054728
  • GC19P054735
  • GC19P054742
  • GC19P054749
  • GC19P054755
  • GC19P054767
  • GC19P054779
  • GC19P049999
  • GC19P046377

Summaries for RPS11 Gene

Entrez Gene Summary for RPS11 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPS11 Gene

RPS11 (Ribosomal Protein S11) is a Protein Coding gene. Diseases associated with RPS11 include Cyclosporiasis and Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include rRNA binding.

Gene Wiki entry for RPS11 Gene

Additional gene information for RPS11 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPS11 Gene

Genomics for RPS11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPS11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPS11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPS11

Top Transcription factor binding sites by QIAGEN in the RPS11 gene promoter:
  • AP-4
  • E47
  • FOXL1
  • GATA-1
  • NF-1
  • NF-1/L
  • STAT3
  • Tal-1beta
  • TBP

Genomic Locations for RPS11 Gene

Genomic Locations for RPS11 Gene
chr19:49,496,365-49,499,708
(GRCh38/hg38)
Size:
3,344 bases
Orientation:
Plus strand
chr19:49,999,622-50,002,946
(GRCh37/hg19)
Size:
3,325 bases
Orientation:
Plus strand

Genomic View for RPS11 Gene

Genes around RPS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS11 Gene

Proteins for RPS11 Gene

  • Protein details for RPS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62280-RS11_HUMAN
    Recommended name:
    40S ribosomal protein S11
    Protein Accession:
    P62280
    Secondary Accessions:
    • B2R4F5
    • P04643
    • Q498Y6
    • Q6IRY0

    Protein attributes for RPS11 Gene

    Size:
    158 amino acids
    Molecular mass:
    18431 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS11 Gene

neXtProt entry for RPS11 Gene

Post-translational modifications for RPS11 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys12, Lys30, Lys32, Lys38, Lys59, and Lys136
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS11 Gene

No data available for DME Specific Peptides for RPS11 Gene

Domains & Families for RPS11 Gene

Gene Families for RPS11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPS11 Gene

GenScript: Design optimal peptide antigens:
  • 40S ribosomal protein S11 (RS11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62280

UniProtKB/Swiss-Prot:

RS11_HUMAN :
  • Belongs to the universal ribosomal protein uS17 family.
Family:
  • Belongs to the universal ribosomal protein uS17 family.
genes like me logo Genes that share domains with RPS11: view

Function for RPS11 Gene

Molecular function for RPS11 Gene

GENATLAS Biochemistry:
40S ribosomal protein S11,18kDa

Phenotypes From GWAS Catalog for RPS11 Gene

Gene Ontology (GO) - Molecular Function for RPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
GO:0005515 protein binding IPI 14743216
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS11: view
genes like me logo Genes that share phenotypes with RPS11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS11 Gene

Localization for RPS11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS11 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus HDA 16791210
GO:0005737 cytoplasm HDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA,NAS 3267208
genes like me logo Genes that share ontologies with RPS11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS11 Gene

Pathways & Interactions for RPS11 Gene

PathCards logo

SuperPathways for RPS11 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.53
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS11: view

Pathways by source for RPS11 Gene

1 KEGG pathway for RPS11 Gene
1 GeneGo (Thomson Reuters) pathway for RPS11 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation IEA,NAS 1577483
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0019083 viral transcription TAS --
genes like me logo Genes that share ontologies with RPS11: view

No data available for SIGNOR curated interactions for RPS11 Gene

Drugs & Compounds for RPS11 Gene

No Compound Related Data Available

Transcripts for RPS11 Gene

mRNA/cDNA for RPS11 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS11

Alternative Splicing Database (ASD) splice patterns (SP) for RPS11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for RPS11 Gene

GeneLoc Exon Structure for
RPS11

Expression for RPS11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS11 Gene

This gene is overexpressed in Tlymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS11 Gene



Protein tissue co-expression partners for RPS11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPS11

SOURCE GeneReport for Unigene cluster for RPS11 Gene:

Hs.433529

Evidence on tissue expression from TISSUES for RPS11 Gene

  • Lung(5)
  • Liver(4.9)
  • Eye(4.9)
  • Blood(4.8)
  • Nervous system(4.8)
  • Intestine(4.6)
  • Pancreas(4.5)
  • Stomach(4.5)
  • Muscle(4.4)
  • Bone(4.3)
  • Skin(4.3)
  • Kidney(3.7)
  • Heart(3.6)
  • Spleen(3.4)
  • Lymph node(3.4)
  • Bone marrow(3.3)
  • Thyroid gland(3)
  • Adrenal gland(2.8)
  • Gall bladder(2.7)
genes like me logo Genes that share expression patterns with RPS11: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS11 Gene

Orthologs for RPS11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPS11 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPS11 31
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPS11 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RPS11 30 31
  • 91.98 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPS11 30 31
  • 90.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rps11 30
  • 90.3 (n)
Mouse
(Mus musculus)
Mammalia Rps11 30 17 31
  • 90.08 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RPS11 30 31
  • 86.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPS11 31
  • 99 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rps11 30
  • 85.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia rps11-prov 30
Zebrafish
(Danio rerio)
Actinopterygii rps11 30 31
  • 81.86 (n)
OneToMany
RPS11 (2 of 2) 31
  • 72 (a)
OneToMany
Dr.1339 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8696 30
African malaria mosquito
(Anopheles gambiae)
Insecta RS11_ANOGA 30
  • 71.46 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8857 32
  • 71 (a)
RpS11 30 31
  • 69.68 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea rps-11 30 31 32
  • 66 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS11B 31 33
  • 69 (a)
OneToMany
RPS11A 30 31 33
  • 66.44 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABL091C 30
  • 66.89 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10483g 30
  • 65.1 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RPS11-BETA 30
  • 62.5 (n)
Soybean
(Glycine max)
eudicotyledons Gma.13177 30
Rice
(Oryza sativa)
Liliopsida Os04g0502300 30
  • 63.49 (n)
Os.9405 30
Barley
(Hordeum vulgare)
Liliopsida Hv.837 30
Wheat
(Triticum aestivum)
Liliopsida Ta.1289 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7869 31
  • 74 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1102 30
  • 65.98 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU03102 30
  • 65.37 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7405 30
Species where no ortholog for RPS11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS11 Gene

ENSEMBL:
Gene Tree for RPS11 (if available)
TreeFam:
Gene Tree for RPS11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS11: view image

Paralogs for RPS11 Gene

No data available for Paralogs for RPS11 Gene

Variants for RPS11 Gene

Additional dbSNP identifiers (rs#s) for RPS11 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS11 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for RPS11 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPS11 Gene

Disorders for RPS11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPS11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cyclosporiasis
  • cyclospora infection
diamond-blackfan anemia
  • diamond-blackfan anemia 1
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search RPS11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPS11

genes like me logo Genes that share disorders with RPS11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS11 Gene

Publications for RPS11 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4
  2. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PMID: 21909109) Kim YJ … Cho YS (Nature genetics 2011) 3 41
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome. (PMID: 10580157) Higa S … Kenmochi N (Gene 1999) 3 4

Products for RPS11 Gene