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Aliases for RPS10-NUDT3 Gene

Aliases for RPS10-NUDT3 Gene

  • RPS10-NUDT3 Readthrough 2 3 5
  • Ribosomal Protein S10 Homologue 3
  • RPS10-NUDT3 Protein 3

External Ids for RPS10-NUDT3 Gene

Previous GeneCards Identifiers for RPS10-NUDT3 Gene

  • GC06U902178
  • GC06M035243
  • GC06M035740
  • GC06M034554
  • GC06M035577
  • GC06M036317
  • GC06M036686
  • GC06M037041
  • GC06M037395
  • GC06M037753
  • GC06M038099

Summaries for RPS10-NUDT3 Gene

Entrez Gene Summary for RPS10-NUDT3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RPS10 (ribosomal protein S10) and NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3) genes on chromosome 6. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for RPS10-NUDT3 Gene

RPS10-NUDT3 (RPS10-NUDT3 Readthrough) is a Protein Coding gene. Diseases associated with RPS10-NUDT3 include Diamond-Blackfan Anemia 9 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is RPS10.

Additional gene information for RPS10-NUDT3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS10-NUDT3 Gene

Genomics for RPS10-NUDT3 Gene

GeneHancer (GH) Regulatory Elements for RPS10-NUDT3 Gene

Promoters and enhancers for RPS10-NUDT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J034423 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.8 830 2.9 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B CBX5 RPS10 RPS10-NUDT3 LEMD2 NUDT3
GH06J034390 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.3 +34.0 33989 3.6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NUDT3 RPS10 TAF11 ENSG00000272374 LEMD2 PHF1 ITPR3 ZNF76 SNRPC SYNGAP1
GH06J034465 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 0.3 -39.9 -39876 0.4 HDAC1 BCOR PKNOX1 ZIC2 HIC1 ZFHX2 CTBP1 GLIS2 POLR2A EGR1 PACSIN1 UHRF1BP1 RPS10 RPS10-NUDT3
GH06J034421 Promoter 0.7 EPDnew 0.7 +4.3 4307 0.1 SMAD5 POLR2A SUPT5H RPS10 RPS10-NUDT3 NUDT3
GH06J034414 Enhancer 1.2 Ensembl ENCODE 0.4 +10.9 10944 1.7 PKNOX1 FOXA2 ARNT ARID4B DMAP1 YY1 ARID2 ZNF143 KDM4B RXRA LEMD2 RPS10 RPS10-NUDT3 NUDT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS10-NUDT3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RPS10-NUDT3 Gene

Genomic Locations for RPS10-NUDT3 Gene
chr6:34,284,887-34,426,125
(GRCh38/hg38)
Size:
141,239 bases
Orientation:
Minus strand
chr6:34,254,971-34,393,902
(GRCh37/hg19)
Size:
138,932 bases
Orientation:
Minus strand

Genomic View for RPS10-NUDT3 Gene

Genes around RPS10-NUDT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS10-NUDT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS10-NUDT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS10-NUDT3 Gene

Proteins for RPS10-NUDT3 Gene

  • Protein details for RPS10-NUDT3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1W2PQS6-A0A1W2PQS6_HUMAN
    Recommended name:
    RPS10-NUDT3 readthrough
    Protein Accession:
    A0A1W2PQS6

    Protein attributes for RPS10-NUDT3 Gene

    Size:
    291 amino acids
    Molecular mass:
    33141 Da
    Quaternary structure:
    No Data Available
  • Protein details for RPS10-NUDT3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    S4R435-S4R435_HUMAN
    Recommended name:
    RPS10-NUDT3 readthrough
    Protein Accession:
    S4R435

    Protein attributes for RPS10-NUDT3 Gene

    Size:
    198 amino acids
    Molecular mass:
    22973 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPS10-NUDT3 Gene

Post-translational modifications for RPS10-NUDT3 Gene

No Post-translational modifications

Other Protein References for RPS10-NUDT3 Gene

No data available for DME Specific Peptides for RPS10-NUDT3 Gene

Domains & Families for RPS10-NUDT3 Gene

Gene Families for RPS10-NUDT3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RPS10-NUDT3: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RPS10-NUDT3 Gene

Function for RPS10-NUDT3 Gene

Gene Ontology (GO) - Molecular Function for RPS10-NUDT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RPS10-NUDT3: view

Phenotypes for RPS10-NUDT3 Gene

genes like me logo Genes that share phenotypes with RPS10-NUDT3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS10-NUDT3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPS10-NUDT3 Gene

Localization for RPS10-NUDT3 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPS10-NUDT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0022627 cytosolic small ribosomal subunit IBA --
genes like me logo Genes that share ontologies with RPS10-NUDT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RPS10-NUDT3 Gene

Pathways & Interactions for RPS10-NUDT3 Gene

SuperPathways for RPS10-NUDT3 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
genes like me logo Genes that share pathways with RPS10-NUDT3: view

Pathways by source for RPS10-NUDT3 Gene

1 KEGG pathway for RPS10-NUDT3 Gene

Interacting Proteins for RPS10-NUDT3 Gene

Gene Ontology (GO) - Biological Process for RPS10-NUDT3 Gene

None

No data available for SIGNOR curated interactions for RPS10-NUDT3 Gene

Drugs & Compounds for RPS10-NUDT3 Gene

No Compound Related Data Available

Transcripts for RPS10-NUDT3 Gene

mRNA/cDNA for RPS10-NUDT3 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPS10-NUDT3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS10-NUDT3 Gene

No ASD Table

Relevant External Links for RPS10-NUDT3 Gene

GeneLoc Exon Structure for
RPS10-NUDT3
ECgene alternative splicing isoforms for
RPS10-NUDT3

Expression for RPS10-NUDT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS10-NUDT3 Gene

Protein differential expression in normal tissues from HIPED for RPS10-NUDT3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for RPS10-NUDT3 Gene



Protein tissue co-expression partners for RPS10-NUDT3 Gene

genes like me logo Genes that share expression patterns with RPS10-NUDT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS10-NUDT3 Gene

Orthologs for RPS10-NUDT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS10-NUDT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS10 33
  • 100 (n)
RPS10-NUDT3 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps10 34
  • 93 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100361240 33
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RPS10 34
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps10 33
  • 80.48 (n)
zebrafish
(Danio rerio)
Actinopterygii rps10 34 33
  • 78.51 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000739 33
  • 63.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpS10b 34 33
  • 62.42 (n)
ManyToMany
RpS10a 34
  • 55 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rps-10 34 33
  • 61.15 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS10A 34
  • 53 (a)
ManyToMany
RPS10B 34
  • 52 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G52650 33
  • 57.45 (n)
rice
(Oryza sativa)
Liliopsida Os04g0430100 33
  • 57.26 (n)
Species where no ortholog for RPS10-NUDT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS10-NUDT3 Gene

ENSEMBL:
Gene Tree for RPS10-NUDT3 (if available)
TreeFam:
Gene Tree for RPS10-NUDT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPS10-NUDT3: view image

Paralogs for RPS10-NUDT3 Gene

Paralogs for RPS10-NUDT3 Gene

(6) SIMAP similar genes for RPS10-NUDT3 Gene using alignment to 1 proteins:

  • S4R435_HUMAN
genes like me logo Genes that share paralogs with RPS10-NUDT3: view

Variants for RPS10-NUDT3 Gene

Sequence variations from dbSNP and Humsavar for RPS10-NUDT3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs111597547 likely-benign, Diamond-Blackfan anemia 34,426,074(-) A/C 5_prime_UTR_variant
rs113071821 likely-benign, Diamond-Blackfan anemia 34,426,129(-) A/G upstream_transcript_variant
rs140822093 likely-benign, Diamond-Blackfan anemia 34,426,060(-) G/A 5_prime_UTR_variant
rs146246722 conflicting-interpretations-of-pathogenicity, Diamond-Blackfan anemia 34,425,216(-) C/T coding_sequence_variant, synonymous_variant
rs147566753 conflicting-interpretations-of-pathogenicity, Diamond-Blackfan anemia 34,418,417(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS10-NUDT3 Gene

Variant ID Type Subtype PubMed ID
nsv981133 CNV duplication 23825009
nsv602886 CNV loss 21841781
nsv602863 CNV loss 21841781
nsv5253 CNV insertion 18451855
nsv473801 CNV novel sequence insertion 20440878
nsv1034978 CNV gain 25217958
esv3608657 CNV loss 21293372
esv3608656 CNV loss 21293372
esv3608655 CNV loss 21293372
esv3567619 CNV deletion 23714750
esv3425871 CNV insertion 20981092
esv33496 CNV loss 17666407
esv29044 CNV loss 19812545
esv2759418 CNV gain 17122850
esv2731907 CNV deletion 23290073
esv2674771 CNV deletion 23128226
esv1159599 CNV insertion 17803354
dgv1115e199 CNV deletion 23128226
dgv10623n54 CNV loss 21841781
dgv10622n54 CNV loss 21841781
dgv10621n54 CNV loss 21841781
dgv10620n54 CNV loss 21841781
dgv10619n54 CNV loss 21841781
dgv10618n54 CNV loss 21841781

Variation tolerance for RPS10-NUDT3 Gene

Gene Damage Index Score: 0.25; 5.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS10-NUDT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS10-NUDT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS10-NUDT3 Gene

Disorders for RPS10-NUDT3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS10-NUDT3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 9
  • dba9
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPS10-NUDT3

genes like me logo Genes that share disorders with RPS10-NUDT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS10-NUDT3 Gene

Publications for RPS10-NUDT3 Gene

  1. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  2. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 58
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 58
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58

Products for RPS10-NUDT3 Gene

Sources for RPS10-NUDT3 Gene

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