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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011]
RPS10 (Ribosomal Protein S10) is a Protein Coding gene. Diseases associated with RPS10 include Diamond-Blackfan Anemia 9 and Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. An important paralog of this gene is RPS10-NUDT3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0003735 | structural constituent of ribosome | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 20159986 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IEA,IDA | 20159986 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
CFTR translational fidelity (class I mutations)
.79
.77
.53
|
|
2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
3 | Influenza Viral RNA Transcription and Replication | ||
4 | rRNA processing in the nucleus and cytosol |
.89
|
|
5 | HIV Life Cycle |
.45
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000028 | ribosomal small subunit assembly | IBA | 21873635 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
GO:0006412 | translation | IC | 8706699 |
GO:0006413 | translational initiation | TAS | -- |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
RPS10 30 31 |
|
OneToMany | |||
Chimpanzee (Pan troglodytes) |
Mammalia | LOC742827 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rps10-ps1 31 |
|
OneToMany | |
Rps10 30 17 |
|
||||
Cow (Bos Taurus) |
Mammalia | RPS10 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Rps10 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | RPS10 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | rps10 31 |
|
OneToMany | |
zgc65936 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG14206 32 |
|
|
|
RpS10a 30 31 |
|
ManyToMany | |||
RpS10b 31 |
|
ManyToMany | |||
BcDNA:LD32148 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | rps-10 31 32 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR569W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B08173g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPS10A 30 31 33 |
|
ManyToMany | |
RPS10B 31 |
|
ManyToMany | |||
Barley (Hordeum vulgare) |
Liliopsida | Hv.2081 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.20182 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.14409 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rps1001 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06743 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
6186 | Pathogenic: Diamond-Blackfan anemia 9 | 34,424,730(-) | C/CG | FRAMESHIFT_VARIANT | |
645567 | Uncertain Significance: Diamond-Blackfan anemia | 34,424,769(-) | C/T | SYNONYMOUS_VARIANT | |
653431 | Pathogenic: Diamond-Blackfan anemia | 34,424,698(-) | CGGCTACGG/C | FRAMESHIFT_VARIANT | |
702019 | Benign: Diamond-Blackfan anemia | 34,418,433(-) | T/C | INTRON_VARIANT | |
731598 | Likely Benign: not provided | 34,425,063(-) | C/T | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759418 | CNV | gain | 17122850 |
nsv981133 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
diamond-blackfan anemia 9 |
|
|
diamond-blackfan anemia |
|
|
macrocytic anemia |
|
|
shwachman-diamond syndrome 1 |
|
|
treacher collins syndrome 1 |
|
|