Aliases for RPRML Gene

Aliases for RPRML Gene

  • Reprimo Like 2 3 5
  • Reprimo-Like Protein 3 4
  • Reprimo-Like 2
  • MGC43894 2
  • RPRML 5

External Ids for RPRML Gene

Previous GeneCards Identifiers for RPRML Gene

  • GC17M042411
  • GC17M045055
  • GC17M040433

Summaries for RPRML Gene

GeneCards Summary for RPRML Gene

RPRML (Reprimo Like) is a Protein Coding gene. Diseases associated with RPRML include Retinitis Pigmentosa 6. An important paralog of this gene is RPRM.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPRML Gene

Genomics for RPRML Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPRML Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPRML on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPRML

Top Transcription factor binding sites by QIAGEN in the RPRML gene promoter:
  • AhR
  • aMEF-2
  • AML1a
  • AREB6
  • E47
  • GATA-1
  • Hand1
  • MEF-2
  • MEF-2A
  • Pax-5

Genomic Locations for RPRML Gene

Latest Assembly
chr17:46,978,156-46,979,253
(GRCh38/hg38)
Size:
1,098 bases
Orientation:
Minus strand

Previous Assembly
chr17:45,055,522-45,056,619
(GRCh37/hg19 by Entrez Gene)
Size:
1,098 bases
Orientation:
Minus strand

chr17:45,055,523-45,056,614
(GRCh37/hg19 by Ensembl)
Size:
1,092 bases
Orientation:
Minus strand

Genomic View for RPRML Gene

Genes around RPRML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPRML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPRML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRML Gene

Proteins for RPRML Gene

  • Protein details for RPRML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4K4-RPRML_HUMAN
    Recommended name:
    Reprimo-like protein
    Protein Accession:
    Q8N4K4

    Protein attributes for RPRML Gene

    Size:
    120 amino acids
    Molecular mass:
    12312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPRML Gene

Post-translational modifications for RPRML Gene

No Post-translational modifications

Other Protein References for RPRML Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPRML Gene

Domains & Families for RPRML Gene

Gene Families for RPRML Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RPRML Gene

Suggested Antigen Peptide Sequences for RPRML Gene

GenScript: Design optimal peptide antigens:
  • Reprimo-like protein (RPRML_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N4K4

UniProtKB/Swiss-Prot:

RPRML_HUMAN :
  • Belongs to the reprimo family.
Family:
  • Belongs to the reprimo family.
genes like me logo Genes that share domains with RPRML: view

Function for RPRML Gene

Phenotypes From GWAS Catalog for RPRML Gene

genes like me logo Genes that share phenotypes with RPRML: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPRML

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPRML Gene

Localization for RPRML Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRML Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPRML gene
Compartment Confidence
plasma membrane 2
peroxisome 1
nucleus 1
cytosol 1
extracellular 0
mitochondrion 0

Gene Ontology (GO) - Cellular Components for RPRML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RPRML: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RPRML Gene

Pathways & Interactions for RPRML Gene

PathCards logo

SuperPathways for RPRML Gene

No Data Available

Interacting Proteins for RPRML Gene

Gene Ontology (GO) - Biological Process for RPRML Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RPRML Gene

Drugs & Compounds for RPRML Gene

No Compound Related Data Available

Transcripts for RPRML Gene

mRNA/cDNA for RPRML Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPRML

Alternative Splicing Database (ASD) splice patterns (SP) for RPRML Gene

No ASD Table

Relevant External Links for RPRML Gene

GeneLoc Exon Structure for
RPRML

Expression for RPRML Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPRML Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRML Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x10.4), Brain - Putamen (basal ganglia) (x9.0), Brain - Caudate (basal ganglia) (x6.8), Brain - Cortex (x4.6), and Brain - Frontal Cortex (BA9) (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPRML

SOURCE GeneReport for Unigene cluster for RPRML Gene:

Hs.367999

Evidence on tissue expression from TISSUES for RPRML Gene

  • Nervous system(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with RPRML: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPRML Gene

Orthologs for RPRML Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPRML Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPRML 29 30
  • 98.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPRML 29 30
  • 92.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RPRML 29 30
  • 90.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rprml 29
  • 89.17 (n)
Mouse
(Mus musculus)
Mammalia Rprml 29 16 30
  • 88.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPRML 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RPRML 29 30
  • 72.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPRML 30
  • 64 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii rprml 29 30
  • 68.79 (n)
OneToOne
Species where no ortholog for RPRML was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RPRML Gene

ENSEMBL:
Gene Tree for RPRML (if available)
TreeFam:
Gene Tree for RPRML (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPRML: view image
Alliance of Genome Resources:
Additional Orthologs for RPRML

Paralogs for RPRML Gene

Paralogs for RPRML Gene

(1) SIMAP similar genes for RPRML Gene using alignment to 1 proteins:

  • RPRML_HUMAN
genes like me logo Genes that share paralogs with RPRML: view

Variants for RPRML Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RPRML Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RPRML Gene

Variant ID Type Subtype PubMed ID
dgv41n68 CNV loss 17160897
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
nsv1146669 OTHER inversion 26484159
nsv953917 CNV deletion 24416366

Variation tolerance for RPRML Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPRML Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPRML
Leiden Open Variation Database (LOVD)
RPRML

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPRML Gene

Disorders for RPRML Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPRML Gene - From: COP

Disorder Aliases PubMed IDs
retinitis pigmentosa 6
  • rp6
- elite association - COSMIC cancer census association via MalaCards
Search RPRML in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPRML

genes like me logo Genes that share disorders with RPRML: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPRML Gene

Publications for RPRML Gene

  1. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  2. The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer. (PMID: 33322837) Alarcón MA … Corvalán AH (International journal of molecular sciences 2020) 3
  3. The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties. (PMID: 29941787) Amigo JD … Corvalán AH (International journal of molecular sciences 2018) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for RPRML Gene

Sources for RPRML Gene