Aliases for RPRM Gene

Aliases for RPRM Gene

  • Reprimo, TP53 Dependent G2 Arrest Mediator Homolog 2 3 5
  • REPRIMO 2 2 3
  • Reprimo, TP53 Dependant G2 Arrest Mediator Candidate 2 3
  • Reprimo, TP53 Dependent G2 Arrest Mediator Candidate 2 3
  • Candidate Mediator Of The P53 Dependent G2 Arrest 2 3
  • Protein Reprimo 3 4
  • FLJ90327 2
  • RPRM 5

External Ids for RPRM Gene

Previous GeneCards Identifiers for RPRM Gene

  • GC02M154159
  • GC02M154042
  • GC02M154333
  • GC02M146220

Summaries for RPRM Gene

GeneCards Summary for RPRM Gene

RPRM (Reprimo, TP53 Dependent G2 Arrest Mediator Homolog) is a Protein Coding gene. Diseases associated with RPRM include Gastric Adenocarcinoma and Breast Cancer. Among its related pathways are DNA Damage Response. An important paralog of this gene is RPRML.

UniProtKB/Swiss-Prot Summary for RPRM Gene

  • May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPRM Gene

Genomics for RPRM Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPRM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J153476 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 610.2 +1.0 961 4 CTCF PRDM10 ZNF629 LARP7 PRDM1 ZNF143 ZIC2 PATZ1 REST RAD21 RPRM GALNT13 HSALNG0019702 ENSG00000200377 ENSG00000227400 PRPF40A
GH02J153533 Enhancer 0.3 Ensembl ENCODE 15.8 -55.4 -55429 2 piR-32559-223 piR-30444-155 piR-37567-095 RPRM piR-48576 ENSG00000227400 GALNT13
GH02J153431 Enhancer 0.4 Ensembl 11 +46.6 46561 1.6 ZNF316 MAFK ZNF24 MAFF ENSG00000227400 RPRM piR-38580-171 TUBAP13 PRPF40A
GH02J153531 Enhancer 0.2 Ensembl 15.5 -53.4 -53439 0.8 RPRM piR-32559-223 piR-48576 ENSG00000227400 GALNT13
GH02J153442 Enhancer 0.2 Ensembl 11.3 +36.0 35961 0.4 piR-38580-171 RPRM TUBAP13 ENSG00000227400 PRPF40A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPRM on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPRM

Top Transcription factor binding sites by QIAGEN in the RPRM gene promoter:
  • E47
  • Hand1
  • IRF-2
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1beta
  • STAT2

Genomic Locations for RPRM Gene

Genomic Locations for RPRM Gene
chr2:153,477,338-153,478,762
(GRCh38/hg38)
Size:
1,425 bases
Orientation:
Minus strand
chr2:154,333,852-154,335,322
(GRCh37/hg19)
Size:
1,471 bases
Orientation:
Minus strand

Genomic View for RPRM Gene

Genes around RPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRM Gene

Proteins for RPRM Gene

  • Protein details for RPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS64-RPRM_HUMAN
    Recommended name:
    Protein reprimo
    Protein Accession:
    Q9NS64
    Secondary Accessions:
    • B2R4V1

    Protein attributes for RPRM Gene

    Size:
    109 amino acids
    Molecular mass:
    11774 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • 'Reprimo' signifies stop/repress.

neXtProt entry for RPRM Gene

Post-translational modifications for RPRM Gene

  • Glycosylation at Asn7 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for RPRM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPRM Gene

Domains & Families for RPRM Gene

Gene Families for RPRM Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RPRM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPRM Gene

GenScript: Design optimal peptide antigens:
  • Protein reprimo (RPRM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NS64

UniProtKB/Swiss-Prot:

RPRM_HUMAN :
  • Belongs to the reprimo family.
Family:
  • Belongs to the reprimo family.
genes like me logo Genes that share domains with RPRM: view

Function for RPRM Gene

Molecular function for RPRM Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
UniProtKB/Swiss-Prot Induction:
By p53/TP53, following X-ray irradiation.

Phenotypes From GWAS Catalog for RPRM Gene

Gene Ontology (GO) - Molecular Function for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPRM: view
genes like me logo Genes that share phenotypes with RPRM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPRM

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPRM

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPRM Gene

Localization for RPRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRM Gene

Cytoplasm. Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPRM gene
Compartment Confidence
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RPRM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RPRM Gene

Pathways & Interactions for RPRM Gene

PathCards logo

SuperPathways for RPRM Gene

SuperPathway Contained pathways
1 DNA Damage Response
genes like me logo Genes that share pathways with RPRM: view

Pathways by source for RPRM Gene

1 KEGG pathway for RPRM Gene

Gene Ontology (GO) - Biological Process for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS,IEA --
GO:0007346 regulation of mitotic cell cycle IBA 21873635
genes like me logo Genes that share ontologies with RPRM: view

No data available for SIGNOR curated interactions for RPRM Gene

Drugs & Compounds for RPRM Gene

No Compound Related Data Available

Transcripts for RPRM Gene

mRNA/cDNA for RPRM Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPRM

Alternative Splicing Database (ASD) splice patterns (SP) for RPRM Gene

No ASD Table

Relevant External Links for RPRM Gene

GeneLoc Exon Structure for
RPRM

Expression for RPRM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPRM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRM Gene

This gene is overexpressed in Uterus (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPRM

SOURCE GeneReport for Unigene cluster for RPRM Gene:

Hs.100890

Evidence on tissue expression from TISSUES for RPRM Gene

  • Lung(4.2)
  • Nervous system(2.6)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RPRM: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPRM Gene

Orthologs for RPRM Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPRM Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPRM 30 31
  • 99.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RPRM 30 31
  • 94.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rprm 30
  • 90.83 (n)
Mouse
(Mus musculus)
Mammalia Rprm 30 17 31
  • 90.52 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPRM 31
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26514 30
Zebrafish
(Danio rerio)
Actinopterygii rprma 30 31
  • 72.82 (n)
OneToMany
rprmb 31
  • 70 (a)
OneToMany
zgc73361 30
Species where no ortholog for RPRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RPRM Gene

ENSEMBL:
Gene Tree for RPRM (if available)
TreeFam:
Gene Tree for RPRM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPRM: view image

Paralogs for RPRM Gene

Paralogs for RPRM Gene

(1) SIMAP similar genes for RPRM Gene using alignment to 1 proteins:

  • RPRM_HUMAN
genes like me logo Genes that share paralogs with RPRM: view

Variants for RPRM Gene

Additional dbSNP identifiers (rs#s) for RPRM Gene

Structural Variations from Database of Genomic Variants (DGV) for RPRM Gene

Variant ID Type Subtype PubMed ID
esv3592922 CNV loss 21293372
nsv7331 OTHER inversion 18451855

Variation tolerance for RPRM Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPRM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPRM Gene

Disorders for RPRM Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPRM Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric adenocarcinoma
  • adenocarcinoma of stomach
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search RPRM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPRM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RPRM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPRM Gene

Publications for RPRM Gene

  1. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. (PMID: 10930422) Ohki R … Taniguchi T (The Journal of biological chemistry 2000) 2 3 4
  2. Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study. (PMID: 18197409) Beasley WD … Parry JM (International journal of colorectal disease 2008) 3 41
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Effect of Reprimo Down-regulation on Malignant Transformation of Intraductal Papillary Mucinous Neoplasm. (PMID: 29401170) Nakazato T … Sugiyama M (Pancreas 2018) 3

Products for RPRM Gene

  • Signalway ELISA kits for RPRM
  • Signalway Proteins for RPRM

Sources for RPRM Gene