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Aliases for RPRM Gene

Aliases for RPRM Gene

  • Reprimo, TP53 Dependent G2 Arrest Mediator Homolog 2 3 5
  • Reprimo, TP53 Dependant G2 Arrest Mediator Candidate 2 3
  • Reprimo, TP53 Dependent G2 Arrest Mediator Candidate 2 3
  • Candidate Mediator Of The P53 Dependent G2 Arrest 2 3
  • REPRIMO 2 3
  • Protein Reprimo 3

External Ids for RPRM Gene

Previous GeneCards Identifiers for RPRM Gene

  • GC02M154159
  • GC02M154042
  • GC02M154333
  • GC02M146220

Summaries for RPRM Gene

GeneCards Summary for RPRM Gene

RPRM (Reprimo, TP53 Dependent G2 Arrest Mediator Homolog) is a Protein Coding gene. Among its related pathways are DNA Damage Response. An important paralog of this gene is RPRML.

UniProtKB/Swiss-Prot for RPRM Gene

  • May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).

Additional gene information for RPRM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRM Gene

Genomics for RPRM Gene

GeneHancer (GH) Regulatory Elements for RPRM Gene

Promoters and enhancers for RPRM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I153476 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 557.3 +0.9 944 2.7 SIN3A FEZF1 ZNF2 ZNF48 GLIS2 ZNF143 KLF7 ZHX2 REST GLIS1 RPRM ENSG00000200377 GC02M153447 ENSG00000227400
GH02I153479 Enhancer 0.6 FANTOM5 552.1 -0.7 -738 0.2 ZNF335 STAT1 PKNOX1 MAZ ZNF366 ZNF223 DPF2 RPRM GALNT13 PIR41575 ENSG00000227400
GH02I153533 Enhancer 0.2 ENCODE 15.8 -55.8 -55782 1.2 RPRM PIR41575 GC02P153569 ENSG00000227400
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPRM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPRM gene promoter:

Genomic Locations for RPRM Gene

Genomic Locations for RPRM Gene
chr2:153,477,338-153,478,808
(GRCh38/hg38)
Size:
1,471 bases
Orientation:
Minus strand
chr2:154,333,852-154,335,322
(GRCh37/hg19)

Genomic View for RPRM Gene

Genes around RPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRM Gene

Proteins for RPRM Gene

  • Protein details for RPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS64-RPRM_HUMAN
    Recommended name:
    Protein reprimo
    Protein Accession:
    Q9NS64
    Secondary Accessions:
    • B2R4V1

    Protein attributes for RPRM Gene

    Size:
    109 amino acids
    Molecular mass:
    11774 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Reprimo signifies stop/repress.

neXtProt entry for RPRM Gene

Post-translational modifications for RPRM Gene

  • Glycosylation at posLast=77 and isoforms=18

Other Protein References for RPRM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPRM Gene

Domains & Families for RPRM Gene

Gene Families for RPRM Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RPRM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPRM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS64

UniProtKB/Swiss-Prot:

RPRM_HUMAN :
  • Belongs to the reprimo family.
Family:
  • Belongs to the reprimo family.
genes like me logo Genes that share domains with RPRM: view

Function for RPRM Gene

Molecular function for RPRM Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
UniProtKB/Swiss-Prot Induction:
By p53/TP53, following X-ray irradiation.

Phenotypes From GWAS Catalog for RPRM Gene

Gene Ontology (GO) - Molecular Function for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPRM: view
genes like me logo Genes that share phenotypes with RPRM: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPRM Gene

Localization for RPRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRM Gene

Cytoplasm. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPRM gene
Compartment Confidence
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RPRM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RPRM Gene

Pathways & Interactions for RPRM Gene

SuperPathway Contained pathways
1 DNA Damage Response
genes like me logo Genes that share pathways with RPRM: view

Pathways by source for RPRM Gene

1 KEGG pathway for RPRM Gene

Gene Ontology (GO) - Biological Process for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS,IEA --
GO:0007346 regulation of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with RPRM: view

No data available for SIGNOR curated interactions for RPRM Gene

Drugs & Compounds for RPRM Gene

No Compound Related Data Available

Transcripts for RPRM Gene

mRNA/cDNA for RPRM Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPRM Gene

Reprimo, TP53 dependent G2 arrest mediator candidate:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPRM Gene

No ASD Table

Relevant External Links for RPRM Gene

GeneLoc Exon Structure for
RPRM
ECgene alternative splicing isoforms for
RPRM

Expression for RPRM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPRM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRM Gene

This gene is overexpressed in Uterus (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of RPRM Gene:

RPRM

SOURCE GeneReport for Unigene cluster for RPRM Gene:

Hs.100890

Evidence on tissue expression from TISSUES for RPRM Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with RPRM: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPRM Gene

Orthologs for RPRM Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPRM 33 34
  • 99.08 (n)
cow
(Bos Taurus)
Mammalia RPRM 33 34
  • 94.19 (n)
rat
(Rattus norvegicus)
Mammalia Rprm 33
  • 90.83 (n)
mouse
(Mus musculus)
Mammalia Rprm 33 16 34
  • 90.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPRM 34
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26514 33
zebrafish
(Danio rerio)
Actinopterygii rprma 33 34
  • 72.82 (n)
rprmb 34
  • 70 (a)
OneToMany
zgc73361 33
Species where no ortholog for RPRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPRM Gene

ENSEMBL:
Gene Tree for RPRM (if available)
TreeFam:
Gene Tree for RPRM (if available)

Paralogs for RPRM Gene

Paralogs for RPRM Gene

(1) SIMAP similar genes for RPRM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPRM: view

Variants for RPRM Gene

Sequence variations from dbSNP and Humsavar for RPRM Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000435194 -- 153,477,237(-) C/G/T downstream_transcript_variant
rs1000527137 -- 153,480,501(-) C/T upstream_transcript_variant
rs1003023147 -- 153,478,700(-) A/C 5_prime_UTR_variant
rs1004359758 -- 153,479,670(-) C/T upstream_transcript_variant
rs1004433347 -- 153,479,424(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPRM Gene

Variant ID Type Subtype PubMed ID
nsv7331 OTHER inversion 18451855
esv3592922 CNV loss 21293372

Variation tolerance for RPRM Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPRM Gene

Disorders for RPRM Gene

Additional Disease Information for RPRM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RPRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPRM Gene

Publications for RPRM Gene

  1. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. (PMID: 10930422) Ohki R … Taniguchi T (The Journal of biological chemistry 2000) 2 3 4 58
  2. Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study. (PMID: 18197409) Beasley WD … Parry JM (International journal of colorectal disease 2008) 3 44 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Reprimo tissue-specific expression pattern is conserved between zebrafish and human. (PMID: 28562620) Figueroa RJ … Amigo JD (PloS one 2017) 3 58
  5. Methylation-Sensitive Melt Curve Analysis of the Reprimo Gene Methylation in Gastric Cancer. (PMID: 27992600) Wang H … Chen Q (PloS one 2016) 3 58

Products for RPRM Gene

Sources for RPRM Gene

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