Aliases for RPRD1A Gene
External Ids for RPRD1A Gene
Previous GeneCards Identifiers for RPRD1A Gene
This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]
GeneCards Summary for RPRD1A Gene
RPRD1A (Regulation Of Nuclear Pre-MRNA Domain Containing 1A) is a Protein Coding gene. Diseases associated with RPRD1A include Retroperitoneal Leiomyosarcoma and Retroperitoneal Sarcoma. Among its related pathways are Gene Expression and HIV Transcription Elongation. An important paralog of this gene is RPRD1B.
UniProtKB/Swiss-Prot Summary for RPRD1A Gene
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.